Short communication
BIlateral juxtapapillary retinal capillary haemangioma: Usefulness of aflibercept in the management of its complications
Hemangioma capilar retiniano yuxtapapilar bilateral: utilidad de aflibercept en el manejo de sus complicaciones
R. Campos Polo
, C. Rubio Sánchez, D.M. García Guisado, M.J. Díaz Luque
Corresponding author
Servicio de Oftalmología, Hospital Virgen del Puerto, Plasencia (Cáceres), Spain
Read
4
Timeswas read the article
3
Total PDF
1
Total HTML
Share statistics
array:24 [ "pii" => "S217357941730141X" "issn" => "21735794" "doi" => "10.1016/j.oftale.2017.07.003" "estado" => "S300" "fechaPublicacion" => "2017-10-01" "aid" => "1152" "copyright" => "Sociedad Española de Oftalmología" "copyrightAnyo" => "2017" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Arch Soc Esp Oftalmol. 2017;92:477-80" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0365669117300278" "issn" => "03656691" "doi" => "10.1016/j.oftal.2016.12.015" "estado" => "S300" "fechaPublicacion" => "2017-10-01" "aid" => "1152" "copyright" => "Sociedad Española de Oftalmología" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Arch Soc Esp Oftalmol. 2017;92:477-80" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 44 "formatos" => array:2 [ "HTML" => 36 "PDF" => 8 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Comunicación corta</span>" "titulo" => "Hemangioma capilar retiniano yuxtapapilar bilateral: utilidad de aflibercept en el manejo de sus complicaciones" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "477" "paginaFinal" => "480" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "BIlateral juxtapapillary retinal capillary haemangioma: Usefulness of aflibercept in the management of its complications" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1500 "Ancho" => 1500 "Tamanyo" => 375861 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">a) Retinografía, b) angiografía, c) mapa de la superficie macular y d) OCT del OI al mes de la cuarta inyección de aflibercept. La hemorragia y el DEP han desaparecido; persiste un pequeño acúmulo de contraste en la angiografía.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Campos Polo, C. Rubio Sánchez, D.M. García Guisado, M.J. Díaz Luque" "autores" => array:4 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Campos Polo" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Rubio Sánchez" ] 2 => array:2 [ "nombre" => "D.M." "apellidos" => "García Guisado" ] 3 => array:2 [ "nombre" => "M.J." "apellidos" => "Díaz Luque" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S217357941730141X" "doi" => "10.1016/j.oftale.2017.07.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357941730141X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365669117300278?idApp=UINPBA00004N" "url" => "/03656691/0000009200000010/v1_201709270108/S0365669117300278/v1_201709270108/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173579417301068" "issn" => "21735794" "doi" => "10.1016/j.oftale.2017.05.009" "estado" => "S300" "fechaPublicacion" => "2017-10-01" "aid" => "1148" "copyright" => "Sociedad Española de Oftalmología" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Arch Soc Esp Oftalmol. 2017;92:481-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Short communication</span>" "titulo" => "Bilateral exudative retinal detachment associated with central serous chorioretinopathy in a patient treated with corticosteroids" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "481" "paginaFinal" => "485" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Desprendimiento de retina exudativo bilateral asociado con coriorretinopatía serosa central en una paciente tratada con corticoesteroides" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0025" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1208 "Ancho" => 2500 "Tamanyo" => 249452 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Final stage of 2 eyes. Intense subretinal fibrosis, RPE atrophy and hypertrophy and epiretinal membranes.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "T. Rueda-Rueda, J.L. Sánchez-Vicente, L. Llerena-Manzorro, A. Medina-Tapia, L. González-García, A. Alfaro-Juárez, C. Vital-Berral, F. López-Herrero, A. Muñoz-Morales, L.S. Ortega, Á. Herrador-Montiel" "autores" => array:11 [ 0 => array:2 [ "nombre" => "T." "apellidos" => "Rueda-Rueda" ] 1 => array:2 [ "nombre" => "J.L." "apellidos" => "Sánchez-Vicente" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Llerena-Manzorro" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Medina-Tapia" ] 4 => array:2 [ "nombre" => "L." "apellidos" => "González-García" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Alfaro-Juárez" ] 6 => array:2 [ "nombre" => "C." "apellidos" => "Vital-Berral" ] 7 => array:2 [ "nombre" => "F." "apellidos" => "López-Herrero" ] 8 => array:2 [ "nombre" => "A." "apellidos" => "Muñoz-Morales" ] 9 => array:2 [ "nombre" => "L.S." "apellidos" => "Ortega" ] 10 => array:2 [ "nombre" => "Á." "apellidos" => "Herrador-Montiel" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0365669117300230" "doi" => "10.1016/j.oftal.2017.01.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365669117300230?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173579417301068?idApp=UINPBA00004N" "url" => "/21735794/0000009200000010/v1_201709270057/S2173579417301068/v1_201709270057/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173579417301524" "issn" => "21735794" "doi" => "10.1016/j.oftale.2017.07.006" "estado" => "S300" "fechaPublicacion" => "2017-10-01" "aid" => "1134" "copyright" => "Sociedad Española de Oftalmología" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Arch Soc Esp Oftalmol. 2017;92:472-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Anatomical and refractive outcomes in patients with treated retinopathy of prematurity" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "472" "paginaFinal" => "476" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Resultados anatómicos y refractivos en pacientes tratados por retinopatía del prematuro" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 757 "Ancho" => 991 "Tamanyo" => 98627 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Ocular fundus photograph showing posterior aggressive retinopathy with plus disease in 4 quadrants.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Lolas, A. Tuma, M. Zanolli, R. Agurto, R. Stevenson, D. Ossandón" "autores" => array:6 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Lolas" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Tuma" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Zanolli" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Agurto" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Stevenson" ] 5 => array:2 [ "nombre" => "D." "apellidos" => "Ossandón" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0365669117300096" "doi" => "10.1016/j.oftal.2016.12.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0365669117300096?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173579417301524?idApp=UINPBA00004N" "url" => "/21735794/0000009200000010/v1_201709270057/S2173579417301524/v1_201709270057/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Short communication</span>" "titulo" => "BIlateral juxtapapillary retinal capillary haemangioma: Usefulness of aflibercept in the management of its complications" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "477" "paginaFinal" => "480" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "R. Campos Polo, C. Rubio Sánchez, D.M. García Guisado, M.J. Díaz Luque" "autores" => array:4 [ 0 => array:4 [ "nombre" => "R." "apellidos" => "Campos Polo" "email" => array:1 [ 0 => "rafacampospolo@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Rubio Sánchez" ] 2 => array:2 [ "nombre" => "D.M." "apellidos" => "García Guisado" ] 3 => array:2 [ "nombre" => "M.J." "apellidos" => "Díaz Luque" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Oftalmología, Hospital Virgen del Puerto, Plasencia (Cáceres), Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hemangioma capilar retiniano yuxtapapilar bilateral: utilidad de aflibercept en el manejo de sus complicaciones" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1500 "Ancho" => 1500 "Tamanyo" => 222335 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">LE images after the first aflibercept injection: (a) retinograph, (d) angiograph, (g) OCT. After the 2nd injection: (b) retinograph, (e) angiograph, (h) OCT. After the 3rd injection: (c) retinograph, (f) angiograph, (i) OCT. Improvement is notable.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Clinic case report</span><p id="par0005" class="elsevierStylePara elsevierViewall">Male, age 45, recently diagnosed with suprarenal phaeochromocytoma, who consulted due to black spot in the left eye visual field, associated to metamorphopsiae with 2 days evolution.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Visual acuity (VA) was 1 in the right eye (RE) and 0.7 in the left eye (LE), with description of paracentral metamorphopsia. Anterior segment was normal and tonometry was 13<span class="elsevierStyleHsp" style=""></span>mmHg in both eyes. In ocular fundus of LE, a subretinal hemorrhage having 4 papillary diameters was observed adjacent to the optic nerve, while the RE showed a small vascular tumor in the papillomacular bundle associated to small dot-shaped hemorrhages. In fluorescein angiography, the blood produced a screen effect that prevented visualization of leak area in the LE, while the RE showed quick filling of the mass in arterial times that increased during the arteriovenous phase and remained stable in the late phase. Optical coherence tomography (OCT) showed pigment epithelium detachment (PED) in LE at the central level of the hemorrhage as well as in the papillomacular bundle, together with foveal profile rectification. The RE displayed a small PED that did not alter the macular area (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). All these findings were compatible with bilateral retinal capillary hemangioma (RCH).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was diagnosed with the von Hippel Lindau (VHL) disease and it was decided to prescribe a single aflibercept injections in the LE (Eylea, Regéneron, Tarrytown, NY, USA, and Bayer, Leverkusen, Germany) as compassionate indication due to the small distance between the tumor and the optic nerve. One month after the injection, LE VA increased to 0.8 and PED height and hemorrhage size diminished. Accordingly, it was decided to follow PRN treatment, consisting in monthly checkups, proceeding to inject if the condition improved vis-à-vis the previous checkup (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). After 4 aflibercept doses (in 4 consecutive months), LE VA increased from 0.7 to 1 (without metamorphopsia) and the hemorrhage resolved completely together with the PED. A small contrast aggregate corresponding to the hemangioma persisted but without increasing and remaining stable in late phases (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The same occurred in the contralateral eye that did not require treatment. The patient remains stable without treatment to this date, with a follow-up period of 13 months.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">The presence of RCH together with some characteristic injuries (such as cerebral hemangioblastoma, pheochromocytoma) confirmed the VHL disease<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> diagnostic.</p><p id="par0025" class="elsevierStylePara elsevierViewall">When said tumors are in the peripapillary area, management becomes complicated above all iF VA is relatively good because treatment could produce injuries in adjacent structures.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Different guides recommend observation in asymptomatic patients where the tumor remained stable. A range of treatments have been proposed including laser photocoagulation, photodynamic therapy (PTD) or anti-VEGF treatment, among others.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The efficacy of antiangiogenic treatment is due to the fact that stromal cells, that form the neoplastic hemangioma component, exhibit VEGF overexpression.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Fenestration in hemangioma capillaries mean that, after anti-VEGF treatment, contrast exhibits a localized diffusion that diminishes the exudative or hemorrhagic activity of the lesion. Ach et al. described good results after 9 doses of bevacizumab for treating progressive RCH located in the mid-periphery, halting lesion growth.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Chelala et al. obtained improvements in the size and exudation of a juxtapapillary RCH with a single ranibizumab injection.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Ziemssen et al. referred positive evolution of RCH treated with bevacizumab and PTD in what concerns diminished tumor size, exudation and visual acuity. Said authors proposed that the association of an anti-VEGF enables a reduction of PTD treatment fluency and minimizing damages to adjacent structures.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> It has been proposed that anti-VEGF could be efficient for treating small tumors due to the higher cellular proliferation rate that is sensitive to angiogenesis inhibition.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> In addition, of all proposed treatments, this is the one that presents the lowest potential complications, which is extremely important because the affected part is the most sensitive area of the retina.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> The authors consider that aflibercept could be a useful medicament due to its efficacy demonstrated in other retinal conditions that produce PED<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> which, in the present case, was due to the endophytic component of the tumor associated to significant hemorrhage. In this way it was possible to control complications associated to RCH and restore patient VA by means of aflibercept monotherapy without causing damages in structures adjacent to the lesion.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conflict of interests</span><p id="par0035" class="elsevierStylePara elsevierViewall">No conflict of interests was declared by the authors.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:3 [ "identificador" => "xres906141" "titulo" => "Abstract" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Case report" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Discussion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec886583" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres906142" "titulo" => "Resumen" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "abst0015" "titulo" => "Caso clínico" ] 1 => array:2 [ "identificador" => "abst0020" "titulo" => "Discusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec886584" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Clinic case report" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Discussion" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflict of interests" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-11-29" "fechaAceptado" => "2016-12-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec886583" "palabras" => array:5 [ 0 => "Phaeochromocytoma" 1 => "Retinal capillary haemangioma" 2 => "Subretinal juxtapapillary hemorrhage" 3 => "Von Hippel Lindau disease" 4 => "Aflibercept" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec886584" "palabras" => array:5 [ 0 => "Feocromocitoma" 1 => "Hemangioma capilar retiniano" 2 => "Hemorragia subretiniana yuxtapapilar" 3 => "Enfermedad de von Hippel Lindau" 4 => "Aflibercept" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Case report</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A 45 year-old man with a history of adrenal phaeochromocytoma presented with a subretinal juxtapapillary hemorrhage on his left eye and a small asymptomatic vascular tumor in the contralateral eye. With the mentioned findings, the patient was diagnosed with bilateral retinal capillary haemangioma in the context of a von Hippel Lindau disease. Intravitreal aflibercept was prescribed, with a good outcome of the disease.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Many treatments have been proposed for the management of juxtapapillary retinal capillary haemangioma with variable results. Intravitreal aflibercept can be a useful treatment with a good safety profile.</p></span>" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Case report" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Discussion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Caso clínico</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Varón de 45 años, con antecedentes personales de feocromocitoma suprarrenal, que presenta una hemorragia subretiniana yuxtapapilar en el ojo izquierdo y un pequeño tumor vascular asintomático en el ojo contralateral. Con los hallazgos mencionados, el paciente fue diagnosticado de hemangioma capilar retiniano bilateral en el contexto de una enfermedad de von Hippel Lindau y se pautó aflibercept intravítreo, con una buena evolución del cuadro.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se han propuesto múltiples tratamientos para el manejo del hemangioma capilar retiniano yuxtapapilar, con unos resultados variables. El aflibercept intravítreo puede ser un tratamiento de utilidad, con un buen perfil de seguridad.</p></span>" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "abst0015" "titulo" => "Caso clínico" ] 1 => array:2 [ "identificador" => "abst0020" "titulo" => "Discusión" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Campos Polo R, Rubio Sánchez C, García Guisado DM, Díaz Luque MJ. Hemangioma capilar retiniano yuxtapapilar bilateral: utilidad de aflibercept en el manejo de sus complicaciones. Arch Soc Esp Oftalmol. 2017;92:477–480.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1500 "Ancho" => 1500 "Tamanyo" => 299067 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">RE images: (a) retinograph, (c) angiograph, (e) OCT. LE images: (b) retinograph, (d) angiograph (screen effect of subretinal hemorrhage preventing visualization of RCH), (f) OCT (subretinal hemorrhage produces PED).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1500 "Ancho" => 1500 "Tamanyo" => 222335 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">LE images after the first aflibercept injection: (a) retinograph, (d) angiograph, (g) OCT. After the 2nd injection: (b) retinograph, (e) angiograph, (h) OCT. After the 3rd injection: (c) retinograph, (f) angiograph, (i) OCT. Improvement is notable.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1500 "Ancho" => 1500 "Tamanyo" => 375861 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">(a) Retinograph, (b) angiograph, (c) macular surface map, and (d) LE OCT one month after the 4th aflibercept injection. Hemorrhage and PED have disappeared, with small contrast aggregate persisting in angiograph.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Juxtapapillary capillary hemangiomas: clinical features and visual acuity outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.M. McCabe" 1 => "H.W. Flynn Jr." 2 => "C.L. Shields" 3 => "J.A. Shields" 4 => "C.D. Regillo" 5 => "H.R. McDonald" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ophthalmology" "fecha" => "2000" "volumen" => "107" "paginaInicial" => "2240" "paginaFinal" => "2248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11097604" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Benefits and complications of photodynamic therapy of papillary capillary hemangiomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "U.M. Schmidt-Erfurth" 1 => "C. Kusserow" 2 => "I.A. Barbazetto" 3 => "H. Laqua" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ophthalmology" "fecha" => "2002" "volumen" => "109" "paginaInicial" => "1256" "paginaFinal" => "1266" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12093647" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapeutic options for capillary papillary hemangiomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J1 Garcia-Arumi" 1 => "L.H. Sararols" 2 => "L. Cavero" 3 => "F. Escalada" 4 => "B.F. Corco¿stegui" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ophthalmology" "fecha" => "2000" "volumen" => "107" "paginaInicial" => "48" "paginaFinal" => "54" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10647718" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Juxtapapillary capillary hemangiomas: clinical features and visual acuity outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.M. McCabe" 1 => "H.W. Flynn Jr." 2 => "C.L. Shields" 3 => "J.A. Shields" 4 => "C.D. Regillo" 5 => "H.R. McDonald" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ophthalmology" "fecha" => "2000" "volumen" => "107" "paginaInicial" => "2240" "paginaFinal" => "2248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11097604" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intravitreal bevacizumab for retinal capillary haemangioma: longterm results" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T. Ach" 1 => "D. Thiemeyer" 2 => "A.E. Hoeh" 3 => "K.B. Schaal" 4 => "S. Dithmar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1755-3768.2009.01594.x" "Revista" => array:6 [ "tituloSerie" => "Acta Ophthalmol" "fecha" => "2010" "volumen" => "88" "paginaInicial" => "e137" "paginaFinal" => "e138" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19681788" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intravitreal anti-VEGF injection for the treatment of progressive juxtapapillary retinal capillary hemangioma: a case report and mini review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Chelala" 1 => "A. Dirani" 2 => "A. Fadlallah" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/OPTH.S53243" "Revista" => array:6 [ "tituloSerie" => "Clin Ophthalmol" "fecha" => "2013" "volumen" => "7" "paginaInicial" => "2143" "paginaFinal" => "2146" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24204117" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combined treatment of a juxtapapillary retinal capillary haemangioma with intravitreal bevacizumab and photodynamic therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F. Ziemssen" 1 => "M. Voelker" 2 => "W. Inhoffen" 3 => "K.U. Bartz-Schmidt" 4 => "F. Gelisken" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eye (Lond)" "fecha" => "2007" "volumen" => "21" "paginaInicial" => "1125" "paginaFinal" => "1126" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intravitreal ranibizumab therapy for retinal capillary hemangioblastoma related to von Hippel–Lindau disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "W.T. Wong" 1 => "K.J. Liang" 2 => "K. Hammel" 3 => "H.R. Coleman" 4 => "E.Y. Chew" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ophtha.2008.04.033" "Revista" => array:6 [ "tituloSerie" => "Ophthalmology" "fecha" => "2008" "volumen" => "115" "paginaInicial" => "1957" "paginaFinal" => "1964" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18789534" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Massive exudative retinal detachment following photodynamic therapy forretinal hemangioma in von Hippel-Lindau syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Y. Chen" 1 => "H. Liu" 2 => "K. Zhang" 3 => "L. Gao" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.pdpdt.2014.02.013" "Revista" => array:6 [ "tituloSerie" => "Photodiagnosis Photodyn Ther" "fecha" => "2014" "volumen" => "11" "paginaInicial" => "250" "paginaFinal" => "253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24632330" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resolution of a giant pigment epithelial detachment with half-dose aflibercept" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Nagiel" 1 => "S.R. Sadda" 2 => "S.D. Schwartz" 3 => "D. Sarraf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ICB.0000000000000184" "Revista" => array:6 [ "tituloSerie" => "Retin Cases Brief Rep" "fecha" => "2015" "volumen" => "9" "paginaInicial" => "269" "paginaFinal" => "272" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26237136" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735794/0000009200000010/v1_201709270057/S217357941730141X/v1_201709270057/en/main.assets" "Apartado" => array:4 [ "identificador" => "5812" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Short communications" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735794/0000009200000010/v1_201709270057/S217357941730141X/v1_201709270057/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357941730141X?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2023 March | 1 | 2 | 3 |
| 2020 September | 0 | 1 | 1 |
