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Variations in the technique for autologous limbal transplantation
Variaciones en la técnica del trasplante limbar autólogo
B. Mataix
Corresponding author
b1mataix@yahoo.es

Corresponding author.
, A. Alcántara, M. Caro, J. Montero, B. Ponte, E. Rodríguez de la Rúa
Sección de Superficie Ocular y Córnea, Servicio de Oftalmología, Hospital Universitario Virgen Macarena, Sevilla, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The corneal surface epithelium is produced by a population of self-renewable cells derived from germinal or stem cells located in the sclerocorneal limbus&#44; at the level of the Vogt palisades&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">When said cells lose their function&#44; limbar insufficiency &#40;LI&#41; arises&#46; The key sign of LI is corneal conjunctivalization&#44; the most significant clinical expression being persistent epithelial defect&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In complete unilateral LI&#44; the autologous transplant of two 60&#176; corneoconjunctival segments &#40;2<span class="elsevierStyleHsp" style=""></span>h&#41; taken from the contralateral eye with or without amniotic membrane transplant &#40;AMT&#41;&#44; is one of the main therapeutic strategies&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> Even though variations of the classic technique has been described&#44; there is some controversy about the necessary size of the grafts&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The present article reports 2 cases in which the corneal surface was restored with a single segment and AMT&#46; In one it was necessary to perform sequential conjunctival epitheliectomies in the post-surgery period&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Clinic cases</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Clinic case report 1</span><p id="par0025" class="elsevierStylePara elsevierViewall">Female&#44; 21&#44; who visited due to loss of vision&#44; photophobia and recurring red eye after suffering caustication 2 years before in both eyes&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Impression cytology showed epithelial cells with a moderate-severe grade of metaplasia&#44; as well as observing very altered goblet cells&#46; Clinic and impressions cytology led to the diagnostic of full LI&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Due to the caustication antecedent also involving the right eye&#44; heterologous transplant of 2 limbar &#40;corneoconjunctival&#41; segments were placed at 6 and 12 o&#8217;clock together with the AMT&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Post-surgery&#44; 2 complications were observed&#58; on the one hand&#44; acute rejection which did not respond to the medical treatment&#44; and on the other an excessively thick inferior segment&#44; for which reason it was explanted&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Due to the persistence of signs and symptoms &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; an autologous transplant of a single 60&#176; graft was performed in the inferior limbus together with the AMT&#46; Persistent postoperative neovascularization was treated with cauterization using thin needle and intra-stromal corneal injections of bevacizumab &#40;Avastin&#44; Genetech&#44; San Francisco&#44; CA&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">After the second intervention&#44; even though significant stromal fibrosis remained&#44; the patient exhibited clear improvements of symptoms and signs&#46; A smooth and even epithelial surface was obtained with normal stains&#44; which remains normal after 2 years follow-up &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Clinic case report 2</span><p id="par0055" class="elsevierStylePara elsevierViewall">Female&#44; 48&#44; referred with LI diagnostic&#46; Ocular antecedents included prolonged contact lens use and persistent epithelial defect&#46; AMT had been performed without success&#46; The patient referred intense photophobia and epiphora&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Autologous transplant with a 90&#176; segment was performed together with AMT &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Postoperatively&#44; progressive re-epithelialization occurred with an epithelium having corneal characteristics&#46; At 2 months&#44; re-epithelialization was completed except in the corneal periphery where neovascularization and conjunctivalization persisted and were treated with sequential sectoral epitheliectomies &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">After 18 months follow-up&#44; the surface presented stable epithelium with diminished subepithelial fibrosis and neovascularization&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Discussion</span><p id="par0075" class="elsevierStylePara elsevierViewall">Traditionally&#44; autologous limbus transplant is performed on the basis of two 60&#176; segments&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> although the potential of provoking LI in the donor eye has given rise to considering the needs to diminish the size of the necessary graft&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">In what concerns total LI conditions&#44; there is only one successfully treated case with a single 60&#176; segment&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a> Moldovan et al&#46; required a segment between 90 and 100&#176; together with AMT&#46; Smaller sizes were insufficient&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">In the present 2 cases&#44; the authors partially attribute success to the AMT with conjunctival suture &#40;after 360&#176; peritomy&#41;&#46; The therapeutic usefulness of amniotic membrane is due to its mechanical and mainly biological properties&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> It comprises numerous growth factors and performs as a substrate&#44; promoting epithelial cell migration and adhesion&#46; Although traditionally the amniotic membrane has been sutured over the conjunctiva&#44; when placing the edges thereof over the membrane produces conjunctival epithelial cell growth over the membrane and not over the corneal surface&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">In some cases&#44; as in the second clinic case reported herein&#44; despite achieving normal epithelialization of the visual axis and the majority of the surface&#44; some peripheral conjunctivalization tufts may remain&#44; which can be treated with sequential conjunctival epitheliectomies without requiring the implant of a second graft&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Even though the results obtained cannot be extrapolated for treating all patients&#44; the use of a single 60&#8211;90&#176; segment together with AMT could be an option to be considered in cases where the donor eye comprises the risk of developing LI&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflict of interests</span><p id="par0100" class="elsevierStylePara elsevierViewall">No conflict of interests was declared by the authors&#46;</p></span></span>"
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            0 => "Limbal stem cell deficiency"
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            0 => "Insuficiencia limbar"
            1 => "Membrana amni&#243;tica"
            2 => "Trasplante limbar aut&#243;geno"
            3 => "Epiteliectom&#237;a conjuntival sectorial secuencial"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To present the results on the use of a single block limbal autograft&#44; combined with amniotic membrane transplantation and sectoral sequential postoperative epitheliectomy of the conjunctiva in 2 patients with unilateral total limbal stem cell deficiency&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conclusions</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A single block limbal autograft combined with amniotic membrane transplantation may be sufficient to restore a stable corneal surface&#44; but sometimes sequential sectoral conjunctival epitheliectomy may be required to treat anomalous epithelial remnants&#46;</p></span>"
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        "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Objetivo</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Presentar los resultados del uso de un &#250;nico segmento de autoinjerto limbar combinado con trasplante de membrana amni&#243;tica y epiteliectom&#237;as conjuntivales sectoriales secuenciales postoperatorias en 2 pacientes con insuficiencia l&#237;mbica unilateral total&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Un solo segmento de autoinjerto limbal junto con el trasplante de membrana amni&#243;tica puede ser suficiente para restaurar una superficie corneal estable&#44; siendo en ocasiones necesario realizar en el postoperatorio epiteliectom&#237;as conjuntivales secuenciales en zonas remanentes de epitelio an&#243;malo&#46;</p></span>"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Persistent limbar insufficiency after the first heterologous limbar transplant&#46; &#40;A&#41; 360&#176; neovascularization with thin and uneven epithelium covering the corneal surface in the upper temporal quadrant and conjunctivalization of the rest of the surface&#46; &#40;B&#41; Late fluorescein staining&#46;</p>"
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Article information
ISSN: 21735794
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos