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Fungal keratitis caused by Colletotrichum spp. A presentation of case
Queratitis fúngica por Colletotrichum spp. A propósito de un caso
M. Morcillo Guardiola
Corresponding author
nellymed03@hotmail.com

Corresponding author.
, N. Hurtado Montalbán, J.A. Martínez Morales, M.P. Villegas Pérez, J. Miralles de Imperal Mora Figueroa
Servicio de Oftalmologia, Hospital General Universitario Reina Sofía, Murcia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The cornea can be affected by any species of fungus&#46; Over 100 fungi have been identified as causing fungal keratitis &#40;FK&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> This disease is more frequent in tropical countries but is rare in cool and cold climates&#44; even though in recent years FK has increased due to technical diagnostic developments as well as increased incidence&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The risk factors for FK are diverse<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#58; chronic ocular surface disease&#44; contact lenses&#44; atopical disease&#44; use of topical steroids&#44; corneal surgery and diabetes mellitus among others&#44; although in most cases ocular trauma is a part of the patient history&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The main pathogens causing FK are yeasts such as <span class="elsevierStyleItalic">Candida</span><a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> and filamented septated non-pigmented fungii such as <span class="elsevierStyleItalic">Fusarium</span> and <span class="elsevierStyleItalic">Aspergillus</span>&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The authors present an FK case caused by an unusual fungal species in ophthalmology such as <span class="elsevierStyleItalic">Colletotrichum</span> spp&#46; P<span class="elsevierStyleItalic">olletotrichum</span> is a filamented septated and pigmented fungi&#44; which parasites subtropical and tropical plants and is difficult to identify with culturing&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> It can be observed under microscope with its characteristic canoe-shaped form&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Clinical case</span><p id="par0025" class="elsevierStylePara elsevierViewall">Male&#44; 23&#44; without relevant personal history who visited the emergency section due to right eye &#40;RE&#41; traumatism caused by a lemon tree branch 48<span class="elsevierStyleHsp" style=""></span>h earlier&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Ophthalmological examination revealed visual acuity of one in both eyes&#46; RE biomicroscopy showed moderate conjunctival hyperemia and upper temporal corneal erosion with whitish and arborescent stromal infiltrate&#44; the central area of which stained under fluorescein&#46; The anterior chamber exhibited a Tyndall of &#43;&#47;&#43;&#43; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Corneal sample was taken for culturing and Gram staining&#44; while establishing treatment with broad spectrum and reinforced antibiotics&#58; vancomycin 25<span class="elsevierStyleHsp" style=""></span>mg&#47;ml and ceftazidime 50<span class="elsevierStyleHsp" style=""></span>mg&#47;ml&#44; alternating every hour&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The following day&#44; the Gram staining showed the pathogen organism as gram-positive&#46; Agar Sabouraud culture exhibited fungi growth after 72<span class="elsevierStyleHsp" style=""></span>h&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">With said results at hand&#44; topical treatment was established with amphotericin B at a concentration of 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;ml every 4<span class="elsevierStyleHsp" style=""></span>h without respecting sleep&#44; as well as tobramycin every 3<span class="elsevierStyleHsp" style=""></span>h&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">One week after obtaining the sample and having the confirmation of fungal keratitis&#44; our laboratory sent the sample to the National Microbiology Center &#40;Carlos III Health Institute in Majadahonda&#41;&#44; which returned the results of minimum inhibiting concentrations determination&#58; 5-fluorocytosine &#40;128<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;ml&#41;&#44; amphotericin B &#40;0&#46;5<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;ml&#41; and itraconazole &#40;1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;ml&#41;&#46; Upon exhibiting sensitivity to amphotericin B&#44; the same treatment pattern was maintained&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Three weeks later&#44; biomicroscopy revealed slight conjunctival hyperemia with increasingly transparent and smaller corneal infiltrates&#46; Due to this positive evolution&#44; amphotericin B was reduced to one drop every 6<span class="elsevierStyleHsp" style=""></span>h&#44; respecting sleep&#44; and progressively reducing the treatment in the course of 6 more weeks up to suspension&#46; Slit lamp exploration revealed upper temporal corneal leukoma&#44; a vestige of the former disorder &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figs&#46; 3 and 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Three months after disorder onset&#44; the pathogen was identified as <span class="elsevierStyleItalic">Colletotrichum</span> spp&#46; by the Carlos III Health Institute&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Discussion</span><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Colletotrichum</span> is an infrequent cause of FK&#46; Out of 125 FK cases diagnosed in the Bascom Palmer Institute in Florida in 1994&#44; only one case &#40;0&#46;8&#37;&#41; was found to be caused by <span class="elsevierStyleItalic">Colletotrichum atramentum</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Subsequently&#44; another review covering the period from January 1990 to February 2001<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> in the same institution identified 10 cases of <span class="elsevierStyleItalic">Colletotrichum</span> &#40;2&#46;8&#37;&#41; out of 360 positive cultures for fungi&#44; isolating <span class="elsevierStyleItalic">Gloeosporioides</span> and <span class="elsevierStyleItalic">Dematium</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">FK caused by filamented fungi such as <span class="elsevierStyleItalic">Colletotrichum</span> are more frequent in tropical regions<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and in most cases affected normal eyes after corneal abrasion caused by some type of vegetal substance<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46; These keratitis are generally central or paracentral with irregular&#44; seesaw or arborescent edges accompanied by anterior stromal infiltrate&#46; Occasionally&#44; brown pigmentation appears in the ulcer substrate&#46; The evolution of keratitis caused by <span class="elsevierStyleItalic">Colletotrichum</span> is slowly progressive in comparison with <span class="elsevierStyleItalic">Aspergillus</span> and <span class="elsevierStyleItalic">Fusarium</span>&#46; For its identification by culturing&#44; the most frequently used media are Saboraud dextrose agar &#40;SDA&#41;&#44; potato dextrose agar &#40;PDA&#41; and moderate yeast agar&#44; and the optimum growth temperature is of 25<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; characterized by the formation of conidia with appressorium and acervulum with mushrooms&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The cases reported herein represents the first reported positive culturing of <span class="elsevierStyleItalic">Colletotrichum</span> in our country&#46; Even though our patient evolved positively with antifungal pharmacological treatments&#44; in a high percentage of cases FK exhibits torpid evolution affecting visual acuity&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;5</span></a> Accordingly&#44; early identification and immediate treatment is crucial for avoiding complications such as corneal perforation<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and endophthalmitis<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> which would require surgical intervention&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3&#44;5</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Despite the absence of consensus regarding the pharmacological treatment of FK&#44; it has been determined in vitro<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> that <span class="elsevierStyleItalic">Colletotrichum</span> has greater sensitivity to clotrimazole followed by miconazole&#44; lactones and amphotericin B&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> As in this case&#44; other authors<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> have found that <span class="elsevierStyleItalic">Colletotrichum</span> is mainly sensitive to amphotericin B and also responds to natamycin&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Even though <span class="elsevierStyleItalic">Colletotrichum</span> continues to be a rare cause of FK&#44; the authors believe that due to its potential severity it must be included in differential diagnostic for fungal corneal infections&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflict of interests</span><p id="par0090" class="elsevierStylePara elsevierViewall">No conflict of interests has been declared by the authors&#46;</p></span></span>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Case report</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A 23-year-old male with an unremarkable past medical history suffered an injury in the right eye two days prior to presentation due to a freak accident with a branch of a lemon tree&#46; The slit-lamp examination showed a central corneal erosion with a white tree-shaped stromal infiltrate and Tyndall &#43;&#47;&#43;&#43; in anterior chamber&#46; Cultivation of corneal scraping was positive for <span class="elsevierStyleItalic">Colletotrichum</span> spp&#46; The patient responded favorably to topical amphotericin&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Colletotrichum</span> spp&#46; is an uncommon cause of keratitis&#44; usually secondary to corneal erosion caused by plant material and should be included in the differential diagnosis of fungal keratitis&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0025">Caso clinico</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Paciente var&#243;n de 23 a&#241;os sin antecedentes personales de inter&#233;s que acude por traumatismo con rama de limonero en ojo derecho hac&#237;a dos d&#237;as&#46; En la biomicroscop&#237;a se observaba una erosi&#243;n corneal central&#44; un infiltrado estromal arboriforme blanquecino y un tyndall &#43;&#47;&#43;&#43;&#46; El cultivo de raspado corneal fue positivo para <span class="elsevierStyleItalic">Colletotrichum</span> spp&#46; El paciente respondi&#243; favorablemente a la anfotericina t&#243;pica&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Discusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Colletotrichum</span> spp&#46; constituye una causa infrecuente de queratitis&#44; secundaria generalmente a erosiones ocasionadas por productos de origen vegetal y debe ser incluido en el diagn&#243;stico diferencial de las queratitis f&#250;ngicas&#46;</p>"
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Article information
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