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Necrobiotic xanthogranuloma. Differential diagnosis, treatment and systemic involvement. Case report
Xantogranuloma necrobiótico. Diagnóstico diferencial, tratamiento e implicaciones sistémicas. A propósito de un caso
E. Sanz-Marcoa,
Corresponding author
empar19@hotmail.com

Corresponding author.
, E. Españaa,b, M.J. López-Pratsa, M. Chirivella-Casanovac, J. Aviñoa, M. Díaz-Llopisa,d,e
a Servicio de Oftalmología, Hospital Universitario La Fe, Valencia, Spain
b Facultad de Óptica, Universidad de Valencia, Valencia, Spain
c Servicio de Anatomía Patológica, Hospital Universitario La Fe, Valencia, Spain
d Departamento de Cirugía, Facultad de Medicina, Universidad de Valencia, Valencia, Spain
e Centro de Investigación de Enfermedades Raras (CIBERER), Valencia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">There are 4 types of orbital xanthogranulomae&#58; necrobiotic xanthogranuloma &#40;NBX&#41;&#44; adult onset xanthogranuloma &#40;AOX&#41;&#44; asthma-associated adult periocular xanthogranuloma &#40;AAPOX&#41; and the Erdheim&#8211;Chester disease &#40;ECD&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">AOX affects the eyelids and the anterior orbit without systemic involvement&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> AAPOX exhibits periocular and anterior orbit lesions&#44; typically associating asthma&#44; benign lymphadenopathy and IgG polyclonal paraproteinemia IgG&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">ECD is the most severe form&#44; which is lethal between 3 months and 15 years despite different therapies and is characterized by medium and posterior orbital xanthogranulomatous fibrosclerosis with proptosis and progressive visual acuity loss&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> together with fibrosclerosis of long bone metaphysis and of deep organs&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">NBX is characterized by bilateral palpebral&#44; orbital and periocular lesions&#44; including the conjunctiva&#44; which can infiltrate other bodily areas and deep organs&#46; Said lesions tend to greater ulceration and fibrosis vis-&#224;-vis the previous subtypes&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a> Systemic involvement is frequently associated to monoclonal gammopathy and malign lymph proliferative processes&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A necrobiotic xanthogranuloma case is presented with the systemic involvement and good response to intralesional corticoid treatment&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Clinical case</span><p id="par0030" class="elsevierStylePara elsevierViewall">A male&#44; 48&#44; referred to our hospital due to bilateral palpebral tumors of unknown origin with recurring inflammation episodes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The patient history included smoking habit &#40;20 cigarettes per day&#41; with a diagnosis of idiopathic thrombocytopenic purpura&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Upon exploration the patient exhibited bilateral yellowish injuries in upper eyelids&#44; aponeurotic ptosis and increased intraocular pressure &#40;IOP&#41; &#40;27&#47;26<span class="elsevierStyleHsp" style=""></span>mmHg&#41; in both eyes&#44; in combined treatment with cusimolol and dorzolamide &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#59; in addition&#44; 2 orange infiltration-like lesions were observed in the left elbow and the right pretibial region&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Orbital MR was carried out due to suspected xanthogranulomatosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; observing occupation of the anterior half of both orbits by multiple soft tissue lesions&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Palpebral biopsy revealed the presence of Touton-type multinucleated cells together with lymphoplasmocitary infiltrates rich in interstitial cells and collagen necrobiosis&#59; biopsy suggested NBX and matched the result of pretibial and elbow biopsies &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Systemic study revealed IgG monoclonal gammopathy &#40;1960<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; and elevation of &#946;2-microglobulin &#40;3&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#44; together with thrombopenia &#40;169&#44;000<span class="elsevierStyleHsp" style=""></span>platelets&#47;mm<span class="elsevierStyleSup">3</span>&#41;&#44; leukopenia &#40;2700<span class="elsevierStyleHsp" style=""></span>leukocytes&#47;mm<span class="elsevierStyleSup">3</span>&#41; with neutropenia &#40;800<span class="elsevierStyleHsp" style=""></span>cells&#47;mm<span class="elsevierStyleSup">3</span>&#41; and VSG 100<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#46; In addition&#44; the patient presented non-nephrotic proteinuria&#46; Bone marrow biopsy was negative for myeloma and skin biopsy was negative for amyloidosis&#46; Accordingly&#44; monoclonal gammopathy of uncertain significance &#40;MGUS&#41; was diagnosed&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The orbital lesions were treated without initial response with high doses of methylprednisolone &#40;1<span class="elsevierStyleHsp" style=""></span>g&#47;kg&#47;day&#41; and subsequently with cyclosporine 150<span class="elsevierStyleHsp" style=""></span>mg&#47;day for one year&#44; suspended due to nephrotoxicity&#44; after which 2 monthly intralesional triamcinolone injections were administered &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; After 6 injections&#44; IOP was controlled without medication and the number and size of the lesions had diminished &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41; without local &#40;cataracts&#44; ocular perforation&#44; etc&#46;&#41; or systemic complications &#40;cushingoid reactions&#44; and adrenal suppression&#41;&#46; Two years after treatment the lesions remained stable &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>&#41; and the patient is being followed up by hematology due to MGUS&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="fig0030"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">Differential diagnosis is important in lesions similar to large xanthelasmae&#59; depth&#44; orbit involvement and adhesion to keep levels are distinctive signs of xanthogranuloma&#46; Classification in the 4 subtypes is based on clinic and biopsy&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The patient of this case who exhibited palpebral and anterior orbit involvement leads to consider NBX&#44; AOX and AAPOX&#44; discarding ECD which usually affects the posterior half of the orbit&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The biopsy confirmed the diagnosis with the presence of non-Langerhans histiocytes and Touton-type cells&#59; in ECD proliferative fibroblasts with areas of fibrosis would appear together with dispersed lymphocytes and histiocytes&#59; in AXG and AAPOX&#44; mostly lymphocytes aggregates and germinal centers&#59; and in NBX&#44; geographic areas of necrosis surrounded by epithelioid histiocytes palisades as in this case&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">For NBX&#44; concomitant lymphoproliferative disorder must be discarded as in the present patient who exhibited IgG monoclonal gammopathy &#40;1&#44;960<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#46; In the presence of a monoclonal component exceeding 1&#44;500<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; malign hemopathy must be discarded with spinal biopsy&#44; bone radiology light chains in urine and in patients with cutaneous injuries as in this case&#44; amyloidosis with skin biopsy&#46; The present patient did not exhibit malignity symptoms or signs and therefore the diagnosis was MGUS&#44; in which case it is advised to carry out 6 monthly and subsequently the annual checkups without requiring baseline treatment&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The low prevalence of this type of lesions hinders the assessment of different treatments&#44; most of which are not very effective&#44; particularly for ECD&#44; with multiagent chemotherapy treatments being most efficient&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In what concerns cyclosporine&#44; it has been observed that the lymphocyte-T population is more numerous<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and therefore should be more efficient&#46; In the present case&#44; cyclosporine was not efficient and caused nephrotoxicity without slowing the disease progression&#46; In contrast&#44; intralesional corticoid injections&#44; an option described in the literature with contradictory results&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> turned out to be effective&#46; Corticoids could slow down the inflammatory cascade which appears to be involved in these tumors and for this reason might reduce lesion size&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">In what concerns IOP reduction&#44; attendant to diminished lesion size&#44; the authors suspect that it could be due to the reduction of hypothetical ocular compression caused by the orbit xanthogranulomae&#46; However&#44; it is not possible to confirm this hypothesis as it could simply be a casual finding&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Finally&#44; it is important to diagnose the different xanthogranulomatous entities due to their possible systemic involvement which&#44; in NBX&#44; could involve early diagnosis of a malign lymphoproliferative disorder&#46; As regards treatment&#44; the use of intralesional triamcinolone was efficient to control palpebral and orbital lesions&#46; Even so&#44; subsequent studies are necessary to verify this observation&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflict of interests</span><p id="par0095" class="elsevierStylePara elsevierViewall">No conflict of interests has been declared by the authors&#46;</p></span></span>"
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    "fechaRecibido" => "2011-01-24"
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          "clase" => "keyword"
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            0 => "Xanthogranuloma"
            1 => "Necrobiotic xanthogranuloma"
            2 => "Xanthogranulomatosis"
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            0 => "Xantogranuloma"
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      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Case report</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A 48-year-old male was referred to our hospital for further evaluation of eyelid edema with bilateral yellowish ulcerated nodules&#46; Suspecting a xanthogranulomatosis&#44; imaging tests and biopsy were performed with diagnosis of necrobiotic xanthogranuloma&#46; IgG monoclonal gammapathy was diagnosed in a systemic study&#46; Systemic corticosteroids and cyclosporine were initiated unsuccessfully&#59; therefore&#44; intra-lesional injections of triamcinolone were started&#44; which controlled the orbital disease&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Necrobiotic xanthogranuloma is a rare condition that usually affects the eyelids and anterior orbit&#46; Its diagnosis is important as it is associated with malignant lymphoproliferative processes&#46; Intra-lesional corticosteroids were effective in our patient&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0025">Caso cl&#237;nico</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Var&#243;n de 48 a&#241;os remitido por edema palpebral con n&#243;dulos ulcerados amarillentos en ambos p&#225;rpados superiores&#46; Las t&#233;cnicas de imagen demostraron infiltraci&#243;n en ambas &#243;rbitas anteriores que fueron biopsiadas con el resultado de xantogranuloma necrobi&#243;tico&#46; En el estudio sist&#233;mico se hall&#243; una gammapat&#237;a monoclonal IgG no conocida&#46; Se inici&#243; tratamiento con corticoides y ciclosporina orales sin &#233;xito&#44; por lo que se pautaron inyecciones intralesionales de triamcinolona que controlaron la enfermedad orbitaria&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Discusi&#243;n</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El xantogranuloma necrobi&#243;tico es una rara entidad que suele afectar a p&#225;rpados y &#243;rbita anterior&#46; Su diagn&#243;stico es importante porque se asocia a procesos linfoproliferativos malignos&#46; Los corticoides intralesionales fueron efectivos en su manejo&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Sanz-Marco E&#44; Espa&#241;a E&#44; L&#243;pez-Prats MJ&#44; Chirivella-Casanova M&#44; Avi&#241;o J&#44; D&#237;az-Llopis M&#46; Xantogranuloma necrobi&#243;tico&#46; Diagn&#243;stico diferencial&#44; tratamiento e implicaciones sist&#233;micas&#46; A prop&#243;sito de un caso&#46; Arch Soc Esp Oftalmol&#46; 2014&#59;89&#58;186&#8211;189&#46;</p>"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Xanthomatous tumors in both upper eyelids&#44; with adjacent soft tissue inflammation and secondary mechanical ptosis&#46; Top image&#44; first visit&#59; bottom image&#44; one month after the first visit&#46;</p>"
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Bilateral tumors with soft tissue consistency involved in the anterior portion of the orbit&#44; without surrounding fatty and muscular inflammation&#46; &#40;a&#41; Axial T2&#59; &#40;b&#41; sagittal T1 image&#59; &#40;c&#41; coronal STIR&#59; &#40;d&#41; coronal image with gadolinium&#46;</p>"
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Histopathological image with hematoxylin&#8211;eosin staining &#40;400 increases&#44; HE 400&#215;&#41;&#46; Giant multinucleated cells over background with geographic areas of necrosis&#44; mononucleated cells and histiocytes&#46;</p>"
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          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">After treatment with systemic corticosteroids and cyclosporine&#44; no lesion size reduction was appreciated at the macroscopic level&#46;</p>"
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The patient remains stable up to 2 years of treatment with intralesional corticoid injection&#44; with good esthetic-functional results&#46; &#40;a&#41; Photograph&#59; &#40;b&#41; axial T1 with contrast&#59; &#40;c&#41; axial T2&#59; &#40;d&#41; coronal T1&#59; &#40;e&#41; coronal STIR&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
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                      ]
                    ]
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Article information
ISSN: 21735794
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos