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Management of the neovascular choroidal membrane secondary to ocular toxoplasmosis
Manejo de la membrana neovascular coroidea secundaria a toxoplasmosis ocular
E. Martín García
Corresponding author
elisabetmaga@gmail.com

Corresponding author.
, J.J. Chávarri García, L. Rodríguez Vicente, B. Jiménez del Río, S.M. Guallar Leza, J.L. del Río Mayor
Servicio de Oftalmología, Hospital San Pedro, Logroño, La Rioja, Spain
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secondary glaucoma&#44; cystic macular edema&#44; epiretinal membrane&#44; retina detachment&#44; choroidal neovascular membrane &#40;CNVM&#41; and optical atrophy&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The prevalence of choroidal neovascular membrane in ocular toxoplasmosis cases ranges between 2 &#37; and 19 &#37; according to different series and constitutes one of the most important causes of visual acuity &#40;VA&#41; impairment in young patients&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The case of a young patients that developed CNVM in the context of ocular toxoplasmosis is described below&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinic case report</span><p id="par0025" class="elsevierStylePara elsevierViewall">Male patient&#44; age 12&#44; diagnosed at birth with congenital toxoplasmosis after seroconversion of IgG and IgA toxoplasmosis antibodies in the mother at gestation week 34&#46; Subsequently&#44; treatment was established with Rovamycine&#174; 1&#46;5 million UI&#47;4 capsules twice a day&#46; Even though the patient did not present associated systemic symptoms at any point in time&#44; after birth he was preventively treated with anti-toxoplasmosis drugs during his first 2 years of life&#46; At present he was without treatment&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient visited the ophthalmological practice referred by the pediatrician after observing left eye &#40;LE&#41; significant VA impairment in a routine checkup&#46; Ocular examination showed that the VA of the right eye &#40;RE&#41; was of 1 and &#60;0&#46;05 in the LE&#46; Anterior segment did not exhibit relevant pathological details&#46; Right eye ocular fundus showed an isolated temporal juxtaposed papillary inactive pigmented scar with less than one papillary diameter&#44; while the left eye showed slight papillary paleness&#44; minimum vitritis as well as an active chorioretinitis locus with one papilla diameter adjacent to an old pigmented macular scar and a large subretinal hemorrhage that reached the inferior temporal vascular arcade &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Angiofluorescein graph &#40;AFG&#41; and optical coherence tomography &#40;OCT&#41; confirmed CNVM&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">After establishing the diagnostic of CNVM secondary to ocular toxoplasmosis&#44; oral treatment was initiated with sulfadiazin 500<span class="elsevierStyleHsp" style=""></span>mg&#47;6<span class="elsevierStyleHsp" style=""></span>h&#44; pyrimethamine 25<span class="elsevierStyleHsp" style=""></span>mg&#47;12<span class="elsevierStyleHsp" style=""></span>h and folinic acid 10<span class="elsevierStyleHsp" style=""></span>mg&#47;3 times a week&#46; Forty-eight hours later&#44; 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day methylprednisolone was added&#46; After initiating systemic treatment&#44; one dose of intravitreal anti-VEGF &#40;ranibizumab 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#41; was administered in the LE&#46; After 2 weeks LE VA recovered to reach 0&#46;3 with partial hemorrhage reabsorption &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; At that time a second dose of 0&#46;5<span class="elsevierStyleHsp" style=""></span>mg ranibizumab was considered&#44; finally reaching a VA of 0&#46;4 and complete disappearance of the hemorrhage&#44; leaving a residual inactive pigmented scar &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The classic anti-toxoplasmosis prescription was maintained 6 weeks with progressive reduction of corticoid therapy and terminated one week before suspending pyrimethamine and sulfadiazine&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">At present the patient remains stable after more than 5 months of strict follow-up and is in preventive therapy with trimethoprim&#47;sulfamethoxazole 800&#47;160<span class="elsevierStyleHsp" style=""></span>mg&#47;1 capsule &#47;3 days a week on a permanent basis associated to folinic acid at 2 capsules of 5<span class="elsevierStyleHsp" style=""></span>mg every 2 days as well as serial analytics every 3 months&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">In 1977&#44; Willerson et al&#46; reported the first case of CNVM associated to an active locus of retinochoroiditis due to toxoplasmosis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> CNVM generally appears on the edge of a previous toxoplasma scar although it could appear in active phases of the infection&#46; Etiopathogeny is unknown although it is broadly accepted that it is caused by the rupture of Bruch&#8217;s membrane and the choriocapillary due to intense retinal inflammation&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The options for treating these CNVM depend on the location thereof and include observation&#44; corticoids&#44; laser photocoagulation&#44; photodynamic therapy &#40;PDT&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> macular surgery<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and the application of anti-VEGF&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Anti-VEGF have been associated to the reactivation of old chorioretinal lesions and for this reason the prophylactic use of oral anti-toxoplasmosis drugs is recommended prior to intravitreal administration&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> One of the main benefits of the application of anti-VEGF compared to treatment with PTD&#44; laser photocoagulation or macular surgery is that it substantially diminishes collateral damages on the healthy retina&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; in cases of CNVM associated to ocular toxoplasmosis close follow-up of patients is very important as well as initiating treatment with anti-toxoplasmosis drugs associating intravitreal therapy with anti-VEGF as soon as possible in order to obtain the best anatomic and functional results&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflict of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">No conflict of interests was declared by the authors&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A 12-year-old patient diagnosed with congenital toxoplasmosis&#44; with no systemic treatment at the time&#44; who presented with a decreased visual acuity &#40;VA&#41; in his left eye &#40;LE&#41;&#46; On examination&#44; VA in the LE was 0&#46;05 and the fundus examination revealed a focus of chorioretinitis adjacent to a pigmented macular scar&#44; as well as a large associated subretinal haemorrhage&#46; After confirming the diagnosis of choroidal neovascular membrane secondary to ocular toxoplasmosis&#44; treatment was started with systemic anti-toxoplasmosis drugs and two anti-VEGF intravitreal injections separated by one month&#46; Finally&#44; the patients had a VA in OI of 0&#46;4&#44; with reabsorption of the haemorrhage&#44; leaving an inactive pigmented macular scar&#46; The use of anti-VEGF intravitreal injections in cases of ocular toxoplasmosis has been associated with a reactivation of old lesions&#44; so the prophylactic use of oral anti-toxoplasmosis drugs is recommended in these cases&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Paciente de 12 a&#241;os diagnosticado de toxoplamosis cong&#233;nita sin tratamiento sist&#233;mico en el momento actual que acude por disminuci&#243;n de agudeza visual &#40;AV&#41; por su ojo izquierdo &#40;OI&#41;&#46; A la exploraci&#243;n se objetiva una AV en su OI de 0&#44;05 y al examen fundusc&#243;pico un foco de coriorretinitis adyacente a una cicatriz macular pigmentada y una gran hemorragia subretiniana asociada&#46; Tras confirmar el dign&#243;stico de membrana neovascular coroidea &#40;NVC&#41; secundaria a toxoplasmosis ocular&#44; se inicia tratamiento con f&#225;rmacos antitoxopl&#225;smicos sist&#233;micos y dos dosis de AntiVEGF intravitreos separadas por un mes de diferencia&#46; Finalmente&#44; alcanza una AV en OI de 0&#44;4 y se logra una reabsoci&#243;n de la hemorragia quedando una cicatriz pigmentada macular inactiva&#46; El uso de AntiVEGF intravitreos en cuadros de toxoplasmosis ocular se han asociado a la reactivaci&#243;n de antiguas lesiones&#44; por lo que se recomienda el uso profil&#225;ctico de f&#225;rmacos antitoxopl&#225;smicos orales en estos casos&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Mart&#237;n Garc&#237;a E&#44; Ch&#225;varri Garc&#237;a JJ&#44; Rodr&#237;guez Vicente L&#44; Jim&#233;nez del R&#237;o B&#44; Guallar Leza SM&#44; del R&#237;o Mayor JL&#46; Manejo de la membrana neovascular coroidea secundaria a toxoplasmosis ocular&#46; Arch Soc Esp Oftalmol&#46; 2020&#59;95&#58;90&#8211;93&#46;</p>"
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ISSN: 21735794
Original language: English
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