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Acute narrow-angle glaucoma induced by topiramate with acute myopia and macular striae: A case report
Glaucoma agudo de ángulo cerrado inducido por topiramato con miopización aguda y estrías maculares: a propósito de un caso
M.A. Sierra-Rodríguez
Corresponding author
sffera@hotmail.com

Corresponding author.
, L. Rodríguez-Vicente, J.J. Chavarri-García, J.L. del Río-Mayor
Servicio de Oftalmología, Hospital San Pedro, Logroño, La Rioja, Spain
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and &#8722;1&#46;50&#59; &#8722;0&#46;75 at 100&#176; in the left eye &#40;LE&#41;&#44; with best corrected visual acuity &#40;BCVA&#41; of 1 in BE at the latest checkup 6 months before&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Ophthalmological examination produced finger counting VA at 3<span class="elsevierStyleHsp" style=""></span>m in BE with usual spectacles&#46; Refractometry showed myopization of &#8722;13 diopters in BE with respect to the previous grade&#46; Anterior pole exhibited slight conjunctival injection&#44; conjunctival chemosis&#44; narrow anterior chambers without cell reaction &#40;negative Tyndall&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41; and bilateral angle closure evidenced with gonioscopy&#46; Intraocular pressure &#40;IOP&#41; was 38<span class="elsevierStyleHsp" style=""></span>mmHg in BE and ocular fundus exhibited macular striae &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; in BE&#44; confirmed with macular optical coherence tomography &#40;OCT&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#41;&#46; Considering bilateral compromise and topiramate treatment history&#44; the diagnostic of angle closure acute glaucoma &#40;ACAG&#41; secondary to topiramate was concluded&#46; Systemic treatment was administered with 250<span class="elsevierStyleHsp" style=""></span>cc of 20&#37; mannitol&#44; topical treatment with timolol and brinzolamide&#44; forcing midriasis with cycloplegic&#44; suspending treatment in agreement with the prescribing physician&#46; A few hours after beginning treatment&#44; anterior chambers gained depth&#44; myopization diminished in 4 diopters and IOP was 16<span class="elsevierStyleHsp" style=""></span>mmHg in BE&#46; Three days after the first visit&#44; VA had improved to 1 in BE with usual spectacles&#44; IOP was 14<span class="elsevierStyleHsp" style=""></span>mmHg in BE and anterior and posterior pole ophthalmological examination &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41; was completely normal&#46; An additional macular OCT was taken&#44; evidencing the disappearance of macular striae &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B&#41;&#46; Three months after onset of the disorder&#44; the patient remains stable&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">Topiramate is an anti-convulsive used mainly for treating epilepsy and as prophylactic treatment for migraine&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Most frequent adverse reactions include nervous disorders and weight loss&#44; with ocular compromise being infrequent&#46; Of described ocular adverse effects of topiramate&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> ACAG is the most frequent &#40;58&#46;3&#8211;74&#46;8&#37; of cases&#41;&#46; It arises approximately between 7 and 12&#46;8 days of administration&#46; Myopization occurs in 14&#46;8&#8211;20&#46;2&#37; of cases and appears at 8&#46;59 days&#44; prior to ACAG&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Other effects such as choroidal effusion&#44; visual field defects&#44; scleritis&#44; maculopathy&#44; retinal striae&#44; diplopia and nystagmus have been described&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Approximately 85&#37; of patients &#40;generally females&#41; exhibit symptoms such as blurred vision due to myopization and headaches caused by sharp IOP increase within 2 weeks from beginning treatment or when changing dose&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;4</span></a> In the present case&#44; symptoms appeared 2 days after increasing the dose and 9 days of treatment&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Angle closure induced by topiramate is usually bilateral and occurs in the absence of pupil blockage&#44; as a consequence of ciliochoroidal effusion and ciliary body edema which give rise to anterior ciliary body rotation&#44; anterior displacement of iris lens diaphragm and lens curving due to relaxation of the zonule&#44; in turn giving rise to anterior chamber narrowing and increased distance between the lens and the retina&#44; which accounts for the myopization and angle closure&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;3</span></a> The authors were not able to confirm the existence of ciliochoroidal effusion due to the unavailability of ultrasound biomicroscopy&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In the present case&#44; in addition to ACAG and myopization&#44; macular striae were observed in OCT&#46; Even though these have been described in other cases&#44; very few reports include retinography and OCT Images&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;6</span></a> Guier<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> suggests that the striae are caused by folds in the internal limiting membrane &#40;ILM&#41; due to the volume effect of choroidal effusion&#44; causing redundancy of the overlying retina&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Oral or intravenous acetazolamide and topical hypotensors can be used for treating ACAG after suspending topiramate&#46; However&#44; prostaglandin analogs and miotics &#40;pilocarpine&#41; should be avoided because topiramate-induced ACAG comprises an underlying inflammatory component&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> The present case did not exhibit cellular reaction in the anterior chamber&#44; although cases of uveitis<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> and vitritis<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> have been reported in patients with topiramate-induced ACAG&#44; in which case the use of topical steroids is recommended&#46; Miotics could even worsen angle closure by producing relative pupil blockage and anterior displacement of the iris lens diaphragm&#46; In contrast&#44; cycloplegics diminish IOP by producing a retraction of ciliary processes and deepening the anterior chamber due to posterior displacement of the iris lens diaphragm&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Laser iridotomy is not recommended in these patients because the main mechanism is not pupil blockage&#44; although some authors suggest that it could be useful in refractory cases&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The present case responded positively to treatment with intravenous mannitol&#44; topical hypotensors and cycloplegic after suspending topiramate&#46; VA&#44; IOP&#44; the refractive condition&#44; the angle and anterior chamber recovered their original condition&#44; while ciliochoroidal effusion and macula striae resolved in a few days&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">It is important to differentiate a case of topiramate-induced ACAG from a primary ACAG case because clinic presentation&#44; action mechanism and treatment are all different&#46; Inadequate management could involve potentially severe consequences leading to blindness due to persistent high IOP&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflict of interests</span><p id="par0045" class="elsevierStylePara elsevierViewall">No conflict of interests was declared by the authors&#46;</p></span></span>"
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            0 => "Topiramato"
            1 => "Efusi&#243;n ciliocoroidea"
            2 => "Glaucoma agudo de &#225;ngulo cerrado"
            3 => "Miopizaci&#243;n"
            4 => "Estr&#237;as maculares"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We report the case of a 29-year-old epileptic woman who had been on treatment with topiramate 25<span class="elsevierStyleHsp" style=""></span>mg&#47;day for 9 days&#46; She was referred to the Emergency Department due to reduction in far visual acuity &#40;VA&#41; after increasing the dose to 50<span class="elsevierStyleHsp" style=""></span>mg&#47;day two days before&#46; The ocular examination showed bilateral acute angle closure glaucoma &#40;AACG&#41; and macular striae in both eyes &#40;AO&#41; observed by Retinography and Optical Coherence Tomography &#40;OCT&#41;&#46; The AACG is a well-known side effect of topiramate&#44; but the macular striae rarely accompanies it&#46; Although macular striae have been previously described in other cases&#44; very few document those using retinography and OCT images&#46; Therefore&#44; it is important to differentiate a case of AACG induced by topiramate from a case of primary AACG&#44; since they differ in their clinical presentation&#44; mechanism of action&#44; and treatment&#46; Mismanagement can have potentially serious consequences&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Presentamos el caso cl&#237;nico de una mujer epil&#233;ptica de 29 a&#241;os en tratamiento con topiramato 25<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a desde 9 d&#237;as previos a la presentaci&#243;n del cuadro&#44; que acude a urgencias por disminuci&#243;n de la agudeza visual &#40;AV&#41; tras incrementar la dosis a 50<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a 2 d&#237;as antes&#46; En la exploraci&#243;n presenta un glaucoma agudo de &#225;ngulo cerrado &#40;GAAC&#41; bilateral y estr&#237;as maculares en ambos ojos &#40;AO&#41; objetivadas mediante retinograf&#237;a y tomograf&#237;a de coherencia &#243;ptica &#40;OCT&#41;&#46; El GAAC es un efecto secundario conocido y ampliamente descrito del topiramato&#44; sin embargo&#44; las estr&#237;as maculares que ocasionalmente acompa&#241;an al GAAC&#44; aunque se han descrito anteriormente en otros casos&#44; muy pocos las documentan mediante im&#225;genes de retinograf&#237;a y OCT&#46; Es importante diferenciar un caso de GAAC inducido por topiramato de un caso de GAAC primario ya que difieren en su presentaci&#243;n cl&#237;nica&#44; mecanismo de acci&#243;n y tratamiento&#46; Su manejo inadecuado puede tener consecuencias potencialmente graves&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Sierra-Rodr&#237;guez MA&#44; Rodr&#237;guez-Vicente L&#44; Chavarri-Garc&#237;a JJ&#44; del R&#237;o-Mayor JL&#46; Glaucoma agudo de &#225;ngulo cerrado inducido por topiramato con miopizaci&#243;n aguda y estr&#237;as maculares&#58; a prop&#243;sito de un caso&#46; Arch Soc Esp Oftalmol&#46; 2019&#59;94&#58;130&#8211;133&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Anterior pole image showing slight conjunctival injection&#44; conjunctival chemosis and narrow anterior chamber in BE&#46; &#40;B&#41; Resolution of the condition&#46;</p>"
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Article information
ISSN: 21735794
Original language: English
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