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Differences in intermediate vision: Monofocal intraocular lenses vs. monofocal extended depth of focus intraocular lenses
Diferencias en la visión intermedia: lenteintraocular monofocal vs. lente intraocularmonofocal de rango extendido
B. de Luis Eguileora,
Corresponding author
beatrizdeluis@gmail.com

Corresponding author.
, L. Martínez-Indartb, N. Martínez Aldaya, C. Sacristán Egüéna, C. Cuadros Sáncheza
a Hospital Universitario Cruces, Barakaldo, Spain
b Biocruces Bizkaia Health Research Institute, Barakaldo, Spain
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multifocal IOLs&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Nonetheless&#44; the Spanish public health system provides monofocal IOLs that correct far vision&#46; Currently&#44; most monofocal IOLs have an aspherical design to partially or completely compensate for the spherical aberration induced by the cornea&#44; thereby improving the optical quality of the visual system&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;6</span></a> On the other hand&#44; a new monofocal IOL with a different design has become available&#44; namely&#44; the Eyhance IOL with EDOF&#46; This new feature of monofocal IOLs allows them to provide a fuller range of clear vision without the need for multifocal IOLs&#46; Numerous studies have been conducted on multifocal IOLs and diffractive EDOF IOLs&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;7&#44;8</span></a> but this is not the case for EDOF monofocal IOLs&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In our setting&#44; cataract surgery is the most common surgical intervention in older people&#46; Having an EDOF monofocal IOL that could be used in the public health system would allow us to improve not only far vision of patients undergoing cataract surgery&#44; but also their intermediate vision&#46; This implies enhancing not only their visual acuity &#40;VA&#41;&#44; but also their quality of life&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The purpose of this study is to analyse whether an EDOF monofocal IOL &#40;TECNIS Eyhance&#41; provides better intermediate VA than another monofocal IOL &#40;TECNIS 1-piece&#41; from the same platform&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">We conducted a randomised prospective observational study&#46; It was carried out in accordance with best practice guidelines and the principles of the Declaration of Helsinki and was approved by the Basque Ethics Committee on drug research &#40;CEIm-E&#59; PS2019021&#41;&#46; Patients who were on the waiting lists of the Ophthalmology Department at Cruces University Hospital for bilateral cataract surgery were included&#46; These patients were provided with information about the study and asked to give written informed consent to receive either TECNIS 1-piece or Eyhance monofocal IOLs&#46; After&#44; the patients were randomly assigned to each group using the SPSS vs 23&#46;0 program&#46; The specific characteristics of these IOLs are described in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Patients</span><p id="par0025" class="elsevierStylePara elsevierViewall">The exclusion criteria were&#58; corneal astigmatism greater than 1&#46;5 dioptres&#44; previous corneal or retinal disease&#44; previous ocular surgery and amblyopia&#46; Both the examination prior to inclusion on the waiting list for surgery and postoperative treatment were carried out following the protocol established in the Ophthalmology Department at our hospital&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Corneal aberration parameters&#44; root mean square high-order aberration &#40;RMS-HOA&#41; and spherical aberration &#40;Z<span class="elsevierStyleInf">4</span><span class="elsevierStyleSup">0</span>&#41; for a diameter of 6&#8239;mm&#44; and pupil size were assessed in the examination before the cataract surgery&#46; These parameters were measured with a Pentacam high-resolution camera system &#40;Oculus&#59; Optikger&#228;te&#44; Wetzlar&#44; Germany&#41;&#46; All the tomographic images to be included in the study&#44; we required that they were of adequate reliability&#44; that is&#44; the test had to obtain an &#8220;OK&#8221; rating by the Pentacam HR system&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The other measurements&#44; namely&#44; for the far and intermediate VA and defocus curve&#44; were taken at 1 month after surgery&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The biometry measurements were made by the same evaluator &#40;BLE&#41; with the IOLMaster optical biometer &#40;Carl Zeiss Meditec AG&#41; using the SRK&#47;T equation with constant A of 119&#46;3 for both IOLs&#46; The IOL power was selected with emmetropia as the target outcome&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Surgical technique</span><p id="par0045" class="elsevierStylePara elsevierViewall">All the surgical procedures were carried out by the same surgeon &#40;NMA&#41; with topical anaesthesia and sedation using tropicamide 1&#46;0&#37; and phenylephrine 10&#37; to achieve mydriasis&#46; A temporal surgical approach was used for both right and left eyes&#46; A clear corneal incision of 2&#46;4&#8239;mm was made in all patients&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">All patients received the same postoperative treatment with tapered doses of tobramycin 0&#46;3&#37; and dexamethasone 0&#46;1&#37; until 1-month after surgery&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Postoperative examinations</span><p id="par0055" class="elsevierStylePara elsevierViewall">At 1 month after surgery in the second eye&#44; the tests for this study were carried out&#46; The best far monocular and binocular VA was measured using the Early Treatment Diabetic Retinopathy Study &#40;ETDRS&#41; chart for testing at 4&#8239;m under photopic conditions &#40;85&#8239;cd&#47;m<span class="elsevierStyleSup">2</span>&#41;&#46; In addition&#44; the best monocular and binocular intermediate &#40;66&#8239;cm&#41; VA was measured using the ETDRS chart for testing at this distance&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The primary objective of the study was to assess the intermediate VA&#44; using a binocular defocus curve ranging between &#8722;2&#46;50 D and &#43;0&#46;50 D in 0&#46;50 D steps&#46; The defocus curve was obtained considering the best-corrected far VA under photopic conditions using the ETDRS chart as the reference refraction&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Statistical analysis</span><p id="par0065" class="elsevierStylePara elsevierViewall">Categorical variables were described using frequency tables and percentages and continuous variables using means and standard deviations&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Comparisons between groups were made with Mann-Whitney nonparametric tests for continuous variables and chi-squared tests for categorical variables&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The relationship between the continuous variables was assessed using the Spearman correlation&#44; since the data were not normally distributed&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Statistical analysis was carried out with SPSS vs 23&#46;0&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><p id="par0085" class="elsevierStylePara elsevierViewall">We studied a total of 30 patients &#40;60 eyes&#41;&#44; 15 patients receiving TECNIS 1-piece and 15 patients Eyhance IOLs&#44; with a total of 30 eyes in each group&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> summarises the preoperative characteristics of the study patients&#46; The male-to-female ratio and Z<span class="elsevierStyleInf">4</span><span class="elsevierStyleSup">0</span> differed significantly between the groups&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">We did not find statistically difference in the postoperative subjective refraction between the 2 gropus&#46; The SE was &#8722;030&#8239;&#177;&#8239;044 in the Eyhance group and -0&#46;21&#8239;&#177;&#8239;0&#46;47 in the TECNIS 1-piece group &#40;p 0&#46;205&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> summarises the VA results&#46; Patients obtained a far VA of 0&#46;00 logMAR both with the TECNIS 1-piece and the Eyhance lenses&#46; On the other hand&#44; for intermediate vision&#44; the VA observed was better with the Eyhance EDOF monofocal IOL&#44; the difference being statistically significant &#40;p&#8239;&#60;&#8239;0&#46;001&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> presents the binocular defocus curve obtained&#46; As can be seen&#44; for intermediate vision&#44; the Eyhance IOL achieved better VA&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Regarding the correlation between the binocular intermediate VA and various parameters analysed &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#44; we only found a statistically significant correlation between RMS-HOA and Z<span class="elsevierStyleInf">4</span><span class="elsevierStyleSup">0</span> in the case of the Eyhance IOL&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Discussion</span><p id="par0110" class="elsevierStylePara elsevierViewall">The Eyhance IOL is part of the same family of IOLs as the TECNIS 1-piece&#44; that is&#44; they have the same mechanical and behavioural properties when inserted into the capsular bag during cataract surgery&#46; The main distinctive feature is that the power of the Eyhance TECNIS IOL gradually increases from the periphery towards the centre of the lens and this provides better intermediate VA&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">In our public hospital setting&#44; the IOLs used are always monofocal&#46; The possibility of using an EDOF monofocal IOL would allow many patients to benefit from better intermediate vision&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">This is one of the first studies that analyses intermediate vision with an Eyhance IOL&#46; Mencucci et al<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> obtein VA results similar to ours in intermediate vision &#40;0&#46;27 logMAR with Eyhance ICB00 and 0&#46;37 logMAR with ZCB00&#41;&#46; Our findings demonstrated that with an EDOF monofocal IOL&#44; we were able to improve intermediate vision &#40;VA of logMAR 0&#46;37 with the TECNIS 1-piece monofocal IOL and 0&#46;16 with the Eyhance IOL&#41; without a negative impact on far vision &#40;VA of logMAR &#8722;0&#46;06 with the TECNIS 1-piece monofocal IOL and &#8722;0&#46;05 with the Eyhance IOL&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Other studies comparing diffractive EDOF IOLs have obtained similar findings to ours for intermediate and far vision&#46; On the other hand&#44; compared to multifocal IOLs&#44; there are differences in intermediate and far vision&#44; outcomes being worse than with EDOF IOLs&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;10</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Bellucci et al<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> compare variations on the same design of hydrophilic IOL&#58; a monofocal IOL and a progressive aspheric IOL with EDOF&#46; In that study&#44; the EDOF IOL achieved better VA for intermediate but not for far distances&#44; for which VA was better with the monofocal than with the EDOF IOL&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Various different studies have determined that depth of focus varies as a function of spherical aberration&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a> Therefore&#44; we assessed whether the effectiveness of Eyhance and TECNIS 1-piece IOLs varies at intermediate distances as a function of corneal aberration&#46; The correlation found between RMS-HOA and Z<span class="elsevierStyleInf">4</span><span class="elsevierStyleSup">0</span> in the case of the Eyhance IOL suggests that&#44; with intermediate values of these aberrometric parameters&#44; the Eyhance IOL provides better intermediate VA&#46; This seems to indicate that&#44; in order to optimise visual outcomes&#44; corneal aberration should be a criterion for selection of the Eyhance IOL in cataract surgery&#46; Nonetheless&#44; there is a need for studies based on larger samples to be able to establish the values of the aberrometric parameters that would ensure the best outcomes in terms of vision&#46; We should also note that in our study RMS-HOA and Z<span class="elsevierStyleInf">4</span><span class="elsevierStyleSup">0</span> values varied significantly between the two groups&#44; again indicating the need for further studies with a larger number of eyes to confirm our findings&#46; Additionally&#44; the corneal RMS-HOA and Z<span class="elsevierStyleInf">4</span><span class="elsevierStyleSup">0</span> values in both groups are somewhat higher than normal mean values&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a> This underlines the need for further studies to confirm whether our findings are generalizable&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Neither age nor pupil size were correlated with better intermediate VA&#46; That is&#44; our findings indicate that the Eyhance IOL was not dependent on pupil size&#44; as would be expected of a monofocal IOL&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">To conclude&#44; the new monofocal Eyhance EDOF IOL offers sufficient depth of focus to provide patients with comfortable intermediate vision without impairing far vision&#46; Nonetheless&#44; further studies are required to confirm the improvement in intermediate vision and determine in which patients the Eyhance IOL can be expected to perform the best as a function of corneal aberration&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors have no funding or conflicts of interest to disclose&#46;</p></span></span>"
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    "fechaRecibido" => "2020-04-14"
    "fechaAceptado" => "2020-06-05"
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          "clase" => "keyword"
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            0 => "Depth of focus"
            1 => "Intermediate visual acuity"
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
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            0 => "Profundidad de foco"
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    "resumen" => array:2 [
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Purpose</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The purpose of this study was to analyse whether an extended depth of focus &#40;EDOF&#41; monofocal intraocular lens &#40;IOL&#41; &#40;TECNIS Eyhance&#41; provides better intermediate visual acuity &#40;VA&#41; than another monofocal IOL &#40;TECNIS 1-piece&#41; from the same platform&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Randomised prospective observational study&#46; Patients who required cataract surgery in both eyes were included&#46; Patients in one group were implanted with Tecnis 1-piece IOL and those in the other group with Eyhance EDOF monofocal IOL&#46; One month after surgery in the second eye&#44; we assessed the corrected intermediate VA &#40;66&#8239;cm&#41; and obtained defocus curves&#46; We also explored the correlation of&#58; high-order and spherical aberrations with intermediate VA&#44; pupil size with intermediate VA and age with intermediate VA&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">We analysed 30 patients &#40;60 eyes&#41;&#44; 15 patients in the TECNIS 1-piece group and 15 in the Eyhance group&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Both groups achieved a far VA of 0&#46;00 logMAR&#46; In contrast&#44; for intermediate vision&#44; VA was better with the Eyhance EDOF monofocal IOLs &#40;0&#46;16&#8239;&#177;&#8239;0&#46;12 LogMAR&#41;&#44; the difference being statistically significant &#40;p&#8239;&#60;&#8239;0&#46;001&#41;&#46; In addition&#44; binocular intermediate VA was found to be significantly correlated with corneal &#40;6&#8239;mm&#41; RMS high-order aberrations &#40;<span class="elsevierStyleItalic">&#961;</span> 0&#46;476&#41; and Z<span class="elsevierStyleInf">4</span><span class="elsevierStyleSup">0</span> &#40;<span class="elsevierStyleItalic">&#961;</span> 0&#46;483&#41; with the Eyhance IOL&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">The new EDOF monofocal IOL &#40;Eyhance&#41; offers sufficient depth of focus to provide patients with comfortable vision without impairing far vision&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
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          1 => array:2 [
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            "titulo" => "Methods"
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          2 => array:2 [
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio es analizar si una lente intraocular &#40;LIO&#41; monofocal &#40;TECNIS Eyhance&#41; de profundidad de enfoque extendida &#40;PEE&#41; proporciona una mejor agudeza visual &#40;AV&#41; intermedia que otras LIO monofocales &#40;TECNIS 1-pieza&#41; de la misma plataforma&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio observacional prospectivo y aleatorizado con pacientes que necesitaban cirug&#237;a de cataratas en ambos ojos&#46; Un grupo de pacientes recibi&#243; el implante con la LIO Tecnis 1-pieza y otro grupo recibi&#243; la LIO Eyhance PEE monofocal&#46; Un mes desde la cirug&#237;a en el segundo ojo se evalu&#243; la AV intermedia corregida &#40;66&#8239;cm&#41; y se obtuvieron las curvas de desenfoque&#46; Tambi&#233;n se explor&#243; la correlaci&#243;n de aberraciones de orden elevado y esf&#233;ricas con AV intermedia&#44; tama&#241;o pupilar con AV intermedia y edad con AV intermedia&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">El estudio analiz&#243; a 30 pacientes &#40;60 ojos&#41;&#44; 15 de ellos en el grupo TECNIS 1-pieza y 15 en el grupo Eyhance&#46; Ambos grupos consiguieron una AV lejana de 0&#44;00 logMAR&#46; En contraste&#44; para la visi&#243;n intermedia la AV fue mejor con las LIO Eyhance PEE monofocal &#40;0&#44;16&#8239;&#177;&#8239;0&#44;12 LogMAR&#41;&#44; siendo la diferencia estad&#237;sticamente significativa &#40;p&#8239;&#60;&#8239;0&#44;001&#41;&#46; Adem&#225;s&#44; se observ&#243; que la AV intermedia binocular guardaba una correlaci&#243;n significativa con las aberraciones corneales &#40;6&#8239;mm&#41; RMS de alto orden &#40;&#961; 0&#44;476&#41; y Z40 &#40;&#961; 0&#44;483&#41; con la LIO Eyhance&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">La nueva LIO monofocal PEE &#40;Eyhance&#41; ofrece suficiente profundidad de foco para proporcionar a los pacientes una visi&#243;n confortable sin afectar la visi&#243;n lejana&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; de Luis Eguileor B&#44; Mart&#237;nez-Indart L&#44; Mart&#237;nez Alday N&#44; Sacrist&#225;n Eg&#252;&#233;n C&#44; Cuadros S&#225;nchez C&#46; Diferencias en la visi&#243;n intermedia&#58; lente intraocular monofocal vs&#46; lente intraocular monofocal de rango extendido&#46; Arch Soc Esp Oftalmol&#46; 2020&#59;95&#58;523&#8211;527&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">TECNIS 1-piece &#40;monofocal&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">TECNIS Eyhance &#40;EDOF monofocal&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Design</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Monoblock</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Monofocal&#44; biconvex&#44; aspheric anterior surface &#40;Z<span class="elsevierStyleInf">4</span><span class="elsevierStyleSup">0</span> &#40;6&#8239;mm&#41;-0&#46;27&#41;&#46;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Continuous aspheric anterior surface&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ProTEC frosted continuous 360&#176; posterior squared edge</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Material&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hydrophobic acrylic UV filtering</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;47 to 35&#176;</td></tr></tbody></table>
                  """
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">TECNIS 1-piece &#40;monofocal&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">TECNIS Eyhance &#40;EDOF monofocal&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">74&#46;1&#8239;&#177;&#8239;7&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#46;2&#8239;&#177;&#8239;7&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;390&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Man&#47;woman &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#47;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;3&#47;46&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Axial length &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;42&#8239;&#177;&#8239;1&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;71&#8239;&#177;&#8239;0&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;090&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Corneal astigmatism &#40;D&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;91&#8239;&#177;&#8239;0&#46;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;84&#8239;&#177;&#8239;0&#46;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;549&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IOL power &#40;D&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;87&#8239;&#177;&#8239;2&#46;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;52&#8239;&#177;&#8239;1&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;439&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pupil diameter &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;52&#8239;&#177;&#8239;0&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;40&#8239;&#177;&#8239;0&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;284&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">RMS-HOA &#40;6&#8239;mm&#41; &#40;&#956;m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;838&#8239;&#177;&#8239;0&#46;450&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;676&#8239;&#177;&#8239;0&#46;228&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;178&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Z<span class="elsevierStyleInf">4</span><span class="elsevierStyleSup">0</span> &#40;6&#8239;mm&#41; &#40;&#956;m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;419&#8239;&#177;&#8239;0&#46;162&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;329&#8239;&#177;&#8239;0&#46;137&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">TECNIS 1-piece &#40;monofocal&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">TECNIS Eyhance &#40;EDOF monofocal&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Best monocular far acuity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;00&#8239;&#177;&#8239;0&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;02&#8239;&#177;&#8239;0&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;703&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Best binocular far acuity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;06&#8239;&#177;&#8239;0&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;05&#8239;&#177;&#8239;0&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;736&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Best monocular intermediate &#40;66&#8239;cm&#41; acuity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;45&#8239;&#177;&#8239;0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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