metricas
covid
Buscar en
Archivos de la Sociedad Española de Oftalmología (English Edition)
Toda la web
Inicio Archivos de la Sociedad Española de Oftalmología (English Edition) Choroidal neovascularization secondary to angioid streaks: A familial case repor...
Journal Information

Statistics

Follow this link to access the full text of the article

Short communication
Choroidal neovascularization secondary to angioid streaks: A familial case report
Neovascularización coroidea secundaria a estrías angioides: un caso familiar
J. Benitez-Herreros
Corresponding author
jbenitezherreros@hotmail.com

Corresponding author.
, C. Camara-Gonzalez, L. Lopez-Guajardo, C. Beckford-Torngren, J. Pareja-Esteban
Servicio de Oftalmología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain
Read
1365
Times
was read the article
264
Total PDF
1101
Total HTML
Share statistics
 array:24 [
  "pii" => "S2173579414001091"
  "issn" => "21735794"
  "doi" => "10.1016/j.oftale.2014.07.003"
  "estado" => "S300"
  "fechaPublicacion" => "2014-05-01"
  "aid" => "457"
  "copyright" => "Sociedad Española de Oftalmología"
  "copyrightAnyo" => "2012"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Soc Esp Oftalmol. 2014;89:190-3"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1371
    "formatos" => array:3 [
      "EPUB" => 13
      "HTML" => 1096
      "PDF" => 262
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0365669112005369"
      "issn" => "03656691"
      "doi" => "10.1016/j.oftal.2012.11.005"
      "estado" => "S300"
      "fechaPublicacion" => "2014-05-01"
      "aid" => "457"
      "copyright" => "Sociedad Española de Oftalmología"
      "documento" => "article"
      "crossmark" => 0
      "subdocumento" => "fla"
      "cita" => "Arch Soc Esp Oftalmol. 2014;89:190-3"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 1617
        "formatos" => array:3 [
          "EPUB" => 11
          "HTML" => 1298
          "PDF" => 308
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Comunicaci&#243;n corta</span>"
        "titulo" => "Neovascularizaci&#243;n coroidea secundaria a estr&#237;as angioides&#58; un caso familiar"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "190"
            "paginaFinal" => "193"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Choroidal neovascularization secondary to angioid streaks&#58; A familial case report"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0015"
            "etiqueta" => "Figura 3"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr3.jpeg"
                "Alto" => 754
                "Ancho" => 1794
                "Tamanyo" => 245214
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Caso 1&#44; ojo derecho&#58; A&#41; retinograf&#237;a pretratamiento&#58; atrofia coriorretiniana macular OD y hemorragias extrafoveales&#46; B&#41; AFG pretratamiento&#58; &#225;reas de atrofia macular&#44; hiperfluorescencia a nivel de las EA y foco extrafoveal que fuga contraste en tiempos tard&#237;os&#46; C&#41; OCT pretratamiento&#58; Depresi&#243;n foveal conservada&#46; Ausencia de l&#237;quido intrarretiniano&#46; D&#41; AFG postratamiento&#58; &#225;reas de atrofia macular e hiperfluorescencia a nivel de las EA&#59; no se observa fuga de contraste que sugiera MNVC activa&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46; Benitez-Herreros, C&#46; Camara-Gonzalez, L&#46; Lopez-Guajardo, C&#46; Beckford-Torngren, J&#46; Pareja-Esteban"
            "autores" => array:5 [
              0 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Benitez-Herreros"
              ]
              1 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Camara-Gonzalez"
              ]
              2 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Lopez-Guajardo"
              ]
              3 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Beckford-Torngren"
              ]
              4 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Pareja-Esteban"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173579414001091"
          "doi" => "10.1016/j.oftale.2014.07.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173579414001091?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365669112005369?idApp=UINPBA00004N"
      "url" => "/03656691/0000008900000005/v2_201405240439/S0365669112005369/v2_201405240439/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S217357941400108X"
    "issn" => "21735794"
    "doi" => "10.1016/j.oftale.2014.07.002"
    "estado" => "S300"
    "fechaPublicacion" => "2014-05-01"
    "aid" => "456"
    "copyright" => "Sociedad Espa&#241;ola de Oftalmolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Soc Esp Oftalmol. 2014;89:194-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1989
      "formatos" => array:3 [
        "EPUB" => 11
        "HTML" => 1739
        "PDF" => 239
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Short communication</span>"
      "titulo" => "Multiple retinal pigment epithelial detachments&#58; A case report"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "194"
          "paginaFinal" => "198"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "M&#250;ltiples desprendimientos de epitelio pigmentario idiop&#225;tico&#58; a prop&#243;sito de un caso"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Fig&#46; 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 1078
              "Ancho" => 1600
              "Tamanyo" => 221270
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">&#40;A and B&#41; FA in early times&#44; showing well defined hyperfluorescent rounded lesions distributed throughout the posterior pole&#46; &#40;C and D&#41; FA in later times&#44; where the lesions maintain form and size&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46;B&#46; Gonz&#225;lez-Escobar, J&#46;L&#46; Gonz&#225;lez de Gor-Crooke, M&#46;A&#46; L&#243;pez-Egea-Bueno, J&#46;M&#46; Garc&#237;a-Campos"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;B&#46;"
              "apellidos" => "Gonz&#225;lez-Escobar"
            ]
            1 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "Gonz&#225;lez de Gor-Crooke"
            ]
            2 => array:2 [
              "nombre" => "M&#46;A&#46;"
              "apellidos" => "L&#243;pez-Egea-Bueno"
            ]
            3 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Garc&#237;a-Campos"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0365669112005357"
        "doi" => "10.1016/j.oftal.2012.11.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365669112005357?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357941400108X?idApp=UINPBA00004N"
    "url" => "/21735794/0000008900000005/v1_201409070245/S217357941400108X/v1_201409070245/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S217357941400111X"
    "issn" => "21735794"
    "doi" => "10.1016/j.oftale.2014.07.005"
    "estado" => "S300"
    "fechaPublicacion" => "2014-05-01"
    "aid" => "460"
    "copyright" => "Sociedad Espa&#241;ola de Oftalmolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Soc Esp Oftalmol. 2014;89:186-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1975
      "formatos" => array:3 [
        "EPUB" => 11
        "HTML" => 1662
        "PDF" => 302
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Short communication</span>"
      "titulo" => "Necrobiotic xanthogranuloma&#46; Differential diagnosis&#44; treatment and systemic involvement&#46; Case report"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "186"
          "paginaFinal" => "189"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Xantogranuloma necrobi&#243;tico&#46; Diagn&#243;stico diferencial&#44; tratamiento e implicaciones sist&#233;micas&#46; A prop&#243;sito de un caso"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Fig&#46; 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 974
              "Ancho" => 1000
              "Tamanyo" => 100347
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Bilateral tumors with soft tissue consistency involved in the anterior portion of the orbit&#44; without surrounding fatty and muscular inflammation&#46; &#40;a&#41; Axial T2&#59; &#40;b&#41; sagittal T1 image&#59; &#40;c&#41; coronal STIR&#59; &#40;d&#41; coronal image with gadolinium&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "E&#46; Sanz-Marco, E&#46; Espa&#241;a, M&#46;J&#46; L&#243;pez-Prats, M&#46; Chirivella-Casanova, J&#46; Avi&#241;o, M&#46; D&#237;az-Llopis"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Sanz-Marco"
            ]
            1 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Espa&#241;a"
            ]
            2 => array:2 [
              "nombre" => "M&#46;J&#46;"
              "apellidos" => "L&#243;pez-Prats"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Chirivella-Casanova"
            ]
            4 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Avi&#241;o"
            ]
            5 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "D&#237;az-Llopis"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0365669112005394"
        "doi" => "10.1016/j.oftal.2012.11.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365669112005394?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357941400111X?idApp=UINPBA00004N"
    "url" => "/21735794/0000008900000005/v1_201409070245/S217357941400111X/v1_201409070245/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Short communication</span>"
    "titulo" => "Choroidal neovascularization secondary to angioid streaks&#58; A familial case report"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "190"
        "paginaFinal" => "193"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46; Benitez-Herreros, C&#46; Camara-Gonzalez, L&#46; Lopez-Guajardo, C&#46; Beckford-Torngren, J&#46; Pareja-Esteban"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "J&#46;"
            "apellidos" => "Benitez-Herreros"
            "email" => array:1 [
              0 => "jbenitezherreros&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "C&#46;"
            "apellidos" => "Camara-Gonzalez"
          ]
          2 => array:2 [
            "nombre" => "L&#46;"
            "apellidos" => "Lopez-Guajardo"
          ]
          3 => array:2 [
            "nombre" => "C&#46;"
            "apellidos" => "Beckford-Torngren"
          ]
          4 => array:2 [
            "nombre" => "J&#46;"
            "apellidos" => "Pareja-Esteban"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servicio de Oftalmolog&#237;a&#44; Hospital Universitario Pr&#237;ncipe de Asturias&#44; Alcal&#225; de Henares&#44; Madrid&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Neovascularizaci&#243;n coroidea secundaria a estr&#237;as angioides&#58; un caso familiar"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1130
            "Ancho" => 1600
            "Tamanyo" => 413381
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Case 1&#44; left eye&#58; &#40;A&#41; retinograph&#58; subfoveal CNVM image in LE&#46; &#40;B&#41; FA&#58; hyperfluorescence at AS level&#44; in addition to subfoveal leak in late times&#46; &#40;C&#41; OCT&#58; intraretinal liquid in the form of micro-cysts and neurosensory retina detachment&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Angioid streaks &#40;AS&#41; are a dehiscence of the Bruch membrane which irradiate from the papilla&#44; the main complication being the development of choroidal neovascular membranes &#40;CNVM&#41;&#46; AS could be associated to systemic diseases&#44; although the most frequently associated disease of AS is pseudoxanthoma elasticum &#40;PXE&#41;&#44; an autosomic recessive disease caused by the mutation of gene ABCC6&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Other diseases which AS could associate include the Ehlers-Darlos syndrome&#44; of dominant autosomic inheritance&#44; Paget&#39;s disease &#40;of unknown origin&#41; and sickle cell anemia of recessive autosomic inheritance&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Clinical cases</span><p id="par0010" class="elsevierStylePara elsevierViewall">Two siblings with AS and PXE who developed CNVM in 3 out of 4 eyes&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Case 1</span><p id="par0015" class="elsevierStylePara elsevierViewall">Female&#44; 51 years&#44; who referred metamorphopsiae in left eye &#40;LE&#41;&#46; Visual acuity &#40;VA&#41; was of 20&#47;20 in both eyes &#40;BE&#41;&#46; Left ocular fundus &#40;OF&#41; exhibited extrafoveal hemorrhages and hard drusen above the superior temporal arch&#44; while angiofluorograph &#40;FA&#41; revealed extrafoveal hyperfluorescent area corresponding to CNVM&#44; and macular optic coherence tomography &#40;OCT&#41; showed absence of intraretinal liquid &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The therapeutic options were explained to the patient&#44; who decided to maintain an expectant attitude&#46; Nine months later&#44; when the condition progressed and affected the foveal area &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; and VA diminished to 20&#47;200&#44; she accepted treatment with ranibizumab &#40;Lucentis<span class="elsevierStyleSup">&#174;</span>&#59; Genentech&#44; Inc&#46;&#44; South San Francisco&#44; CA&#44; USA&#41;&#46; After one injection per month during 3 months&#44; LE VA remained at 20&#47;200 and FA revealed inactivity in the lesion&#46; Six months later&#44; LE remained stable but metamorphopsiae began to appear in the right eye &#40;RE&#41;&#46; VA was 20&#47;20&#46; OF exhibited extrafoveal hemorrhages which&#44; under FA&#44; corresponded to CNVM&#44; while OCT revealed absence of intraretinal liquid &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#8211;C&#41;&#46; On this occasion&#44; the patient accepted treatment with ranibizumab&#46; After 3 injections&#44; VA continued at 20&#47;20&#44; metamorphopsiae had disappeared and FA exhibited no activity &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>D&#41;&#46; Thirty months later&#44; the condition remained stable in BE&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Case 2</span><p id="par0020" class="elsevierStylePara elsevierViewall">Male&#44; 57 years&#44; brother of the Case 1 patient&#44; referred metamorphopsiae in LE and finger-counting VA at 1<span class="elsevierStyleHsp" style=""></span>m in LE&#46; OF exhibited intense chorioretinal atrophy and sub- and extrafoveal hemorrhages with absence of drusen&#44; while FA revealed sub- and extrafoveal hyperfluorescent sites and OCT revealed the presence of intraretinal fluid &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>A&#8211;C&#41;&#46; Three ranibizumab injections were prescribed after which metamorphopsiae disappeared&#44; VA remained stable and both FA and OCT showed neovascular inactivity &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>D&#8211;E&#41;&#46; The patient remained stable during the 18-month follow-up&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">The main complication of AS is the development of CNVM&#46; Photodynamic therapy&#44; transpupilar thermal therapy and surgery have not obtained good results in the treatment of said CNVM&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In recent years&#44; the injection of anti-VEGF drugs has become the predominant treatment&#46; The use of bevacizumab seems to be effective<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> even though there are very few published reports on the use of ranibizumab or pegaptanib&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The age of the 2 siblings with PXE and AS who developed CNVM was within the range in which CNVM develops in AS&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;4&#44;5</span></a> but an earlier age in which neovascularization appears in ARMD&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In addition to AS&#44; the examination revealed macular RPE atrophy and some drusen&#46; In this regard&#44; other authors have described the presence of broad chorioretinal atrophy areas and drusen in patients with AS&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;7&#8211;9</span></a> Treatment with 3 ranibizumab injections stabilized the situation of the 3 eyes&#44; deactivating neovascular lesions and maintaining previous VA&#46; In addition&#44; during the follow-up the condition did not reactivate&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The results in this case are similar to those obtained by Lazaros<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and Gonz&#225;lez-G&#243;mez&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> who prescribed a charge dose of 3 ranibizumab injections in smaller series of patients with AS and CNVM&#59; the lesions were resolved and remained inactive during the follow-up of both studies &#40;27 and 12 months&#44; respectively&#41;&#59; none of the cases exhibited worsened VA&#46; Mimoun<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> treated 35 eyes affected by AS and CNVM with a dose of ranibizumab&#44; re-injecting the drug if the lesion became active&#46; The average amount of injections was higher than in the present case &#40;5&#46;7 injections&#44; 24 months follow-up&#41;&#46; However&#44; the 3 injections of this study are within the range of injections applied by said author &#40;2&#8211;14&#41;&#46; Other authors<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a> opted for one monthly injection of ranibizumab during one year &#40;12 injections&#41; in a series of eyes with AS and CNVM&#46; However&#44; their visual results did not improve those obtained in the studies in which&#44; after an initial pattern of one or 3 injections&#44; only one case of CNVM activity was reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#44;10</span></a> Accordingly&#44; in order to optimize the number of injections it seems beneficial to repeat treatments with ranibizumab only in case of CNVM activity&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">As can be seen&#44; ranibizumab appears to be a useful therapeutic strategy to stabilize CNVM in AS&#46; Even so&#44; larger series are necessary to determine the true efficacy of said treatment&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflict of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:9 [
        0 => array:2 [
          "identificador" => "xres368325"
          "titulo" => array:3 [
            0 => "Abstract"
            1 => "Case report"
            2 => "Discussion"
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec347492"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "xres368326"
          "titulo" => array:3 [
            0 => "Resumen"
            1 => "Caso cl&#237;nico"
            2 => "Discusi&#243;n"
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec347491"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Clinical cases"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Case 1"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Case 2"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Conflict of interest"
        ]
        8 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2012-02-15"
    "fechaAceptado" => "2012-11-07"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec347492"
          "palabras" => array:5 [
            0 => "Angioid streaks"
            1 => "Choroidal neovascularization"
            2 => "Ranibizumab"
            3 => "Lucentis"
            4 => "Pseudoxanthoma elasticum"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec347491"
          "palabras" => array:5 [
            0 => "Estr&#237;as angioides"
            1 => "Neovascularizaci&#243;n coroidea"
            2 => "Ranibizumab"
            3 => "Lucentis"
            4 => "Pseudoxantoma el&#225;stico"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Case report</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We report a familial case of 2 siblings that suffered choroidal neovascularization &#40;CNV&#41; secondary to angioid streaks&#46; They were both treated with a monthly intravitreal injection of ranibizumab &#40;Lucentis<span class="elsevierStyleSup">&#174;</span>&#41; for 3 months&#46; Visual acuity was stabilized and fluorescein angiography revealed complete resolution of CNV&#46; Neither recurrent CNV lesion nor new hemorrhages were reported during the follow-up period&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The use of intravitreal ranibizumab for the treatment of CNV in patients with angioid streaks has shown favorable results&#46; However&#44; further studies with a longer follow-up and larger number of patients are necessary to more precisely determine the results of this therapy&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0025">Caso cl&#237;nico</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se expone el caso de dos hermanos que presentaron neovascularizaci&#243;n coroidea asociada a estr&#237;as angioides&#46; Ambos pacientes fueron tratados con una inyecci&#243;n mensual de ranibizumab &#40;Lucentis<span class="elsevierStyleSup">&#174;</span>&#41; intrav&#237;trea durante tres meses&#46; La visi&#243;n se estabiliz&#243; y la angiograf&#237;a fluoresce&#237;nica mostr&#243; resoluci&#243;n completa de la neovascularizaci&#243;n coroidea&#46; Durante el seguimiento&#44; no observamos recurrencia del cuadro&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Discusi&#243;n</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El uso de ranibizumab intrav&#237;treo en caso de neovascularizaci&#243;n coroidea asociada a estr&#237;as angioides ha mostrado resultados favorables&#46; No obstante&#44; ser&#225;n necesarias series de casos mayores que nos permitan conocer la verdadera eficacia de este tratamiento&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Benitez-Herreros J&#44; Camara-Gonzalez C&#44; Lopez-Guajardo L&#44; Beckford-Torngren C&#44; Pareja-Esteban J&#46; Neovascularizaci&#243;n coroidea secundaria a estr&#237;as angioides&#58; un caso familiar&#46; Arch Soc Esp Oftalmol&#46; 2014&#59;89&#58;190&#8211;193&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1115
            "Ancho" => 1600
            "Tamanyo" => 374449
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Case 1&#44; left eye&#58; &#40;A&#41; retinograph&#58; extrafoveal hemorrhages in LE fundus&#46; &#40;B&#41; FA&#58; hyperfluorescence at the AS level&#44; in addition to extrafoveal loci which leaks contrast in late times&#46; &#40;C&#41; OCT&#58; preserved foveal depression&#59; absence of intraretinal liquid&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1130
            "Ancho" => 1600
            "Tamanyo" => 413381
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Case 1&#44; left eye&#58; &#40;A&#41; retinograph&#58; subfoveal CNVM image in LE&#46; &#40;B&#41; FA&#58; hyperfluorescence at AS level&#44; in addition to subfoveal leak in late times&#46; &#40;C&#41; OCT&#58; intraretinal liquid in the form of micro-cysts and neurosensory retina detachment&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Fig&#46; 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 754
            "Ancho" => 1794
            "Tamanyo" => 270143
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Case 1&#44; right eye&#58; &#40;A&#41; pretreatment retinograph&#58; RE macular chorioretinal atrophy and extrafoveal hemorrhages&#46; &#40;B&#41; Pretreatment FA&#58; macular atrophy areas&#44; hyperfluorescence at the level of AS and extrafoveal loci which leaks contrast in late times&#46; &#40;C&#41; Pretreatment OCT&#58; preserved foveal depression&#46; The absence of intraretinal fluid&#46; &#40;D&#41; Posttreatment FA&#58; macular atrophy areas and hyperfluorescence at the level of the AS&#59; contrast leak suggesting active CNVM is not observed&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Fig&#46; 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 759
            "Ancho" => 1798
            "Tamanyo" => 291288
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Case 2&#44; left eye&#58; &#40;A&#41; pretreatment retinograph&#58; intense chorioretinal atrophy&#44; subfoveal and juxtafoveal hemorrhages&#46; &#40;B&#41; Pretreatment FA&#58; macular atrophy areas&#44; hyperfluorescence at the level of AS&#44; sub- and extrafoveal loci which leak contrast in late times&#46; &#40;C&#41; Pretreatment OCT&#58; intraretinal fluid in the form of cysts&#46; &#40;D&#41; Posttreatment FA&#58; macular atrophy areas and hyperfluorescence at the level of AS&#59; contrast leak suggesting neovascular activity is not observed&#46; &#40;E&#41; Posttreatment OCT&#58; chorioretinal atrophy without accumulation of retinal fluid&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Monthly ranibizumab for choroidal neovascularizations secondary to angioid streaks in pseudoxanthoma elasticum&#58; a one-year prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;P&#46; Finger"
                            1 => "P&#46; Charbel Issa"
                            2 => "D&#46; Hendig"
                            3 => "H&#46;P&#46; Scholl"
                            4 => "F&#46;G&#46; Holz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajo.2011.03.022"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ophthalmol"
                        "fecha" => "2011"
                        "volumen" => "152"
                        "paginaInicial" => "695"
                        "paginaFinal" => "703"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21704964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intravitreal ranibizumab for choroidal neovascularization in angioid streaks"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Mimoun"
                            1 => "J&#46; Tilleul"
                            2 => "A&#46; Leys"
                            3 => "G&#46; Coscas"
                            4 => "G&#46; Soubrane"
                            5 => "E&#46;H&#46; Souied"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ajo.2010.06.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ophthalmol"
                        "fecha" => "2010"
                        "volumen" => "150"
                        "paginaInicial" => "692"
                        "paginaFinal" => "700"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20719301"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Choroidal neovascularization in angioid streaks and pseudoxanthoma elasticum&#58; 1 year follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Schiano Lomoriello"
                            1 => "M&#46;C&#46; Parravano"
                            2 => "A&#46; Chiaravalloti"
                            3 => "M&#46; Varano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Ophthalmol"
                        "fecha" => "2009"
                        "volumen" => "19"
                        "paginaInicial" => "151"
                        "paginaFinal" => "153"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19123166"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Choroidal neovascularization secondary to pseudoxanthoma elasticom treated with ranibizumab&#58; a report of 2 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Gonz&#225;lez-G&#243;mez"
                            1 => "M&#46;J&#46; Morillo"
                            2 => "A&#46;B&#46; Gonz&#225;lez-Escobar"
                            3 => "J&#46;M&#46; Garc&#237;a-Campos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.oftal.2011.06.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Soc Esp Oftalmol"
                        "fecha" => "2012"
                        "volumen" => "87"
                        "paginaInicial" => "153"
                        "paginaFinal" => "156"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22554559"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intravitreal ranibizumab for treatment of choroidal neovascularization secondary to angioid streaks in pseudoxanthoma elasticum&#58; five-year follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46; Zebardast"
                            1 => "R&#46;A&#46; Adelman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/08820538.2012.680644"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Ophthalmol"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "61"
                        "paginaFinal" => "64"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22784267"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration&#58; two-year results of the ANCHOR study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;M&#46; Brown"
                            1 => "M&#46; Michels"
                            2 => "P&#46;K&#46; Kaiser"
                            3 => "J&#46;S&#46; Heier"
                            4 => "J&#46;P&#46; Sy"
                            5 => "T&#46; Ianchulev"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ophtha.2008.10.018"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ophthalmology"
                        "fecha" => "2009"
                        "volumen" => "116"
                        "paginaInicial" => "57"
                        "paginaFinal" => "65"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19118696"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fundus autofluorescence in pseudoxanthoma elasticum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46;P&#46; Finger"
                            1 => "P&#46; Charbel Issa"
                            2 => "M&#46; Ladewig"
                            3 => "C&#46; G&#246;tting"
                            4 => "F&#46;G&#46; Holz"
                            5 => "H&#46;P&#46; Scholl"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/IAE.0b013e3181aade47"
                      "Revista" => array:6 [
                        "tituloSerie" => "Retina"
                        "fecha" => "2009"
                        "volumen" => "29"
                        "paginaInicial" => "1496"
                        "paginaFinal" => "1505"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19823106"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pseudoxanthoma elasticum&#58; clinical&#44; histologic&#44; and genetic studies&#58; a report of two sisters"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;K&#46; Kaimbo"
                            1 => "A&#46; Mutosh"
                            2 => "A&#46; Leys"
                            3 => "R&#46; Parys-van Ginderdeuren"
                            4 => "A&#46;A&#46; Bergen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Skinmed"
                        "fecha" => "2011"
                        "volumen" => "9"
                        "paginaInicial" => "119"
                        "paginaFinal" => "121"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21548520"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multimodal fundus imaging of pseudoxanthoma elasticum"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;A&#46; Zweifel"
                            1 => "Y&#46; Imamura"
                            2 => "K&#46;B&#46; Freund"
                            3 => "R&#46;F&#46; Spaide"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/IAE.0b013e3181f056ce"
                      "Revista" => array:6 [
                        "tituloSerie" => "Retina"
                        "fecha" => "2011"
                        "volumen" => "31"
                        "paginaInicial" => "482"
                        "paginaFinal" => "491"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20966826"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intravitreal ranibizumab as primary treatment neovascular membrane associated with angioid streaks"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Lazaros"
                            1 => "Z&#46; Leonidas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Ophthalmol"
                        "fecha" => "2010"
                        "volumen" => "88"
                        "paginaInicial" => "100"
                        "paginaFinal" => "101"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735794/0000008900000005/v1_201409070245/S2173579414001091/v1_201409070245/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "5812"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Short communications"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735794/0000008900000005/v1_201409070245/S2173579414001091/v1_201409070245/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173579414001091?idApp=UINPBA00004N"
]
Article information
ISSN: 21735794
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2023 March 4 2 6
2020 September 1 0 1
2018 March 2 0 2
2018 February 6 0 6
2018 January 9 1 10
2017 December 9 0 9
2017 November 10 0 10
2017 October 13 3 16
2017 September 6 2 8
2017 August 10 3 13
2017 July 8 2 10
2017 June 22 11 33
2017 May 34 0 34
2017 April 33 3 36
2017 March 34 46 80
2017 February 46 0 46
2017 January 37 0 37
2016 December 64 3 67
2016 November 43 4 47
2016 October 51 15 66
2016 September 74 6 80
2016 August 47 3 50
2016 July 27 2 29
2016 June 18 4 22
2016 May 19 11 30
2016 April 25 7 32
2016 March 35 14 49
2016 February 32 13 45
2016 January 21 12 33
2015 December 28 13 41
2015 November 15 11 26
2015 October 23 17 40
2015 September 34 5 39
2015 August 36 3 39
2015 July 43 6 49
2015 June 27 2 29
2015 May 31 3 34
2015 April 41 14 55
2015 March 23 7 30
2015 February 19 4 23
2015 January 13 3 16
2014 December 12 5 17
2014 November 14 4 18
2014 October 2 0 2
Show all

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos