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Original article
Clinical course of HTLV-1 infection associated intermediate uveitis
Evolución clínica de la uveítis intermedia asociada a infección por el virus linfotrópico de células T humano tipo 1 (HTLV-1)
C. Siverio-Llosaa,
Corresponding author
csiverio@hotmail.com

Corresponding author.
, I. Silva-Ocasb, T. Gálvez-Olórteguic,d, G. Arana-Kaike
a Departamento de Úvea, Oftálmica Clínica de la Visión, Lima, Peru
b Unidad de Investigación Clínica, Scientia Clinical and Epidemiological Research Institute, Trujillo, Peru
c Departamento de Oftalmología, Hospital Nacional Guillermo Almenara Yrigoyen, Lima, Peru
d Unidad de Oftalmología Basada en Evidencias (Oftalmoevidencia), Scientia Clinical and Epidemiological Research Institute, Trujillo, Peru
e Departamento de Retina, Oftálmica Clínica de la Visión, Lima, Peru
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Human T-cell lymphotropic virus type 1 &#40;HTLV-1&#41; uveitis was described by Nakao in 1989 in patients with tropical spastic paraparesis<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and later&#44; in isolation&#44; by Mochizuki&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> It is characterised by intermediate uveitis with vitreous opacity and retinal vasculitis&#46; Diagnosis is based on seropositivity for HTLV-1 virus&#44; but can also be arrived at by polymerase chain reaction in aqueous humour and peripheral blood samples&#44; as well as exclusion of other known causes of uveitis&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> without association with known human leukocyte antigens&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Treatment is with local corticosteroids&#44; avoiding systemic immunosuppression&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">HTLV-1 uveitis occurs most frequently in endemic regions such as Japan&#44; central and equatorial Africa&#44; Oceania and South America&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6&#8211;8</span></a> In Europe&#44; HTLV-1 infection is uncommon and&#44; in Spain&#44; it occurs exceptionally in Spanish patients with blood transfusions&#44; and more frequently in those who have resided in endemic areas or migrants from Latin America and Africa&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;12</span></a> In Latin America&#44; it occurs more frequently in Amerindian populations in Argentina&#44; Colombia&#44; Paraguay&#44; Chile&#44; Bolivia and Peru &#40;Quechua and Aymara ethnicity&#41;&#44; in Afro-American populations in Brazil&#44; French Guyana&#44; Suriname&#44; Colombia and Peru&#44; in Japanese migrants in Bolivia&#44; Brazil and Peru&#44; and in the general population in Brazil&#44; Colombia and Peru&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;13&#44;14</span></a> In Peru&#44; HTLV-1 seroprevalence in the general population is around 2&#37;&#44; being higher in at-risk populations&#44; such as sex workers&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In a series of uveitis cases conducted in Lima &#40;Peru&#41;&#44; Siverio and Campos reported that intermediate uveitis associated with HTLV-1 infection accounted for 29&#46;4&#37; of all cases of intermediate uveitis&#44; being the second most frequent after idiopathic intermediate uveitis&#46; In patients over 50 years of age this entity accounted for 45&#46;5&#37; of intermediate uveitis cases &#40;personal communication&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> The aim of the present study is to describe the characteristics associated with the presentation&#44; treatment and follow-up of HTLV-1-associated intermediate uveitis in patients seen at a clinic in Lima&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">A retrospective&#44; descriptive and longitudinal study was conducted that included patients with a diagnosis of intermediate uveitis associated with HTLV-1 infection&#44; seen and diagnosed consecutively in a private ophthalmology referral clinic &#40;Oft&#225;lmica Cl&#237;nica de la Visi&#243;n&#44; Lima&#44; Peru&#41; by an ophthalmologist specialising in uveitis &#40;C&#46; Siverio&#41; from 2012 to 2018&#46; Intermediate uveitis was defined as uveitis in which the presence of inflammatory cells is observed mainly in the vitreous humour &#40;intermediate uveitis proper&#44; according to the SUN classification<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#41; or in the vitreous humour and anterior chamber equally &#40;intermediate and anterior uveitis&#44; according to the SUN classification&#41; without inflammatory lesions in the choroids or retina&#46; A case of intermediate uveitis associated with HTLV-1 infection was defined as a case with positive ELISA serology for HTLV 1 and 2 and negative for treponemal &#40;FTA-Abs&#41;&#44; non-treponemal &#40;VDRL or RPR&#41; tests&#44; without suspicion of tuberculosis &#40;normal chest X-ray or negative PPD&#41; and without symptoms suggestive of demyelinating neurological disease &#40;therefore no brain MRI was requested&#41;&#46; The degree of cellularity in the anterior chamber and the course of the disease was determined using the SUN criteria<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> and the degree of opacity in the vitreous cavity according to the scheme described by Foster et al&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">To investigate the presence of cystoid macular edema&#44; posterior pole optical coherence tomography was performed in 9 patients with fundus examination suspected of having this condition&#46; Retinal angiofluoresceinography was used in only one patient&#46; Eyes diagnosed with HTLV-1-associated intermediate uveitis were treated with periocular injections of depot corticosteroids &#40;40&#8239;mg&#47;ml triamcinolone acetate or methylprednisolone acetate&#41;&#44; which were repeated at intervals of no less than 4 weeks until significant improvement in the patient&#39;s symptoms and inflammatory signs was evident&#46; Prednisolone acetate drops and oral prednisone were also administered as warranted by the inflammatory condition&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Episodes of <span class="elsevierStyleItalic">acute</span> uveitis were classified as <span class="elsevierStyleItalic">acute</span> if inflammatory cells were present in the intraocular cavity for less than 3 months&#44; <span class="elsevierStyleItalic">recurrent</span> if they recurred 3 months or more after the previous episode&#44; and <span class="elsevierStyleItalic">chronic</span> if inflammatory cells were present for more than 3 months&#46; In some chronic cases&#44; attempts were made to reduce recurrences by using low doses of oral prednisone &#40;5-7&#46;5&#8239;mg&#47;day&#41; for prolonged periods &#40;more than 3 months&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The medical records system of the clinic was accessed and data were obtained on the epidemiological&#44; clinical&#44; therapeutic and follow-up characteristics of patients with a diagnosis of uveitis evaluated between 2012 and 2018&#46; Qualitative variables were expressed as proportions and percentages&#44; and quantitative variables as averages&#44; means and standard deviation&#46; Microsoft Excel 2019 &#174; and SPSS v&#46; 25&#46;0 &#174; were used for data processing and analysis&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">Out of 389 patients with uveitis evaluated in the study period&#44; 74 exhibited intermediate uveitis&#44; of which 18 &#40;28 eyes&#41; had a diagnosis of intermediate uveitis associated with HTLV-1 infection&#46; The mean age of these patients at presentation was 57&#46;3 years &#40;range&#58; 38-76&#41;&#46; Of the total&#44; 14 patients &#40;77&#46;8&#37;&#41; were aged 50 or older&#46; The sex distribution was&#58; 12 females &#40;66&#46;6&#37;&#41; and 6 males &#40;33&#46;3&#37;&#41;&#46; The average follow-up time was 1280 days &#40;range&#58; 0-4105&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">At presentation&#44; 12 patients &#40;66&#46;6&#37;&#41; had involvement in only one eye and 6 patients &#40;33&#46;3&#37;&#41; in both eyes&#46; The most frequent symptoms were blurred or decreased vision in 22 eyes &#40;78&#46;6&#37;&#41; and floaters in 16 eyes &#40;57&#46;1&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Initial best corrected visual acuity &#40;BCVA&#41; was between 20&#47;20 and hand movement&#44; being 20&#47;40 or better in 15 eyes &#40;53&#46;6&#37;&#41; and 20&#47;70 or better in 23 eyes &#40;82&#46;1&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Mean baseline intraocular pressure was 14&#46;95&#8239;mmHg&#59; in 2 eyes it was 22&#8239;mmHg while 5 eyes had a history of uveitis associated with ocular hypertension prior to the current presentation&#46; Clinical examination of the anterior segment revealed retrokeratotic precipitates in 14 eyes &#40;50&#37;&#41;&#44; with spiculated precipitates being more frequent&#58; 5 eyes &#40;17&#46;9&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Cells in the aqueous humour were found in 17 eyes &#40;60&#46;7&#37;&#41;&#44; in which the most frequent degree of cellularity was 0&#46;5&#43; to 1&#43;&#58; 11 eyes &#40;39&#46;3&#37;&#41;&#46; The degree of vitreous opacity was mild &#40;1-2&#8239;&#43;&#8239;&#41; in 22 eyes &#40;78&#46;5&#37;&#41;&#46; Fundus examination revealed the presence of retinal vasculitis in 5 eyes &#40;17&#46;9&#37;&#41;&#46; Other clinical signs were found at presentation&#44; including epiretinal infiltrates in 7 eyes &#40;25&#37;&#41;&#46; No <span class="elsevierStyleItalic">pars plana</span> exudates&#44; retinal hemorrhages or hemovitreous hemorrhages were found in any eye&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Patients affected in both eyes increased from 6 &#40;33&#37;&#41; at presentation to 10 &#40;55&#46;5&#37;&#41; at the end of follow-up&#46; The course of the disease was chronic in 17 eyes &#40;60&#46;7&#37;&#41;&#44; recurrent in 5 eyes &#40;17&#46;9&#37;&#41; and acute in 4 eyes &#40;14&#46;3&#37;&#41;&#46; In 2 eyes the follow-up time was less than 3 months&#44; so the course of the disease could not be established&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The most frequent treatment for acute conditions with greater symptomatology or inflammatory signs was periocular injection of triamcinolone or methylprednisolone &#40;40&#8239;mg&#47;1 cc&#41;&#44; which was applied at some point during follow-up in 15 eyes &#40;53&#46;6&#37;&#41;&#46; The number of applications ranged from 1 to 7 applications per eye&#44; with a minimum time of 4 weeks between multiple applications&#46; Prednisolone acetate 1&#37; drops were used in 16 eyes &#40;60&#46;7&#37;&#41;&#46; Oral prednisone was administered in some cases to control the acute condition at a dose of 1&#8239;mg&#47;kg per day for a short time and&#44; in other cases&#44; to prevent recurrences at doses of 7&#46;5&#8239;mg&#47;kg per day or less for a long time&#46; Prednisolone acetate 1&#37; drops were also used in 16 eyes &#40;60&#46;7&#37;&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The following complications occurred&#58; epimacular membrane in 14 eyes &#40;50&#37;&#41;&#44; cataract in 6 eyes &#40;21&#46;4&#37;&#41; and glaucoma in 2 eyes &#40;7&#46;1&#37;&#41;&#46; No eyes were found with cystoid macular edema&#46; Surgeries performed during the follow-up time were cataract in 3 eyes &#40;10&#46;7&#37;&#41; and glaucoma in 2 eyes &#40;7&#46;2&#37;&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">At the end of follow-up&#44; only 2 eyes lost one line of vision&#44; 2 maintained initial visual acuity &#40;VA&#41; and the other 24 &#40;85&#46;7&#37;&#41; improved to varying degrees &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The final VA was 20&#47;40 or better in 24 eyes &#40;85&#46;7&#37;&#41; and 20&#47;70 or better in 27 eyes &#40;96&#46;4&#37;&#41;&#46; The causes of a final VA of 20&#47;50 or worse were&#58; vitreous opacity in 2 eyes&#44; epimacular membrane in one eye and keratoconus &#40;not related to uveitis&#41; in one eye&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0070" class="elsevierStylePara elsevierViewall">In the present study&#44; intermediate uveitis associated with HTLV-1 infection was observed to occur predominantly in the second half of life&#44; with an average patient age of 57&#46;3 years&#46; In other case series&#44; the average age was 42&#46;8 years &#40;Nakao et al&#46;&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> 47 years &#40;Rathsam-Pinheiro&#41;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> and 49&#46;5 years&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> This contrasts with the younger age of presentation reported for other types of intermediate uveitis&#44; such as <span class="elsevierStyleItalic">pars planitis</span>&#44; which is more common in children and adolescents&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Female patients predominated over male patients&#44; at a ratio of approximately 2&#58;1&#44; similar to that shown in other series&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#8211;25</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Regarding the clinical picture at presentation&#44; we observed that this disease produced a mild to moderate decrease in VA &#40;82&#37; of eyes with vision of 20&#47;70 or better&#41;&#44; similar to that reported in other series&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;25&#44;26</span></a> Similarly&#44; we found that the degree of cellular infiltration in both the vitreous and anterior chamber was mild to moderate&#46; No exudates were seen in the <span class="elsevierStyleItalic">pars plana</span>&#44; unlike those seen in cases of <span class="elsevierStyleItalic">pars planitis</span>&#46; Some eyes showed small&#44; spiculated retrokeratic precipitates&#44; similar to those seen in Fuchs&#8217; heterochromic iridocyclitis&#46; This finding&#44; to our knowledge&#44; has not been described in other series&#46; At the end of the study&#44; more than half of the patients had involvement in both eyes&#46; Other authors report a higher proportion of patients with unilateral uveitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;27</span></a> The course of uveitis was recurrent or chronic in 78&#46;6&#37; of eyes&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In terms of treatment&#44; the most symptomatic cases were treated with periocular injections of depot corticosteroids &#40;triamcinolone or methylprednisolone&#41;&#44; as this is the most effective treatment with the least adverse effects&#46; However&#44; in several cases multiple injections were necessary to control inflammation&#46; In some&#44; low-dose oral prednisone was used in an attempt to reduce the number of recurrences&#59; however&#44; we cannot conclude from the present study that this measure had an effect&#46; There are no studies demonstrating the effectiveness and safety of immunosuppressive therapy in patients with uveitis associated with systemic HTLV-1 infection&#46; Biological treatments such as adalimumab&#44; a tumour necrosis factor monoclonal antibody -&#945;&#44; one of the most widely used medicament for treating inflammatory diseases&#44; could increase the viral load and put the patient at risk of developing systemic manifestations&#44; such as adult T-cell leukaemia&#47;lymphoma or HTLV-1-associated myelopathy&#46; However&#44; an <span class="elsevierStyleItalic">in vitro</span> study has been conducted with this drug for the topical treatment of HTLV-1-associated uveitis with apparently beneficial results&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Complications were mild&#44; the most frequent being epimacular membrane&#59; however&#44; this was clinically significant in only one eye&#46; No other complications were found&#44; such as cystoid macular edema or vitreous hemorrhage&#44; which are common in other intermediate uveitis such as <span class="elsevierStyleItalic">pars planitis</span>&#46; In the present study&#44; 85&#46;7&#37; of eyes improved one or more lines of vision at the end of follow-up&#44; which is better than reported in other studies&#58; Nakao<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> &#40;63&#46;5&#37;&#41; and Kase<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> &#40;71&#46;4&#37;&#41;&#46; At the end of follow-up&#44; most patients had good VA&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The limitations of the present study are due to its retrospective nature&#46; Diagnosis was based on a compatible clinical picture and serological tests&#44; but not on molecular tests for virus detection in intraocular fluids&#46; However&#44; the proportion of HTLV-1 seropositivity in patients with intermediate uveitis in Peru &#40;29&#46;4&#37;&#41; compared to the general population &#40;2&#37;&#41; suggests a very strong causal association&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusion</span><p id="par0095" class="elsevierStylePara elsevierViewall">Intermediate uveitis associated with HTLV-1 infection occurred mainly in patients in the second half of life&#44; with a recurrent or chronic course and with a good visual prognosis&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Funding</span><p id="par0100" class="elsevierStylePara elsevierViewall">Self-financed by the authors&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicts of interest</span><p id="par0105" class="elsevierStylePara elsevierViewall">No conflicts of interest were declared by the authors&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">To describe the clinical features at presentation&#44; delivered treatment and follow-up of a case series of human T-cell lymphotropic virus type 1 &#40;HTLV-1&#41; associated intermediate uveitis&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Retrospective&#44; descriptive and longitudinal study of patients with HTLV-1 associated intermediate uveitis treated at a reference ophthalmology facility in Lima&#44; Peru&#44; during the years 2012 to 2018&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A total of 18 patients &#40;28 eyes&#41; were included&#44; the average age at presentation was 57&#46;3 years&#44; 66&#46;6&#37; were women&#44; and the average follow-up time was 1&#44;280 days&#46; The most frequent symptoms were blurred or diminished vision &#40;78&#46;6&#37;&#41; and floaters &#40;57&#46;1&#37;&#41;&#46; Best corrected visual acuity was 20&#47;40 or better in 53&#46;6&#37;&#46; The mean initial intraocular pressure was 14&#46;95 mmHg&#46; Keratic precipitates were observed in 50&#37; of eyes&#44; 17&#46;9&#37; were of the stellate type&#46; The most frequent treatment was periocular corticosteroid injections &#40;53&#46;6&#37;&#41;&#46; Complications such as epimacular membrane &#40;50&#37;&#41;&#44; cataract &#40;21&#46;4&#37;&#41; and glaucoma &#40;7&#46;1&#37;&#41; occurred&#46; At the end of follow-up&#44; only 2 eyes lost one line of vision&#59; the final best corrected visual acuity was 20&#47;40 or better in 85&#46;7&#37;&#44; and 20&#47;70 or better in 96&#46;4&#37;&#46; Patients with both eyes affected increased from 33&#37; at presentation to 55&#46;5&#37;&#46; The course of the disease was chronic in 60&#46;7&#37;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">HTLV-1 associated intermediate uveitis mainly occurred in patients in the second half of life&#44; developing a chronic course and with good visual prognosis&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Describir las caracter&#237;sticas asociadas a la presentaci&#243;n&#44; tratamiento y seguimiento de una serie de casos de uve&#237;tis intermedia asociada al virus linfotr&#243;pico de c&#233;lulas T humano de tipo 1 &#40;HTLV-1&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo&#44; descriptivo y longitudinal&#46; Se incluy&#243; a pacientes con uve&#237;tis intermedia asociada a infecci&#243;n por HTLV-1 atendidos en una cl&#237;nica oftalmol&#243;gica de referencia de Lima &#40;Per&#250;&#41;&#44; durante 2012-2018&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 18 pacientes &#40;28 ojos&#41;&#46; La edad promedio a la presentaci&#243;n fue de 57&#44;3 a&#241;os&#59; el 66&#44;6&#37; fueron mujeres&#46; El tiempo de seguimiento promedio fue de 1&#46;280 d&#237;as&#46; Los s&#237;ntomas m&#225;s frecuentes fueron visi&#243;n borrosa o disminuida &#40;78&#44;6&#37;&#41; y visi&#243;n de cuerpos flotantes &#40;57&#44;1&#37;&#41;&#46; La agudeza visual mejor corregida fue de 20&#47;40 o mejor en el 53&#44;6&#37;&#46; La presi&#243;n intraocular inicial promedio fue de 14&#44;95 mmHg&#46; Se observaron precipitados retroquer&#225;ticos en el 50&#37; de ojos&#44; siendo el tipo m&#225;s frecuente el espiculado &#40;17&#44;9&#37; de los ojos&#41;&#46; El tratamiento m&#225;s frecuente fue la inyecci&#243;n periocular de corticoides &#40;en el 53&#44;6&#37; de los ojos&#41;&#46; Se presentaron complicaciones como membrana epimacular &#40;50&#37;&#41;&#44; catarata &#40;21&#44;4&#37;&#41; y glaucoma &#40;7&#44;1&#37;&#41;&#46; Al final del seguimiento&#44; solo 2 ojos perdieron una l&#237;nea de visi&#243;n&#59; la agudeza visual mejor corregida final fue de 20&#47;40 o mejor en el 85&#44;7&#37;&#44; y de 20&#47;70 o mejor en el 96&#44;4&#37;&#46; Los pacientes afectados en ambos ojos aumentaron de 33&#37; a la presentaci&#243;n a 55&#44;5&#37;&#46; El curso de la enfermedad fue cr&#243;nico en el 60&#44;7&#37;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">La uve&#237;tis intermedia asociada a infecci&#243;n por HTLV-1 se present&#243; principalmente en la segunda mitad de la vida&#44; con curso cr&#243;nico y buen pron&#243;stico visual&#46;</p></span>"
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          3 => array:2 [
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Siverio-Llosa C&#44; Silva-Ocas I&#44; G&#225;lvez-Ol&#243;rtegui T&#44; Arana-Kaik G&#46; Evoluci&#243;n cl&#237;nica de la uve&#237;tis intermedia asociada a infecci&#243;n por el virus linfotr&#243;pico de c&#233;lulas T humano tipo 1 &#40;HTLV-1&#41;&#46; Arch Soc Esp Oftalmol&#46; 2022&#59;97&#58;386&#8211;390&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Symptoms and signs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Blurred or impaired vision&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;78&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Floating vision&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;57&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Redness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Photophobia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;10&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Photopsies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Epiretinal infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chorioretinal scars&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Snowballs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cellular precipitates on posterior hyaloid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diffuse atrophy of the iris&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Mild eye redness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Corneal edema&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;7&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Multiple subretinal infiltrates&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;3&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">14 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">20&#47;50-20&#47;70&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8 &#40;28&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#47;100-20&#47;150&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;3&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#47;200-20&#47;400&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;10&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">HM&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;3&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Small spiculated&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;17&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Cells in endothelium&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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