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Validation of a Rapid Antigen Test in the Diagnosis of Pharyngitis Caused by Group A Beta-Haemolytic Streptococcus
Validación de una técnica antigénica rápida en el diagnóstico de la faringitis por estreptococo betahemolítico del grupo A
Carles Llora, Silvia Hernández Anadóna, Frederic Frances Gómez Bertomeub, Josep Maria Santamaria Puigb, Olga Calviño Domínguezaa, Yvonne Fernández Pagésa
a Family Medicine, Jaume I Health Centre, Tarragona, Spain.
b Microbiology Department, Joan XXIII Hospital, Tarragona, Spain. Funding: The Genzyme OSOM StrepA strips were free of charge and provided Laboratorio Leti. We have not received any direct or indirect funding from this Laboratory for carrying out this study.
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          "en" => "General Scheme of the Study&#46; Prospective&#44; observational study&#44; carried out between January 2007 and March 2008&#46; &#42;One patient had nausea during the procedure&#44; although the 2 swabs could be collected&#46;GABHS indicates group A beta-haemolytic Streptococcus&#46;"
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold"> Introduction</span></p><p class="elsevierStylePara">Pharyngitis&#44; along with rhinitis&#44; is the most common reason for being seen by a primary care doctor in</p><p class="elsevierStylePara"> Spain&#46;<span class="elsevierStyleSup">1</span> It is also one of the most common reasons for prescribing antibiotics in our country&#44; with an estimated prescription rate of 80&#37;<span class="elsevierStyleSup">1-3</span>&#59; despite this&#44; only 50&#37; of pharyngitis in children and 15&#37;-25&#37; of adults is of bacterial origin&#46;<span class="elsevierStyleSup">2-4</span> It should be systematically treated with antibiotics as&#44; according to meta-analyses carried out&#44; most pharyngitis is cured without antibiotics being given&#46;<span class="elsevierStyleSup">5</span> Only infections caused by <span class="elsevierStyleItalic"><span class="elsevierStyleItalic">Streptococcus pyogenes</span></span> or group A beta-haemolytic <span class="elsevierStyleItalic"><span class="elsevierStyleItalic">Streptococcus</span></span> &#40;GABHS&#41; require the use of an antibiotic&#44; as it stops the transmission and spreading of <span class="elsevierStyleItalic"><span class="elsevierStyleItalic">S pyogenes</span></span> in the community&#44; reduces the symptomatology compared to the non-treated group in a mean of 16 hours&#44; and because it prevents suppurative complications&#46; According to the Cochrane review&#44; for every 100 patients treated with antibiotics compared to the group assigned to the placebo it produces 1 case less of rheumatic fever&#44; 2 cases less of acute otitis media&#44; and 3 cases less of peritonsillar abscess&#46;<span class="elsevierStyleSup">5&#44;6</span> However&#44; the majority of studies included in this review were carried out in the 1950&#39;s and 60&#39;s&#44; and the incidence of complications is much less in the last 20 years or so than in the period when these clinical studies were performed&#46;<span class="elsevierStyleSup">7</span> A paper was recently published in the United Kingdom confirmed that the decrease in prescribing antibiotics for the treatment of pharyngitis in the last few years is not accompanied by a greater number of cases of rheumatic fever or peritonsillar abscesses&#46;<span class="elsevierStyleSup">8</span> Acute pharyngitis creates problems for the primary care doctor&#44; since it is difficult to clinically differentiate the aetiology due to GABHS from that of nonstreptococcal origin&#46; Its diagnostic standard is still the pharyngeal culture&#44; but this has significant limitations&#44; such as the delay in obtaining the results and&#44; also&#44; it does not help in distinguishing between acute infection and a carrier state&#46;</p><p class="elsevierStylePara">Clinical criteria are normaly used in practice to identify patients who need to be treated with antibiotics&#46; In this case&#44; the most well-known are the 4 criteria proposed by Centor<span class="elsevierStyleSup">9</span>&#58; presence or history of fever&#44; tonsillar exudate&#44; painful lateral cervical lymph nodes&#44; and absence of cough&#46; Later&#44; McIsaac also included age&#44; with an age less than 15 years being considered as another criterion&#46;<span class="elsevierStyleSup">10</span> In the last few years&#44; new rapid antigen techniques &#40;RAT&#41; have been developed for the diagnosis of acute pharyngeal tonsillitis caused by GABHS&#44; with improved sensitivity and specificity than those of the 1990&#39;s&#46; In this study we aim to assess the validity of the Genzyme OSOM StrepA in patients with 2 or more Centor criteria&#46;</p><p class="elsevierStylePara"><img src="27v40n10-13127243fig01.jpg"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Methods</span></p><p class="elsevierStylePara">This was a prospective observational study carried out between January 2007 and March 2008&#46; Patients over 14 years old seen in 6 clinics in our health centre were consecutively include if they had clinical symptoms of odynophagia and 2 or more of Centor criteria&#58; tonsillopharyngeal exudate&#44; painful lateral cervical lymph nodes&#44; absence of cough&#44; and&#47;or presence or history of fever &#40;&#62;38<span class="elsevierStyleSup">o</span>C&#41;&#46; Patients were excluded if they had received antibiotic treatment in the previous 2 weeks and if a swab could not be collected&#46; The sample size was calculated to be 170 subjects for a precision of 6&#37; and expected proportion of 20&#37;&#44; with a 95&#37; confidence interval &#40;95&#37; CI&#41;&#46; A data report form was prepared which contained&#44; age&#44; sex&#44; presence of these 4 criteria and whether the infection was recurrent &#40;less than 2 months since the last episode&#41; or non-recurrent&#46;Two samples were taken for the culture from each patient for this study&#44; by swabbing the tonsils and&#47;or posterior wall of the pharynx with a swab&#44; without touching the tongue&#44; teeth or gums&#46; The samples were taken by the 6 family doctors who had been previously trained to carry out the correct technique&#46; OSOM StrepA &#40;Laboratorio Genzyme&#41; following the manufacturers instructions&#44; was performed on one of the samples&#46; The other swab&#44; using an AMIES type transport medium &#40;Copan Innovation Italy&#41;&#44; was sent to the Microbiology Department of the Joan XXIII Hospital&#44; Tarragona&#44; Spain&#46; It was cultivated on a blood agar plate and incubated at a temperature of 37<span class="elsevierStyleSup">o</span>C in a 5&#37; CO<span class="elsevierStyleInf">2</span> atmosphere for 48 hours&#46; The culture was considered positive for <span class="elsevierStyleItalic"><span class="elsevierStyleItalic">S pyogenes</span></span> if there was&#44; growth of any number beta-haemolytic colonies&#44; a positive Gram stain with streptococcal morphology&#44; and a negative catalase test&#44; with subsequent identification using a WIDER automated screen &#40;Francisco Soria Melguizo&#41; for Gram positive cocci&#46; The results were then confirmed by serotyping using the Streptococcal Grouping Kit &#40;Oxford&#44; United Kingdom&#41;&#46; The culture was considered negative if there were no beta-haemolytic colonies seen after 48 hours incubation&#46;</p><p class="elsevierStylePara">For the statistical analysis&#44; the c<span class="elsevierStyleSup">2</span> test was used for the analysis of the qualitative variables and the Student-Fisher <span class="elsevierStyleItalic"><span class="elsevierStyleItalic">t</span></span> test was used for comparing the means&#46; The sensitivity&#44; specificity&#44; the positive predictive value&#44; and the negative predictive value were calculated for the different Centor criteria and for the RAT&#46; Values of <span class="elsevierStyleItalic"><span class="elsevierStyleItalic">P</span></span>&#60;&#46;05 were considered to be statistically significant differences&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Results Results</span></p><p class="elsevierStylePara">The study included 184 consecutive patients with pharyngitis symptoms and at least 2 Centor criteria&#44; and as 2 swabs were lost in transport to the Microbiology Department&#44; there were 182 evaluable cases &#40;see the General Scheme of the Study&#41;&#46; The mean age was 30&#46;6&#177;12&#46;1 years&#44; with 116 females &#40;63&#46;7&#37;&#41;&#46; A total of 63 patients had 2 Centor criteria&#44; 83 had 3 criteria&#44; and 36 patients with 4 criteria&#46; The Centor criteria most often seen in the patients was&#44; tonsillopharyngeal exudate &#40;158 cases&#59; 86&#46;8&#37;&#41;&#44; followed by a history of fever &#40;140 cases&#59; 76&#46;9&#37;&#41;&#59; while the least frequent was the presence of painful lateral cervical lymph nodes &#40;89 cases&#59; 48&#46;9&#37;&#41;&#46; The culture was positive for any microorganism in 102 cases &#40;56&#37;&#41;&#44; and was more common among those who had 4 criteria &#40;25 cases&#59; 69&#46;4&#37;&#41;&#44; with no statistically significant differences seen with the other patient groups&#46; Table 1 shows the aetiology according to the number of Centor criteria&#44; and the different aetiological agents isolated in the cultures are shown in Figure 1&#46;</p><p class="elsevierStylePara"><img src="27v40n10-13127243fig02.jpg"></img></p><p class="elsevierStylePara"><img src="27v40n10-13127243fig03.jpg"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">FIGURE 1</span>  Aetiology observed in the pharyngeal cultures&#46;</p><p class="elsevierStylePara">No statistically significant differences were observed between sex and the incidence of streptococcal tonsillopharyngitis&#46; The mean age of those with positive GABHS was slightly lower than those who had negative cultures&#44; although no statistically significant differences were seen &#40;29&#46;7&#177;11 compared to 30&#46;9&#177;12&#46;3 years&#41;&#46; The incidence of GABHS infection was significantly higher among those with 4 Centor criteria&#44; followed by the patients with 3 criteria and then those who had only 2 criteria &#40;<span class="elsevierStyleItalic"><span class="elsevierStyleItalic">P</span></span>&#62;&#46;001&#41;&#46;</p><p class="elsevierStylePara">The Centor criteria associated with a higher frequency of infection due to GABHS was the absence of cough and the presence of painful lateral-cervical lymph nodes&#46; Thus&#44; GABHS was isolated in 27&#46;6&#37; of patients who did not have a cough&#44; a significantly higher percentage than that observed among subjects who did have a cough &#40;9&#46;1&#37;&#59; <span class="elsevierStyleItalic"><span class="elsevierStyleItalic">P</span></span>&#60;&#46;01&#41;&#46; GABHS infection is seen more often among patients who have painful lateral-cervical lymph nodes &#40;29&#46;2&#37; compared to 15&#46;1&#37; in those who do not&#59; <span class="elsevierStyleItalic"><span class="elsevierStyleItalic">P</span></span>&#60;&#46;05&#41;&#46; Infection due to GABHS is also more frequent among those who have or had a history of fever &#40;23&#46;6&#37; vs 16&#46;7&#37;&#41; and among those with tonsillopharyngeal exudate &#40;22&#46;8&#37; vs 16&#46;7&#37;&#41;&#46; However&#44; no statistically significant differences were observed in these 2 cases &#40;Figure 2&#41;&#46; Table 2 describes the validity of the Centor criteria in the diagnosis of pharyngitis due to GABHS&#46;</p><p class="elsevierStylePara"><img src="27v40n10-13127243fig04.jpg"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">FIGURE 2</span> Confirmed group A beta-haemolytic Streptococcus infection according to the presence or absence of Centor criteria&#46;</p><p class="elsevierStylePara"><img src="27v40n10-13127243fig05.jpg"></img></p><p class="elsevierStylePara">The RAT was positive in 48 cases and negative in the remaining 134 determinations &#40;Table 3&#41;&#46; The sensitivity observed with this technique was 0&#46;95 and the specificity&#44; 0&#46;93&#46; There were 10 false positives and 2 false negatives&#46; The positive predictive value was 0&#46;79 and the negative predictive value&#44; 0&#46;98&#46;</p><p class="elsevierStylePara"><img src="27v40n10-13127243fig06.jpg"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Discussion</span></p><p class="elsevierStylePara">The sensitivity and specificity achieved &#40;greater than 90&#37;&#41; with the RAT used&#44; along with the high negative predictive value &#40;98&#46;5&#37; in our study&#41;&#44; make this test a very helpful diagnostic tool for the family doctor&#46; Before discussing the results we should mention the points where our study differs compared to others&#46; We have included patients with clinical symptoms of pharyngitis with a suspected streptococcal aetiology&#59; that is to say&#44; those with 2 or more of the Centor criteria&#46; Even so&#44; the observed incidence of GABHS was 22&#37;&#46; In other studies published in this journal&#44; the inclusion criteria were wider&#44; and this&#44; without a doubt&#44; is one of the reasons for having found more favourable results in our study&#46;<span class="elsevierStyleSup">11-13</span></p><p class="elsevierStylePara">Only the study by D&#237;az-Berenguer showed validity values similar to ours&#44; although the positive predictive value of the RAT was somewhat lower in that one&#44; which was due to a lower prevalence of GABHS&#46;<span class="elsevierStyleSup">12</span></p><p class="elsevierStylePara">It would be wrong to compare the results of current RAT with those obtained at the beginning of the 1990&#180;s&#44; since the current RAT kits are more sensitive&#46; Neither can the microbiology study be compared&#44; as&#44; for example&#44; in the study by D&#237;az-Berenguer&#44; bacitracin disks were used&#44; and also because this method is not used nowadays&#44; as it produced a high rate of false negatives&#46;<span class="elsevierStyleSup">12</span></p><p class="elsevierStylePara">Another of the conclusions of our study&#44; already documented in other studies&#44; is the low reliability of the clinical criteria for the diagnosis of streptococcal pharyngitis&#46;</p><p class="elsevierStylePara">Even among patients with all the Centor criteria&#44; the probability of having a streptococcal infection was less than 40&#37;&#46; In our study&#44; the presence of any of these criteria makes a streptococcal aetiology more likely&#44; as has been observed in other studies&#44; and of these criteria&#44; the fundamental ones are painful laterocervical lymph nodes and absence of cough&#46;<span class="elsevierStyleSup">11&#44;12&#44;14</span> Only these criteria were significantly more prevalent among patients with GABHS infection&#46; On the other hand&#44; no statistically significant differences have been seen with the presence of an exudate or with the presence of a fever&#46; This same data have been observed in other studies&#46; In the study by Lind&#230;k et al&#44; the prevalence of GABHS was even higher among patients who did not have an exudate&#46;<span class="elsevierStyleSup">14</span></p><p class="elsevierStylePara">In a study recently published in this journal by Marin et al&#44;<span class="elsevierStyleSup">13</span> it mentioned that the clinical score system obtained a higher negative predictive value and a specificity that allowed nonstreptococcal pharyngitis to be diagnosed with sufficient certainty&#46; However&#44; in our study the probability of infection due to another microorganism other than GABHS was greater than 60&#37; among patients who had 4 criteria and over 70&#37; among those who had 3 criteria&#46; The use of clinical criteria to rule out streptococcal pharyngitis may be useful in developing countries&#44; but in these cases it has been seen that the combination of other criteria&#44; besides the Centor&#44; may be more useful&#46;<span class="elsevierStyleSup">15</span> However&#44; in Spain&#44; with the very significant use of antibiotics to treat this infection&#44; it is essential to change habits and use RATs&#46; Only in this way will a reduction in antibiotic prescriptions be achieved&#44; just as was observed in a clinical trial carried out in Canada&#46;<span class="elsevierStyleSup">16</span></p><p class="elsevierStylePara">One aspect of great concern to the doctor who sees a patient with supposedly streptococcal pharyngitis is the reliability of the negative result&#46; In our study&#44; the doctors were free to use antibiotic treatment regardless of the RAT result&#46; The guides indicate that if results are found to be negative&#44; particularly in pharyngitis with all the Centor criteria&#44; they should be confirmed by means of a culture&#46;<span class="elsevierStyleSup">6</span> However&#44; this practice is not usually implemented&#44; since the result takes between 24 and 48 hours&#46; In our study&#44; only 2 patients with a negative result &#40;the 2 cases with 3 Centor criteria&#41; actually had a GABHS infection&#46; Also&#44; in another study carried out in Spain&#44; the usefulness of RAT has also been shown&#44; up to the point of considering the culture unnecessary in negative cases&#46;<span class="elsevierStyleSup">17</span> Mostov&#44;<span class="elsevierStyleSup">18</span> in a recent review&#44; does not recommend it either&#46; A line of research that could be followed in the future is the high observed incidence of infections due to group C beta-haemolytic <span class="elsevierStyleItalic"><span class="elsevierStyleItalic"> Streptococcus</span></span>&#44; 14&#46;3&#37; in our country&#46; The pathogenic role of this bacteria is currently being discussed&#44; since Zwart et al<span class="elsevierStyleSup">19</span> observed that penicillin could reduce&#44; although marginally&#44; the duration of the symptoms of pharyngitis due to group C beta-haemolytic <span class="elsevierStyleItalic"><span class="elsevierStyleItalic"> Streptococcus</span></span>&#46; It has virulence factors similar to those of <span class="elsevierStyleItalic"><span class="elsevierStyleItalic">S pyogenes</span></span> and could cause the same type of infections&#46; It has been associated with outbreaks of pharyngitis with a clinical picture similar to that produced by GABHS&#44; but the non-suppurative after effects are much less common&#46;</p><p class="elsevierStylePara">In conclusion&#44; we believe that all primary care centres should be provided with RAT for the diagnosis of GABHS infections&#46; RAT is easy to perform&#44; it requires no technical support or specialist staff and is rapid&#46; A RAT determination cost between 2 and 3 euros depending on the different manufacturers&#44; a price that is offset by the cost of a box of amoxicillin&#44; penicillin V&#44; or amoxicillinclavulanic acid&#46; Anyway&#44; this not so much an economic problem than one of health care quality&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Acknowledgement</span></p><p class="elsevierStylePara">We would like to thank Laboratorio Leti for its generosity in providing the Genzyme OSOM StrepA strips free of charge&#44; whenever we needed them for the smooth running of this study&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">What Is Known About the Subject</span><br></br>  &#8226; <span class="elsevierStyleBold"><span class="elsevierStyleSup"> Beta-haemolytic</span></span><span class="elsevierStyleItalic"><span class="elsevierStyleBold"><span class="elsevierStyleSup">Streptococcus</span></span></span><span class="elsevierStyleBold">is the cause of 15&#37;-25&#37; of acute pharyngotonsillitis in adults and its incidence increases the more Centor criteria the patient has&#58; tonsillar&#47;pharyngeal exudate&#44; history or presence of fever&#44; absence of cough&#44; and&#47;or presence of painful lateral-cervical lymph nodes&#46;<br></br></span>&#8226; <span class="elsevierStyleBold">The use of clinical criteria to diagnose streptococcal pharyngitis is of no use&#46; Even in patients with all the Centor criteria the incidence of streptococcal pharyngitis is less than 50&#37;&#46;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold">What This Study Contributes<br></br></span>&#8226;<span class="elsevierStyleBold"><span class="elsevierStyleBold"></span></span><span class="elsevierStyleBold"><span class="elsevierStyleBold">The rapid antigen technique is an ideal method for diagnosing pharyngitis due to</span></span><span class="elsevierStyleBold"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">S pyogenes</span></span></span><span class="elsevierStyleBold"><span class="elsevierStyleBold">in the community&#44; since its determination is easy and rapid&#44; and has a sensitivity and specificity of over 90&#37;&#46;<br></br></span></span>&#8226;<span class="elsevierStyleBold"><span class="elsevierStyleBold"></span></span><span class="elsevierStyleBold"><span class="elsevierStyleBold">The high negative predictive value of the rapid antigen technique &#40;with a negative result aetiology due to GABHS is ruled out&#41; means there is no need to carry out a subsequent culture&#46;<br></br></span></span>&#8226;<span class="elsevierStyleBold"><span class="elsevierStyleBold"></span></span><span class="elsevierStyleBold"><span class="elsevierStyleBold">The use of these rapid antigen techniques should be taken considered&#44; particularly in patients with more than 2 Centor criteria&#46;<br></br></span></span>&#8226;<span class="elsevierStyleBold"><span class="elsevierStyleBold"></span></span><span class="elsevierStyleBold"><span class="elsevierStyleBold">The incidence of pharyngitis caused by Group C beta-haemolytic</span></span><span class="elsevierStyleBold"><span class="elsevierStyleItalic"><span class="elsevierStyleBold"> Streptococcus</span></span></span><span class="elsevierStyleBold"><span class="elsevierStyleBold">&#44; around 15&#37; in our population&#44; opens an interesting line of investigation&#44; since there is currently no clear consensus on its treatment&#46;</span></span></p><p class="elsevierStylePara">Spanish version available <span class="elsevierStyleBold"><span class="elsevierStyleBold"><a href="http&#58;&#47;&#47;www&#46;elsevier&#46;es&#47;270&#46;210" class="elsevierStyleCrossRefs">www&#46;elsevier&#46;es&#47;270&#46;210</a><br></br></span></span> A commentary follow this article &#40;page&#46; 495&#41;</p><hr></hr><p class="elsevierStylePara"> Correspondence&#58; C&#46; Llor&#46; Foixarda&#44; 95&#46; 43008 Tarragona&#46; Espa&#241;a&#46;<br></br> E-mail&#58; <a href="mailto&#58;carles&#46;llor&#64;urv&#46;cat" class="elsevierStyleCrossRefs"> carles&#46;llor&#64;urv&#46;cat</a></p><p class="elsevierStylePara">Manuscript received March 26&#44; 2008&#46;<br></br> Accepted for publication April 28&#44; 2008&#46;</p>"
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        "resumen" => "Objective&#46; To determine the validity of the rapid antigen test &#40;RAT&#41; OSOM StrepA Genzyme for the diagnosis of acute pharyngitis caused by group A beta-haemolytic strep &#40;GABHS&#41;&#46; Design&#46; Diagnostic techniques survey&#46; Setting&#46; Urban primary care centre&#44; Spain&#46; Participants&#46; All patients over 14 years old seen in 6 surgeries with sore throat and 2 or more Centor criteria&#58; pharyngotonsillar exudate&#44; tender laterocervical nodes&#44; absence of coughing&#44; and&#47;or history or presence of fever&#46; Principal measurements&#46; Pharyngeal swabs were taken from all the patients&#44; one for RAT and another to send for culture in the microbiology department&#46; Results&#46; A total of 182 patients were evaluable&#44; with a mean age of 30&#46;6 &#40;12&#46;1&#41; years of which 116 were women &#40;63&#46;7&#37;&#41;&#59; 63 patients had 2 Centor criteria&#59; 83 had 3 and 36&#44; the 4 criteria&#46; The culture was positive in 102 patients &#40;56&#37;&#41;&#44; with GABHS showing infection in forty &#40;22&#37;&#59; 95&#37; confidence interval &#91;CI&#93;&#44; 21&#46;2-22&#46;8&#41;&#46; Group C Streptococcus was isolated in 26 patients &#40;14&#46;3&#37;&#41;&#46; GABHS was higher among patients with four Centor criteria &#40;38&#46;9&#37; vs 25&#46;3&#37; observed among those with 3 criteria and 7&#46;9&#37; with 2 criteria&#59; P&#60;&#46;001&#41;&#46; Sensitivity of RAT was 95&#37;&#44; with a specificity of 93&#37;&#44; a positive predictive value of 79&#46;2&#37; and a negative predictive value of 98&#46;5&#37;&#46; Conclusions&#46; These results show the usefulness of RAT for diagnosing streptococcal pharyngitis&#46; Its use should be spread to all primary care practices&#46;"
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        "resumen" => "Objetivo&#46; Determinamos la validez de la t&#233;cnica antig&#233;nica r&#225;pida &#40;TAR&#41; OSOM StrepA Genzyme en el diagn&#243;stico de la faringitis aguda causada por estreptococo betahemol&#237;tico del grupo A &#40;EBHGA&#41;&#46; Dise&#241;o&#46; Estudio de pruebas diagn&#243;sticas&#46; Emplazamiento&#46; Equipo urbano de atenci&#243;n primaria&#46; Participantes&#46; Todos los pacientes mayores de 14 a&#241;os atendidos en 6 consultas con s&#237;ntomas de odinofagia y 2 o m&#225;s de los criterios de Centor &#40;exudado faringoamigdalar&#44; adenopat&#237;as laterocervicales dolorosas&#44; ausencia de tos y&#47;o historia o presencia de fiebre&#41;&#46; Mediciones principales&#46; A todos los pacientes se les tom&#243; una muestra faringoamigdalar con 2 hisopos&#44; uno para TAR y otro que fue remitido al servicio de microbiolog&#237;a para realizar cultivo&#46; Resultados&#46; Fueron evaluables 182 sujetos&#44; con una edad media de 30&#44;6 &#177; 12&#44;1 a&#241;os&#44; 116 mujeres &#40;63&#44;7&#37;&#41;&#46; Presentaron 2&#44; 3 y 4 criterios de Centor 63&#44; 83 y 36 sujetos&#44; respectivamente&#46; El cultivo fue positivo en 102 casos &#40;56&#37;&#41;&#44; observ&#225;ndose infecci&#243;n por EBHGA en 40 pacientes &#40;22&#37;&#59; intervalo de confianza &#91;IC&#93; del 95&#37;&#44; 21&#44;2-22&#44;8&#41;&#59; en 26 casos se aisl&#243; estreptococo del grupo C &#40;14&#44;3&#37;&#41;&#46; La infecci&#243;n por EBHGA present&#243; una mayor prevalencia entre los pacientes con 4 criterios &#40;un 38&#44;9&#37; frente a un 25&#44;3&#37; observado con 3 criterios y frente al 7&#44;9&#37; con 2 criterios&#59; p &#60; 0&#44;001&#41;&#46; La TAR tuvo una sensibilidad del 95&#37;&#44; una especificidad del 93&#37;&#44; un valor predictivo positivo del 79&#44;2&#37; y un valor predictivo negativo del 98&#44;5&#37;&#46; Conclusiones&#46; Estos resultados demuestran la utilidad de la TAR para el diagn&#243;stico de la faringitis estreptoc&#243;cica&#46; Su uso deber&#237;a extenderse a todas las consultas de atenci&#243;n primaria&#46;"
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos