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Pyogenic granuloma after cosmetic eye whitening
Granuloma piogénico tras blanqueamiento ocular cosmético
V.A. Romero-Moralesa,b, A. Marchesea, E. Miserocchia,
Corresponding author
miserocchi.elisabetta@hsr.it

Corresponding author.
, F. Bandelloa, G. Modoratia
a Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy
b Department of Retina, Instituto Mexicano de Oftalmologia, Queretaro, Mexico
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a broad range of complications from cosmetic eye whitening have been reported&#44; including persistent conjunctival epithelial defects&#44; scleral thinning&#44; necrotizing scleritis<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#44;5</span></a> chronic dysfunctional tear syndrome&#44; limbal stem cell deficiency&#44; lymphangiectasis&#44; infectious endophthalmitis and others&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Here we report the case of a localized pyogenic granuloma and necrotizing scleritis developed after cosmetic eye whitening procedure&#46; To the best of our knowledge&#44; this represents the first documented case with pyogenic granuloma after eye whitening procedure&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Case presentation</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 46-year-old Caucasian male presented to our hospital complaining of redness in his right eye &#40;OD&#41;&#46; He noted a &#8220;red spot in the inner corner&#8221; of OD&#44; developed during the previous two months&#46; This appeared five years after he underwent bilateral surgical treatment of cosmetic eye whitening and postoperative topical MMC 0&#46;02&#37; 4 times daily for 5 days in another institution&#46; And during the five years following the procedure he reported it was successful&#44; with decreased conjunctival hyperemia in both eyes &#40;OU&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">At the first visit&#44; he was using lubricant eye drops and his best corrected visual acuity &#40;BCVA&#41; at distance was OU 20&#47;20&#46; Examination of the nasal sclera in OD revealed an elevated&#44; fleshy&#44; reddish mass with an ovoid shape &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The lesion was pedunculated&#44; with an underlying stalk of blood vessels and connective tissue&#46; The conjunctiva was bilaterally avascular in temporal and nasal areas adjacent to the limbo&#44; also whitish scleral thinning with corresponding fluorescein pooling&#46; No other signs of ocular inflammation were observed&#46; The nasal reddish mass in OD was successfully excised without recurrence and the histopathologic analysis resulted in a pyogenic granuloma&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">More than one year after the excision surgery&#44; the patient presented to our emergency department with severe ocular pain and decreased vision in OS&#46; BCVA was 20&#47;20 in OD and 20&#47;40 in OS&#46; The sclera in OU was whitish in the nasal and temporal sectors&#59; moreover&#44; in OS&#44; the sclera showed a marked hyperemia in the superior and inferior sectors&#46; The cornea was transparent&#44; the anterior chamber had 1&#43; cells in OD and 4&#43; cells in OS&#59; the vitreous was clear&#44; and the posterior segment was normal&#46; No synechiae or iris nodules were noted&#46; After the excision of pyogenic granuloma&#44; the diagnosis of bilateral necrotizing scleritis associated with acute nongranulomatous anterior uveitis was made&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The Ocular Inflammatory Disease Review of Systems Questionnaire was applied as well as a full immunologic and infective work-up excluded specific immunologic or infectious etiologies&#46; The Blood test demonstrated leucocytosis and neutrophilia&#46; The other investigations were non-contributory&#44; including hepatic and renal function&#44; antinuclear antibodies &#40;ANA&#41;&#44; perinuclear and cytoplasmic anti-neutrophil cytoplasmic antibodies &#40;P-ANCA as well as C-ANCA&#41;&#44; angiotensin-converting enzyme &#40;ACE&#41;&#44; rheumatoid factor &#40;RF&#41;&#44; and computerized axial tomography of the brain and orbit&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The patient was prescribed aggressive lubrication with preservative-free artificial tears and ointment&#44; topical levofloxacin and dexamethasone&#44; and oral prednisone &#40;1&#8239;mg&#47;kg&#47;day&#41;&#46; After three weeks&#44; ocular pain&#44; had slowly diminished and subcutaneous methotrexate was initiated &#40;20&#8239;mg&#47;week&#41;&#46; Topical therapies were continued&#44; while oral corticosteroids gradually tapered&#44; improvements in scleral erosion and hyperemia were also evident&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">At the final follow up visit&#44; the left eye still had scleral thinning with necrotizing scleritis&#44; without inflammation in the anterior chamber &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; BCVA was 20&#47;20 in OU&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Discussion</span><p id="par0050" class="elsevierStylePara elsevierViewall">Pyogenic granuloma or lobular capillary hemangioma is a benign&#44; rapidly growing vascular proliferation&#44; classified as a vascular tumor of proliferating endothelium&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Although the concept of this lesion changed&#44; the name has persisted in medical literature&#46; Pyogenic granuloma is a proliferative fibrovascular response to previous inflammatory traumatic or chemical insult&#44; either surgical or nonsurgical&#44; as a result of tissue irritation&#46; The traumatic insult could be as a result of surgical procedure where chemical irritation may also occur with the presence of an absorbable suture or a silicone product &#40;tube or plug&#41;&#46; The hypothesis is that tissue injury or inflammation sets up a wound-repair response in the adjacent tissue&#46; The pyogenic granuloma formation results from a disruption of the healing process&#44; with an imbalance in the several factors that stimulate&#44; inhibit and modulate angiogenesis&#46; The histologic exam of pyogenic granuloma shows mixed inflammatory cells&#44; blood vessels&#44; and connective tissue&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Regarding epidemiology&#44; it represented the 0&#46;7&#37; in a clinical survey of 1643 conjunctival tumors reported by Shields et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The exact etiology of this case remains uncertain because the pyogenic granuloma developed after five years from the eye whitening procedure&#59; in other locations such as the skin or the gingival mucosa&#44; some authors have related pyogenic granuloma to estrogens and progesterone vascular endothelial growth factor expression has also shown an association with pyogenic granuloma in gingival mucosa&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">In the presented case&#44; pyogenic granuloma can be associated with regional conjunctivectomy combined with post-surgical topical MMC&#44; as a result of tissue damage and vascular impairment&#46; The iatrogenic deprivation of vessels can cause localized ischemia and epithelial defects&#44; promoting an inflammatory reaction&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">About the presence of the necrotizing scleritis could be associate with the second surgery in a tissue with a previous injury&#44; however there are many reports about complications after cosmetic eye whitening&#44; but not with five years from the procedure&#44; for that reason the case is interesting&#46; Ji YW et al&#46; reported necrotizing scleritis in 4&#47;231 cases of cosmetic conjunctivectomy which included mitomycin&#44; with 51 months average length of time from the procedure&#59; all of them unilateral&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Nevertheless&#44; Rhiu et al&#46; described complications after cosmetic conjunctivectomy and postsurgical topical application of 0&#46;02&#37;MMC on the nasal and temporal conjunctiva in both eyes&#46; They found that 44 of 48 patients &#40;91&#46;67&#37;&#41; demonstrated complications&#44; such as 50&#37; chronic epithelial defects&#44; 46&#46;67&#37; scleral thining&#44; 33&#46;33&#37; fibrovascular adhesions&#44; 24&#46;4&#37; chronic dysfunctional tear syndrome&#44; 11&#46;11&#37; abnormal vessel growth in the conjunctiva&#44; 6&#46;67&#37; lymphangiectasis and 20&#37; diplopia&#46; The mean time to the onset of complications was less than 1&#8239;year&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">In conclusion&#44; the cosmetic eye whitening treatment should be applied to patients with no systemic risk factors and a cost-benefit of the procedure should also be carried out&#46; In addition&#44; the patient should be informed about the possibility of presenting a conjunctival lesion even five years after the surgical cosmetic procedure&#44; as in this case with the presentation of necrotizing scleritis&#44; acute nongranulomatous anterior uveitis and pyogenic granuloma which can be successfully resolved with surgery&#44; systemic and topical treatment&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Financial support</span><p id="par0085" class="elsevierStylePara elsevierViewall">None&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflict of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">VR&#44; AM&#44; EM and GM have no disclosures&#46; FB has the following disclosures&#58; Allergan &#40;S&#41;&#44; Alimera &#40;S&#41;&#44; Bayer &#40;S&#41;&#44; Farmila-Thea &#40;S&#41;&#44; Schering Pharma &#40;S&#41;&#44; Sanofi-Aventis &#40;S&#41;&#44; Novagali &#40;S&#41;&#44; Pharma &#40;S&#41;&#44; Hoffmann-La roche &#40;S&#41;&#44; Genetech &#40;S&#41;&#44; Novartis &#40;S&#41;&#46;</p></span></span>"
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            0 => "Granuloma pi&#243;geno"
            1 => "Escleritis necrotizante"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Clinical case</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A 46-year-old Caucasian male with a history of chronic conjunctival hyperemia&#44; presented at our clinic 5 years after he underwent the surgical procedure of cosmetic eye whitening&#46; On examination we observed pyogenic granuloma in the right eye&#59; besides acute nongranulomatous anterior uveitis and necrotizing scleritis in both eyes&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Result</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Complete clinical evaluation and full work-up exclusion of systemic diseases was done&#46; The pyogenic granuloma was treated with surgical resection&#44; as well as anterior uveitis and necrotizing scleritis were successfully treated with systemic corticoesteroids and methotrexate&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The surgical cosmetic eye whitening could have as complication the pyogenic granuloma in addition to necrotizing scleritis and nongranulomatous anterior uveitis&#59; and be present 5 years after the procedure&#46; The surgical resection is a successful treatment for this presentation of pyogenic granuloma&#46;</p></span>"
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        "resumen" => "<span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Caso cl&#237;nico</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hombre cauc&#225;sico de 46 a&#241;os con antecedente de hiperemia conjuntival cr&#243;nica acude a nuestra cl&#237;nica 5 a&#241;os despu&#233;s de realizar el procedimiento quir&#250;rgico de blanqueamiento ocular cosm&#233;tico&#46; En la exploraci&#243;n observamos granuloma pi&#243;geno en el ojo derecho adem&#225;s de uve&#237;tis anterior no granulomatosa aguda y escleritis necrosante en ambos ojos&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Resultado</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; una evaluaci&#243;n cl&#237;nica con exclusi&#243;n de enfermedades sist&#233;micas completas&#46; El granuloma pi&#243;geno se trat&#243; con resecci&#243;n quir&#250;rgica y la uve&#237;tis anterior y escleritis necrotizante se trataron con &#233;xito con corticoesteroides sist&#233;micos y metotrexato&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El blanqueamiento ocular cosm&#233;tico quir&#250;rgico podr&#237;a tener como complicaci&#243;n el granuloma pi&#243;geno adem&#225;s de la escleritis necrosante y la uve&#237;tis anterior no granulomatosa y presentarse 5 a&#241;os despu&#233;s del procedimiento&#46; La resecci&#243;n quir&#250;rgica es un tratamiento exitoso para esta presentaci&#243;n de granuloma pi&#243;geno&#46;</p></span>"
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      "titulo" => "References"
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