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Unilateral retinitis pigmentosa. A case report
Retinitis pigmentosa unilateral a propósito de un caso
C. Nazar
Corresponding author
canazar@uc.cl

Corresponding author.
, M. Feldman, R. González, R. Espinoza
Departamento de Oftalmología, Pontificia Universidad Católica de Chile, Santiago, Chile
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Retinitis pigmentosa &#40;RP&#41; is the most frequent retinal dystrophy&#44; characterized by being hereditary&#44; causing progressive dysfunction and loss of cells&#44; first compromising rods and then cones&#46; RP is also known as rod&#8211;cone dystrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Generally&#44; RPE expresses bilaterally within the first three decades of life and is characterized by nyctalopia and progressive loss of peripheral visual field&#46; In the early stages&#44; central vision is preserved although it deteriorates with the progressive loss of photoreceptors and for this reason it is diagnosed in more advanced stages&#46; RP is associated to cystoid macular edema &#40;20&#37; of cases&#41; and posterior subcapsular cataracts &#40;50&#37; of cases&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Ocular fundus examinations reveal pigment changes known as bone spicules due to their shape&#44; a typical characteristic of the disease&#46; Additional signs include optic nerve paleness&#44; retina pigment epithelium atrophy and vascular attenuation&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">RP may express sporadically or follow a hereditary pattern with genetic heterogeneity&#46; Its inheritance mechanism can be autosomal dominant &#40;30&#8211;40&#37; of cases&#41;&#44; autosomal recessive &#40;50&#8211;60&#37;&#41; or X-linked &#40;5&#8211;15&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In RP&#44; alterations are usually limited to the eyes&#46; However&#44; extraocular involvement has been described in the context of some syndromes&#44; approximately 20&#8211;30&#37; of cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The therapeutic options are limited&#46; Vitamin A supplementation in diet has been proposed&#44; although its role is controversial&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">A clinic case of a patient with unilateral RP is described below&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Clinic case report</span><p id="par0040" class="elsevierStylePara elsevierViewall">Female&#44; 27&#44; with a history of nyctalopia and right eye &#40;RE&#41; visual field constriction of 2 years evolution was admitted&#46; No history of traumatism or other ophthalmological events&#44; use of medicaments&#44; systemic&#44; pneumatic or vasculitic diseases or familial antecedents&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Ophthalmological examination showed a visual acuity of 20&#47;20 in both eyes&#44; preserved color vision and RE relative afferent pupillary defect&#46; Biomicroscopy revealed poorly vitreous pigments in the RE&#44; while funduscopy showed a paler right papilla with generalized attenuation of vasculature and bone-shaped pigment in the periphery with perifoveal macular atrophy &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Left eye &#40;LE&#41; biomicroscopy and funduscopy were normal &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">The patient was evaluated with a range of examinations&#44; i&#46;e&#46;&#44; computerized visual field that showed a tubular field in the RE&#44; being normal in the LE &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; RE autofluorescence evidenced increased fluorescence at the parafoveal level &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; In addition&#44; OCT showed increased granular hyper-reflectiveness&#44; collapse of nuclear layers&#44; particularly the internal one&#44; generalized retinal thickness thinning and increased internal limiting membrane signal &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46; Standard and multifocal electroretinogram &#40;ERG&#41; did not show response of rods or cones in the RE&#46; However&#44; these were normal in the LE &#40;<a class="elsevierStyleCrossRef" href="#fig0030">Fig&#46; 6</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Other causes such as syphilis&#44; rubeola&#44; toxoplasmosis&#44; diffuse unilateral subacute neuroretinitis and self immune diseases were discarded&#46; At one year follow-up&#44; unilateral involvement persisted&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">Unilateral RP is a rare condition first described in 1865&#44; with a frequency between 0&#46;2 and 5&#37; of RP<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a>&#46; About 70&#37; of described cases are females in more advanced ages than bilateral RP&#44; in the area of 30 years of age&#44; probably because they visit at a later stage due to adequate unilateral vision&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Overall&#44; the approximately 70 cases published since the 19th century did not report bilateralization during follow-up&#44; with one reported case reaching 30 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3&#44;7</span></a> Only 2 cases had familial RP antecedents&#44; mostly sporadic as in the present case&#46; Genetic studies were the exception in reported cases as only 6 has been studied&#44; only two of which were positive&#44; with autosomal dominant mutations for RP&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">A definitive diagnostic must include a unilateral altered eye fundus&#44; with unilateral altered ERG examination showing reduction in amplitude and delay in rods and cones response&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Autofluorescence should also be taken into account as it can exhibit areas with high fluorescence generated by higher concentration of lipofuscin at the retina pigment epithelium&#46; In turn&#44; these regions produce lower response amplitudes when measured with multifocal ERG&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Finally&#44; infectious&#44; inflammatory and vascular causes should be excluded&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Funding</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors state that they have not received funding for this study&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflict of interests</span><p id="par0080" class="elsevierStylePara elsevierViewall">No conflict of interests was declared by the authors&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Clinical case</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A 27-year-old woman with a history of nyctalopia and constriction of visual field of the right eye&#46; The ophthalmological examination showed a visual field and electroretinogram that were compatible with unilateral retinitis pigmentosa &#40;RP&#41;&#46; After a one year follow-up&#44; the unilateral condition remained&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Unilateral retinitis pigmentosa is a rare condition&#44; with a frequency between 0&#46;2&#37; and 5&#37; of the RP&#46; It mainly affects women and older age groups than bilateral RP&#46; For a definitive diagnosis&#44; it is necessary to have a funduscopy and electroretinogram &#40;ERG&#41; altered unilaterally&#44; and exclude infectious&#44; inflammatory&#44; and vascular causes&#46;</p></span>"
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        "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Caso cl&#237;nico</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Mujer de 27 a&#241;os con historia de nictalop&#237;a y constricci&#243;n de campo visual del ojo derecho&#46; El examen oftalmol&#243;gico&#44; campo visual y electrorretinograma &#40;ERG&#41; fueron compatibles con una retinitis pigmentosa &#40;RP&#41; unilateral&#46; Al seguimiento de un a&#241;o&#44; permanec&#237;a la afecci&#243;n unilateral&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discusi&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La RP unilateral es un trastorno infrecuente&#44; con una frecuencia entre el 0&#44;2-5&#37; de las RP&#46; Afecta principalmente a mujeres&#44; y en edades m&#225;s avanzadas que las bilaterales&#46; Para dar un diagn&#243;stico definitivo tiene que haber un fondo de ojo y ERG alterados unilateralmente&#44; y excluir causas infecciosas&#44; inflamatorias y vasculares&#46;</p></span>"
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Article information
ISSN: 21735794
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos