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Bilateral acute iris depigmentation and bilateral acute iris transillumination syndrome
Síndrome de despigmentación aguda bilateral de iris y transiluminación aguda bilateral de iris
T. Rueda-Ruedaa, L.J. Sánchez-Vicenteb, A. Moruno-Rodríguezc,
Corresponding author
antoniomoruno_89@hotmail.com

Corresponding author.
, J. Monge-Esquivelc, A. Muñoz-Moralesd, F. López-Herreroe
a Servicio de Oftalmología, Sección de Uveítis, Hospital Universitario Virgen del Rocío, Sevilla, Spain
b Servicio de Oftalmología, Sección de Retina Quirúrgica, Hospital Universitario Virgen del Rocío, Sevilla, Spain
c Servicio de Oftalmología, Sección General, Hospital Universitario Virgen del Rocío, Sevilla, Spain
d Servicio de Oftalmología, Sección de Córnea, Hospital Universitario Virgen del Rocío, Sevilla, Spain
e Servicio de Oftalmología, Sección de Retina Médica, Hospital Universitario Virgen del Rocío, Sevilla, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The bilateral acute transillumination of iris syndrome &#40;BATI&#41; was first described in 2011 by Tugal-Tutkun et al&#46; who reported 26 patients with acute and bilateral clinic characterized by the loss of iridian pigment&#44; iris transillumination&#44; pigment dispersion in anterior chamber&#44; pupils in medium mydriasis with poor or null response to light and increased intraocular pressure &#40;IOP&#41; in some cases&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In 2006 the same author described the bilateral acute depigmentation of the iris syndrome &#40;BADI&#41;&#44; with pigment dispersion in anterior chamber&#44; iris stroma depigmentation and pigment deposits in anterior chamber&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">BADI exhibits a more benign course with absence of transillumination&#44; considerably less frequent IOP increases and absence of pupil compromise&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The case of a patient with BATI is presented&#44; exhibiting iris stromal depigmentation areas which are typical of said syndrome&#46; This supports the idea that both entities are parts of the same disease&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinic case report</span><p id="par0025" class="elsevierStylePara elsevierViewall">Patient&#44; 34&#44; referred from the Emergency Dept&#46; due to acute bilateral panuveitis with ocular hypertension&#46; The patient referred sudden loss of vision in both eyes with maximum corrected visual acuity &#40;MCVA&#41; of 0&#46;2 in the right eye &#40;RE&#41; and 0&#46;3 in the left eye &#40;LE&#41;&#46; IOP was 32<span class="elsevierStyleHsp" style=""></span>mmHg in RE and 42<span class="elsevierStyleHsp" style=""></span>mmHg in LE&#46; The episode was preceded by fever with headaches related to tonsillitis treated with azithromycin and paracetamol&#46; The condition was treated with oral and topical corticoids &#40;prednisolone at 3<span class="elsevierStyleHsp" style=""></span>h intervals&#41; and topical hypotensors &#40;0&#46;5&#37; brinzolamide&#44; brimonidine and timolol every 12<span class="elsevierStyleHsp" style=""></span>h&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Examined at the practice 2 days later&#44; the patient exhibited significant improvement of symptoms&#46; MCVA had improved to 0&#46;6 in the RE and 0&#46;5 in the LE&#44; while IOP had diminished to 20 and 14<span class="elsevierStyleHsp" style=""></span>mmHg in the RE and LE&#44; respectively&#46; Biomicroscopy showed hardly reactive medium mydriasis&#46; The iris showed depigmentation areas with some transillumination areas&#46; Anterior chamber evidenced the existence of pigment dispersion with pigment deposits in the corneal endothelium and anterior chamber angle &#40;visible with gonioscopy&#41;&#46; No inflammatory keratic precipitates were observed &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; Similarly&#44; iris concave surface or posterior displacement was not observed&#46; These findings were confirmed with anterior segment optical coherence tomography &#40;DRI OCT Triton plus&#44; Topcon Medical Systems&#44; Inc&#46;&#41;&#44; discarding the possibility of pigment dispersion syndrome &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">No signs of inflammation were observed in the vitreous or the retina&#46; Papilla exhibited poorly defined edges&#44; initially attributed to the possible presence of drusen in the optic disc&#46; This was subsequently confirmed with OCT and ocular echography &#40;Aviso&#44; Quantel MedicaLikewise&#44; the presence of macular edema was discarded by means of macular OCT&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In the absence of inflammatory cells&#44; posterior synechiae and keratic precipitates that could point to iridocyclitis&#44; a suspected diagnostic of BADI transillumination was established&#44; initiating uveitis study to discard other causes&#46; Analytics and serological studies produced normal results &#40;<span class="elsevierStyleItalic">Bartonella</span>&#44; <span class="elsevierStyleItalic">Coxiella</span>&#44; <span class="elsevierStyleItalic">Rickettsia</span>&#44; cytomegalovirus&#44; Epstein&#8211;Barr virus&#44; hepatitis B and <span class="elsevierStyleSmallCaps">C</span> virus&#44; herpes zoster&#44; herpes simplex&#44; <span class="elsevierStyleItalic">Toxocara</span>&#44; toxoplasma and syphilis&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Six months later&#44; MCVA was 1&#46;0 in both eyes with IOP under control with 0&#46;5&#37; brinzolamide&#44; brimonidine and timolol every 12<span class="elsevierStyleHsp" style=""></span>h&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">BADI as well as BATI exhibit typical characteristics enabling differentiation between both&#46; In the case of BADI&#44; geographic or diffuse depigmentation of the iridium stroma is found&#44; without papillary compromise and absence of transillumination defects&#46; In contrast&#44; patients with BATI presented with dilated and atonic pupils&#44; transillumination defects and absence of iris stroma compromise&#46; In BADI&#44; pigment dispersion occurs from the iris stroma while in BATI it arises from the pigment epithelium of the iris&#46; In addition&#44; BADI exhibits a more benign course with lower ocular hypertension incidence which is generally temporary as well as reversibility of iris alterations in some cases&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Despite the above differences&#44; some authors consider the possibility that both entities constitute different expressions of the same disease&#44; basically due to the presence of common characteristics such as debut with acute red eye together with photophobia and pigment dispersion&#44; higher prevalence in females&#44; the fact of being preceded by high airways infection and positive response to corticoids&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;3</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The present patient exhibited geographic depigmentation of the iris associated to typical BATI characteristics such as iris transillumination&#44; dilated and atonic pupils and increased IOP&#46; The coexistence of said findings in the same patient gives rise to the possibility of an intermediate clinic in evolution between BADI and BATI&#44; supporting the idea that both entities are expressions of the same disease&#46; Accordingly&#44; BADI would be an earlier expression with less severe clinic expressions than BATI&#44; which would be found in the other extreme of the disease&#44; with severe signs and symptoms&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The etiology of the disease is unknown&#46; Some authors have related it to the use of moxifloxacin and other quinolones<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4&#44;5</span></a> or other antibiotics&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a> Other authors<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> do not endorse said hypothesis&#46; Active viral infection has also been suggested&#44; including herpes&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2&#44;7</span></a> On the basis of a possible viral cause&#44; topical antivirals have been utilized &#40;0&#46;15&#37; ganciclovir ophthalmic gel&#41; in some isolated cases with positive response to treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> However&#44; Tugal-Tutkun et al&#46; consider that the reversibility of changes in the iris is not compatible with active viral inflammation or infection&#46; Said author argues that reversibility could be explained by a neuropathic effect&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Amin et al&#46; reported a simultaneous occurrence in 2 twins&#46; On the basis of this finding and the fact that the majority of cases have been described in Turkey in geographically close locations and with common genetic characteristics&#44; said author proposed the possibility of genetic predisposition toward the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">A differential diagnostic must consider the possibility of iridocyclitis&#44; particularly due to herpes virus and cytomegalovirus which could give rise to hypotensive uveitis&#44; Fuchs&#8217; uveitis syndrome&#44; pigment dispersion syndrome and pseudoexfoliative syndrome&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The BADI-BATI syndrome constitutes a new clinic entity of unknown etiology&#44; the diagnostic of which is based on a group of clinic characteristics&#46; Both entities could be part of the range of a single disease&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflict of interests</span><p id="par0085" class="elsevierStylePara elsevierViewall">No conflict of interests was disclosed by the authors who also state that they have not received any financial support&#46;</p></span></span>"
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            0 => "Iris transillumination"
            1 => "Iris depigmentation"
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            0 => "Transiluminaci&#243;n de iris"
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            2 => "Dispersi&#243;n pigmentaria"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The case is presented of a 32 year-old male who arrived with acute bilateral symptoms with blurred vision&#44; red eye&#44; severe photophobia and severe ocular pain after suffering from a flu-like syndrome&#46; The patient presented with a clinical picture of bilateral involvement characterized by pupils in mid-mydriasis&#44; scarcely reactive to light&#44; iris transillumination&#44; diffuse depigmentation of the iridian stroma&#44; pigment dispersion in the anterior chamber&#44; and ocular hypertension&#46; After the eye examination an inflammatory syndrome and pigmentary glaucoma were ruled out&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The patient showed depigmentation characteristics as well as bilateral iris transillumination&#46; Both conditions could form part of the spectrum of the same disease&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Var&#243;n de 32 a&#241;os que acude con un cuadro agudo bilateral caracterizado por visi&#243;n borrosa&#44; ojo rojo&#44; fotofobia severa y dolor ocular tras un cuadro seudogripal&#46; El paciente presentaba un cuadro con afectaci&#243;n bilateral caracterizado por pupilas en midriasis media&#44; escasamente reactivas a la luz&#44; transiluminaci&#243;n del iris&#44; despigmentaci&#243;n difusa del estroma iridiano&#44; dispersi&#243;n de pigmento en la c&#225;mara anterior e hipertensi&#243;n ocular&#46; Tras el examen ocular se descart&#243; un cuadro inflamatorio y un glaucoma pigmentario&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El paciente presentaba caracter&#237;sticas tanto de la despigmentaci&#243;n como de la transiluminaci&#243;n bilateral de iris&#46; Ambas entidades podr&#237;an formar parte del espectro de la misma enfermedad&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Rueda-Rueda T&#44; S&#225;nchez-Vicente LJ&#44; Moruno-Rodr&#237;guez A&#44; Monge-Esquivel J&#44; Mu&#241;oz-Morales A&#44; L&#243;pez-Herrero F&#46; S&#237;ndrome de despigmentaci&#243;n aguda bilateral de iris y transiluminaci&#243;n aguda bilateral de iris&#46; Arch Soc Esp Oftalmol&#46; 2019&#59;94&#58;355&#8211;358&#46;</p>"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">&#40;a&#41; Pupils in medium mydriasis&#44; irregular and with depigmentation areas&#59; &#40;b&#41; pigment deposits in the endothelium&#59; &#40;c&#41; pigment deposits in anterior chamber angle&#46;</p>"
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ISSN: 21735794
Original language: English
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