Assessment of the biometric modifications of the eye in LASIK during suction | Archivos de la Sociedad Española de Oftalmología (English Edition)

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Fernández-Vigo, I. Almorín-Fernández-Vigo, B. Burgos-Blasco, L. De-Pablo-Gómez-de-Liaño, I. Sánchez-Guillén, A. Macarro-Merino, J.Á. Fernández-Vigo" "autores" => array:7 [ 0 => array:4 [ "nombre" => "J.I." "apellidos" => "Fernández-Vigo" "email" => array:2 [ 0 => "jfvigo@hotmail.com" 1 => "joseignacio.fernandez-vigo@salud.madrid.org" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "I." "apellidos" => "Almorín-Fernández-Vigo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "B." "apellidos" => "Burgos-Blasco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "L." 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"apellidos" => "Fernández-Vigo" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "f" "identificador" => "aff0030" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Centro Internacional de Oftalmología Avanzada, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria (IdISSC), Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Centro Internacional de Oftalmología Avanzada, Badajoz, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Department of Ophthalmology, Hospital 12 de Octubre, Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Department of Ophthalmology, Hospital Perpetuo Socorro, Badajoz, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Department of Ophthalmology, Universidad de Extremadura, Badajoz, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación de las modificaciones biométricas del ojo durante la succión del LASIK" ] ] "textoCompleto" => "IntroductionLASIK technique (Laser-assisted in Situ Keratomileusis) continues to be the most widely performed in corneal refractive surgery, with millions of patients having undergone and still undergoing surgery with this technique.<a class="elsevierStyleCrossRefs" href="#bib0005">1,2</a> Due to its social and health relevance, and although it modifies the cornea, the possible repercussion of this surgical technique on other ocular structures is still being studied.The safety of this technique remains controversial due to the hypothetical increase in alterations caused to the posterior segment. The frequent spontaneous appearance of vitreoretinal lesions in myopic patients and their possible coincidence with the postoperative period of refractive surgery keeps the issue relevant, especially considering the medical and legal implications.Various authors have studied the relationship between LASIK and vitreous,<a class="elsevierStyleCrossRefs" href="#bib0015">3,4</a> retinal,<a class="elsevierStyleCrossRefs" href="#bib0025">5–7</a> macular<a class="elsevierStyleCrossRefs" href="#bib0040">8–11</a> and optic nerve<a class="elsevierStyleCrossRef" href="#bib0060">12</a> disorders. An extensive review carried out by Arevalo assessed the subject, trying to analyze the possible mechanisms that could explain retinal damage.<a class="elsevierStyleCrossRef" href="#bib0065">13</a> Most of the published studies refer to complications in isolated clinical cases and the date of presentation of the complication in the postoperative period also being highly variable. Hence, studies that provide conclusive data to demonstrate their potential relationship are mandatory.Based on this possible association, our interest has been to study what could the pathophysiological mechanism that could justify the relationship between LASIK and posterior segment complications. Some hypothesis state that suction deforms the globe and increases its posterior length.<a class="elsevierStyleCrossRef" href="#bib0065">13</a> This deformation would cause changes in the anatomical relationship between intraocular structures, especially in the vitreous and vitreoretinal adhesions, which would be the cause of retinal lesions.The main objective of our work is to analyze the biometric changes that undergo the eye in LASIK surgery during suction, discussing whether these could justify potential injuries in the posterior segment.MethodsProspective observational study in which 43 consecutive patients were included. All patients underwent LASIK surgery to correct their refractive error (myopia and/or astigmatism) and signed the corresponding consent form. The study protocol adhered to the tenets of the Declaration of Helsinki and was approved by the Ethics Committee of the center.Patients with systemic diseases that, while not being a contraindication to LASIK, could be associated with retinal circulatory disorders (diabetes, arterial hypertension or vascular accidents) were not included in the study. Only myopic patients were included, hypermetropic individuals were excluded.The preoperative exam was the one usually performed in candidates for LASIK, which includes a complete ophthalmological exam (with biomicroscopy with a 78-diopter lens and indirect ophthalmoscopy) with the specific refractive surgery protocol: Orbscan (Bausch and Lomb, Germany) topography and pachymetry and ultrasonic pachymetry.The surgeries were performed by the same surgeon (JAFV) and the LASIK technique used was the standard technique using the One-use Plus microkeratome (MORIA, Antony, France) with the 600 mmHg vacuum setting.<a class="elsevierStyleCrossRef" href="#bib0070">14</a> The biometry was performed using the axis II-Quantel M® biometer (Quantel Medical, Cedex, France) with an 11 Mhz transducer whose electronic resolution is 0 ± 0.04 mm. The first biometry was performed immediately before applying the suction ring and the second was once the vacuum was reached after the ocular pressure had risen above 60 mmHg (controlled using a Barraquer tonometer) with the loss of light perception. In each case, the mean of 10 measurements was taken as the value.During the biometry, the following were measured: the aqueous depth (AQD, distance between the posterior face of the cornea and the anterior face of the lens), the lens thickness (LT, distance between the anterior and posterior face), the cavity length vitreous (VCL, distance between the posterior face of the lens and the inner limiting membrane) and the modified axial length (AXL, distance between the corneal endothelium and the retina). One eye was randomly selected for analysis. In seven patients, both eyes were measured and the data were compared in another analysis.Statistical analysisThe sample size calculation was performed using GRANMO (7.12 software, Barcelona, Spain). To achieve a power beta of 0.8 with an alpha risk of 0.05 in a two-sided contrast, a sample of 32 subjects was estimated to detect a difference equal to or greater than 0.5 units, assuming a standard deviation of 1 unit in paired measurements. Data were collected in an Access ® (Microsoft) database and later exported to SPSS® (Statistical Package for Social Sciences, v25.0; SPSS Inc., Chicago, IL, USA) for analysis. The Kolmogorov-Smirnov test was used to evaluate the normality of the data; all variables had a normal distribution. The mean values of each of the biometrics performed were analyzed, comparing the data obtained before and during suction using the Student's t-test for paired samples. An increase in the measurements was considered if it was >0.10, a decrease if it was <0.10, and stability if it was ±0.10 mm given the possible variability of the measurements.<a class="elsevierStyleCrossRef" href="#bib0075">15</a> Statistical significance was established at p < 0.05.ResultsThe mean age of the patients was: 38.3 ± 11.5 years (range: 26–52 years), of whom 19 were women (44.2%) and 15 were men (34.9%). The mean refractive error of the patients was −4.5 ± 2.3 diopters in spherical equivalent.As for the parameters measured before and during suction, mean values are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. The mean AXL before suction was 24.55 ± 1.11 mm and during suction, it was 24.67 ± 1.03 mm (p = 0.039). The average increase was 0.12 mm, which implies a relative increase of 0.5% of its total value. The AQD was 3.24 ± 0.34 mm before suction and 3.28 ± 0.26 mm during suction (p = 0.231). The mean increase in AQD was 0.04 mm, which represents an increase of 1.2% of its total value. Regarding the LT, this was 4.18 ± 0.35 mm before suction and 3.98 ± 0.34 mm during suction (p < 0.001). The lens decreased its thickness by 0.20 mm, which represents 4.8% of its value. The VCL was 17.23 ± 1.15 mm before suction and 17.45 ± 1.22 mm during suction (p < 0.001). This length increased by 0.22 mm, which represents 1.3%.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>The results obtained according to the biometric modifications during suction (increase, without change or decrease) are reflected in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>. It is noteworthy that in a considerable percentage of patients, AXL (42%), VCL (70%) and AQD (35%) increased, the increase in LT being in a low proportion of patients (2%), while there was a decrease in the latter in 67% of cases.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> describes the results of the group of seven patients who underwent measurements in both eyes, where we especially highlight the behaviour of the vitreous cavity and the AXL in this subgroup. Thus, we found that the measurements were highly variable since the anterior-posterior distance increased in both eyes in one patient, increased in the right eye and decreased in the left eye in three patients, increased in the left eye and decreased in the right eye in three patients and did not decrease in both eyes in any patient. In these same patients, the length of the vitreous cavity increased in both eyes in five patients and increased in one eye and decreased in the other in two patients.<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>In the individual analysis, we highlighted the most relevant changes: the greatest increase in AXL was from 23.00 to 23.60 mm. The greatest increase in the vitreous cavity was from 15.78 to 17.32 mm. The greatest decrease in LT was from 4.41 to 3.73 mm, and in AQD from 3.26 to 2.65 mm.DiscussionRefractive surgery must be proven safe given it is an elective surgery. To discard any doubts, studies must be carried out to demonstrate its safety. Therefore, analyzing the potential side effects of the technique should be a fundamental line of research in refractive surgery.Although there are many patients operated of LASIK, it has not been possible to demonstrate a significant relationship between the surgery and the lesions in the different ocular structures that could be attributed to the surgical maneuvres. However, there are reports of isolated clinical cases with different ocular complications in patients undergoing LASIK. In this line of study, a case of bilateral serous detachment of the macula<a class="elsevierStyleCrossRef" href="#bib0055">11</a> and some cases of optic neuropathy<a class="elsevierStyleCrossRef" href="#bib0060">12</a> have been described. Besides these anecdotal findings, vitreous and retinal changes have been studied with special interest. In general, the most important series describe very low incidences of retinal detachments in LASIK patients, between 0.08 and 0.033%.<a class="elsevierStyleCrossRefs" href="#bib0030">6,7</a> Something similar happens with posterior vitreous detachment (PVD) where the association is discussed.<a class="elsevierStyleCrossRef" href="#bib0020">4</a> In addition to complications, studies on the impact on different ocular structures, for example on the nerve fiber layer or the optic nerve, have been carried out without finding significant alterations.<a class="elsevierStyleCrossRef" href="#bib0075">15</a>Therefore, there does not seem to be a clear relationship between the LASIK technique and vitreoretinal complications. However, studies are needed to definitively confirm or rule out this relationship. The explanation given on a model made in cadaver eyes indicates that the AXL increases (1.125 mm), suggesting an anterior movement of the vitreous base that would cause traction that could predispose, in susceptible eyes, to retinal tears during and after LASIK.<a class="elsevierStyleCrossRef" href="#bib0080">16</a> In the eye in vivo, it is hypothesized that suction deforms the eye in the anterior-posterior axis and the globe length increases. Also, because it is a closed system, the eye contracts on the horizontal axis and the equatorial axis decreases.<a class="elsevierStyleCrossRef" href="#bib0065">13</a>During LASIK surgery there are two changes whose importance or significance we are unaware of: a great and abrupt increase of the intraocular pressure, although for a very short duration (generally less than 10 s), and a deformation of the globe in two phases, when inducing suction and with the cut of the microkeratome.In the present work, the modifications suffered by the eye in its antero-posterior axis and some of its components during suction have been measured. In the most common hypothesis, the eye undergoes anteroposterior elongation at the moment of suction, since the globe would herniate through the suction ring and consequently suffer compression in the herniated area. Therefore, there would be traction which could be the cause of vitreoretinal complications. Besides the fact that for this to happen the vitreous would have to be rigid and not follow the deformation of the globe’s walls, the magnitude of the changes would have to be clinically relevant in order to cause complications. The changes observed in the suction in the present work do fit this explanation, given that the anterior-posterior length or AXL increased. The thickness of the lens decreases and the vitreous cavity increases its length, that is, there is a slight increase in the vitreous cavity caused by an anterior displacement of the posterior capsule of the lens.Our results are similar to those obtained by Mirshahi and Kohnen, although with small variations.<a class="elsevierStyleCrossRef" href="#bib0015">3</a> These authors described that the mean AXL of the eyes was 25.08 mm without producing significant changes (−0.01 mm; p = 0.51). In our study, the average AXL was 24.55 mm, there being a significant increase (+0.12). The lens in this study decreased in agreement with the present study, undergoing modifications of a similar magnitude (mean change -0.20 mm in both studies). The vitreous cavity increased in 76.2% of the eyes by a mean of 0.20 mm, as in our study where 70% of the eyes suffered an elongation with a mean of 0.22 mm. Finally, the anterior chamber depth or AQD did not change significantly in both studies. Similarly, Davis and Evangelista observed by ultrasound a decrease in LT of -0.14 ± 0.45 mm (p < 0.05) during suction, while there was an increase in VCL of 0.25 ± 0.36 mm (p < 0.05) and a trend not significant to the increase in AXL.<a class="elsevierStyleCrossRef" href="#bib0085">17</a> The only difference observed was that they appreciated a decrease in anterior chamber depth of −0.06 ± 0.36 mm (p < 0.05), that is, of a very low magnitude.Thus, the changes that the eye undergoes during suction are minimal in intensity and with enormous variability. This last statement is based on two findings. In the patients in which we measured both eyes, only 1 patient out of 7 produced a bilateral increase in AXL, while in the other 6 patients, one eye increased and the other decreased (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). Regarding the vitreous cavity, of the 7 patients studied, in 5 it increased in both eyes and in two patients it increased in one eye and decreased in the contralateral eye. Therefore, variations do not occur in all cases. From a conceptual point of view, two aspects must also be differentiated: although some changes are frequent and statistically significant, their magnitude is minimal, so these changes are of such a low magnitude that they could hardly justify injuries. As we have described, the vitreous underwent a minimal mean increase of 0.22 mm, which represents 1.3% of its size, while the AXL underwent a percentage change of 0.5% of its absolute value.In this regard, the deformation of the globe could justify a change in the relationships between the intraocular structures, especially between the vitreous and the retina. Mirshasi and Kohnen observed that after surgery, 3/14 eyes (21.4%) would develop PVD for which there were no ultrasound signs preoperatively.<a class="elsevierStyleCrossRef" href="#bib0015">3</a> After femto-LASIK surgery, Gavrilov et al. observed a partial or total PVD in 5 eyes (16%) and concluded that although less vacuum is required than in LASIK with a microkeratome, the reported incidence of PVD is similar between both techniques.<a class="elsevierStyleCrossRef" href="#bib0090">18</a>However, if we compare LASIK with other common surgical ocular procedures, the changes caused by the former are very small. The important changes that the eye undergoes in surgery of the anterior segment such as cataract surgery (hypotension and hypothalamia or athalamia, hypertension and deepening of the anterior chamber after viscoelastic injection or when introducing the phacoemulsification or irrigation-aspiration terminals with the constant displacement of the posterior capsule and its effect on the anterior vitreous, as well as the marked deformation of the eye when the intraocular lens is inserted) or in vitreoretinal surgery with exchanges or indentations, are much more relevant than those that occur in LASIK surgery.In this work, certain limitations must be commented. First, the eye was only assessed during suction, but the deformation during the microkeratome cut was not measured, which could result in other ocular changes that should be analyzed in subsequent works. Because an ultrasound probe was used to measure biometric parameters, modified AXL and AQD are included, given that measurements are made from the corneal endothelium. The subgroup of patients in which both eyes are analyzed is very small (7 patients), so the conclusions do not have statistical power, and their clinical relevance is limited. Nevertheless, in our opinion and in light of the data presented, it is difficult to think that the changes produced by suction could cause injuries to the eye.In conclusion, LASIK suction maneuvres cause biometric changes in the eye globe, especially resulting in a decrease in the thickness of the lens and an increase in the vitreous cavity and AXL. Although they are notable due to their frequency, the small magnitude of the induced changes may hardly cause anatomical alterations.Conflict of interestThe authors declare that they have no conflict of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1940801" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Purpose" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1672280" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1940802" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1672279" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Statistical analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0020" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0025" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2023-03-16" "fechaAceptado" => "2023-05-05" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1672280" "palabras" => array:6 [ 0 => "Biometry" 1 => "LASIK eye globe suction" 2 => "Refractive surgery" 3 => "Myopia" 4 => "Lens thickness" 5 => "Vitreous cavity" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1672279" "palabras" => array:6 [ 0 => "Biometría" 1 => "Succión LASIK" 2 => "Cirugía refractiva" 3 => "Miopía" 4 => "Cristalino" 5 => "Cavidad vítrea" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "PurposeTo study the biometric modifications of the eyeball during suction in Laser assisted in Situ Keratomileusis (LASIK). MethodsObservational and cross-sectional study. We studied 43 patients who underwent surgery for myopia and myopic astigmatism. Mean age was 38.3 ± 11.5 years, and 19 were female (44.2%). Conventional LASIK surgery with a manual microkeratome was performed. Before and during the suction maneuvre the following parameters were measured using an 11 Mhz biometric probe: aqueous depth (AQD), lens thickness (LT), vitreous cavity length (VCL) and axial length (AXL). Paired t-test was used to compare the biometric measurements before and during suction. ResultsThe mean spherical equivalent refractive error was −4.5 ± 2.3 diopters. During suction, the AQD did not change significantly (p = 0.231). However, AXL and VCL increased by 0.12 mm and 0.22 mm respectively (p = 0.039 and <0.01) and LT decreased by 0.20 mm (p < 0.01). AXL increased in 42% of the eyes and decreased in 16%, VCL increased in 70% of the eyes and decreased in 9%, and the LT was reduced in 67% of the eyes. ConclusionsSuction maneuvres during LASIK surgery produce changes of little magnitude in the eye globe, mainly a decrease in LT and an increase in VCL and AXL. Therefore, these modifications are expected to produce minimal anatomic alterations." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Purpose" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "ObjetivoEstudiar las modificaciones biométricas del globo ocular durante la succión en la cirugía de Keratomileusis In Situ asistida por Láser (LASIK). MétodosEstudio observacional transversal. Se estudiaron 43 pacientes intervenidos de miopía y astigmatismo miópico. La edad media fue de 38,3 ± 11,5 años, 19 eran mujeres (44,2%). Se realizó una cirugía LASIK convencional con microqueratomo manual. Antes y durante la maniobra de succión se midieron los siguientes parámetros mediante una sonda biométrica de 11 Mhz: profundidad acuosa (AQD), espesor del cristalino (LT), longitud de la cavidad vítrea (VCL) y longitud axial (AXL). Se utilizó la prueba t pareada para comparar las medidas biométricas antes y durante la succión. ResultadosEl equivalente esférico medio fue de -4,5 ± 2,3 dioptrías. Durante la succión, la AQD no aumentó significativamente (p = 0,231). Sin embargo, la AXL y VCL aumentaron en 0,12 mm y 0,2 mm respectivamente (p = 0,039 y <0,01) y LT disminuyó en 0,20 mm (p < 0,01). La AXL aumentó en el 42% de los ojos y disminuyó en el 16%, mientras que la VCL aumentó en el 70% de los ojos y disminuyó en el 9%, y el LT se redujo en el 67% de los ojos. ConclusionesLas maniobras de succión durante la cirugía LASIK producen cambios de poca magnitud en el globo ocular, principalmente disminución de LT y aumento de VCL y AXL. Por lo tanto, es esperable que estas modificaciones produzcan alteraciones anatómicas mínimas." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "AXL = axial length; AQD = aqueous depth; LT = lens thickness; VCL = vitreous cavity length." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Parameter \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Before suction \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">During suction \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AXL (mm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.55 ± 1.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.67 ± 1.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.039 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">(22.68–27.01) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">(22.77–27.43) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AQD (mm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.24 ± 0.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.28 ± 0.26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.231 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">(2.52–4.12) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">(2.70–3.87) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LT (mm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.18 ± 0.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.98 ± 0.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">(3.66–5.14) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">(3.45–4.85) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">VCL (mm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.23 ± 1.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.45 ± 1.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">(14.88–20.06) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">(14.89–20.36) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3233365.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Results of the biometric modifications of the eye during the suction maneuvre in LASIK surgery. Mean ± standard deviation, range." ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "AXL = axial length; AQD = aqueous depth; LT = lens thickness; VCL = vitreous cavity length." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Parameter \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Increase \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No change \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Decrease \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AXL (mm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 eyes (42%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 eyes (42%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 eyes (16%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AQD (mm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 eyes (35%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 eyes (35%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 eyes (30%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LT (mm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 eye (2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 eyes (30%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29 eyes (67%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">VCL (mm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 eyes (70%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 eyes (21%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 eyes (9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3233366.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Distribution of the eyes by groups according to the modifications suffered by the different intraocular structures during LASIK suction." ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "R = right eye; L = left eye; AXL = axial length; AQD = aqueous depth; LT = lens thickness; VCL = vitreous cavity length." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="4" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Before suction</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="4" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">During suction</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patient \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">AQD (mm) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LT (mm) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">VCL (mm) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">AXL (mm) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">AQD (mm) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LT (mm) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">VCL (mm) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">AXL (mm) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 R \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.79 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.86 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.72 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 R \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.98 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.79 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.04 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.93 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 R \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.05 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.67 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 R \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.36 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.07 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.71 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 R \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.60 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.81 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.62 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 R \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.86 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.08 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.98 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.07 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 R \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.98 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.62 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; 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Original article

Assessment of the biometric modifications of the eye in LASIK during suction

Evaluación de las modificaciones biométricas del ojo durante la succión del LASIK

J.I. Fernández-Vigoa,b,

Corresponding author

jfvigo@hotmail.com
joseignacio.fernandez-vigo@salud.madrid.org

Corresponding author.

, I. Almorín-Fernández-Vigoc, B. Burgos-Blascob, L. De-Pablo-Gómez-de-Liañoa,d, I. Sánchez-Guillénc,e, A. Macarro-Merinoa, J.Á. Fernández-Vigoa,c,f

a Centro Internacional de Oftalmología Avanzada, Madrid, Spain

b Department of Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria (IdISSC), Madrid, Spain

c Centro Internacional de Oftalmología Avanzada, Badajoz, Spain

d Department of Ophthalmology, Hospital 12 de Octubre, Madrid, Spain

e Department of Ophthalmology, Hospital Perpetuo Socorro, Badajoz, Spain

f Department of Ophthalmology, Universidad de Extremadura, Badajoz, Spain

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        "titulo" => "Evaluaci&#243;n de las modificaciones biom&#233;tricas del ojo durante la succi&#243;n del LASIK"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">LASIK technique &#40;Laser-assisted in Situ Keratomileusis&#41; continues to be the most widely performed in corneal refractive surgery&#44; with millions of patients having undergone and still undergoing surgery with this technique&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Due to its social and health relevance&#44; and although it modifies the cornea&#44; the possible repercussion of this surgical technique on other ocular structures is still being studied&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The safety of this technique remains controversial due to the hypothetical increase in alterations caused to the posterior segment&#46; The frequent spontaneous appearance of vitreoretinal lesions in myopic patients and their possible coincidence with the postoperative period of refractive surgery keeps the issue relevant&#44; especially considering the medical and legal implications&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Various authors have studied the relationship between LASIK and vitreous&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> retinal&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;7</span></a> macular<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#8211;11</span></a> and optic nerve<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> disorders&#46; An extensive review carried out by Arevalo assessed the subject&#44; trying to analyze the possible mechanisms that could explain retinal damage&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Most of the published studies refer to complications in isolated clinical cases and the date of presentation of the complication in the postoperative period also being highly variable&#46; Hence&#44; studies that provide conclusive data to demonstrate their potential relationship are mandatory&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Based on this possible association&#44; our interest has been to study what could the pathophysiological mechanism that could justify the relationship between LASIK and posterior segment complications&#46; Some hypothesis state that suction deforms the globe and increases its posterior length&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> This deformation would cause changes in the anatomical relationship between intraocular structures&#44; especially in the vitreous and vitreoretinal adhesions&#44; which would be the cause of retinal lesions&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The main objective of our work is to analyze the biometric changes that undergo the eye in LASIK surgery during suction&#44; discussing whether these could justify potential injuries in the posterior segment&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0030" class="elsevierStylePara elsevierViewall">Prospective observational study in which 43 consecutive patients were included&#46; All patients underwent LASIK surgery to correct their refractive error &#40;myopia and&#47;or astigmatism&#41; and signed the corresponding consent form&#46; The study protocol adhered to the tenets of the Declaration of Helsinki and was approved by the Ethics Committee of the center&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Patients with systemic diseases that&#44; while not being a contraindication to LASIK&#44; could be associated with retinal circulatory disorders &#40;diabetes&#44; arterial hypertension or vascular accidents&#41; were not included in the study&#46; Only myopic patients were included&#44; hypermetropic individuals were excluded&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The preoperative exam was the one usually performed in candidates for LASIK&#44; which includes a complete ophthalmological exam &#40;with biomicroscopy with a 78-diopter lens and indirect ophthalmoscopy&#41; with the specific refractive surgery protocol&#58; Orbscan &#40;Bausch and Lomb&#44; Germany&#41; topography and pachymetry and ultrasonic pachymetry&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The surgeries were performed by the same surgeon &#40;JAFV&#41; and the LASIK technique used was the standard technique using the One-use Plus microkeratome &#40;MORIA&#44; Antony&#44; France&#41; with the 600&#8239;mmHg vacuum setting&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> The biometry was performed using the axis II-Quantel M&#174; biometer &#40;Quantel Medical&#44; Cedex&#44; France&#41; with an 11 Mhz transducer whose electronic resolution is 0&#8239;&#177;&#8239;0&#46;04&#8239;mm&#46; The first biometry was performed immediately before applying the suction ring and the second was once the vacuum was reached after the ocular pressure had risen above 60&#8239;mmHg &#40;controlled using a Barraquer tonometer&#41; with the loss of light perception&#46; In each case&#44; the mean of 10 measurements was taken as the value&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">During the biometry&#44; the following were measured&#58; the aqueous depth &#40;AQD&#44; distance between the posterior face of the cornea and the anterior face of the lens&#41;&#44; the lens thickness &#40;LT&#44; distance between the anterior and posterior face&#41;&#44; the cavity length vitreous &#40;VCL&#44; distance between the posterior face of the lens and the inner limiting membrane&#41; and the modified axial length &#40;AXL&#44; distance between the corneal endothelium and the retina&#41;&#46; One eye was randomly selected for analysis&#46; In seven patients&#44; both eyes were measured and the data were compared in another analysis&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Statistical analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">The sample size calculation was performed using GRANMO &#40;7&#46;12 software&#44; Barcelona&#44; Spain&#41;&#46; To achieve a power beta of 0&#46;8 with an alpha risk of 0&#46;05 in a two-sided contrast&#44; a sample of 32 subjects was estimated to detect a difference equal to or greater than 0&#46;5 units&#44; assuming a standard deviation of 1 unit in paired measurements&#46; Data were collected in an Access &#174; &#40;Microsoft&#41; database and later exported to SPSS&#174; &#40;Statistical Package for Social Sciences&#44; v25&#46;0&#59; SPSS Inc&#46;&#44; Chicago&#44; IL&#44; USA&#41; for analysis&#46; The Kolmogorov-Smirnov test was used to evaluate the normality of the data&#59; all variables had a normal distribution&#46; The mean values &#8203;&#8203;of each of the biometrics performed were analyzed&#44; comparing the data obtained before and during suction using the Student&#39;s <span class="elsevierStyleItalic">t</span>-test for paired samples&#46; An increase in the measurements was considered if it was &#62;0&#46;10&#44; a decrease if it was &#60;0&#46;10&#44; and stability if it was &#177;0&#46;10&#8239;mm given the possible variability of the measurements&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Statistical significance was established at p&#8239;&#60;&#8239;0&#46;05&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">The mean age of the patients was&#58; 38&#46;3&#8239;&#177;&#8239;11&#46;5 years &#40;range&#58; 26&#8211;52 years&#41;&#44; of whom 19 were women &#40;44&#46;2&#37;&#41; and 15 were men &#40;34&#46;9&#37;&#41;&#46; The mean refractive error of the patients was &#8722;4&#46;5&#8239;&#177;&#8239;2&#46;3 diopters in spherical equivalent&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">As for the parameters measured before and during suction&#44; mean values are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The mean AXL before suction was 24&#46;55&#8239;&#177;&#8239;1&#46;11&#8239;mm and during suction&#44; it was 24&#46;67&#8239;&#177;&#8239;1&#46;03&#8239;mm &#40;p&#8239;&#61;&#8239;0&#46;039&#41;&#46; The average increase was 0&#46;12&#8239;mm&#44; which implies a relative increase of 0&#46;5&#37; of its total value&#46; The AQD was 3&#46;24&#8239;&#177;&#8239;0&#46;34&#8239;mm before suction and 3&#46;28&#8239;&#177;&#8239;0&#46;26&#8239;mm during suction &#40;p&#8239;&#61;&#8239;0&#46;231&#41;&#46; The mean increase in AQD was 0&#46;04&#8239;mm&#44; which represents an increase of 1&#46;2&#37; of its total value&#46; Regarding the LT&#44; this was 4&#46;18&#8239;&#177;&#8239;0&#46;35&#8239;mm before suction and 3&#46;98&#8239;&#177;&#8239;0&#46;34&#8239;mm during suction &#40;p&#8239;&#60;&#8239;0&#46;001&#41;&#46; The lens decreased its thickness by 0&#46;20&#8239;mm&#44; which represents 4&#46;8&#37; of its value&#46; The VCL was 17&#46;23&#8239;&#177;&#8239;1&#46;15&#8239;mm before suction and 17&#46;45&#8239;&#177;&#8239;1&#46;22&#8239;mm during suction &#40;p&#8239;&#60;&#8239;0&#46;001&#41;&#46; This length increased by 0&#46;22&#8239;mm&#44; which represents 1&#46;3&#37;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">The results obtained according to the biometric modifications during suction &#40;increase&#44; without change or decrease&#41; are reflected in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; It is noteworthy that in a considerable percentage of patients&#44; AXL &#40;42&#37;&#41;&#44; VCL &#40;70&#37;&#41; and AQD &#40;35&#37;&#41; increased&#44; the increase in LT being in a low proportion of patients &#40;2&#37;&#41;&#44; while there was a decrease in the latter in 67&#37; of cases&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> describes the results of the group of seven patients who underwent measurements in both eyes&#44; where we especially highlight the behaviour of the vitreous cavity and the AXL in this subgroup&#46; Thus&#44; we found that the measurements were highly variable since the anterior-posterior distance increased in both eyes in one patient&#44; increased in the right eye and decreased in the left eye in three patients&#44; increased in the left eye and decreased in the right eye in three patients and did not decrease in both eyes in any patient&#46; In these same patients&#44; the length of the vitreous cavity increased in both eyes in five patients and increased in one eye and decreased in the other in two patients&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">In the individual analysis&#44; we highlighted the most relevant changes&#58; the greatest increase in AXL was from 23&#46;00 to 23&#46;60&#8239;mm&#46; The greatest increase in the vitreous cavity was from 15&#46;78 to 17&#46;32&#8239;mm&#46; The greatest decrease in LT was from 4&#46;41 to 3&#46;73&#8239;mm&#44; and in AQD from 3&#46;26 to 2&#46;65&#8239;mm&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">Refractive surgery must be proven safe given it is an elective surgery&#46; To discard any doubts&#44; studies must be carried out to demonstrate its safety&#46; Therefore&#44; analyzing the potential side effects of the technique should be a fundamental line of research in refractive surgery&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Although there are many patients operated of LASIK&#44; it has not been possible to demonstrate a significant relationship between the surgery and the lesions in the different ocular structures that could be attributed to the surgical maneuvres&#46; However&#44; there are reports of isolated clinical cases with different ocular complications in patients undergoing LASIK&#46; In this line of study&#44; a case of bilateral serous detachment of the macula<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> and some cases of optic neuropathy<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> have been described&#46; Besides these anecdotal findings&#44; vitreous and retinal changes have been studied with special interest&#46; In general&#44; the most important series describe very low incidences of retinal detachments in LASIK patients&#44; between 0&#46;08 and 0&#46;033&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;7</span></a> Something similar happens with posterior vitreous detachment &#40;PVD&#41; where the association is discussed&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In addition to complications&#44; studies on the impact on different ocular structures&#44; for example on the nerve fiber layer or the optic nerve&#44; have been carried out without finding significant alterations&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Therefore&#44; there does not seem to be a clear relationship between the LASIK technique and vitreoretinal complications&#46; However&#44; studies are needed to definitively confirm or rule out this relationship&#46; The explanation given on a model made in cadaver eyes indicates that the AXL increases &#40;1&#46;125&#8239;mm&#41;&#44; suggesting an anterior movement of the vitreous base that would cause traction that could predispose&#44; in susceptible eyes&#44; to retinal tears during and after LASIK&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> In the eye in vivo&#44; it is hypothesized that suction deforms the eye in the anterior-posterior axis and the globe length increases&#46; Also&#44; because it is a closed system&#44; the eye contracts on the horizontal axis and the equatorial axis decreases&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">During LASIK surgery there are two changes whose importance or significance we are unaware of&#58; a great and abrupt increase of the intraocular pressure&#44; although for a very short duration &#40;generally less than 10&#8239;s&#41;&#44; and a deformation of the globe in two phases&#44; when inducing suction and with the cut of the microkeratome&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">In the present work&#44; the modifications suffered by the eye in its antero-posterior axis and some of its components during suction have been measured&#46; In the most common hypothesis&#44; the eye undergoes anteroposterior elongation at the moment of suction&#44; since the globe would herniate through the suction ring and consequently suffer compression in the herniated area&#46; Therefore&#44; there would be traction which could be the cause of vitreoretinal complications&#46; Besides the fact that for this to happen the vitreous would have to be rigid and not follow the deformation of the globe&#8217;s walls&#44; the magnitude of the changes would have to be clinically relevant in order to cause complications&#46; The changes observed in the suction in the present work do fit this explanation&#44; given that the anterior-posterior length or AXL increased&#46; The thickness of the lens decreases and the vitreous cavity increases its length&#44; that is&#44; there is a slight increase in the vitreous cavity caused by an anterior displacement of the posterior capsule of the lens&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Our results are similar to those obtained by Mirshahi and Kohnen&#44; although with small variations&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> These authors described that the mean AXL of the eyes was 25&#46;08&#8239;mm without producing significant changes &#40;&#8722;0&#46;01&#8239;mm&#59; p&#8239;&#61;&#8239;0&#46;51&#41;&#46; In our study&#44; the average AXL was 24&#46;55&#8239;mm&#44; there being a significant increase &#40;&#43;0&#46;12&#41;&#46; The lens in this study decreased in agreement with the present study&#44; undergoing modifications of a similar magnitude &#40;mean change -0&#46;20&#8239;mm in both studies&#41;&#46; The vitreous cavity increased in 76&#46;2&#37; of the eyes by a mean of 0&#46;20&#8239;mm&#44; as in our study where 70&#37; of the eyes suffered an elongation with a mean of 0&#46;22&#8239;mm&#46; Finally&#44; the anterior chamber depth or AQD did not change significantly in both studies&#46; Similarly&#44; Davis and Evangelista observed by ultrasound a decrease in LT of -0&#46;14&#8239;&#177;&#8239;0&#46;45&#8239;mm &#40;p&#8239;&#60;&#8239;0&#46;05&#41; during suction&#44; while there was an increase in VCL of 0&#46;25&#8239;&#177;&#8239;0&#46;36&#8239;mm &#40;p&#8239;&#60;&#8239;0&#46;05&#41; and a trend not significant to the increase in AXL&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> The only difference observed was that they appreciated a decrease in anterior chamber depth of &#8722;0&#46;06&#8239;&#177;&#8239;0&#46;36&#8239;mm &#40;p&#8239;&#60;&#8239;0&#46;05&#41;&#44; that is&#44; of a very low magnitude&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Thus&#44; the changes that the eye undergoes during suction are minimal in intensity and with enormous variability&#46; This last statement is based on two findings&#46; In the patients in which we measured both eyes&#44; only 1 patient out of 7 produced a bilateral increase in AXL&#44; while in the other 6 patients&#44; one eye increased and the other decreased &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Regarding the vitreous cavity&#44; of the 7 patients studied&#44; in 5 it increased in both eyes and in two patients it increased in one eye and decreased in the contralateral eye&#46; Therefore&#44; variations do not occur in all cases&#46; From a conceptual point of view&#44; two aspects must also be differentiated&#58; although some changes are frequent and statistically significant&#44; their magnitude is minimal&#44; so these changes are of such a low magnitude that they could hardly justify injuries&#46; As we have described&#44; the vitreous underwent a minimal mean increase of 0&#46;22&#8239;mm&#44; which represents 1&#46;3&#37; of its size&#44; while the AXL underwent a percentage change of 0&#46;5&#37; of its absolute value&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In this regard&#44; the deformation of the globe could justify a change in the relationships between the intraocular structures&#44; especially between the vitreous and the retina&#46; Mirshasi and Kohnen observed that after surgery&#44; 3&#47;14 eyes &#40;21&#46;4&#37;&#41; would develop PVD for which there were no ultrasound signs preoperatively&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> After femto-LASIK surgery&#44; Gavrilov et al&#46; observed a partial or total PVD in 5 eyes &#40;16&#37;&#41; and concluded that although less vacuum is required than in LASIK with a microkeratome&#44; the reported incidence of PVD is similar between both techniques&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">However&#44; if we compare LASIK with other common surgical ocular procedures&#44; the changes caused by the former are very small&#46; The important changes that the eye undergoes in surgery of the anterior segment such as cataract surgery &#40;hypotension and hypothalamia or athalamia&#44; hypertension and deepening of the anterior chamber after viscoelastic injection or when introducing the phacoemulsification or irrigation-aspiration terminals with the constant displacement of the posterior capsule and its effect on the anterior vitreous&#44; as well as the marked deformation of the eye when the intraocular lens is inserted&#41; or in vitreoretinal surgery with exchanges or indentations&#44; are much more relevant than those that occur in LASIK surgery&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">In this work&#44; certain limitations must be commented&#46; First&#44; the eye was only assessed during suction&#44; but the deformation during the microkeratome cut was not measured&#44; which could result in other ocular changes that should be analyzed in subsequent works&#46; Because an ultrasound probe was used to measure biometric parameters&#44; modified AXL and AQD are included&#44; given that measurements are made from the corneal endothelium&#46; The subgroup of patients in which both eyes are analyzed is very small &#40;7 patients&#41;&#44; so the conclusions do not have statistical power&#44; and their clinical relevance is limited&#46; Nevertheless&#44; in our opinion and in light of the data presented&#44; it is difficult to think that the changes produced by suction could cause injuries to the eye&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">In conclusion&#44; LASIK suction maneuvres cause biometric changes in the eye globe&#44; especially resulting in a decrease in the thickness of the lens and an increase in the vitreous cavity and AXL&#46; Although they are notable due to their frequency&#44; the small magnitude of the induced changes may hardly cause anatomical alterations&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interest</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Statistical analysis"
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        6 => array:2 [
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          "titulo" => "Results"
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        7 => array:2 [
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          "titulo" => "Discussion"
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          "titulo" => "References"
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    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2023-03-16"
    "fechaAceptado" => "2023-05-05"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1672280"
          "palabras" => array:6 [
            0 => "Biometry"
            1 => "LASIK eye globe suction"
            2 => "Refractive surgery"
            3 => "Myopia"
            4 => "Lens thickness"
            5 => "Vitreous cavity"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1672279"
          "palabras" => array:6 [
            0 => "Biometr&#237;a"
            1 => "Succi&#243;n LASIK"
            2 => "Cirug&#237;a refractiva"
            3 => "Miop&#237;a"
            4 => "Cristalino"
            5 => "Cavidad v&#237;trea"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Purpose</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To study the biometric modifications of the eyeball during suction in Laser assisted in Situ Keratomileusis &#40;LASIK&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Observational and cross-sectional study&#46; We studied 43 patients who underwent surgery for myopia and myopic astigmatism&#46; Mean age was 38&#46;3&#8239;&#177;&#8239;11&#46;5 years&#44; and 19 were female &#40;44&#46;2&#37;&#41;&#46; Conventional LASIK surgery with a manual microkeratome was performed&#46; Before and during the suction maneuvre the following parameters were measured using an 11 Mhz biometric probe&#58; aqueous depth &#40;AQD&#41;&#44; lens thickness &#40;LT&#41;&#44; vitreous cavity length &#40;VCL&#41; and axial length &#40;AXL&#41;&#46; Paired <span class="elsevierStyleItalic">t</span>-test was used to compare the biometric measurements before and during suction&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The mean spherical equivalent refractive error was &#8722;4&#46;5&#8239;&#177;&#8239;2&#46;3 diopters&#46; During suction&#44; the AQD did not change significantly &#40;p&#8239;&#61;&#8239;0&#46;231&#41;&#46; However&#44; AXL and VCL increased by 0&#46;12&#8239;mm and 0&#46;22&#8239;mm respectively &#40;p&#8239;&#61;&#8239;0&#46;039 and &#60;0&#46;01&#41; and LT decreased by 0&#46;20&#8239;mm &#40;p&#8239;&#60;&#8239;0&#46;01&#41;&#46; AXL increased in 42&#37; of the eyes and decreased in 16&#37;&#44; VCL increased in 70&#37; of the eyes and decreased in 9&#37;&#44; and the LT was reduced in 67&#37; of the eyes&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Suction maneuvres during LASIK surgery produce changes of little magnitude in the eye globe&#44; mainly a decrease in LT and an increase in VCL and AXL&#46; Therefore&#44; these modifications are expected to produce minimal anatomic alterations&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Purpose"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
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            "identificador" => "abst0015"
            "titulo" => "Results"
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            "titulo" => "Conclusions"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Estudiar las modificaciones biom&#233;tricas del globo ocular durante la succi&#243;n en la cirug&#237;a de Keratomileusis In Situ asistida por L&#225;ser &#40;LASIK&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional transversal&#46; Se estudiaron 43 pacientes intervenidos de miop&#237;a y astigmatismo mi&#243;pico&#46; La edad media fue de 38&#44;3&#8239;&#177;&#8239;11&#44;5 a&#241;os&#44; 19 eran mujeres &#40;44&#44;2&#37;&#41;&#46; Se realiz&#243; una cirug&#237;a LASIK convencional con microqueratomo manual&#46; Antes y durante la maniobra de succi&#243;n se midieron los siguientes par&#225;metros mediante una sonda biom&#233;trica de 11 Mhz&#58; profundidad acuosa &#40;AQD&#41;&#44; espesor del cristalino &#40;LT&#41;&#44; longitud de la cavidad v&#237;trea &#40;VCL&#41; y longitud axial &#40;AXL&#41;&#46; Se utiliz&#243; la prueba t pareada para comparar las medidas biom&#233;tricas antes y durante la succi&#243;n&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">El equivalente esf&#233;rico medio fue de -4&#44;5&#8239;&#177;&#8239;2&#44;3 dioptr&#237;as&#46; Durante la succi&#243;n&#44; la AQD no aument&#243; significativamente &#40;p&#8239;&#61;&#8239;0&#44;231&#41;&#46; Sin embargo&#44; la AXL y VCL aumentaron en 0&#44;12&#8239;mm y 0&#44;2&#8239;mm respectivamente &#40;p&#8239;&#61;&#8239;0&#44;039 y &#60;0&#44;01&#41; y LT disminuy&#243; en 0&#44;20&#8239;mm &#40;p&#8239;&#60;&#8239;0&#44;01&#41;&#46; La AXL aument&#243; en el 42&#37; de los ojos y disminuy&#243; en el 16&#37;&#44; mientras que la VCL aument&#243; en el 70&#37; de los ojos y disminuy&#243; en el 9&#37;&#44; y el LT se redujo en el 67&#37; de los ojos&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Las maniobras de succi&#243;n durante la cirug&#237;a LASIK producen cambios de poca magnitud en el globo ocular&#44; principalmente disminuci&#243;n de LT y aumento de VCL y AXL&#46; Por lo tanto&#44; es esperable que estas modificaciones produzcan alteraciones anat&#243;micas m&#237;nimas&#46;</p></span>"
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            "titulo" => "Resultados"
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            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">AXL&#8239;&#61;&#8239;axial length&#59; AQD&#8239;&#61;&#8239;aqueous depth&#59; LT&#8239;&#61;&#8239;lens thickness&#59; VCL&#8239;&#61;&#8239;vitreous cavity length&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Before suction&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#46;28&#8239;&#177;&#8239;0&#46;26&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;231&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;2&#46;52&#8211;4&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#40;2&#46;70&#8211;3&#46;87&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">LT &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#46;98&#8239;&#177;&#8239;0&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#46;66&#8211;5&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#46;45&#8211;4&#46;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">VCL &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Results of the biometric modifications of the eye during the suction maneuvre in LASIK surgery&#46; Mean&#8239;&#177;&#8239;standard deviation&#44; range&#46;</p>"
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Increase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No change&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Decrease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AXL &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 eyes &#40;42&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 eyes &#40;42&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 eyes &#40;16&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AQD &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 eyes &#40;35&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 eyes &#40;35&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 eyes &#40;30&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LT &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 eye &#40;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 eyes &#40;30&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 eyes &#40;67&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VCL &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 eyes &#40;70&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 eyes &#40;21&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 eyes &#40;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3233366.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Distribution of the eyes by groups according to the modifications suffered by the different intraocular structures during LASIK suction&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">R&#8239;&#61;&#8239;right eye&#59; L&#8239;&#61;&#8239;left eye&#59; AXL&#8239;&#61;&#8239;axial length&#59; AQD&#8239;&#61;&#8239;aqueous depth&#59; LT&#8239;&#61;&#8239;lens thickness&#59; VCL&#8239;&#61;&#8239;vitreous cavity length&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Before suction</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">During suction</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">AQD &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LT &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">VCL &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">AXL &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">AQD &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LT &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">VCL &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">AXL &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 R&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 R&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;55&nbsp;\t\t\t\t\t\t\n
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Article information

ISSN: 21735794
Original language: English

DOI:10.1016/j.oftale.2023.06.011

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