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Case report: Orbital epithelioid haemangioendothelioma
Caso clínico: hemangioendotelioma epitelioide orbitario
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"apellidos" => "Borbolla-Pertierra" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Hospital Central Militar, Mexico City, Mexico" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Órbita, Párpados y Vía Lagrimal, Hospital Central Militar, Mexico City, Mexico" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Patología, Hospital Central Militar, Mexico City, Mexico" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Radiología e Imagen, Hospital Central Militar, Mexico City, Mexico" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Caso clínico: hemangioendotelioma epitelioide orbitario" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1827 "Ancho" => 2502 "Tamanyo" => 296812 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">(a) Orbit tomography in axial view, in simple and contrasted phase. Ovoid neoplasia with well-defined edges producing volume effect, without apparent infiltration over the medial rectus muscle and ocular globe, reshaping the lamina papyracea, presenting intense reinforcement of the lesion with persistence of hypodense areas in the central portion, probably due to necrosis. (b) Magnetic resonance in phase T1 and T2. Isointense component to neoplasia soft tissue in the periphery with cystic center, without infiltrating medial rectus or ocular globe.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Case report</span><p id="par0005" class="elsevierStylePara elsevierViewall">Male, 13, without personal pathology antecedents, presenting with proptosis and exotropia in the right eye with 6 weeks evolution, without associated symptoms, denying traumatism (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Ophthalmological examination. VA: right eye: 20/30, left eye: 20/26, with visual capacity in both eyes of 20/20. External examination showed right eye proptosis and exodeviation, with 22–18<span class="elsevierStyleHsp" style=""></span>mm exophthalmometry, palpation of soft mass in the superomedial portion of the orbit, euthermic, without color changes or pulsation, and does not increase in volume with Valsalva maneuver. In addition, the patient presented 30-diopter to right eye exotropia in primary gaze position, with adduction limitation in the right eye of −1 (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><p id="par0015" class="elsevierStylePara elsevierViewall">Biomicroscopy in both eyes did not show alterations. Right eye fundus showed vertical folds in posterior pole, left eye without alterations.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Computerized tomography defined ovoid neoplasia with well-defined edges located in extraconal fatty tissue, without apparent infiltration on the medial rectus muscle or the ocular globe, reshaping the lamina papyracea which exhibited intense reinforcement of the lesion with contrast medium in the periphery, persisting with hypodense areas in the central portion, suggesting probable necrosis.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Magnetic resonance revealed isointense component to soft tissue in the periphery, with cystic content in the center that does not infiltrate the ocular globe or the medial rectus muscle (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The main diagnostic suspicion was orbitary lymphangioma due to age at presentation, location, proptosis characteristics and radiological data. Excisional biopsy was performed with transcaruncular approach, finding an encapsulated and pedunculated mass (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>) that was sent for histopathological study, reporting “epithelioid haemangioendothelioma” diagnostic with major axis of 2.5<span class="elsevierStyleHsp" style=""></span>cm, cystic degeneration and hemorrhage (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). The patient was assessed at 7 days, one month and 6 months after surgery, exhibiting ocular parallelism. To date, no clinical signs of relapse or metastasis have been observed (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">Haemangioendothelioma is a vascular tumor exhibiting a clinical behavior between hemangioma and angiosarcoma, for which reason it is known as “<span class="elsevierStyleItalic">borderline</span>”.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Epithelioid endothelial cells are the main characteristics of haemangioendothelioma. However said cells are not pathognomonic as they can be seen in other vascular neoplasiae, performing differential diagnostic with endothelial markers.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Haemangioendotheliomae are divided into large groups, i.e., soft tissue and bones. The former more frequently affect individuals between 10 and 30 years of age regardless of sex, the most frequent location being the liver, lung and long bones. Orbital involvement by this tumor is very rare. The review carried out by the authors found 11 cases, 4 derived from soft tissue and 7 originated in orbital bones. The present case is the twelfth published case in worldwide references as orbita haemangioendothelioma (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Some authors have reported a recurrence rate of 13%, metastasis of 31% and mortality in 13% of patients with epithelioid haemangioendothelioma in a four-year period.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Metastases cases have been published up to 10 years after the first surgery.</p><p id="par0050" class="elsevierStylePara elsevierViewall">At the histopathological level, haemangioendothelioma exhibits uneven vascular elements defined by immature endothelial cells and variable anaplasia. All are positive for at least one endothelial marker such as CD31, CD34, Ulex europaeus and factor <span class="elsevierStyleSmallCaps">VIII.</span><a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> The present patient was positive for CD31 and CD34, thus completing the definitive diagnostic.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Soft tissue haemangioendotheliomae are subdivided in three histological variants: epithelioid, kaposiform and Dabska type. The epithelioid variant is more frequent and consists in endothelial cells arranged as an epithelium. It is distributed around medium and large veins, forming well-defined and discrete vascular channels.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> The kaposiform variant is a rare diagnostic entity occurring predominantly in children, with the skin being the most frequent location. The Dabska type is a locally invasive vascular neoplasia with low metastatic potential which predominantly affects children. It expresses lymphatic endothelial markers.</p><p id="par0060" class="elsevierStylePara elsevierViewall">It is worthy of note that 10 of the 11 cases found in the review were of the epithelioid type, being the most frequent histological variant in this location. Malign behavior was referred only in 2 cases.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Treatment of choice is the complete excision of the tumor and resection of lymphatic nodes, as the latter are the most frequent sites for metastasis. Chemo- and radiotherapy are not regarded as effective for haemangioendothelioma, although cases exhibiting malign behavior are usually treated with adjuvant radiotherapy.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusion</span><p id="par0070" class="elsevierStylePara elsevierViewall">Haemangioendothelioma is a tumor exhibiting clinic between hemangioma and angiosarcoma. The histopathological diagnostic determines its histological variant. Treatment of choice is complete excision of the lesion. Close follow-up should be maintained as relapses and metastasis are not rare.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Funding</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors did not receive any type of funding for this article.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflict of interests</span><p id="par0080" class="elsevierStylePara elsevierViewall">No conflict of interests was declared by the authors.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres818617" "titulo" => "Abstract" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Case report" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Discussion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec815667" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres818618" "titulo" => "Resumen" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "abst0015" "titulo" => "Caso clínico" ] 1 => array:2 [ "identificador" => "abst0020" "titulo" => "Discusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec815666" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Case report" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Discussion" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Conclusion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Funding" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflict of interests" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-12-15" "fechaAceptado" => "2016-03-21" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec815667" "palabras" => array:5 [ 0 => "Epithelioid haemangioendothelioma" 1 => "Epithelioid haemangioendothelioma treatment" 2 => "Epithelioid haemangioendothelioma review" 3 => "Haemangioendothelioma" 4 => "Epithelioid haemangioendothelioma case report" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec815666" "palabras" => array:5 [ 0 => "Hemangioendotelioma epitelioide" 1 => "Tratamiento hemangioendotelioma epitelioide" 2 => "Revisión hemangioendotelioma epitelioide" 3 => "Hemangioendotelioma" 4 => "Reporte de caso hemangioendotelioma epitelioide" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Case report</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A 13-year-old boy presented with right eye proptosis and lateral dystopia. A soft non-pulsatile mass was found in the superomedial orbital region. An excisional biopsy was performed, for which the histopathology reported an epithelioid haemangioendothelioma.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Haemangioendothelioma is a borderline vascular lesion within the spectrum of clinically benign and malignant tumors. These can arise from soft tissue or bone. There are few reports of these tumors located in the orbit.</p></span>" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Case report" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Discussion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Caso clínico</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Paciente masculino de 13 años de edad, el cual presenta proptosis y desplazamiento lateral de ojo derecho. Se palpa tumoración blanda no pulsátil en región orbitaria superomedial. Se realizó biopsia excisional de la masa que fue informada como hemangioendotelioma epitelioide.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El hemangioendotelioma epitelioide es un tumor vascular de comportamiento intermedio entre tumores vasculares malignos y benignos. Estos pueden presentarse en tejidos blandos o a partir de hueso. En la literatura hay pocos casos publicados de aparición en órbita.</p></span>" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "abst0015" "titulo" => "Caso clínico" ] 1 => array:2 [ "identificador" => "abst0020" "titulo" => "Discusión" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Zaragoza-Herrera A, Morales-Baños DR, Velasco-Ramos P, Garrido-Sánchez GA, López-Hernández CM, Borbolla-Pertierra AM. Caso clínico: hemangioendotelioma epitelioide orbitario. Arch Soc Esp Oftalmol. 2017;92:184–188.</p>" ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 513 "Ancho" => 1245 "Tamanyo" => 58753 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Patient with right eye proptosis and exodeviation.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1827 "Ancho" => 2502 "Tamanyo" => 296812 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">(a) Orbit tomography in axial view, in simple and contrasted phase. Ovoid neoplasia with well-defined edges producing volume effect, without apparent infiltration over the medial rectus muscle and ocular globe, reshaping the lamina papyracea, presenting intense reinforcement of the lesion with persistence of hypodense areas in the central portion, probably due to necrosis. (b) Magnetic resonance in phase T1 and T2. Isointense component to neoplasia soft tissue in the periphery with cystic center, without infiltrating medial rectus or ocular globe.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1088 "Ancho" => 2335 "Tamanyo" => 314590 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Extraction of encapsulated tumor through transcaruncular approach.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 777 "Ancho" => 3167 "Tamanyo" => 582270 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">10× histological images stained with hematoxylin–eosine showing: (a) hypercellular tissue with rounded cell covers, some fusiform, moderate cytoplasm, showing vessels and erythrocytes; (b) poorly developed vascular channels covered with endothelium and containing erythrocytes, without atypia or necrosis; (c) positive CD34/CD31 staining.</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1248 "Ancho" => 3000 "Tamanyo" => 327510 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">One month post-surgery, showing orthoposition and no duction limitations.</p>" ] ] 5 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"># \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Age \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Sex \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Location and characteristics \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Author \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Year \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Left orbit<br>Soft tissue<br>Epithelioid<br>Benign \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mortada<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a><br>(Egypt) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1963 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">35 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Left orbit<br>Soft tissue<br>Epithelioid<br>Benign<br> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mortada<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a><br>(Egypt) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1963 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">15 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Left orbit<br>Soft tissue<br>Epithelioid<br>Benign \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Bisaria et al.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a><br>(India) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1966 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3 m 15 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Left orbit<br>Maxillary bone<br>Epithelioid<br>Malign \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lyon et al.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a><br>(USA) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1992 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">30 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Right orbit<br>Maxillary bone<br>Epithelioid<br>Malign \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Misra et al.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a><br>(India) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1999 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">29 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Right orbit<br>Frontal bone<br>Epithelioid<br>Benign \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">De la Lama et al.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a><br>(Spain) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2000 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">26 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Left cranial-orbital<br>Sphenoid and temporal bone<br>Epithelioid<br>Benign \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Koh and Yoo<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a><br>(Korea) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Left orbit<br>Frontal bone<br>kaposi<br>Benign \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cansiz et al.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a><br>(Turkey) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Left orbit<br>Maxillary bone<br>Epithelioid<br>Benign \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Rosen et al.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a><br>(USA) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2006 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Left orbit<br>Ethmoidal bone<br>Cavernous sinus<br>Epithelioid<br>Malign \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Aniba et al.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a><br>(Morocco) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2012 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">22 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Palpebral lobule of left lacrimal gland<br>Soft tissue<br>Epithelioid<br>Benign \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Kiratli et al.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a><br>(Turquía) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2013 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="char" valign="top">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Right orbit<br>Soft tissue<br>Epithelioid<br>Benign \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Zaragoza<br>(Mexico) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2015 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1375940.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Orbital haemangioendothelioma cases reported in world literature.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Orbital benign haemangioendothelioma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2020 September | 0 | 1 | 1 |
| 2018 March | 3 | 0 | 3 |
| 2018 February | 5 | 1 | 6 |
| 2018 January | 6 | 3 | 9 |
| 2017 December | 9 | 1 | 10 |
| 2017 November | 4 | 0 | 4 |
| 2017 October | 9 | 6 | 15 |
| 2017 September | 0 | 0 | 0 |
