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Lateral rectus muscle biopsy as diagnosis of unknown metastatic breast cancer
Biopsia del músculo recto lateral orbitario como diagnóstico de cáncer de mama metastásico no conocido
F. Hernández Pardinesa,
Corresponding author
oftalmofer@yahoo.es

Corresponding author.
, M.C. Serra Verdúa, A. Bernal Vidalb, J.M. Mayol Beldac, E. Mengual Verdúa
a Servicio de Oftalmología, Hospital de San Juan de Alicante, Alicante, Spain
b Servicio de Oncología, Hospital de San Juan de Alicante, Alicante, Spain
c Servicio de Anatomía Patológica, Hospital de San Juan de Alicante, Alicante, Spain
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In addition&#44; bone marrow aspiration was performed&#44; the analysis of which reported hypoplasia secondary to metastatic infiltration of unknown primary source&#44; and proteingram in blood and urine with normal results&#44; diminishing the probability of myeloma diagnostic&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Thoracoabdominal CT without contrast due to kidney insufficiency revealed multiple paratracheal and infrahilar mediastinic adenopathies&#44; pre-vascular&#44; supraclavicular and axillary bilateral ganglions&#44; left pleural effusion&#44; thin pericardium effusion and pathological rib fractures&#46; The abdomen also exhibited retroperitoneal adenopathies and multiple vertebral diffuse lytic lesions with permeation pattern&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Cranial CT without contrast due to kidney insufficiency showed diffuse and lytic bone involvement in the calotte in permeating &#8220;salt and pepper&#8221; pattern with associated soft parts component&#46; In addition&#44; a lesion adjacent to the lateral wall of the left orbit was observed&#44; exhibiting soft parts density measuring 3<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1&#46;2<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>1&#46;6<span class="elsevierStyleHsp" style=""></span>cm&#44; that includes the external rectus muscle exerting a mass effect on the optic nerve causing medial displacement &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Due to these findings&#44; external rectus lesion biopsy was indicated&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">With prior transfusion of platelets&#44; in the same day the CT-guided sacral bone biopsy and the lateral rectus muscle biopsy &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; were taken&#46; Both biopsies produced the same result&#44; i&#46;e&#46;&#44; the epithelial cells with positive CK 19 and 7 immunophenotype&#44; hormonal receptors for positive diffuse estrogens and for progesterone positive &#40;30&#37;&#41;&#44; with a Ki67 cell proliferation index &#40;MIB1&#41; of 12&#37; and negative herceptest&#46; These findings suggested carcinoma metastases compatible with mammary origin&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Subsequent physical examination confirmed the presence of a supra-areolar nodule through palpation of the left breast&#44; although it was decided not to take a mammography or biopsy due to the clinic condition of the patient&#46; Due to the persistence of thrombocytopenia and anemia secondary to bone marrow infiltration together with the clinic worsening of the patient despite medical treatment&#44; together with visceral crisis due to metastatic breast cancer stage&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSmallCaps">IV</span> luminal A&#44; chemotherapy treatment was initiated on the basis of paclitaxel scheme &#40;Taxol<span class="elsevierStyleSup">&#174;</span>&#41; 80<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span> at 80&#37; of the dosage on days 1&#44; 8 and 15 every 21 days&#44; associating zolendronic acid &#40;Zometa<span class="elsevierStyleSup">&#174;</span>&#41; with each cycle&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">After beginning chemotherapy treatment&#44; the patient exhibited progressive clinic improvement with control of dyspnea&#44; beginning ambulation with rehabilitation treatment&#44; progressive improvement of thrombocytopenia and without treatment-derived toxicity&#46; Ophthalmological clinic did not evidence anatomical or clinical improvement or worsening of the lesion in successive radiological controls&#46; After 73 days in the hospital&#44; the patient requested transfer to her country to continue recovery with rest and prescribed treatment&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">An atypical case of horizontal diplopia in the context of a patient with severe overall condition without established diagnostic is presented&#46; Lateral rectus biopsy together with brain marrow biopsy were key to reach confirmation diagnostic&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Tumor orbital metastases is a rare disease with an incidence of 1&#8211;13&#37; of all orbital tumors&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a> accounting for a lower percentage than metastasis at the ocular level&#46; In up to 25&#37; of cases&#44; orbital metastasis is the initial presentation of undiagnosed cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Breast cancer is the tumor that most frequently produces metastases at the orbital level in adults&#44; mainly compromising periorbital fat and extraocular muscles&#44; with a preference for the lateral orbital quadrant&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Ophthalmological clinic generally debuts with diplopia&#44; proptosis or ocular movement alterations&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a> The latency period observed in breast cancer metastasis is longer compared to other types of primary cancer &#40;mean 4&#46;5&#8211;6&#46;5 years&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Histological diagnostic through orbital biopsy should only be carried out if the primary tumor is not known as in this case&#44; or when the orbit is the only likely metastasis location as this would involve a significant prognostic modification&#46; The most widely accepted technique at present is open surgical biopsy&#44; as PAAF has demonstrated to involve the risk of tumor dissemination&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">4</span></a> In the present case&#44; presentation symptom was ocular &#40;binocular diplopia&#41; with the orbital lesion biopsy being decisive for diagnostic&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflict of interests</span><p id="par0075" class="elsevierStylePara elsevierViewall">No conflict of interests was declared by the authors&#46;</p></span></span>"
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            0 => "Met&#225;stasis de c&#225;ncer de mama"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The case concerns a 58 year-old female with no medical history of interest who consulted due to binocular diplopia of one week onset&#46; It was associated with costal pain&#44; dyspnea&#44; intense asthenia and weight loss of 2 months onset&#46; In the blood analysis in the Emergency Department it showed hypercalcaemia&#44; renal failure&#44; and bicytopenia&#46; The chest X-ray showed lytic bone lesions that initially lead to multiple myeloma with extra-osseous involvement&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">In addition to the corresponding study&#44; in case of horizontal diplopia&#44; a cranial CT scan without contrast was performed where an adjacent lesion to the lateral wall of the left orbit is observed&#46; This was of soft tissue density&#44; and included the external rectus muscle that exerts a mass effect on the optic nerve by displacing it medially&#46; Many lytic bone diffuse lesions with salt and pepper pattern were found in the calotte&#46; A rectus lateral muscle and bone biopsy of the sacral wing was performed&#44; resulting in metastasis of carcinoma compatible with mammary origin&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">An atypical case is presented of horizontal diplopia in the context of a patient with a severe constitutional picture with no established diagnosis&#44; in which the biopsy of the lateral rectum was key to the confirmation diagnosis&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Mujer de 58 a&#241;os sin antecedentes m&#233;dicos de inter&#233;s que consulta por diplop&#237;a binocular de una semana de evoluci&#243;n&#44; asociada a dolor costal&#44; disnea&#44; astenia intensa y p&#233;rdida de peso de 2 meses de evoluci&#243;n&#46; En la anal&#237;tica de urgencia presenta hipercalcemia&#44; insuficiencia renal y bicitopenia&#44; y en la radiograf&#237;a de t&#243;rax de urgencias se observan m&#250;ltiples im&#225;genes osteocl&#225;sticas que orientan inicialmente a mieloma m&#250;ltiple con afectaci&#243;n extra&#243;sea&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Adem&#225;s del estudio correspondiente&#44; ante la diplop&#237;a horizontal se realiza TC craneal sin contraste&#44; donde se observa una lesi&#243;n adyacente a la pared lateral de la &#243;rbita izquierda&#44; de densidad de partes blandas&#44; que incluye el m&#250;sculo recto externo y ejerce efecto masa sobre el nervio &#243;ptico desplaz&#225;ndolo medialmente&#46; Adem&#225;s se observan m&#250;ltiples lesiones l&#237;ticas de distribuci&#243;n difusa en la calota&#44; con patr&#243;n permeativo &#171;en sal y pimienta&#187;&#46; Se procede a la biopsia del m&#250;sculo recto lateral y &#243;sea de ala sacra&#44; obteniendo como resultado met&#225;stasis de carcinoma compatible con origen mamario&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Presentamos un caso at&#237;pico de diplop&#237;a horizontal en el contexto de una paciente con un cuadro constitucional severo sin diagn&#243;stico establecido&#44; en el que la biopsia del recto lateral&#44; junto con la biopsia de m&#233;dula &#243;sea&#44; son claves a la hora del diagn&#243;stico de confirmaci&#243;n&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Hern&#225;ndez Pardines F&#44; Serra Verd&#250; MC&#44; Bernal Vidal A&#44; Mayol Belda JM&#44; Mengual Verd&#250; E&#46; Biopsia del m&#250;sculo recto lateral orbitario como diagn&#243;stico de c&#225;ncer de mama metast&#225;sico no conocido&#46; Arch Soc Esp Oftalmol&#46; 2019&#59;94&#58;192&#8211;195&#46;</p>"
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ISSN: 21735794
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