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Brevibacterium casei endophthalmitis after intravitreal dexamethasone implant
Endoftalmitis aguda por Brevibacterium casei tras implante intravítreo de dexametasona
A. Olate-Péreza,
Corresponding author
aolatep@hotmail.com

Corresponding author.
, R.A. Díaz-Céspedesb, N. Ruíz-del-Ríoc, D. Hernández-Pérezc, A. Duch-Samperc
a Institut Clínic d’Oftalmología, Hospital Clínic, Barcelona, Spain
b Servicio de Oftalmología, Hospital de Manises, Manises, Valencia, Spain
c Servicio de Oftalmología, Hospital Clínico Universitario, Valencia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Brevibacterium casei</span> is an aerobic gram-positive bacillus&#46; Its presence is described in raw milk&#44; on the surface of cheese and on human skin&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Scarcely pathogenic&#44; few cases of infection have been published&#44; these being mainly in immunosuppressed people&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In the ophthalmological field only two cases of endophthalmitis have been reported&#44; the first one endogenous<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and the second one after vegetable trauma&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> No endophthalmitis cases have been previously described after ophthalmological procedures&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A case of endophthalmitis secondary to <span class="elsevierStyleItalic">B&#46; casei</span> after intravitreal therapy with dexamethasone implant in a patient with diabetic macular edema &#40;DME&#41; is presented&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Clinic case report</span><p id="par0015" class="elsevierStylePara elsevierViewall">A 49-year-old man with a medical history of type 2 diabetes mellitus with poor metabolic control &#40;glycosylated hemoglobin&#58; 8&#46;1&#37;&#41; despite insulin treatment&#46; At the ophthalmological level&#44; the patient presented moderate non-proliferative diabetic retinopathy and DME with foveal involvement in right eye &#40;RE&#41;&#44; refractory to 3 doses of intravitreal therapy with ranibizumab&#46; For this reason it was decided to perform intravitreal injection with dexamethasone implant &#40;Ozurdex&#59; Allergan&#44; California&#44; USA&#41; in RE&#46; Seven days later he visited the emergency room with 24&#8239;-h pain&#44; red eye and blurred vision in RE&#46; Best corrected visual acuity &#40;BCVA&#41; decreased from 20&#47;50 before the implant to hand movement&#46; The scan showed conjunctival secretion&#44; 4&#43; cells in the anterior chamber and 1&#8239;mm high hypopion&#46; Fundoscopy was not possible&#44; so an ocular ultrasound was performed&#44; which showed opacities in vitreous&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Sampling was carried out in the conjunctiva&#44; aqueous and vitreous humor for Gram and bacterial and fungal cultures&#44; and later the intravitreal injection of vancomycin 1&#8239;mg&#47;0&#46;1&#8239;ml and ceftazidime 2&#8239;mg&#47;0&#46;1&#8239;ml&#44; and it was continued with ambulatory management with topical mydriatics and moxifloxacin 5&#8239;mg&#47;mL topical hourly and moxifloxacin 400&#8239;mg oral every 12&#8239;h&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">After 48&#8239;h the patient reported worsening symptoms&#46; BCVA was perception of light &#40;PL&#41;&#46; Biomicroscopy showed a 3&#46;0&#8239;mm hypoxia&#46; It was decided to perform surgery&#44; which consisted of lensectomy&#44; vitreous sampling for culture&#44; <span class="elsevierStyleItalic">pars plana vitrectomy&#44;</span> implant removal and intravitreal silicone oil injection&#46; Hospital management with intravenous moxifloxacin was continued&#46; During the period of admission&#44; the patient evolved with stable hemodynamics&#44; without fever and lower analgesic requirements&#44; so it was decided to continue ambulatory treatment with oral and topical moxifloxacin&#44; progressively decreasing its frequency&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">After 14 days&#44; the patient evolved without pain&#46; Even so&#44; BCVA was kept in PL&#46; Biomicroscopy showed keratic precipitates&#44; without cells in the anterior chamber&#46; Fundoscopy showed fibrotic vessels and isolated hemorrhages that suggested retinal ischemia&#46; Macular optical coherence tomography showed macular atrophy &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The microbiology report certified that the sample&#44; obtained during the surgery&#44; showed gram-positive rods without motility and the blood agar culture&#44; non-hemolytic whitish colonies&#44; catalase-positive&#44; so <span class="elsevierStyleItalic">Brevibacterium species</span> was suspected&#46; Subsequently&#44; this sample was evaluated by means of the API-Coryne System version 2&#46;0 &#40;bioM&#233;rieux&#44; Marcy L&#39;&#201;toile&#44; France&#41; commercial test which finally confirmed <span class="elsevierStyleItalic">B&#46; casei</span> as the agent causing endophthalmitis&#46; The antibiogram performed showed sensitivity to fourth generation fluoroquinolones&#44; so treatment with topical and oral moxifloxacin was maintained until completing one month&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">In the subsequent systemic follow-up&#44; carried out by the internal medicine service of our institution&#44; diagnostic tests were requested to rule out acquired immunosuppression&#58; hemogram&#44; globular sedimentation rate and C-reactive protein&#44; plasma electrolytes&#44; renal function&#44; hepatic laboratory&#44; thyroid hormones&#44; chest X-ray and Mantoux&#44; serology for human immunodeficiency virus&#44; rheumatoid factor&#44; antinuclear antibodies&#44; angiotensin converting enzyme&#44; neutrophil antidote antibodies and electrocardiogram&#44; all within normal or negative limits&#44; according to the case&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">At the ophthalmological level&#44; no reappearance of intraocular inflammation was evident after 3 months of follow-up&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">Endophthalmitis following intravitreal therapy is a rare but potentially devastating complication&#44; requiring prompt and timely management&#46; It occurs more frequently when steroids are injected than with antiangiogens &#40;0&#46;13 versus 0&#46;019&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The most frequently isolated germs in post-intravitreal endophthalmitis are gram-positive bacteria &#40;91&#46;3&#37;&#41;&#44; including coagulase negative <span class="elsevierStyleItalic">Staphylococcus</span> &#40;78&#46;3&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">B&#46; casei</span> is one of 45 species of the <span class="elsevierStyleItalic">Brevibacterium</span> genus and is the most frequently found in clinical samples&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Even so&#44; infections caused by <span class="elsevierStyleItalic">B&#46; casei</span> are rare and occur mostly in immunosuppressed patients&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Cases of catheter sepsis<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and endocarditis<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> have been described in the literature&#44; among others&#46; In the ophthalmological field&#44; a case of acute dacryocystitis<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> was reported&#44; which allows us to suppose that it can be found as saprophyte of the periocular tissue and of the lacrimal ducts&#46; A case of infectious keratitis related to drug abuse has also been described&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In addition&#44; two cases of endophthalmitis by <span class="elsevierStyleItalic">B&#46; casei</span> have been reported&#44; one endogenous<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and the other secondary to vegetable trauma&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In the case of this diabetic patient&#44; local intravitreal corticoid treatment&#44; together with colonization in the skin and&#47;or tear duct&#44; could have acted as facilitators of the infection&#44; thus causing the described devastating visual consequences&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">To corroborate this hypothesis&#44; during the follow-up it was found that the patient did not exhibit symptoms or signs related to another secondary pathology&#44; and through laboratory tests and analyses other frequent causes of acquired immunodeficiency in the adult were ruled out&#46; On the other hand&#44; the patient referred not having drug dependencies&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Thus&#44; it can be said that this is the first case in which acute endophthalmitis by <span class="elsevierStyleItalic">B&#46; casei is</span> described after an ophthalmological procedure&#46; This allows us to confirm this species as a potential intraocular infectious agent&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Financing</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors state that there is no conflict of financial interests in this manuscript&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflict of interests</span><p id="par0080" class="elsevierStylePara elsevierViewall">No conflict of interests was declared by the authors&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Clinical case</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">49-year-old man with diabetic macular edema refractory to antiangiogenics&#44; it is decided to perform therapy with intravitreal dexamethasone implant &#40;Ozurdex&#59; Allergan&#44; California&#44; United States of America&#41;&#46; Seven days after treatment&#44; he showed acute endophthalmitis suggestive signs&#46; Despite the intravitreal injection of antibiotics&#44; the patient got worse&#46; Vitreous sampling was repeated for Gram and cultures&#44; and vitrectomy was performed via <span class="elsevierStyleItalic">pars</span> plana&#46; The culture suggested the development of <span class="elsevierStyleItalic">Brevibacterium species&#46;</span> Through an additional test&#44; the presence of <span class="elsevierStyleItalic">Brevibacterium casei</span> was confirmed&#46; Despite the treatment adjusted by antibiogram&#44; retinal ischemia and macular atrophy was evident&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Brevibacterium casei</span> is a Gram-positive bacterium&#44; barely pathogenic&#44; that mainly affects immunodepressed patients&#46; Only two cases of endophthalmitis are described&#44; one endogenous and the other one secondary to vegetal trauma&#46; This is the first case of endophthalmitis&#44; secondary to an ophthalmological procedure&#46;</p></span>"
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        "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Caso cl&#237;nico</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Hombre de 49 a&#241;os&#44; con edema macular diab&#233;tico refractario a antiangiog&#233;nicos&#44; en el que se realiz&#243; terapia intrav&#237;trea con implante de dexametasona &#40;Ozurdex&#59; Allergan&#44; California&#44; Estados Unidos de Am&#233;rica&#41;&#46; Tras siete d&#237;as&#44; present&#243; signos sugerentes de endoftalmitis aguda&#46; Pese a la inyecci&#243;n intrav&#237;trea de antibi&#243;ticos&#44; el paciente empeor&#243;&#46; Se repiti&#243; la toma de muestras en v&#237;treo para Gram y cultivos&#44; y se realiz&#243; vitrectom&#237;a v&#237;a <span class="elsevierStyleItalic">pars</span> plana&#46; El cultivo sugiri&#243; el desarrollo de <span class="elsevierStyleItalic">Brevibacterium species&#46;</span> Mediante una prueba adicional&#44; se confirm&#243; la presencia de <span class="elsevierStyleItalic">Brevibacterium casei&#46;</span> Pese al tratamiento ajustado por antibiograma&#44; se evidenci&#243; isquemia retiniana y atrofia macular&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discusi&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Brevibacterium casei</span> es una bacteria Gram-positiva&#44; escasamente pat&#243;gena&#44; que afecta principalmente a inmunodeprimidos&#46; Se han descrito solo dos casos de endoftalmitis&#44; una end&#243;gena y otra secundaria a trauma vegetal&#46; Este es el primer caso de endoftalmitis por <span class="elsevierStyleItalic">Brevibacterium casei</span>&#44; secundaria a procedimiento oftalmol&#243;gico&#46;</p></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Images at 14 days of postoperative follow-up&#46; a&#41; Biomicroscopy&#58; pigmented keratin precipitates&#46; b&#41; Fundoscopy&#58; signs of retinal ischemia&#46; c&#41; Macular OCT&#58; foveal atrophy&#46;</p>"
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ISSN: 21735794
Original language: English
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