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Orbital alveolar rhabdomyosarcoma masked by ethmoid sinusitis in a 25-year-old
Rabdomiosarcoma alveolar orbitario enmascarado por sinusitis etmoidal en un adulto de 25 años
E. Sanz-Marcoa,
Corresponding author
empar19@hotmail.com

Corresponding author.
, E. Españaa,b, A. Alamarc,d, J. Pérez-Rojasd,e, M.J. López-Pratsa, M. Díaz-Llopisa,f,g
a Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, Spain
b Facultad de Óptica, Universidad de Valencia, Valencia, Spain
c Servicio de Otorrinolaringología, Hospital Universitario La Fe, Valencia, Spain
d Servicio de Anatomía Patológica, Hospital Universitario La Fe, Valencia, Spain
e Departamento de Anatomía Patológica, Universidad Europea de Madrid (UEM), Madrid, Spain
f Departamento de Cirugía, Facultad de Medicina, Universidad de Valencia, Valencia, Spain
g Centro de Investigación de Enfermedades Raras (CIBERER), Valencia, Spain
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Magnetic resonance&#58; right half-moon intraorbit tumor &#40;35<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>28<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>18<span class="elsevierStyleHsp" style=""></span>mm&#41; involving ethmoidal cells with implantation on the ethmoidal wall&#44; displacing to optic nerve and internal rectus muscle&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Rhabdomyosarcoma is a small cell malign tumor with histological characteristics similar to those of striated muscles in various embryogenic stages&#46; It is the most frequent orbitary tumor in childhood&#44; with a prevalence of 5&#37; of pediatric cancer and 20&#37; of soft tissue malign tumors&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However&#44; it is infrequent in adults and the alveolar subtype expression is rare&#44; particularly in subjects over 45&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Ethmoidal sinus alveolar rhabdomyosarcoma&#44; in a 25-year-old adult&#44; was diagnosed during the drainage of a presumed ethmoidal subperiosteal abscess&#46; The literature includes one case of ethmoidal sinus alveolar rhabdomyosarcoma in adults which&#44; in contrast with the presented case&#44; exhibited typical debut with ocular proptosis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Rhabdomyosarcoma can appear in paranasal sinuses and secondarily affect the orbit&#44; presenting with banal symptomatology simulating sinusitis&#46; Early diagnosis and treatment is particularly important in these cases&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Clinical case</span><p id="par0020" class="elsevierStylePara elsevierViewall">A female&#44; 25&#44; with subacute sinusitis &#40;2 months evolution&#41; treated without improvement of symptoms visited the emergency section due to headaches and discomfort in right eye &#40;RE&#41;&#46; Examination revealed pain to palpation with slight tumefaction in right orbit and discreet 6<span class="elsevierStyleHsp" style=""></span>mm exophthalmos in RE &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; visual acuity &#40;VA&#41; 20&#47;20 in both eyes&#44; isochoric and normally reactive pupils and no diplopia&#46; Funduscopy showed RE papillary diffusion&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">An urgent CT &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; revealed the presence of subperiosteal intra-orbitary abscess in the ethmoid wall&#46; During urgent superomedial external approach through the supratarsal skin fold a solid tumor was found&#44; the biopsy of which led to the diagnosis of alveolar orbitary rhabdomyosarcoma &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Post-surgery MR &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; confirmed the presence of solid tumor in the right ethmoidal walls&#46; The findings led to defining the case as high risk in subgroup G of the European Pediatric Soft Tissue Sarcoma Study Group and subgroup <span class="elsevierStyleSmallCaps">iii</span> of the Rhabdomyosarcoma Study Group&#46; Negative extension study was carried out with chest and abdomen CT and liver echography&#46; While awaiting the extraction of ova prior to chemotherapy&#44; the rhabdomyosarcoma increased in size compromising the orbitary apex &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#44; with the appearance of ophthalmoplegia&#44; RE areactive midriasis with clear afferent pupil defect and VA reduced to perception of light&#46; Treatment was initiated with radio- and chemotherapy according to the IVADo scheme &#40;4 cycles of ifosfamide 3<span class="elsevierStyleHsp" style=""></span>g&#47;m<span class="elsevierStyleSup">2</span>&#44; vincristine 1&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span>&#44; actinomycin D 1&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span>&#44; doxorubicin 30<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The treatment achieved remission and resolution of proptosis and ophthalmoplegia&#44; with RE papillary atrophy and amaurosis which remains unchanged to this date &#40;51 months follow-up&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">There are 4 histological types of rhabdomyosarcoma&#58; pleomorphism&#44; embryonary&#44; alveolar and botryoid&#46; The distribution of subtypes varies according to series being approximately as follows&#58; 49&#37; embryonary&#44; 31&#37; alveolar&#44; 14&#37; pleomorphic and 6&#37; botryoid&#46; Other authors report different proportions in adults&#44; i&#46;e&#46;&#44; 43&#37; pleomorphic&#44; 34&#37; embryonary and 23&#37; alveolar&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The embryonary subtype exhibits a preference for infantile orbits&#44; and is most frequent in this location&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The case reported herein is an alveolar rhabdomyosarcoma with the highest incidence between 10 and 25 years of age with preference for deep soft limb tissue&#44; being infrequent in the orbit&#46; Accordingly&#44; this patient is an atypical case due to adult orbitary rhabdomyosarcoma as well as orbitary alveolar rhabdomyosarcoma&#46; On the other hand and considering the previous sinusitis symptoms&#44; onset seemed ethmoidal instead of paranasal invasion from the orbit&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">CT and MR are essential techniques for diagnosing this disease because they allow to determine location&#44; size and infiltration&#46; CT appears as a circumscribed&#44; homogeneous and isodense mass vis-&#224;-vis extraocular muscles&#46; Generally&#44; in T1 MR the tumor is isointense vis-&#224;-vis extraocular muscles and hypointense vis-&#224;-vis ocular fat&#46; In T2 MR it can be hypo-&#44; iso- or hyperintense vis-&#224;-vis orbitary structures&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The CT of this case exhibited a half-moon shaped mass with partial occupation of the ethmoidal sinus and orbitary vertex&#44; without signs of surrounding infiltration or information&#46; The image is compatible with orbitary phlegmon and rhabdomyosarcoma despite not exhibiting in CT the typical hypodensity of an abscess&#46; However&#44; previous sinusitis inclines the urgent diagnosis toward words subperiosteal phlegmon&#46; The urgent nature of the diagnosis excluded MR which would have discarded the phlegmon diagnosis and confirmed its solid mass &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Rhabdomyosarcoma is a malign tumor with a tendency to local&#44; lymphatic and hematogenous invasion&#46; In addition&#44; due to its undifferentiated nature&#44; the alveolar subtype of this case exhibits high risk of early dissemination&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The most frequent clinic of orbitary rhabdomyosarcoma is rapidly evolving proptosis&#44; diagnosed at an early stage as a space-occupying lesion of probable tumor origin&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> For this reason early detection of paranasal rhabdomyosarcoma is important&#44; as onset can be insidious and lost within a banal condition as in the case reported herein&#46; In these cases&#44; early diagnosis and treatment were crucial for the vital prognosis&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflict of interests</span><p id="par0050" class="elsevierStylePara elsevierViewall">No conflict of interests has been declared by the authors&#46;</p></span></span>"
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2010-12-12"
    "fechaAceptado" => "2012-10-30"
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          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec347481"
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            0 => "Rhabdomyosarcoma"
            1 => "Masked orbital rhabdomyosarcoma"
            2 => "Rhabdomyosarcoma alveolar"
            3 => "Apex"
            4 => "Sinusitis"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:5 [
            0 => "Rabdomiosarcoma"
            1 => "Rabdomiosarcoma orbitario enmascarado"
            2 => "Rabdomiosarcoma alveolar"
            3 => "&#193;pex"
            4 => "Sinusitis"
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Case report</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A 25-year-old woman with right subacute sinusitis complained about discomfort in her right eye&#46; Clinical manifestations and computed tomography were suggestive of sub-periosteal orbital ethmoid wall abscess&#44; for which the patient underwent urgent drainage&#46; A solid tumor was found&#44; with a positive biopsy for alveolar rhabdomyosarcoma&#46; Complete remission and resolution of orbital symptoms were achieved with chemotherapy and radiation therapy&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Alveolar orbital rhabdomyosarcoma in adults is uncommon&#46; Rhabdomyosarcoma has a high risk of spreading&#46; It can simulate a sinusitis&#44; as in our patient&#44; early diagnosis and early treatment being especially important in these patients&#46;</p>"
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      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0025">Caso cl&#237;nico</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mujer de 25 a&#241;os con sinusitis subaguda derecha acudi&#243; por molestias en ojo derecho&#46; Ante cl&#237;nica y tomograf&#237;a urgente sugestiva de absceso subperi&#243;stico orbitario etmoidal&#44; se realiz&#243; un drenaje urgente&#44; hall&#225;ndose una tumoraci&#243;n s&#243;lida con biopsia positiva para rabdomiosarcoma alveolar&#46; Se inici&#243; tratamiento con quimioterapia y radioterapia con remisi&#243;n completa y resoluci&#243;n del cuadro cl&#237;nico&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Discusi&#243;n</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El rabdomiosarcoma orbitario alveolar en adultos es infrecuente&#46; Presenta un alto riesgo de diseminaci&#243;n y puede debutar simulando una sinusitis&#44; como en este caso&#44; por lo que un diagn&#243;stico y tratamiento precoces son de especial importancia en estos pacientes&#46;</p>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Sanz-Marco E&#44; Espa&#241;a E&#44; Alamar A&#44; P&#233;rez-Rojas J&#44; L&#243;pez-Prats MJ&#44; D&#237;az-Llopis M&#46; Rabdomiosarcoma alveolar orbitario enmascarado por sinusitis etmoidal en un adulto de 25 a&#241;os&#46; Arch Soc Esp Oftalmol&#46; 2014&#59;89&#58;182&#8211;185&#46;</p>"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Discrete right eye exophthalmos over the left one&#46; &#40;B&#8211;E&#41; CT cross-section &#40;B&#41; and coronal &#40;C&#8211;E&#41;&#58; partial right side ethmoidal scene is occupation with discontinued bone extension in the lamina papyracea and presence of well defined soft tissue 27<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>17<span class="elsevierStyleHsp" style=""></span>mm isodense image involving orbitary fat and orbital vertex&#46;</p>"
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Histopathology&#58; &#40;A&#8211;C&#41; the tissue comprises dense aggregates of small cells with hyperchromatic nuclei&#44; with granular cytoplasm with periodic acid-Schiff stain &#40;PAS&#41;&#44; vascularized dense fibrous stroma without fibrillary or neuropil component&#44; without mitosis&#44; with remains of bone trabeculae and mucosa glands&#44; no necrosis or epidermoid&#44; glandular or epithelial differentiation &#40;negative AE1-3 pankeratines&#41;&#46; Ki 67 is intensely positive with a very high proliferation index approaching 70&#37;&#46; Negative immunostaining for lymphoid antigens&#44; S-100&#44; enolase&#44; fibrillary glyal protein and synaptophysin&#44; which discards neuroid or neuroendocrine tumor&#46; Positive immunohistochemistry for&#58; &#40;D&#41; desmin&#44; &#40;E&#41; myoglobin&#44; muscle specific actin&#44; myosine and &#40;F&#41; vimentin&#44; corresponding to an immunophenotype typical of rhabdomyosarcoma&#46; In conclusion&#44; immunohistochemistry is conclusive for rhabdomyosarcoma and arrangements in dense aggregates of small cells in sub classification as alveolar rhabdomyosarcoma&#46;</p>"
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Magnetic resonance&#58; right half-moon intraorbit tumor &#40;35<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>28<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>18<span class="elsevierStyleHsp" style=""></span>mm&#41; involving ethmoidal cells with implantation on the ethmoidal wall&#44; displacing to optic nerve and internal rectus muscle&#46;</p>"
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          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Increased exophthalmos&#44; with right eye proptosis&#44; exotropia&#44; areactive midriasis and vascular congestion&#46;</p>"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Post-surgery&#44; 51 months without modification of post-surgery alterations&#58; &#40;A&#41; right eye exophthalmos disappearance&#46; &#40;B&#8211;D&#41; fibrosis image in control MR&#58; &#40;B&#41; hyperintense image in STIR without gadolinium capture&#44; &#40;C&#41; hypointense in T1 and &#40;D&#41; hyperintense in T2&#46;</p>"
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      "titulo" => "References"
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                      "titulo" => "Rhabdomyosarcoma&#58; review for the ophthalmologist"
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                        0 => array:2 [
                          "etal" => false
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                      ]
                    ]
                  ]
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                    0 => array:1 [
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                          "etal" => false
                          "autores" => array:4 [
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Article information
ISSN: 21735794
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos