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Detecting progression of acute zonal occult outer retinopathy (AZOOR) with optical coherence tomography angiography: A case report
Detección de la progresión de la retinopatía externa oculta zonal aguda (AZOOR) con angiografía por tomografía de coherencia óptica: reporte de un caso
C. de los Santosa,
Corresponding author
hes.oftalmologia.cs@gmail.com

Corresponding author.
, J.M. Herrerasa,b, L. Cochoa,b
a IOBA (Instituto de Oftalmobiología Aplicada), Universidad de Valladolid, Valladolid, Spain
b Departamento de Oftalmología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Acute zonal occult outer retinopathy &#40;AZOOR&#41; is a rare primary disorder of the outer retina &#40;photoreceptoritis&#41; first described by Gass in 1992<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> affecting predominantly young and middle-aged women &#40;13&#8211;63 years&#41; with myopia&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Patients often complain of acute and unilateral onset&#44; although &#190; progresses to bilateral&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> of loss of function of one or more zones of the outer retina &#40;photopsia and scotomas&#41;&#44; sometimes accompanied by photophobia&#44; mimicking migraine&#44; and decreased contrast sensitivity&#46; Fundoscopic changes are absent or minimal at the beginning&#44; however&#44; alterations may be evident in the electroretinogram &#40;ERG&#41; with subsequent visual field defects&#46; Multimodal imaging by fundus autofluorescence &#40;FAF&#41;&#44; optical coherence tomography &#40;OCT&#41;&#44; and indocyanine green &#40;ICG&#41; angiography may show a characteristic trizonal pattern in the subacute and chronic stage&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Lesions usually stabilize in 4&#8211;6 months&#44; and central vision remains good in most cases&#44; although recurrences can occur in one third of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">There are few reports using OCT angiography &#40;OCT-A&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;7</span></a> nonetheless&#44; we highlight its usefulness in detecting disease progression by presenting a case with 4-year follow-up&#46; Furthermore&#44; treatment is controversial given the fact some cases refer viral prodromes or history of autoimmune diseases&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and the pathogenesis has not yet been proven&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> however we report a new effective treatment option&#44; particularly when recurrence ensues&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Clinical case</span><p id="par0015" class="elsevierStylePara elsevierViewall">A 48-year-old woman without history of migraine complaining of superotemporal scotomas accompanied by photopsia and photophobia of 3 days of evolution in both eyes &#40;BE&#41;&#44; with apparent normal ocular fundus &#40;OF&#41;&#44; a Humphrey visual field &#40;HVF&#41; test reporting probable upper bitemporal quadrantanopia&#44; a magnetic resonance imaging of the orbit and brain with contrast without retrobulbar&#44; chiasmatic or parenchymal lesion&#44; and normal visual evoked potentials for BE&#44; who was referred to our institution 2 months later because of persistent symptoms&#46; Autoimmune diseases or any recent viral disease were denied and HVF was repeated &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">At first visit&#44; clinical examination was not remarkable including visual acuity&#44; intraocular pressure&#44; and anterior segment in BE&#44; except for the OF that showed a zone of subtle depigmentation inferotemporal to the optic disc in right eye &#40;RE&#41; and in the peripapillary region in left eye &#40;LE&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Fluorescein angiography demonstrated early and late hyperfluorescence due to retinal pigment epithelium &#40;RPE&#41; window defect and slight optic disc staining in BE without signs of vasculitis or macular edema &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; On FAF these lesions had diffuse hyperautofluorescence demarcated by a continuous line of greater hyperautofluorescence and in later visits they became hypoautofluorescent &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; A conventional electroretinogram was performed revealing mixed cone and rod disfunction and a decreased response of the Pattern ERG &#40;PERG&#41; and oscillatory potentials &#40;OPs&#41; in LE&#44; and the multifocal ERG &#40;MERG&#41; showed reduced response in BE corresponding to HVF defects &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">OCT demonstrated retinal thinning due to outer retinal atrophy with loss of outer plexiform layer&#44; outer nuclear layer&#44; external limiting membrane&#44; ellipsoid zone &#40;EZ&#41;&#44; myoid zone and interdigitation zone&#44; and subsequent RPE and choriocapillaris &#40;CC&#41; atrophy in BE &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; In addition&#44; hyperreflective subretinal deposits were seen within and on the edge of the lesions&#46; OCT-A showed increased decorrelation in the deep plexus with projection artifacts from the superficial plexus and the En Face OCT-A at the EZ level demonstrated hyperreflective dots over a hyporeflective area that was greater than FAF changes&#44; with additional hyporreflective lesions temporally to the main lesion in BE&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">An extensive work-up for infectious&#44; inflammatory or neoplastic disease was performed including Treponema pallidum&#44; Herpes simplex virus type 1 and 2&#44; Toxocara canis&#44; Bartonella henselae&#44; QuantiFERON-TB Gold&#44; serum calcium&#44; angiotensin-converting enzyme&#44; erythrocyte sedimentation rate&#44; c-protein reactive&#44; rheumatoid factor&#44; serum complement C3 and C4&#44; IgM and IgG anticardiolipin antibodies&#44; antinuclear antibodies&#44; antineutrophil cytoplasmic antibodies&#44; tumor markers &#40;carcinoembryonic antigen and CA 19-9&#41;&#44; anti-titin&#44; anti-recoverin&#44; anti-CV2&#44; anti-amphiphysin&#44; anti-Ri&#44; anti-neuronal &#40;Ma2&#41;&#44; anti-Yo&#44; anti-Hu&#44; anti-SOX1&#44; anti-alpha enolase&#44; anti-carbonic anhydrase antibodies and a positron emission tomography &#40;PET&#41; which were all negative&#44; therefore&#44; AZOOR was diagnosed&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">After worsening detected by HVF and ERG in BE at the third month of follow-up &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; immunomodulatory treatment with subcutaneous adalimumab 40&#160;mg every 2 weeks was initiated showing bilateral improvement&#44; nevertheless&#44; 19 months later the patient reported an increase in symptoms and progression was observed in HVF&#44; ERG and OCT-A in BE &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 3</a>&#41;&#44; therefore&#44; adalimumab and anti-adalimumab antibodies levels in serum were tested reporting normal &#91;9&#46;4&#160;&#956;g&#47;mL &#40;reference 5&#8211;12&#41; and &#60;10&#160;ng&#47;mL &#40;reference &#60;10&#160;ng&#47;mL&#41; respectively&#93;&#44; however&#44; mycophenolate mofetil was added 2&#160;g&#47;day with later improvement in BE&#46; Currently&#44; with 4 years of follow-up&#44; the patient reports being asymptomatic&#44; maintains a visual acuity of 1&#46;0 in both eyes&#44; and stability is recorded both in HVF&#44; ERG and multimodal imaging&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">AZOOR is a primary photoreceptoritis with secondary involvement of the RPE and CC&#46; At the beginning it may not be clinically apparent&#44; nevertheless a grayish-white demarcation line may be seen occasionally between the affected and the normal retina if there is active expansion of the disease&#44; which disappears within weeks and is replaced with an orange area&#46; When it progresses&#44; it can present pigment deposition with zonal or multizonal retinochoroidal atrophy&#44; often seen as a peripapillary depigmentation&#44; and in advanced stages is associated with focal perivenous sheathing and retinal arteriolar attenuation&#44; mimicking sectoral or asymmetric retinitis pigmentosa&#44; syphilis&#44; autoimmune retinopathy&#44; diffuse unilateral subacute neuroretinitis and retinal vasculitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> nevertheless&#44; these entities were ruled out in this patient&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The electroretinogram may exhibit disfunction of both cones and rods as well as reduced amplitude in OPs&#44; suggesting that inner retina may be secondarily affected&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> since photoreceptors provide electrical input signals to the more proximal cells that generate the Ops&#46; HVF test may exhibit scotomas that suggest retrobulbar optic neuritis or intracranial tumor which were ruled out in this patient&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Multimodal imaging by FAF&#44; OCT and ICG angiography may show a characteristic trizonal pattern<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> consisting of normal retina &#40;zone 1&#41;&#44; transition line of outer retina atrophy &#40;zone 2&#41;&#44; and an area with additional RPE and CC atrophy &#40;zone 3&#41;&#46; Paraneoplastic and nonparaneoplastic autoimmune retinopathy may also show outer retinal dysfunction resembling AZOOR&#44; but despite the absence of systemic symptoms&#44; antiretinal antibodies&#44; tumor markers and PET-Scan were negative confirming the diagnosis&#46; Several reports have detected OCT-A changes in AZOOR which include increase in deep flow density as a possible source of mediators of inflammation in contrast to inactive phase where it is decreased&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> although this finding was not seen in our patient&#46; Furthermore&#44; others have reported increased decorrelation signal at the level of the deep capillary plexus with projection artifacts from the superficial capillary plexus<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and increased hyperreflective dots on En Face OCT-A at EZ level<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> as in our patient&#44; the latter suggesting outer segments of degraded photoreceptors&#44; however&#44; to the best of our knowledge&#44; this is the first case report to address progression of disease in a long-term context and correlate this findings with worsening in the ERG and HVF&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">There is no consensus on whether treatment alters or not the natural history of the disease because of limited reports in the literature&#44; and the use of antivirals such as acyclovir and valacyclovir is anecdotal with an efficacy not yet proven in this pathology&#46; Moreover&#44; the response to systemic corticosteroids and&#47;or immunosuppressants such as methotrexate&#44; mycophenolate mofetil&#44; azathioprine&#44; cyclosporine&#44; infliximab&#44; and adalimumab is variable&#46; Nevertheless&#44; this patient had a good clinical response combining adalimumab and mycophenolate mofetil when recurred&#44; and so far&#44; there is no more evidence in the literature of this therapeutic approach&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; multimodal imaging is essential to distinguish it from other diseases&#44; however&#44; since this is a primary photoreceptoritis&#44; En Face OCTA at EZ level seems to be a potential imaging technique to monitor progression and treatment response along with ERG&#44; HVF and FAF&#46; Additionally&#44; the combination of adalimumab with mycophenolate mofetil is good treatment option in recurrent disease&#46;</p></span><span id="sec1065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect1125">Funding</span><p id="par1320" class="elsevierStylePara elsevierViewall">The authors confirm that they have not received funding for this article&#46;the realisation of this article&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflict of interest</span><p id="par1325" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Clinical case</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A 48-year-old woman with persistent superotemporal scotomas and photopsias for 2 months&#44; and depigmented zones in the retina of both eyes with a trizonal pattern on multimodal imaging&#46; Brain magnetic resonance imaging&#44; positron emission tomography&#44; antiretinal antibodies&#44; immunological&#44; infectious and tumor markers tests were negative&#44; thus acute zonal occult outer retinopathy was diagnosed&#46; Patient was treated with adalimumab&#46; Nevertheless&#44; 19 months later symptoms increased&#44; and progression was detected on optic coherence tomography angiography&#44; as well as in Humphrey visual field test and electroretinogram&#44; thus&#44; mycophenolate mofetil was added showing improvement and stabilization of the disease in a 4-year follow-up&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Optic coherence tomography angiography may be a potential tool to monitor progression and response to treatment in addition to other imaging modalities in acute zonal occult outer retinopathy&#44; and the combination of adalimumab and mycophenolate may be useful in recurrent disease&#46;</p></span>"
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        "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Caso cl&#237;nico</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Mujer de 48 a&#241;os con escotomas superotemporales persistentes y fotopsias de 2 meses de evoluci&#243;n y zonas despigmentadas en retina de ambos ojos con patr&#243;n trizonal en imagen multimodal&#46; La resonancia magn&#233;tica cerebral&#44; la tomograf&#237;a por emisi&#243;n de positrones&#44; los anticuerpos antirretinianos&#44; los marcadores inmunol&#243;gicos&#44; infecciosos y tumorales fueron negativos&#44; por lo que se diagnostic&#243; retinopat&#237;a externa oculta zonal aguda&#46; La paciente fue tratada con adalimumab&#44; sin embargo&#44; 19 meses despu&#233;s los s&#237;ntomas aumentaron y se detect&#243; progresi&#243;n en la angiograf&#237;a por tomograf&#237;a de coherencia &#243;ptica&#44; as&#237; como tambi&#233;n en la prueba de campo visual Humphrey y el electrorretinograma&#44; por lo que se agreg&#243; micofenolato de mofetilo mostrando mejor&#237;a y estabilizaci&#243;n de la enfermedad durante un seguimiento de 4 a&#241;os&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discusi&#243;n</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La angiograf&#237;a por tomograf&#237;a de coherencia &#243;ptica puede ser una herramienta potencial para monitorear la progresi&#243;n y la respuesta al tratamiento adem&#225;s de otras modalidades de imagen en la retinopat&#237;a externa oculta zonal aguda&#44; y la combinaci&#243;n de adalimumab y micofenolato puede ser &#250;til en la enfermedad recurrente&#46;</p></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Humphrey visual field test at first visit showed a superior arcuate scotoma &#40;a&#41; in right eye &#40;RE&#41; and increased blind spot with paracentral extension &#40;b&#41; in left eye &#40;LE&#41; which improved after treatment in next visits in both eyes &#40;BE&#41; &#40;c and d&#41;&#44; nevertheless&#44; a worsening was detected 19 months later in BE &#40;e and f&#41;&#44; so that treatment was modified showing improvement in the last visit &#40;g and h&#41; in BE&#46; Electroretinogram &#40;ERG&#41; at first visit revealed a reduced response in the amplitude of a and b waves in rod &#40;scotopic&#41; and cone &#40;flicker-30&#160;Hz&#41; responses &#40;i-k&#41;&#44; in P50 of the pattern ERG &#40;PERG&#41; &#40;l&#41; and in the oscillatory potentials &#40;posc&#41; &#40;m&#41; in LE&#46; Multifocal ERG &#40;MERG&#41; exhibited a decrease in the amplitude of P1 wave in the upper macula in BE &#40;n and o&#41;&#44; although more accentuated in LE&#44; which improved after treatment &#40;p and q&#41;&#44; but worsening was seen at 19th month &#40;r and s&#41;&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Ocular fundus at first visit showing a depigmented zone due to retinochoroidal atrophy inferotemporal to the optic disc in right eye &#40;RE&#41; &#40;a&#41; and in the peripapillary region in left eye &#40;LE&#41; &#40;b&#41;&#46; At 7th month &#40;c and d&#41;&#44; 19th month &#40;e and f&#41;&#44; and four years later &#40;g and h&#41; lesions became more evident with pigment deposition and an additional nasal zone was clinically apparent in LE in the last visit &#40;h&#41;&#46; On fundus autofluorescence lesions showed diffuse hyperautofluorescence in both eyes &#40;BE&#41; demarcated by a continuous line of greater hyperautofluorescence &#40;i and j&#41; and two smaller lesions were noticeable nasally in LE&#46; At 7th month &#40;k and l&#41; there was stippling hypoautofluorescence in the center of the lesions that became more regular at 19th month &#40;m and n&#41; and four years later &#40;o and p&#41;&#46; Fluorescein angiography at first visit showed late hyperfluorescence due to retinal pigmentary epithelium window defect with mild optic disc staining and slight arteriolar attenuation in affected areas of BE &#40;q and r&#41;&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Optical coherence tomography angiography &#40;OCT-A&#41; at first visit showing reduced thickness &#40;a and b&#41; and increased decorrelation signal at the deeper capillary plexus along with projection artifacts of the superficial capillary plexus &#40;c and d&#41; in both eyes &#40;BE&#41; due to outer retina atrophy &#40;g&#8211;j&#41;&#46; En Face OCT-A revealed hyperreflective dots at ellipsoid zone level over a hyporreflective background in BE &#40;e and f&#41;&#44; although more evident in left eye &#40;LE&#41;&#44; which correspond to subretinal drusenoid deposits &#40;g&#8211;j&#41;&#46; When progression occurred &#40;k&#8211;t&#41;&#44; new spots of pseudo-increased thickness appeared &#40;k and l&#41; and more numerous hyperreflective dots developed despite the hyporeflective background had decreased in size on En Face OCT-A BE &#40;o and p&#41;&#46; There is also increased penetration of light signal due to retinal pigment epithelium and choriocapillaris atrophy &#40;q&#8211;t&#41;&#46;</p>"
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Acute zonal occult outer retinopathy&#46; Donders Lecture&#58; The Netherlands Ophthalmological Society&#44; Maastricht&#44; Holland&#44; June 19&#44; 1992"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;D&#46; Gass"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Neuroophthalmol"
                        "fecha" => "1993"
                        "volumen" => "13"
                        "paginaInicial" => "79"
                        "paginaFinal" => "97"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8340485"
                            "web" => "Medline"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute zonal occult outer retinopathy&#58; a long-term follow-up study"
                      "autores" => array:1 [
                        0 => array:2 [
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