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"apellidos" => "Domínguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "I." "apellidos" => "Carrio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "V." "apellidos" => "Bango" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "J.J." "apellidos" => "Barbón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Oftalmología, Hospital San Agustín de Avilés, Avilés (Asturias), Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital San Agustín de Avilés, Avilés (Asturias), Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Endoftalmitis endógenas bacterianas. A propósito de 2 casos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1516 "Ancho" => 1516 "Tamanyo" => 261144 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Case 2. Lumbar spine magnetic resonance (sagittal T2) with paraspinal abscess measuring 11.3<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>cm around the arthrodesis.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Endogenous endophthalmitis (EE) or metastatic endophthalmitis is a severe disease with poor visual prognosis caused by the hematogenous dissemination of bacteria or fungi from a primary infectious loci to the ocular globe.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1,2</span></a> EE accounts for 2–8% of endophthalmitis cases, usually with a predisposing previous disease such as diabetes, cardiovascular or hepatic disease, neoplasia, catheterization or other pharmacologically or biological immunosuppressed conditions.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1–3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Two clinical case of bacterian EE are reported, exhibiting different presentations, etiologies and responses to treatment.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Clinical cases</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Case 1</span><p id="par0020" class="elsevierStylePara elsevierViewall">Female, 69, diabetic in treatment with insulin, hypertension and ischemic cardiopathy who had undergone colonoscopy 3 and 6 months earlier due to polyps. She visited the general Ophthalmology Emergency Dept. due to blurred vision and pain in the left eye (LE) with 3 days evolution. She was diagnosed with hemovitreous. Twenty-four hours later, the right eye (RE) exhibited visual acuity of 0.5, whereas the left eye (LE) exhibited hands movement VA with chemosis, hypopyon, and fibrin in the pupillary area, nuclear cataract, 45<span class="elsevierStyleHsp" style=""></span>mmHg IOP and inability to visualize fundus due to vitreous occupancy confirmed with echography (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Due to suspected EE, intravenous therapy was initiated with vancomycin, ceftazidim and fluconazol as well as intravitreal vancomycin repeated 72<span class="elsevierStyleHsp" style=""></span>h later. Blood cultures were negative. Poor evolution required evisceration after 10 days. The microbiological analysis of eviscerated material isolated <span class="elsevierStyleItalic">Streptococcus bovis</span>. The Cardiology Dept considered there were no signs of bacterial endocarditis, for which reason echocardiogram was not carried out.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Case 2</span><p id="par0025" class="elsevierStylePara elsevierViewall">Male, 76, admitted to Internal Medicine exhibiting fever, lumbar pain and right elbow bursitis 9 months after lumbar arthrodesis surgery (reintervened one month later due to cerebrospinal fluid fistula). The bursitis was punctured and methicillin-resistant <span class="elsevierStyleItalic">Staphylococcus aureus</span> (MRSA) was isolated. Intravenous treatment was initiated with rifampicin and cloxacillin but 2 days after admittance the patient exhibited a painless loss of vision in the LE with finger counting VA at 3<span class="elsevierStyleHsp" style=""></span>m, 1<span class="elsevierStyleHsp" style=""></span>mm hypopyon, IOP of 6<span class="elsevierStyleHsp" style=""></span>mmHg, tyndall and dense vitritis that prevented fundus visualization. Right eye examination was normal, with VA of 1. Topical corticoids and antibiotics were added, together with intravitreal vancomycin repeated 72<span class="elsevierStyleHsp" style=""></span>h later despite positive clinic evolution. Computerized action tomography revealed a paraspinal abscess (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) and blood culture as well as abscess samples gave positive for MRSA. Accordingly, simultaneous drainage of the abscess and elbow bursitis was performed, upon which the systemic condition resolved and VA exhibited excellent evolution and recovered the value of 1.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">Bacterial EE is an infrequent disease with very poor visual prognostic.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4,5</span></a> Ocular signs and symptoms are similar to exogenous endophthalmitis with diminished vision, pain, absence of brightness, hypopyon, vitritis, tyndall, palpebral edema and ocular hypertension. Some cases are nonspecific, which could lead to diagnostic error.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> In addition, EE presents bilaterally in 25% of cases and has a mortality of 4%, above all if systemic antibiotics are not administered.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4,5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">When bacterial EE is suspected, empirical treatment must be established with intravenous drugs which are crucial because, in contrast with exogenous endophthalmitis, dissemination takes place through the bloodstream.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">3</span></a> Broad range antibiotics are generally applied, such as a vancomycin for Gram+, ceftazidime for Gram− or fourth-generation quinolones such as moxifloxacin that cover both types of bacteria.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1,4</span></a> Therapy seems to be more effective when associating intravitreal administration such as vancomycin (1<span class="elsevierStyleHsp" style=""></span>mg/0.1<span class="elsevierStyleHsp" style=""></span>ml) and ceftazidime (2<span class="elsevierStyleHsp" style=""></span>mg/0.1<span class="elsevierStyleHsp" style=""></span>ml), that can be repeated 48<span class="elsevierStyleHsp" style=""></span>h later if no clinical improvement is observed.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2–4,6</span></a> The role of vitrectomy is not defined although the best results are obtained when performed with an acceptable baseline VA, even more so if the bacteria is a Gram+ cocci.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4,6</span></a> Fungal endophthalmitis suspicion requires systemic fluconazole and intravitreal amphotericin.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The definitive diagnostic of bacterial EE requires cultures to identify the germ which, in blood, are positive in approximately 50% whereas in intraocular samples (vitreous and aqueous) the percentage ranges between 36 and 73%.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4–6</span></a> The most frequent original loci are hepatic abscesses, catheters, genitourinary tract infections, endocarditis, meningitis, pneumonia, arthritis, peritonitis and cerebral abscesses.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1,2,7</span></a> If the patient presents with isolated ocular symptoms, infectious tracking tests can be carried out such as abdominopelvic CAT, abdominal echography, echocardiography and vertebral magnetic resonance to detect hepatic abscesses, endocarditis or osteomyelitis.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In the first patient, <span class="elsevierStyleItalic">S. bovis</span> was cultured in the evisceration material. This bacteria is typically found in the digestive system, which is consistent with previous colonoscopy that can produce temporary bacteremia.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> The second case had a paraspinal abscess produced by a MRSA, a complication of a lumbar arthrodesis, frequently resistant to fourth-generation quinolones but not to vancomycin.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> In what concerns management, not knowing the germ in the first case recommended the association of intravitreal ceftazidime with a vancomycin, while in the latter case the isolation of MRSA in bursitis justified the exclusive use of intravitreal vancomycin, although the excellent response did not encourage a different dosage. None of the cases underwent vitreous biopsy.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The end result is highly variable, ranging from no perception of light or evisceration to VA similar to pre-existing values. Even so, despite adequate and early treatment, over 50% of cases end up with VA below 0.1, above all with Gram− bacteria.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4,5</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflict of interests</span><p id="par0055" class="elsevierStylePara elsevierViewall">No conflict of interests was declared by the authors.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres845221" "titulo" => "Abstract" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Clinical cases" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Discussion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec840104" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres845222" "titulo" => "Resumen" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "abst0015" "titulo" => "Casos clínicos" ] 1 => array:2 [ "identificador" => "abst0020" "titulo" => "Discusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec840103" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Clinical cases" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Case 1" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Case 2" ] ] ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interests" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-10-04" "fechaAceptado" => "2017-02-06" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec840104" "palabras" => array:5 [ 0 => "Endophthalmitis" 1 => "Endogenous" 2 => "Bacterial" 3 => "Eye infections" 4 => "Risk factors" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec840103" "palabras" => array:5 [ 0 => "Endoftalmitis" 1 => "Endógena" 2 => "Bacteriana" 3 => "Infección ocular" 4 => "Factores de riesgo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Clinical cases</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The cases are presented on 2 patients with bacterial endogenous endophthalmitis. The first one was caused by <span class="elsevierStyleItalic">Streptococcus bovis</span>, developed after colonoscopy, which had a poor outcome and resulted in evisceration. The second case was caused by a methicillin resistant <span class="elsevierStyleItalic">Staphylococcus aureus</span> from an arthrodesis complicated with a para-spinal abscess. It had an excellent visual outcome.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Bacterial endogenous endophthalmitis is a rare, but serious ocular disease that occurs when bacteria reach the eye via the bloodstream. It requires a very early diagnosis based on the clinical symptoms and patient history. A suitable and specific treatment with intravenous and intravitreal antibiotics may prevent a bad visual prognosis in some cases.</p></span>" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Clinical cases" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Discussion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Casos clínicos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Presentamos 2 casos clínicos de endoftalmitis endógena bacteriana. El primero causado por <span class="elsevierStyleItalic">Streptococcus bovis</span> tras la realización de una colonoscopia, con mala evolución que acabó en evisceración. El segundo debido a un <span class="elsevierStyleItalic">Staphylococcus aureus</span> meticilin resistente procedente de un absceso paraespinal que complicaba una artrodesis, con excelente recuperación visual.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La endoftalmitis endógena bacteriana es una enfermedad poco frecuente y grave en la que bacterias procedentes de un foco primario llegan por vía sanguínea hasta el ojo. El diagnóstico de sospecha ha de ser lo más precoz posible, basado en la clínica y los antecedentes del paciente. Un tratamiento adecuado y específico con antibióticos intravenosos e intravítreos puede evitar el mal pronóstico visual en algunos casos.</p></span>" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "abst0015" "titulo" => "Casos clínicos" ] 1 => array:2 [ "identificador" => "abst0020" "titulo" => "Discusión" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Cubillas M, Sampedro A, Domínguez B, Carrio I, Bango V, Barbón JJ. Endoftalmitis endógenas bacterianas. A propósito de 2 casos. Arch Soc Esp Oftalmol. 2017;92:280–282.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1147 "Ancho" => 1516 "Tamanyo" => 169169 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Case 1. Large chemosis with fibrin in pupil area and vitritis that prevents focus on ocular fundus.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1516 "Ancho" => 1516 "Tamanyo" => 261144 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Case 2. Lumbar spine magnetic resonance (sagittal T2) with paraspinal abscess measuring 11.3<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>cm around the arthrodesis.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0050" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Uveítis y escleritis. Diagnóstico y tratamiento. 90 Ponencia de la Sociedad Española de Oftalmología" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Díaz Llopis" 1 => "M. Calonge" 2 => "M.T. Sainz de la Maza" 3 => "J.M. Benitez del Castillo" 4 => "R. Gallego Pinazo" 5 => "J.F. 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