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Haberland syndrome with bilateral ocular involvement
Síndrome de Haberland con afectación ocular bilateral
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Aumento significativo de los espacios subaracnoideos de predominio temporal bilateral, compatible con quistes aracnoideos temporales bilaterales, más significativo en el lado izquierdo.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. Zamorano Martín, M. García Lorente, C. Rocha de Lossada, R. Rachwani Anil, A. Santos Ortega, J. Escudero Gómez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Zamorano Martín" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "García Lorente" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Rocha de Lossada" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Rachwani Anil" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Santos Ortega" ] 5 => array:2 [ "nombre" => "J." 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Un caso raro de alacrimia congénita unilateral" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2458 "Ancho" => 2500 "Tamanyo" => 329266 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) Conjunctival tumour in the upper outer corner of the right eye, orange and lumpy, replacing the palpebral lobe of the lacrimal gland. B) Image of the right eye surface showing fluorescein-stained corneal epithelial erosions C) <span class="elsevierStyleItalic">Short Tau Inversion Recovery (</span>STIR) coronal image of the orbital region showing asymmetric appearance of the upper outer angles of the orbit with hyposignal on the right side by cancellation of the fat signal in the area corresponding to the lipoma-substituted gland (asterisk). D) Axial image through the upper margin of both orbits showing on the right side substitution of the normal gland by a well-defined crescent image with the same signal as the fat in the subcutaneous cellular tissue (asterisk).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.L. Sánchez Sevila, J. Rosas Gómez de Salazar, L. Concepción Aramendía, C. Vivó Devesa" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.L." "apellidos" => "Sánchez Sevila" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Rosas Gómez de Salazar" ] 2 => array:2 [ "nombre" => "L." 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Zamorano Martín, M. García Lorente, C. Rocha de Lossada, R. Rachwani Anil, A. Santos Ortega, J. Escudero Gómez" "autores" => array:6 [ 0 => array:3 [ "nombre" => "F." "apellidos" => "Zamorano Martín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "M." "apellidos" => "García Lorente" "email" => array:1 [ 0 => "glorentemaria@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Rocha de Lossada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "R." "apellidos" => "Rachwani Anil" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "Santos Ortega" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "J." "apellidos" => "Escudero Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Oftalmología, Hospital Regional Universitario de Málaga, Málaga, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Oftalmología, Hospital Clínic de Barcelona, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome de Haberland con afectación ocular bilateral" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1418 "Ancho" => 905 "Tamanyo" => 142644 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) Palpebral coloboma in the inner third of the upper eyelid of both eyes. B) Pedunculated tumor dependent on the left upper tarsal palpebral conjunctiva. C) Soft pink lesions on lower bulbar conjunctiva of both eyes that invade the cornea without affecting the visual axis.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The Haberland syndrome or encephalocranial lipomatosis is a very rare syndrome characterized by the classic triad of skin, eye (in the form of unilateral choristoma and palpebral coloboma) and central nervous system involvement. It was first described in 1970 by Haberland and Perou,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and since then about 60 cases have been reported.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 14-week male patient, first child of non-blood parents. Born at full term by Cesarean section. On examination, a 2<span class="elsevierStyleHsp" style=""></span>cm right temporal alopecia, palpebral coloboma in the inner third of the upper eyelid of both eyes (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A), a pedunculated tumor dependent on the left upper palpebral tarsal conjunctiva (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B) and soft pink lesions on the lower bulbar conjunctiva of both eyes were observed invading the cornea without compromising the visual axis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C). These lesions and the palpebral pedicle tumor were finally catalogued as complex choristomas by pathological anatomy.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The patient exhibited good visual behaviour. The preferential gaze test produced a visual acuity of 8 cycles per degree in binocular vision and 4 cycles per degree with each eye in monocular vision. In fundus examination, a papilla with 0.4 excavation and lower depigmentation stood out.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In view of the suspected neurocutaneous picture, a cerebral magnetic resonance was requested in which an increase of the temporal subarachnoid spaces was appreciated bilaterally with arachnoid cysts (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>), being more significant in the left side, where it exhibited an approximate thickness of 3<span class="elsevierStyleHsp" style=""></span>cm. An increase in the parietal subarachnoid spaces was also observed bilaterally.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Serological tests for HIV and TORCH were negative. The rest of the examination did not provide new data of interest. The diagnosis of Haberland syndrome with bilateral ocular affectation was made.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">The Haberland syndrome or encephalocranial lipomatosis is a very rare syndrome characterized by the classic triad of skin, eye and central nervous system involvement. Its etiology is unknown, although it is postulated that it may be caused by a mutation in a gene during embryogenesis, being only compatible with life in the form of mosaicism.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3–7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The most typical ocular involvement is in the form of unilateral and ipsolateral coristoma to skin lesions, which can cause amblyopia by inducing corneal opacities, refractive defects or both.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,5</span></a> A less frequent form of presentation is palpebral coloboma1.</p><p id="par0040" class="elsevierStylePara elsevierViewall">At the central nervous system, arachnoid cysts appear in the middle cranial fossa, dysplasia or cortical atrophy with adjacent ventricular dilation and cortical calcifications.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4,8</span></a> 60% of patients present epilepsy and 40% psychomotor retardation.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">An atypical case of encephalocraneocutaneous lipomatosis diagnosed at a very early age is presented. The case presents palpebral coloboma and bilateral choristoma, differing from most published cases in which these findings are exhibited unilaterally.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,5</span></a> Associated clinic and imaging tests are essential for classifying this pathology.</p><p id="par0050" class="elsevierStylePara elsevierViewall">In summary, since the Haberland syndrome or encephalocranial lipomatosis is a rare disease with great clinical heterogeneity, the ophthalmologist may be the first specialist consulted to assess a patient with this pathology. The presence of choristomas together with alopecia or other ipsolateral skin alteration should rule out a central nervous system condition by means of imaging tests.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflict of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">None of the authors have any conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1444669" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1318065" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1444670" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1318066" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflict of interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-03-30" "fechaAceptado" => "2020-07-08" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1318065" "palabras" => array:4 [ 0 => "Encephalocraniocutaneous lipomatosis" 1 => "Haberland syndrome" 2 => "Choristoma" 3 => "Arachnoid cyst" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1318066" "palabras" => array:4 [ 0 => "Lipomatosis encefalocraneocutánea" 1 => "Síndrome de haberland" 2 => "Coristoma" 3 => "Quiste aracnoideo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Haberland syndrome or encephalocutaneous lipomatosis is a very uncommon syndrome that is characterised by changes in the skin, eye, and central nervous system. It was first described in 1970 by Haberland and Perou, with about 60 cases having been reported since then. A case is reported of a 14-week-old male diagnosed with Haberland syndrome with bilateral ocular involvement in the form of palpebral coloboma and choristomas.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El síndrome de Haberland o lipomatosis encefalocraneocutánea es un síndrome muy infrecuente caracterizado por la triada clásica de afectación cutánea, ocular y del sistema nervioso central. Fue descrito por primera vez en 1970 por Haberland y Perou,<span class="elsevierStyleSup">1</span> habiéndose reportado unos 60 casos desde entonces.<span class="elsevierStyleSup">2</span> Presentamos un caso de un varón de 14 semanas diagnosticado de síndrome de Haberland con afectación bilateral ocular en forma de coloboma palpebral y coristomas.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Zamorano Martín F, García Lorente M, Rocha de Lossada C, Rachwani Anil R, Santos Ortega A, Escudero Gómez J. Síndrome de Haberland con afectación ocular bilateral. Arch Soc Esp Oftalmol. 2021;96:45–47.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1418 "Ancho" => 905 "Tamanyo" => 142644 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) Palpebral coloboma in the inner third of the upper eyelid of both eyes. B) Pedunculated tumor dependent on the left upper tarsal palpebral conjunctiva. C) Soft pink lesions on lower bulbar conjunctiva of both eyes that invade the cornea without affecting the visual axis.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 919 "Ancho" => 905 "Tamanyo" => 61249 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">T2 axial brain MRI. Significant increase of bilateral temporal predominant subarachnoid spaces, compatible with bilateral temporal arachnoid cysts, more significant in the left side.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Encephalocraniocutaneuos lipomatosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Haberland" 1 => "M. Perou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archneur.1970.00480200050005" "Revista" => array:6 [ "tituloSerie" => "Arch Neurol" "fecha" => "1970" "volumen" => "22" "paginaInicial" => "144" "paginaFinal" => "145" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4902772" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Encephalocraniocutaneous Lipomatosis: Haberland Syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Ö Selçuk" 1 => "S. Ceyhun" 2 => "K. Cumhur" 3 => "G. Hanife" 4 => "K. Mustafa" 5 => "Nail Dl. Ali" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.12659/ajcr.907685" "Revista" => array:7 [ "tituloSerie" => "Am J Case Rep" "fecha" => "2017" "volumen" => "18" "paginaInicial" => "1271" "paginaFinal" => "1275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29192135" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S073510971839034X" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Encephalocraniocutaneous lipomatosis (Haberland syndrome) with bilateral cutaneous and visceral involvement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Rubegni" 1 => "M. Risulo" 2 => "P. Sbano" 3 => "G. Buonocore" 4 => "S. Perrone" 5 => "M. Fimiani" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1365-2230.2003.01329.x" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol." "fecha" => "2003" "volumen" => "28" "paginaInicial" => "387" "paginaFinal" => "390" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12823300" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ecephalocraniocutaneous lipomatosis: A neurocutaneous syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.E. Brown" 1 => "S.M. Goldstein" 2 => "R.S. Douglas" 3 => "J.A. Katowitz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/mpa.2003.S1091853103000120" "Revista" => array:6 [ "tituloSerie" => "J AAPOS." "fecha" => "2003" "volumen" => "7" "paginaInicial" => "148" "paginaFinal" => "149" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12736631" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ecephalocraniocutaneous lipomatosis (Fishman syndrome): A rare neurocutaneous syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.J. Amor" 1 => "A.J. Kornberg" 2 => "L.J. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Paediatr Child H." "fecha" => "2000" "volumen" => "36" "paginaInicial" => "603" "paginaFinal" => "605" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Presurgical evaluation and cognitive functional reorganization in Fishman síndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Donaire" 1 => "M. Carreno" 2 => "N. Bargalló" 3 => "X. Setoanín" 4 => "R. Agudo" 5 => "G. Martín" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Epilepsy Behav." "fecha" => "2005" "paginaInicial" => "440" "paginaFinal" => "443" "itemHostRev" => array:3 [ "pii" => "S0735109714043083" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delleman (oculocerebrocutaneous) síndrome: Few variations in a classical case" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.A. Tambe" 1 => "S.V. Ambekar" 2 => "P.N. Bafna" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s1090-3798(03)00017-5" "Revista" => array:6 [ "tituloSerie" => "Eur J Paediatr Neurol." "fecha" => "2003" "volumen" => "7" "paginaInicial" => "77" "paginaFinal" => "80" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12697431" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antenatal and postnatal findings in encephalocraniocutaneous lipomatosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.J. Nowaczyk" 1 => "J.R. Mernagh" 2 => "J.M. Bourgeois" 3 => "P.J. Thompson" 4 => "E. Jurriaans" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Med Genet." "fecha" => "2000" "volumen" => "91" "paginaInicial" => "261" "paginaFinal" => "266" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735794/0000009600000001/v1_202101050734/S2173579420302139/v1_202101050734/en/main.assets" "Apartado" => array:4 [ "identificador" => "5812" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Short communications" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735794/0000009600000001/v1_202101050734/S2173579420302139/v1_202101050734/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173579420302139?idApp=UINPBA00004N" ]
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