Diabetes in older people: Prevalence, incidence and its association with medium- and long-term mortality from all causes

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"entidad" => "IdiPAZ, Instituto de Investigación Hospital La Paz, Madrid, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Diabetes en personas mayores: prevalencia, incidencia y su asociación con la mortalidad general a medio y largo plazo" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1170 "Ancho" => 2500 "Tamanyo" => 198121 ] ] "descripcion" => array:1 [ "en" => "Medium- and long-term survival of diabetic patients and non-diabetic patients adjusted for age and sex, heart disease and comorbidity." ] ] ] "textoCompleto" => "IntroductionOver the past 20 years, there has been an explosive increase in the number of cases of diabetes mellitus in both developed and developing countries.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> The International Diabetes Federation (IDF) has recently estimated that in 2030, 9.9% of the adult population worldwide will have diabetes (552 million).<a class="elsevierStyleCrossRef" href="#bib0010">2</a> Diabetes mellitus prevalence rates are rising. The prevalence of diagnosed diabetes among US adults aged 18 years and over increased from 5.1% in 1997 to 9.2% in 2010,<a class="elsevierStyleCrossRef" href="#bib0015">3</a> and the number of individuals in the US with a new diagnosis of diabetes is expected to increase in the next decades, with the fastest increase occurring in older and minority subpopulations.<a class="elsevierStyleCrossRef" href="#bib0020">4</a> In Europe, the prevalence of diabetes varies among studies.<a class="elsevierStyleCrossRef" href="#bib0025">5</a> The reasons for this are multiple, and include the different methodologies used.<a class="elsevierStyleCrossRef" href="#bib0030">6</a> The prevalence of diabetes in the adult population of Spain (aged 18 years and over) ranges from 6% to 12% based on self-reported data,<a class="elsevierStyleCrossRef" href="#bib0035">7</a> and from 20% to 25% with measured data.<a class="elsevierStyleCrossRef" href="#bib0040">8</a>Not only the prevalence of diabetes, but also its incidence is rising at an alarming rate. This increase is likely to have a significant public health impact given the high rates of acute myocardial infarction, heart failure, stroke, and death that follow diabetes,<a class="elsevierStyleCrossRef" href="#bib0005">1</a> and implies a substantial burden on both the individual and the healthcare system.<a class="elsevierStyleCrossRef" href="#bib0045">9</a> Yet little research has been conducted on diabetes in elderly populations. In addition, because diabetes is a silent disease, with no sudden or exact date of onset, it is difficult to design studies of disease incidence.<a class="elsevierStyleCrossRef" href="#bib0050">10</a>Lastly, mortality is known to be higher in people with diabetes than in those without it,<a class="elsevierStyleCrossRef" href="#bib0055">11</a> and diabetes accounts for considerable morbidity and mortality in the elderly population.<a class="elsevierStyleCrossRefs" href="#bib0045">9,12</a> However, again, little information is available about how diabetes affects mortality when the diagnosis is made at an older age.<a class="elsevierStyleCrossRef" href="#bib0065">13</a>The longitudinal study “Aging in Leganés”<a class="elsevierStyleCrossRef" href="#bib0070">14</a> offers an opportunity to examine in greater depth the magnitude of diabetes and its association with all-cause mortality in a European Mediterranean population of people aged 65 years and over, an age group for which few data are available. Thus, the aims of this study are to estimate (1) the prevalence and incidence of diabetes and (2) the association between diabetes and medium- and long-term mortality in a population-based cohort of people aged 65 years or older in Spain.MethodsStudy subjectsThis study used data from the population-based longitudinal study “Aging in Leganés” which began in 1993. The methodological characteristics of this study have been described elsewhere.<a class="elsevierStyleCrossRefs" href="#bib0070">14,15</a> In brief, Leganés is a city located in a metropolitan area 8km from Madrid (Spain). The census population in 1991 was 171,400 inhabitants, of whom 13,679 (8%) were over 64 years of age. “Aging in Leganés” was launched in 1993, starting with a gender- and age-stratified random sample obtained from the Leganés census of the population aged 65 years and over. In the baseline cohort 1283 persons completed the study.Data were collected using a standardized questionnaire (a face-to-face home interview) that included sociodemographic variables, health status and history of chronic diseases.<a class="elsevierStyleCrossRefs" href="#bib0070">14,15</a>The present study uses data from the 1993 baseline, as well as the 1995, 1997 and 1999 waves to know the prevalence and incidence of diabetes and the sociodemographic and clinical variables selected for this study. Mortality at 31/12/2011 was obtained from National Death Index.All individuals with available diabetes data were included in the analysis (1277 at baseline, 939 in 1995, 743 in 1997 and 519 in 1999) (see Flow chart for the study).The local ethics committee approved the protocol for the Leganés study, and all participants signed an informed consent form.Variables and proceduresHistory of diabetes was collected by self-reporting using two questions to the participants at baseline and in follow-up waves: “Do you have diabetes?” and “Did you have ever seen a physician in the last year for this problem?” People who answered “yes” to both the questions were considered to have diabetes and were asked to state the year when they became aware of their condition. Diabetes history was measured in years of diabetes at the time of incorporation of the individual in the baseline cohort (1993) and classified in three categories: no diabetes, less than 10 years of diabetes and 10 or more years of diabetes.Mortality data were obtained from the National Death Index (NDI), a computerized database with information on the vital status of all residents in Spain. To compensate for the delay in updating mortality in the NDI, data were collected until June 2012. The cut-off date for the mortality analysis was 31/12/1999 (n=330; 25.8%) for medium-term mortality (6 years) and 31/12/2011 (n=994; 77.8%) for long-term mortality (18 years).Age (years), sex, body mass index, heart disease, comorbidity, self-rated health and years of diabetes, obtained from the 1993 baseline Leganés questionnaire, were used as co-variables in the analysis.Body Mass Index (BMI) in kg/m2 based on measures of weight and height.Self-rated health (response to the question: “How would you describe your health at present?”: fair, poor or very poor versus good or very good).Heart disease includes angina, myocardial infarction and/or heart failure.Comorbidity was defined as having 4 or more chronic conditions of a list of 9 (heart disease, stroke, peripheral vascular disease (PVD), chronic respiratory disease (CRD), joint or bone pain, cancer, Parkinson's, genital or urinary pathology and gastrointestinal pathology). Chronic conditions were assessed by self-report of having been diagnosed by a medical doctor.Statistical analysisDue to the sampling design, prevalence and incidence figures are weighted using the age and sex distribution of the Leganés population in 1995. The data were weighted by assigning a specific weight (W) to each individual in the sample, calculated as W=N1/N:n1/n where N is the total population in Leganés, and n is the number of people in the cohort; N1 and n1 are the respective numbers in each age and sex group.Fort the study of continuous variables, the goodness of fit to the normal distribution was analyzed using the Kolmogorov–Smirnov test; all cases fit the Gaussian curve, therefore the continuous variables were expressed as means±standard deviation, and categorical variables as absolute and relative frequencies (n and %). A bivariate analysis was made for sex with distribution of variables in the baseline using χ2 test. The prevalence of diabetes was calculated by age group (65–74 and ≥75 years) and sex for each of the four waves (1993, 1995, 1997 and 1999). To study the change in the prevalence of diabetes over time, the χ2 tendency test was used.For the calculation of incidence, all non-diabetic individuals in the previous waves were used: 978 persons in 1995, 783 in 1997, and 566 in 1999. The incidence density (incident cases/person-time periods) was calculated for biannual periods and expressed as the number of cases of diabetes per 100 persons by 2-year time periods. In total, 1965 persons/time periods were used.Mortality analyses were conducted with the Kaplan–Meier analysis and adjusted by the Cox regressions. To evaluate the association between diabetes and general mortality, Cox regression was used at two moments: 31/12/1999 (6 years of follow-up) and 31/12/2011 (18 years of follow-up). Median survival was calculated, and the main results were summarized with hazard ratios (HRs) and their 95% CIs. Person follow-up time was calculated from the time people were incorporated into the study in 1993. Individuals were censored if they died or dropped out of the study.Diabetes, as a principal variable, was used as a dummy variable (fictitious variable): (0) no diabetes, (1) less than 10 years of diabetes at baseline (1993), and (2) 10 or more years of diabetes at baseline (1993). Four multivariate Cox models were built: (1) crude diabetes data, (2) diabetes adjusted for age and sex, (3) additionally adjusted for heart disease and (4) additionally adjusted for comorbidity. Results with p less than 0.05 were considered statistically significant. SPSS version 19.0 and Epidat 3.1 were used for the analysis.<elsevierMultimedia ident="fig0005"></elsevierMultimedia>ResultsCharacteristics of the study subjectsOf the 1283 participating individuals in the baseline cohort (1993), diabetes self-reported data were available in 1277 individuals who participated in this wave, of which 50.4% were men and 49.6% were women. The flow chart for the study shows the number of participants in each of the waves, as well as the number of those who died or were lost to follow-up in each wave. The distribution of the variables studied in the baseline cohort is presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. Women had a higher body mass index than men, as well as poorer self-rated health, a higher frequency and longer history of diabetes, and more comorbidity (p≤0.001).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Prevalence of diabetesThe prevalence of diabetes in the study population (weighted data) increased progressively over time, from 10.3% (95% CI: 8.6–11.9) in 1993 to 16.1% in 1999 (95% CI: 13.2–18.9), p≤0.001. In the 1993 and 1995 waves, women had a significantly higher prevalence than men (p≤0.05) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>The mean duration of diabetes in the 142 participants who had the disease at study baseline (1993) was 7.8 years (SD±6.8; range 0–30 years).Incidence of diabetesThe total biannual incidence density of diabetes was 2.6 (95% CI: 1.9–3.3) cases per 100 persons at 2 years of follow-up, 2.8 (95% CI: 1.7–3.8) in men and 2.5 (95% CI: 1.6–3.4) in women. In general, the incidence density of diabetes decreased with increasing age, although this difference was not statistically significant. Differences between sexes were not statistically significant (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>Mortality associated with diabetesOur data show that survival time for older persons with 10 or more years history of diabetes is 2.7 years less than for non-diabetic individuals. The Kaplan–Meier medians in the medium-term models did not reach statistical significance. Median survival in the long term was 10.8 years (95% CI: 10.1–11.5) for non-diabetic persons; 9.0 (95% CI: 6.8–11.1) for persons with less than 10 years’ history of diabetes from baseline (1993); and 8.1 years (95% CI: 5.5–10.6) for those with 10 or more years’ history of diabetes from baseline (1993).As can be seen in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>, the hazard ratio for medium- and long-term mortality in persons with 10 or more years’ history of diabetes was 2.0 (95% CI: 1.2–3.3) and 1.7 (95% CI: 1.1–2.5), respectively, after adjusting for age and sex, heart disease and comorbidity. Accordingly, it can be said that medium-term mortality is twice as high in persons with 10 or more years’ history of diabetes at baseline than in non-diabetic individuals, and is 70% higher in the long term.<elsevierMultimedia ident="tbl0020"></elsevierMultimedia>The hazard ratio for medium- and long-term mortality in diabetic individuals with less than 10 years’ history of diabetes at baseline was 1.3 (95% CI: 0.9–1.9) and 1.5 (95% CI: 1.2–1.9), respectively. Thus, it can be said that in the medium term (6 years), those with less than 10 years’ history at baseline do not have higher mortality than non-diabetic persons, whereas their long-term mortality is almost 50% higher (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 1</a>).<elsevierMultimedia ident="fig0010"></elsevierMultimedia>DiscussionAlthough increasing age is a risk factor for the development of diabetes and its vascular complications, few studies have focused specifically on the impact of diabetes in elderly populations.<a class="elsevierStyleCrossRefs" href="#bib0045">9,12,16</a> In our study, the prevalence of diabetes in individuals aged 65 years and over increased from 10.3% in 1993 to 16.1% in 1999. These data are consistent with other population studies: a Canadian study found that diabetes increased from 10.6% to 17.1% after 10 years of follow-up in a population over age 50,<a class="elsevierStyleCrossRef" href="#bib0085">17</a> while a US study reported that the prevalence of diabetes increased from 12.5% to 17.7% in individuals aged 65 and over during 18 years of follow-up.<a class="elsevierStyleCrossRef" href="#bib0090">18</a>In the DECODE study (Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe),<a class="elsevierStyleCrossRef" href="#bib0095">19</a> which measured plasma glucose in 13 European cohorts, in accordance with WHO recommendations for the diagnosis of diabetes, the prevalence of diabetes was 10–20% in individuals aged 60–79 years. In a recent study,<a class="elsevierStyleCrossRef" href="#bib0100">20</a> conducted in subjects aged >60 years in Spain and with characteristics similar to ours, the overall prevalence of diabetes was 16.8%, slightly higher than ours (13.1%). This variation may be related to the methodology used to collect the information as well as the variability of results when they are self-reported by the patient. In a study in people older than 65 years in the United States using data from Medicare, the prevalence increased from 15.3% at baseline to 24.8% after 9 years of follow-up.<a class="elsevierStyleCrossRef" href="#bib0060">12</a>In general, the prevalence of diabetes in the same age groups was much higher in 1999 than in the previous waves. Also in accordance with other studies<a class="elsevierStyleCrossRefs" href="#bib0085">17,21</a> we found that most cases of diabetes occurred in the oldest individuals. One possible explanation for this could be a progressively greater awareness of diabetes on the part of both patients and medical professionals. Although most studies in the general population have found a higher prevalence of diabetes in men,<a class="elsevierStyleCrossRefs" href="#bib0030">6,20,22</a> some have found that the prevalence in people over age 65 is higher in women.<a class="elsevierStyleCrossRef" href="#bib0115">23</a> The DECODE study has reported diabetes prevalence rates of 8.5% in men and 9.3% in women between the ages of 60 and 69 years, increasing to 12.4% in men and 15.4% in women between age 70 and 79 years, and to 12.9% in men and 22.4% in women between age 80 and 89.<a class="elsevierStyleCrossRef" href="#bib0095">19</a> Our results are consistent with the aforementioned studies. The prevalence in 1993 was 7.6% in men and 12.3% in women, rising to 9.2% and 13.6% respectively, in 1995. The differences by sex found in 1997 and 1999 are not statistically significant.Incidence of diabetesBecause diabetes has a silent course, without a sudden or exact date of onset, it is difficult to design studies of disease incidence.<a class="elsevierStyleCrossRef" href="#bib0050">10</a>In Spain, the few studies that have estimated the incidence of diabetes are not consistent because they did not follow a standardized methodology.<a class="elsevierStyleCrossRef" href="#bib0120">24</a> Moreover, most previous studies in Spain have provided diabetes incidence data in people under age 65 years, and therefore are not comparable with our data.<a class="elsevierStyleCrossRefs" href="#bib0050">10,25</a> A recent study in Spain in persons aged 18–65 years<a class="elsevierStyleCrossRef" href="#bib0125">25</a> found an annual diabetes incidence of 19.1 cases per 1000 person-years, slightly higher than that in our study. However, the annual incidence of diabetes in European studies conducted in the general population varies between 1.2 and 4.1 cases/1000 people,<a class="elsevierStyleCrossRefs" href="#bib0130">26,27</a> which is lower than the figures published for the Spanish population.Our results for diabetes incidence in persons aged 65 years and over show an incidence rate equivalent to 13.1 cases per 1000 person-years (2.6 cases per 100 persons-2 years of follow-up), which is between the 24 per 1000 person-years reported in a study made in US elderly<a class="elsevierStyleCrossRef" href="#bib0060">12</a> and 9.4 cases per 1000 person-years for the population 65 years and over in Spain.<a class="elsevierStyleCrossRef" href="#bib0140">28</a> In these two studies the incidence rates increased with increasing age. In our study the incidence is higher in the 65–74 years age group [3.2 (95% CI: 2.3–4.2)] than in those aged 75 years and over [1.7 (95% CI: 0.8–2.6)].Mortality associated with diabetesDiabetes has been associated with an average 10 years of life lost for individuals diagnosed during middle age.<a class="elsevierStyleCrossRef" href="#bib0145">29</a> Individuals with diabetes have an excess mortality compared with people without diabetes.<a class="elsevierStyleCrossRef" href="#bib0055">11</a> However, it is not clear how diabetes affects mortality when the diagnosis is made at an older age.<a class="elsevierStyleCrossRef" href="#bib0065">13</a> Our data show that the survival time for people in the older population with 10 or more years history of diabetes is 2.7 years less than that for non-diabetic individuals.Mortality in the medium term for persons with 10 or more years history of diabetes is almost double that of people without diabetes, while long-term mortality is almost 70% higher. Those with less than 10 years history of diabetes at baseline do not have higher mortality than non-diabetic individuals in the medium term, but long-term mortality is almost 50% higher. In a systematic review of observational studies<a class="elsevierStyleCrossRef" href="#bib0055">11</a> reporting mortality in patients over age 60 diagnosed with type 2 diabetes, those with diabetes were found to have 40% higher mortality than non-diabetic persons, which is lower than found in our study.Thus, our results show a clear association between diabetes and increased all-cause mortality, although this effect is statistically significant only in patients who have had diabetes for at least 10 years.Strengths and limitationsThe main strength of our study is the long follow-up time (18 years). Added to this is the fact that, to date, few studies of diabetes incidence and mortality have been made in Mediterranean populations.One of the limitations of this study is that we used self-reported data to assess diabetes. Several authors point out that self-reported data could underestimate diabetes prevalence.<a class="elsevierStyleCrossRefs" href="#bib0050">10,12,20</a> Although this underestimation is possible, other authors have confirmed that self-reported diabetes is a reasonably reliable surrogate for diagnosed diabetes, based on their studies of the accuracy of patients’ self-reports compared with medical records.<a class="elsevierStyleCrossRefs" href="#bib0150">30,31</a>In health care systems where general practitioners have a complete vision of their patients’ medical status and in which patients have easy and frequent access to medical services, patients are more likely to be well informed about their diseases, especially in the case of chronic diseases like diabetes. This is the case in Spain,<a class="elsevierStyleCrossRef" href="#bib0160">32</a> where every community-dwelling person is registered in the patient list of a general practice, and access to other health care facilities, including outpatient clinics, is only possible through referral by a general practitioner.Furthermore, in our study, individuals were classified as having diabetes not only based on their awareness of their condition, but also because they had seen a physician in the last year for this problem. The second question on medical consultations in the last year increases the validity of the self-report. In 1993 people in our sample averaged 8.3 consultations with general practitioners, similar to the current rate of general practitioner consultations in Spain.<a class="elsevierStyleCrossRef" href="#bib0165">33</a>Our sample was drawn from a metropolitan area of Madrid, therefore this study may not be comparable to other non-Mediterranean population studies and cannot strictly be generalized to the whole older Spanish population.Together with Sherwin R and Jastreboff AM,<a class="elsevierStyleCrossRef" href="#bib0170">34</a> we can say that “today's message is that a diabetes tsunami is imminent, and the only way to minimize the damage is to create an early warning system and improve interventions to protect those in its path”. Effective public health interventions to prevent diabetes are needed, together with the resources required to manage the increasingly large number of people who are living longer with this debilitating disease.<a class="elsevierStyleCrossRef" href="#bib0085">17</a> In accordance with Rose, we think that the “population strategy” with regard to prevention should always be the discovery and control of the causes of the incidence of chronic diseases.<a class="elsevierStyleCrossRef" href="#bib0175">35</a> In the case of diabetes, important factors for prevention could be reducing obesity, increasing physical activity and maintaining a Mediterranean diet.<elsevierMultimedia ident="tb0005"></elsevierMultimedia>Funding sourcesThis work was supported by the Fondo de Investigaciones en Salud, FIS PI 05 1898, RETICEF RD06/0013/1013 and RD/12/0043/0019.Conflict of interestThe authors declare no conflicts of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:2 [ "identificador" => "xres360554" "titulo" => array:8 [ 0 => "Abstract" 1 => "Objective" 2 => "Design" 3 => "Setting" 4 => "Participants" 5 => "Methods" 6 => "Results" 7 => "Conclusions" ] ] 1 => array:2 [ "identificador" => "xpalclavsec340416" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres360553" "titulo" => array:8 [ 0 => "Resumen" 1 => "Objetivos" 2 => "Diseño" 3 => "Emplazamiento" 4 => "Participantes" 5 => "Mediciones principales" 6 => "Resultados" 7 => "Conclusiones" ] ] 3 => array:2 [ "identificador" => "xpalclavsec340417" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Study subjects" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Variables and procedures" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Statistical analysis" ] ] ] 6 => array:3 [ "identificador" => "sec0030" "titulo" => "Results" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Characteristics of the study subjects" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Prevalence of diabetes" ] 2 => array:2 [ "identificador" => "sec0045" "titulo" => "Incidence of diabetes" ] 3 => array:2 [ "identificador" => "sec0050" "titulo" => "Mortality associated with diabetes" ] ] ] 7 => array:3 [ "identificador" => "sec0055" "titulo" => "Discussion" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0060" "titulo" => "Incidence of diabetes" ] 1 => array:2 [ "identificador" => "sec0065" "titulo" => "Mortality associated with diabetes" ] 2 => array:2 [ "identificador" => "sec0070" "titulo" => "Strengths and limitations" ] ] ] 8 => array:2 [ "identificador" => "sec0085" "titulo" => "Funding sources" ] 9 => array:2 [ "identificador" => "sec0090" "titulo" => "Conflict of interest" ] 10 => array:2 [ "identificador" => "xack89020" "titulo" => "Acknowledgements" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2013-10-08" "fechaAceptado" => "2013-12-23" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec340416" "palabras" => array:6 [ 0 => "Diabetes" 1 => "Elderly" 2 => "Prevalence" 3 => "Incidence" 4 => "Mortality" 5 => "Cohort studies" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec340417" "palabras" => array:6 [ 0 => "Diabetes" 1 => "Mayores" 2 => "Prevalencia" 3 => "Incidencia" 4 => "Mortalidad" 5 => "Estudios de cohortes" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "ObjectiveTo estimate the prevalence and incidence of self-reported diabetes and to study its association with medium- and long-term mortality from all causes in persons ≥65 years. DesignA population-based cohort study begun in 1993. Setting“Envejecer en Leganés” cohort (Madrid). ParticipantsA random sample of persons ≥65 years (n=1277 in the 1993 baseline sample). MethodsParticipants were classified as having diabetes if they so reported and had consulted a physician for this reason within the last year. Diabetes history was categorized in <10 and ≥10 years in 1993. Incidence density was calculated in 2-year periods in non-diabetic individuals (1965 persons/2 years). Vital status was recorded on 31 December 2011. The association between diabetes history ≥10 years and mortality at 6 and 18 years follow-up was studied by the Kaplan–Meier and Cox regression analyses after adjusting for age, sex, heart disease and comorbidity. ResultsThe prevalence of self-reported diabetes rose from 10.3% in 1993 to 16.1% in 1999 (p≤0.001) and was higher in women than men (p≤0.05). Total incidence density was 2.6 cases/100 persons/2 years (95% CI: 2.0–3.3). Medium- and long-term mortality was higher in persons with diabetes history ≥10 years than in non-diabetic individuals (HR: 2.0; 95% CI: 1.2–3.3 and HR: 1.7; 95% CI: 1.1–2.5, respectively). In diabetics with history <10 years the HR was 1.3 (95% CI: 0.9–1.9) and HR: 1.5 (95% CI: 1.2–1.9, respectively). ConclusionsAlthough diabetes is clearly associated with increased risk of mortality, it is significant only for patients with ≥10 years’ history of diabetes." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "ObjetivosCalcular la prevalencia y la incidencia de diabetes autorreferida y analizar su asociación con la mortalidad general a medio y a largo plazo en personas ≥65años. DiseñoEstudio de cohortes de base poblacional iniciado en 1993. EmplazamientoCohorte «Envejecer en Leganés» (Madrid). ParticipantesMuestra aleatoria de los ≥65años (n=1.277 en 1993). Mediciones principalesDiabético: autorreferido y haber visitado al médico por este motivo el último año. Antigüedad de diabetes: más y menos de 10años en 1993. Prevalencia en 1993, 1995, 1997 y 1999. Densidad de incidencia calculada para periodos bianuales (1.965personas/2años). Estado vital registrado a 31 de diciembre de 2011. La asociación entre diabetes y mortalidad a 6 y 18años se estudió mediante Kaplan-Meier y regresión de Cox, ajustando por edad, sexo, enfermedades del corazón y comorbilidad. ResultadosLa prevalencia de diabetes autorreferida aumentó desde el 10,3% (1993) hasta el 16,1% (1999) (p≤0,001), siendo superior en mujeres (p≤0,05). La incidencia de diabetes fue de 2,66casos por 100personas/2años (IC 95%: 1,9-3,3). La mortalidad a medio y a largo plazo fue mayor en diabéticos con ≥10años que en no diabéticos (HR: 2,0; IC 95%: 1,2-3,3, y HR: 1,7; IC 95%: 1,1-2,5, respectivamente). En diabéticos <10años el HR para mortalidad fue 1,3 (IC 95%: 0,9-1,9) y 1,5 (IC 95%: 1,2-1,9), respectivamente. ConclusionesAunque padecer diabetes se asocia a un aumento de la mortalidad, esta asociación es significativa solo para los pacientes con historia de diabetes igual o superior a 10años." ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "Both, the first (MSM) and second (AB) authors, have contributed equally to the paper." "identificador" => "fn1" ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1170 "Ancho" => 2500 "Tamanyo" => 198121 ] ] "descripcion" => array:1 [ "en" => "Medium- and long-term survival of diabetic patients and non-diabetic patients adjusted for age and sex, heart disease and comorbidity." ] ] 1 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Variables \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Men (n=644) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Women (n=633) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Total (n=1277) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age [mean (SD)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">75.6 (8.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">75.9 (8.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">75.8 (8.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Body mass index (BMI) [mean (SD)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.3 (3.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28.0 (4.8)<a class="elsevierStyleCrossRef" href="#tblfn0010">***</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27.1 (4.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Self-rated health fair, poor or very poor [n (%)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">357 (55.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">432 (68.2)<a class="elsevierStyleCrossRef" href="#tblfn0010">***</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">789 (61.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diabetic patients [n (%)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47 (7.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">75 (11.8)<a class="elsevierStyleCrossRef" href="#tblfn0005">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">122 (9.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patients with 10 or more years history of diabetes [n (%)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (0.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28 (4.4)<a class="elsevierStyleCrossRef" href="#tblfn0010">***</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33 (2.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Heart disease [n (%)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">163 (25.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">139 (22.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">302 (23.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Comorbidity (≥4 diseases) [n (%)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">285 (44.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">388 (61.3)<a class="elsevierStyleCrossRef" href="#tblfn0010">***</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">673 (52.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab538908.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "**" "nota" => "p≤0.05." ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "***" "nota" => "p≤0.001." ] ] ] "descripcion" => array:1 [ "en" => "Distribution of variables in the baseline Leganés cohort (1993)." ] ] 2 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1993 (n=1277) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1995 (n=939) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1997 (n=743) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1999 (n=519) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tendency-p \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">% [95% CI] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">% [95% CI] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">% [95% CI] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">% [95% CI] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.3 [8.6–11.9] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.7 [9.7–13.6] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14.5 [12.1–16.9] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.1 [13.2–18.9] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≤0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Men \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.6 [5.4–9.8] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.2 [6.4–11.9] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.5 [9.1–15.9] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.6 [11.2–19.9] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≤0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.3<a class="elsevierStyleCrossRef" href="#tblfn0020">**</a> [9.9–14.6] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.6<a class="elsevierStyleCrossRef" href="#tblfn0020">**</a> [10.8–16.4] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.1 [12.7–19.4] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.4 [12.5–20.3] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≤0.005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65–74 (total) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.1 [8.0–12.2] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.6 [9.0–14.2] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14.0 [10.6–17.3] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.5 [10.9–20.0] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≤0.005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Men \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.1 [5.3–10.9] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.6 [6.1–13.2] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.4 [7.7–17.1] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.8 [9.2–22.4] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≤0.05 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.8<a class="elsevierStyleCrossRef" href="#tblfn0025">*</a> [8.7–14.8] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.4 [9.5–17.2] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.5 [10.4–20.5] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.2 [8.7–21.6] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.148 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥75 (total) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.6 [7.9–13.2] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.2 [9.1–15.3] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14.8 [11.5–18.2] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.7 [12.9–20.5] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≤0.005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Men \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.5 [2.8–10.2] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.9 [4.5–13.4] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.7 [7.6–17.8] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.5 [9.5–21.5] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≤0.002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.9 [9.2–16.7] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14.2<a class="elsevierStyleCrossRef" href="#tblfn0025">*</a> [10.0–18.4] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.2 [11.7–20.8] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.5 [12.5–22.5] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.126 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab538909.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "a" "nota" => "Weighted data." ] 1 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "**" "nota" => "p≤0.05." ] 2 => array:3 [ "identificador" => "tblfn0025" "etiqueta" => "*" "nota" => "p≤0.10." ] ] ] "descripcion" => array:1 [ "en" => "Age-specific prevalence of diagnosed diabetes by sex from 1993 to 1999.<a class="elsevierStyleCrossRef" href="#tblfn0015">a</a>" ] ] 3 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Percentage \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">95% confidence interval \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.0–3.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Men \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.7–3.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.6–3.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (groups), years</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65–74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.3–4.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Men \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.9–4.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.8–4.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8–2.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Men \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2–3.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5–2.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab538907.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0030" "etiqueta" => "a" "nota" => "Weighted data." ] ] ] "descripcion" => array:1 [ "en" => "Age-specific biannual incidence of diagnosed diabetes by sex (per 100 population) from 1993 to 1999.<a class="elsevierStyleCrossRef" href="#tblfn0030">a</a>" ] ] 4 => array:7 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Medium-term mortality (1993–1999)</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Long-term mortality (1993–2011)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">HR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">95% CI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">p-Value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">HR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">95% CI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">p-Value \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="7" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Crude data<a class="elsevierStyleCrossRef" href="#tblfn0035">a</a></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Less than 10 years of diabetes in 1993 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8–1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.394 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.1–1.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.007 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 or more years of diabetes in 1993 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0–2.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.051 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9–2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.096 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="7" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="7" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Adjusted for age and sex<a class="elsevierStyleCrossRef" href="#tblfn0035">a</a></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Less than 10 years of diabetes in 1993 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0–2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.056 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.3–2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 or more years of diabetes in 1993 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.3–3.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.2–2.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="7" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="7" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Additionally adjusted for heart disease<a class="elsevierStyleCrossRef" href="#tblfn0035">a</a></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Less than 10 years of diabetes in 1993 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9–1.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.095 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.2–2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 or more years of diabetes in 1993 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.2–3.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.2–2.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="7" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="7" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Additionally adjusted for comorbidity<a class="elsevierStyleCrossRef" href="#tblfn0035">a</a></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Less than 10 years of diabetes in 1993 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9–1.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.141 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.2–1.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 or more years of diabetes in 1993 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.2–3.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.009 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.1–2.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.009 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab538906.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0035" "etiqueta" => "a" "nota" => "The reference category in diabetes variable was NO DIABETES in baseline (1993)." ] ] ] "descripcion" => array:1 [ "en" => "Association of diabetes with all-cause mortality (Cox regression Hazard Model).<a class="elsevierStyleCrossRef" href="#tblfn0035">a</a>" ] ] 5 => array:6 [ "identificador" => "fig0005" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 3212 "Ancho" => 2500 "Tamanyo" => 329319 ] ] "descripcion" => array:1 [ "en" => "General outline of the study:" ] ] 6 => array:5 [ "identificador" => "tb0005" "tipo" => "MULTIMEDIATEXTO" "mostrarFloat" => false "mostrarDisplay" => true "texto" => array:1 [ "textoCompleto" => "What is known about the topic<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005">•Diabetes mellitus is a chronic disease with major impact on health, and its prevalence and incidence are increasing.</li><li class="elsevierStyleListItem" id="lsti0010">•Because diabetes is a silent disease, with no sudden or exact date of onset, it is difficult to design studies of disease incidence.</li><li class="elsevierStyleListItem" id="lsti0015">•It is known that mortality is higher in diabetics than in non-diabetics, and diabetes in the elderly is responsible for a significant morbidity and mortality.</li></ul>What brings the study<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020">•The article analyzes the prevalence of self-reported diabetes in Spain in a base population cohort of people over 65 years (Aging in Leganes cohort).The prevalence of diabetes increased progressively over time, from 10.3% in 1993 to 16.1% in 1999. Women had a significantly higher prevalence than men.</li><li class="elsevierStyleListItem" id="lsti0025">•The diabetes incidence in this population during the study period (1993–1999) was 13.1 cases per 1000 person-years (2.6 cases per 100 persons/2 years of follow-up). No differences were found between sexes neither between the age group 65–74 years and people over 75 years.</li><li class="elsevierStyleListItem" id="lsti0030">•Although diabetes is clearly associated with increased risk of mortality, it is significant only for patients with ≥10 years history of diabetes. Mortality for persons with 10 or more years of history of diabetes is almost 70% higher than people without diabetes.</li></ul>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:35 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ethnicity and sex affect diabetes incidence and outcomes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.A. Khan" 1 => "H. Wang" 2 => "S. Anand" 3 => "Y. Jin" 4 => "N.R. Campbell" 5 => "L. 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"vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/02126567/0000004600000007/v1_201408130147/S0212656714000080/v1_201408130147/en/main.assets" "Apartado" => array:4 [ "identificador" => "7267" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02126567/0000004600000007/v1_201408130147/S0212656714000080/v1_201408130147/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0212656714000080?idApp=UINPBA00004N"]

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Diabetes in older people: Prevalence, incidence and its association with medium- and long-term mortality from all causes

Diabetes en personas mayores: prevalencia, incidencia y su asociación con la mortalidad general a medio y largo plazo

Mercedes Sánchez Martíneza,f,1,

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mercedes.martinez@uam.es

Corresponding author.

, Augusto Blancoa,b,1, María Victoria Castella,c,f, Alicia Gutiérrez Misisa, Juan Ignacio González Montalvod,f, María Victoria Zunzuneguie, Ángel Oteroa,f

a Departamento de Medicina Preventiva y Salud Pública, Universidad Autónoma de Madrid, Madrid, Spain

b Centro de Salud Reina Victoria, Madrid, Spain

c Centro de Salud Dr. Castroviejo, Madrid, Spain

d Servicio de Geriatría, Hospital Universitario La Paz, Madrid, Spain

e Département de Médecine Sociale et Préventive, Université de Montréal, Québec, Canada

f IdiPAZ, Instituto de Investigación Hospital La Paz, Madrid, Spain

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with the fastest increase occurring in older and minority subpopulations&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In Europe&#44; the prevalence of diabetes varies among studies&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The reasons for this are multiple&#44; and include the different methodologies used&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> The prevalence of diabetes in the adult population of Spain &#40;aged 18 years and over&#41; ranges from 6&#37; to 12&#37; based on self-reported data&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and from 20&#37; to 25&#37; with measured data&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Not only the prevalence of diabetes&#44; but also its incidence is rising at an alarming rate&#46; This increase is likely to have a significant public health impact given the high rates of acute myocardial infarction&#44; heart failure&#44; stroke&#44; and death that follow diabetes&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and implies a substantial burden on both the individual and the healthcare system&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Yet little research has been conducted on diabetes in elderly populations&#46; In addition&#44; because diabetes is a silent disease&#44; with no sudden or exact date of onset&#44; it is difficult to design studies of disease incidence&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Lastly&#44; mortality is known to be higher in people with diabetes than in those without it&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> and diabetes accounts for considerable morbidity and mortality in the elderly population&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;12</span></a> However&#44; again&#44; little information is available about how diabetes affects mortality when the diagnosis is made at an older age&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The longitudinal study &#8220;Aging in Legan&#233;s&#8221;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> offers an opportunity to examine in greater depth the magnitude of diabetes and its association with all-cause mortality in a European Mediterranean population of people aged 65 years and over&#44; an age group for which few data are available&#46; Thus&#44; the aims of this study are to estimate &#40;1&#41; the prevalence and incidence of diabetes and &#40;2&#41; the association between diabetes and medium- and long-term mortality in a population-based cohort of people aged 65 years or older in Spain&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Study subjects</span><p id="par0025" class="elsevierStylePara elsevierViewall">This study used data from the population-based longitudinal study &#8220;Aging in Legan&#233;s&#8221; which began in 1993&#46; The methodological characteristics of this study have been described elsewhere&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a> In brief&#44; Legan&#233;s is a city located in a metropolitan area 8<span class="elsevierStyleHsp" style=""></span>km from Madrid &#40;Spain&#41;&#46; The census population in 1991 was 171&#44;400 inhabitants&#44; of whom 13&#44;679 &#40;8&#37;&#41; were over 64 years of age&#46; &#8220;Aging in Legan&#233;s&#8221; was launched in 1993&#44; starting with a gender- and age-stratified random sample obtained from the Legan&#233;s census of the population aged 65 years and over&#46; In the baseline cohort 1283 persons completed the study&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Data were collected using a standardized questionnaire &#40;a face-to-face home interview&#41; that included sociodemographic variables&#44; health status and history of chronic diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The present study uses data from the 1993 baseline&#44; as well as the 1995&#44; 1997 and 1999 waves to know the prevalence and incidence of diabetes and the sociodemographic and clinical variables selected for this study&#46; Mortality at 31&#47;12&#47;2011 was obtained from National Death Index&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">All individuals with available diabetes data were included in the analysis &#40;1277 at baseline&#44; 939 in 1995&#44; 743 in 1997 and 519 in 1999&#41; &#40;see Flow chart for the study&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The local ethics committee approved the protocol for the Legan&#233;s study&#44; and all participants signed an informed consent form&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Variables and procedures</span><p id="par0050" class="elsevierStylePara elsevierViewall">History of diabetes was collected by self-reporting using two questions to the participants at baseline and in follow-up waves&#58; &#8220;Do you have diabetes&#63;&#8221; and &#8220;Did you have ever seen a physician in the last year for this problem&#63;&#8221; People who answered &#8220;yes&#8221; to both the questions were considered to have diabetes and were asked to state the year when they became aware of their condition&#46; Diabetes history was measured in years of diabetes at the time of incorporation of the individual in the baseline cohort &#40;1993&#41; and classified in three categories&#58; no diabetes&#44; less than 10 years of diabetes and 10 or more years of diabetes&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Mortality data were obtained from the National Death Index &#40;NDI&#41;&#44; a computerized database with information on the vital status of all residents in Spain&#46; To compensate for the delay in updating mortality in the NDI&#44; data were collected until June 2012&#46; The cut-off date for the mortality analysis was 31&#47;12&#47;1999 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>330&#59; 25&#46;8&#37;&#41; for medium-term mortality &#40;6 years&#41; and 31&#47;12&#47;2011 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>994&#59; 77&#46;8&#37;&#41; for long-term mortality &#40;18 years&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Age &#40;years&#41;&#44; sex&#44; body mass index&#44; heart disease&#44; comorbidity&#44; self-rated health and years of diabetes&#44; obtained from the 1993 baseline Legan&#233;s questionnaire&#44; were used as co-variables in the analysis&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Body Mass Index &#40;BMI&#41; in kg&#47;m<span class="elsevierStyleSup">2</span> based on measures of weight and height&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Self-rated health &#40;response to the question&#58; &#8220;How would you describe your health at present&#63;&#8221;&#58; fair&#44; poor or very poor versus good or very good&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Heart disease includes angina&#44; 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all cases fit the Gaussian curve&#44; therefore the continuous variables were expressed as means<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation&#44; and categorical variables as absolute and relative frequencies &#40;<span class="elsevierStyleItalic">n</span> and &#37;&#41;&#46; A bivariate analysis was made for sex with distribution of variables in the baseline using <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span> test&#46; The prevalence of diabetes was calculated by age group &#40;65&#8211;74 and &#8805;75 years&#41; and sex for each of the four waves &#40;1993&#44; 1995&#44; 1997 and 1999&#41;&#46; To study the change in the prevalence of diabetes over time&#44; the <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span> tendency test was used&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">For the calculation of incidence&#44; all non-diabetic individuals in the previous waves were used&#58; 978 persons in 1995&#44; 783 in 1997&#44; and 566 in 1999&#46; The incidence density &#40;incident cases&#47;person-time periods&#41; was calculated for biannual periods and expressed as the number of cases of diabetes per 100 persons by 2-year time periods&#46; In total&#44; 1965 persons&#47;time periods were used&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Mortality analyses were conducted with the Kaplan&#8211;Meier analysis and adjusted by the Cox regressions&#46; To evaluate the association between diabetes and general mortality&#44; Cox regression was used at two moments&#58; 31&#47;12&#47;1999 &#40;6 years of follow-up&#41; and 31&#47;12&#47;2011 &#40;18 years of follow-up&#41;&#46; Median survival was calculated&#44; and the main results were summarized with hazard ratios &#40;HRs&#41; and their 95&#37; CIs&#46; Person follow-up time was calculated from the time people were incorporated into the study in 1993&#46; Individuals were censored if they died or dropped out of the study&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Diabetes&#44; as a principal variable&#44; was used as a dummy variable &#40;fictitious variable&#41;&#58; &#40;0&#41; no diabetes&#44; &#40;1&#41; less than 10 years of diabetes at baseline &#40;1993&#41;&#44; and &#40;2&#41; 10 or more years of diabetes at baseline &#40;1993&#41;&#46; Four multivariate Cox models were built&#58; &#40;1&#41; crude diabetes data&#44; &#40;2&#41; diabetes adjusted for age and sex&#44; &#40;3&#41; additionally adjusted for heart disease and &#40;4&#41; additionally adjusted for comorbidity&#46; Results with <span class="elsevierStyleItalic">p</span> less than 0&#46;05 were considered statistically significant&#46; SPSS version 19&#46;0 and Epidat 3&#46;1 were used for the analysis&#46;<elsevierMultimedia ident="fig0005"></elsevierMultimedia></p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Results</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Characteristics of the study subjects</span><p id="par0110" class="elsevierStylePara elsevierViewall">Of the 1283 participating individuals in the baseline cohort &#40;1993&#41;&#44; diabetes self-reported data were available in 1277 individuals who participated in this wave&#44; of which 50&#46;4&#37; were men and 49&#46;6&#37; were women&#46; The flow chart for the study shows the number of participants in each of the waves&#44; as well as the number of those who died or were lost to follow-up in each wave&#46; The distribution of the variables studied in the baseline cohort is presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Women had a higher body mass index than men&#44; as well as poorer self-rated health&#44; a higher frequency and longer history of diabetes&#44; and more comorbidity &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Prevalence of diabetes</span><p id="par0115" class="elsevierStylePara elsevierViewall">The prevalence of diabetes in the study population &#40;weighted data&#41; increased progressively over time&#44; from 10&#46;3&#37; &#40;95&#37; CI&#58; 8&#46;6&#8211;11&#46;9&#41; in 1993 to 16&#46;1&#37; in 1999 &#40;95&#37; CI&#58; 13&#46;2&#8211;18&#46;9&#41;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#46; In the 1993 and 1995 waves&#44; women had a significantly higher prevalence than men &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">The mean duration of diabetes in the 142 participants who had the disease at study baseline &#40;1993&#41; was 7&#46;8 years &#40;SD<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;8&#59; range 0&#8211;30 years&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Incidence of diabetes</span><p id="par0125" class="elsevierStylePara elsevierViewall">The total biannual incidence density of diabetes was 2&#46;6 &#40;95&#37; CI&#58; 1&#46;9&#8211;3&#46;3&#41; cases per 100 persons at 2 years of follow-up&#44; 2&#46;8 &#40;95&#37; CI&#58; 1&#46;7&#8211;3&#46;8&#41; in men and 2&#46;5 &#40;95&#37; CI&#58; 1&#46;6&#8211;3&#46;4&#41; in women&#46; In general&#44; the incidence density of diabetes decreased with increasing age&#44; although this difference was not statistically significant&#46; Differences between sexes were not statistically significant &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Mortality associated with diabetes</span><p id="par0130" class="elsevierStylePara elsevierViewall">Our data show that survival time for older persons with 10 or more years history of diabetes is 2&#46;7 years less than for non-diabetic individuals&#46; The Kaplan&#8211;Meier medians in the medium-term models did not reach statistical significance&#46; Median survival in the long term was 10&#46;8 years &#40;95&#37; CI&#58; 10&#46;1&#8211;11&#46;5&#41; for non-diabetic persons&#59; 9&#46;0 &#40;95&#37; CI&#58; 6&#46;8&#8211;11&#46;1&#41; for persons with less than 10 years&#8217; history of diabetes from baseline &#40;1993&#41;&#59; and 8&#46;1 years &#40;95&#37; CI&#58; 5&#46;5&#8211;10&#46;6&#41; for those with 10 or more years&#8217; history of diabetes from baseline &#40;1993&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">As can be seen in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#44; the hazard ratio for medium- and long-term mortality in persons with 10 or more years&#8217; history of diabetes was 2&#46;0 &#40;95&#37; CI&#58; 1&#46;2&#8211;3&#46;3&#41; and 1&#46;7 &#40;95&#37; CI&#58; 1&#46;1&#8211;2&#46;5&#41;&#44; respectively&#44; after adjusting for age and sex&#44; heart disease and comorbidity&#46; Accordingly&#44; it can be said that medium-term mortality is twice as high in persons with 10 or more years&#8217; history of diabetes at baseline than in non-diabetic individuals&#44; and is 70&#37; higher in the long term&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0140" class="elsevierStylePara elsevierViewall">The hazard ratio for medium- and long-term mortality in diabetic individuals with less than 10 years&#8217; history of diabetes at baseline was 1&#46;3 &#40;95&#37; CI&#58; 0&#46;9&#8211;1&#46;9&#41; and 1&#46;5 &#40;95&#37; CI&#58; 1&#46;2&#8211;1&#46;9&#41;&#44; respectively&#46; Thus&#44; it can be said that in the medium term &#40;6 years&#41;&#44; those with less than 10 years&#8217; history at baseline do not have higher mortality than non-diabetic persons&#44; whereas their long-term mortality is almost 50&#37; higher &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Discussion</span><p id="par0145" class="elsevierStylePara elsevierViewall">Although increasing age is a risk factor for the development of diabetes and its vascular complications&#44; few studies have focused specifically on the impact of diabetes in elderly populations&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;12&#44;16</span></a> In our study&#44; the prevalence of diabetes in individuals aged 65 years and over increased from 10&#46;3&#37; in 1993 to 16&#46;1&#37; in 1999&#46; These data are consistent with other population studies&#58; a Canadian study found that diabetes increased from 10&#46;6&#37; to 17&#46;1&#37; after 10 years of follow-up in a population over age 50&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> while a US study reported that the prevalence of diabetes increased from 12&#46;5&#37; to 17&#46;7&#37; in individuals aged 65 and over during 18 years of follow-up&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">In the DECODE study &#40;Diabetes Epidemiology&#58; Collaborative analysis of Diagnostic criteria in Europe&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> which measured plasma glucose in 13 European cohorts&#44; in accordance with WHO recommendations for the diagnosis of diabetes&#44; the prevalence of diabetes was 10&#8211;20&#37; in individuals aged 60&#8211;79 years&#46; In a recent study&#44;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> conducted in subjects aged &#62;60 years in Spain and with characteristics similar to ours&#44; the overall prevalence of diabetes was 16&#46;8&#37;&#44; slightly higher than ours &#40;13&#46;1&#37;&#41;&#46; This variation may be related to the methodology used to collect the information as well as the variability of results when they are self-reported by the patient&#46; In a study in people older than 65 years in the United States using data from Medicare&#44; the prevalence increased from 15&#46;3&#37; at baseline to 24&#46;8&#37; after 9 years of follow-up&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">In general&#44; the prevalence of diabetes in the same age groups was much higher in 1999 than in the previous waves&#46; Also in accordance with other studies<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;21</span></a> we found that most cases of diabetes occurred in the oldest individuals&#46; One possible explanation for this could be a progressively greater awareness of diabetes on the part of both patients and medical professionals&#46; Although most studies in the general population have found a higher prevalence of diabetes in men&#44;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;20&#44;22</span></a> some have found that the prevalence in people over age 65 is higher in women&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> The DECODE study has reported diabetes prevalence rates of 8&#46;5&#37; in men and 9&#46;3&#37; in women between the ages of 60 and 69 years&#44; increasing to 12&#46;4&#37; in men and 15&#46;4&#37; in women between age 70 and 79 years&#44; and to 12&#46;9&#37; in men and 22&#46;4&#37; in women between age 80 and 89&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Our results are consistent with the aforementioned studies&#46; The prevalence in 1993 was 7&#46;6&#37; in men and 12&#46;3&#37; in women&#44; rising to 9&#46;2&#37; and 13&#46;6&#37; respectively&#44; in 1995&#46; The differences by sex found in 1997 and 1999 are not statistically significant&#46;</p><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Incidence of diabetes</span><p id="par0160" class="elsevierStylePara elsevierViewall">Because diabetes has a silent course&#44; without a sudden or exact date of onset&#44; it is difficult to design studies of disease incidence&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">In Spain&#44; the few studies that have estimated the incidence of diabetes are not consistent because they did not follow a standardized methodology&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Moreover&#44; most previous studies in Spain have provided diabetes incidence data in people under age 65 years&#44; and therefore are not comparable with our data&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;25</span></a> A recent study in Spain in persons aged 18&#8211;65 years<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> found an annual diabetes incidence of 19&#46;1 cases per 1000 person-years&#44; slightly higher than that in our study&#46; However&#44; the annual incidence of diabetes in European studies conducted in the general population varies between 1&#46;2 and 4&#46;1 cases&#47;1000 people&#44;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;27</span></a> which is lower than the figures published for the Spanish population&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Our results for diabetes incidence in persons aged 65 years and over show an incidence rate equivalent to 13&#46;1 cases per 1000 person-years &#40;2&#46;6 cases per 100 persons-2 years of follow-up&#41;&#44; which is between the 24 per 1000 person-years reported in a study made in US elderly<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> and 9&#46;4 cases per 1000 person-years for the population 65 years and over in Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> In these two studies the incidence rates increased with increasing age&#46; In our study the incidence is higher in the 65&#8211;74 years age group &#91;3&#46;2 &#40;95&#37; CI&#58; 2&#46;3&#8211;4&#46;2&#41;&#93; than in those aged 75 years and over &#91;1&#46;7 &#40;95&#37; CI&#58; 0&#46;8&#8211;2&#46;6&#41;&#93;&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Mortality associated with diabetes</span><p id="par0175" class="elsevierStylePara elsevierViewall">Diabetes has been associated with an average 10 years of life lost for individuals diagnosed during middle age&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> Individuals with diabetes have an excess mortality compared with people without diabetes&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> However&#44; it is not clear how diabetes affects mortality when the diagnosis is made at an older age&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Our data show that the survival time for people in the older population with 10 or more years history of diabetes is 2&#46;7 years less than that for non-diabetic individuals&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Mortality in the medium term for persons with 10 or more years history of diabetes is almost double that of people without diabetes&#44; while long-term mortality is almost 70&#37; higher&#46; Those with less than 10 years history of diabetes at baseline do not have higher mortality than non-diabetic individuals in the medium term&#44; but long-term mortality is almost 50&#37; higher&#46; In a systematic review of observational studies<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> reporting mortality in patients over age 60 diagnosed with type 2 diabetes&#44; those with diabetes were found to have 40&#37; higher mortality than non-diabetic persons&#44; which is lower than found in our study&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Thus&#44; our results show a clear association between diabetes and increased all-cause mortality&#44; although this effect is statistically significant only in patients who have had diabetes for at least 10 years&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Strengths and limitations</span><p id="par0190" class="elsevierStylePara elsevierViewall">The main strength of our study is the long follow-up time &#40;18 years&#41;&#46; Added to this is the fact that&#44; to date&#44; few studies of diabetes incidence and mortality have been made in Mediterranean populations&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">One of the limitations of this study is that we used self-reported data to assess diabetes&#46; Several authors point out that self-reported data could underestimate diabetes prevalence&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;12&#44;20</span></a> Although this underestimation is possible&#44; other authors have confirmed that self-reported diabetes is a reasonably reliable surrogate for diagnosed diabetes&#44; based on their studies of the accuracy of patients&#8217; self-reports compared with medical records&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">30&#44;31</span></a></p><p id="par0200" class="elsevierStylePara elsevierViewall">In health care systems where general practitioners have a complete vision of their patients&#8217; medical status and in which patients have easy and frequent access to medical services&#44; patients are more likely to be well informed about their diseases&#44; especially in the case of chronic diseases like diabetes&#46; This is the case in Spain&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> where every community-dwelling person is registered in the patient list of a general practice&#44; and access to other health care facilities&#44; including outpatient clinics&#44; is only possible through referral by a general practitioner&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Furthermore&#44; in our study&#44; individuals were classified as having diabetes not only based on their awareness of their condition&#44; but also because they had seen a physician in the last year for this problem&#46; The second question on medical consultations in the last year increases the validity of the self-report&#46; In 1993 people in our sample averaged 8&#46;3 consultations with general practitioners&#44; similar to the current rate of general practitioner consultations in Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a></p><p id="par0210" class="elsevierStylePara elsevierViewall">Our sample was drawn from a metropolitan area of Madrid&#44; therefore this study may not be comparable to other non-Mediterranean population studies and cannot strictly be generalized to the whole older Spanish population&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Together with Sherwin R and Jastreboff AM&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> we can say that &#8220;today&#39;s message is that a diabetes tsunami is imminent&#44; and the only way to minimize the damage is to create an early warning system and improve interventions to protect those in its path&#8221;&#46; Effective public health interventions to prevent diabetes are needed&#44; together with the resources required to manage the increasingly large number of people who are living longer with this debilitating disease&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> In accordance with Rose&#44; we think that the &#8220;population strategy&#8221; with regard to prevention should always be the discovery and control of the causes of the incidence of chronic diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> In the case of diabetes&#44; important factors for prevention could be reducing obesity&#44; increasing physical activity and maintaining a Mediterranean diet&#46;<span class="elsevierStyleVsp" style="height:0.5px"></span><elsevierMultimedia ident="tb0005"></elsevierMultimedia></p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0175">Funding sources</span><p id="par0265" class="elsevierStylePara elsevierViewall">This work was supported by the <span class="elsevierStyleGrantSponsor" id="gs0005"><span class="elsevierStyleItalic">Fondo de Investigaciones en Salud</span></span>&#44; <span class="elsevierStyleGrantNumber" refid="gs0005">FIS PI 05 1898</span>&#44; <span class="elsevierStyleGrantNumber" refid="gs0005">RETICEF RD06&#47;0013&#47;1013</span> and <span class="elsevierStyleGrantNumber" refid="gs0005">RD&#47;12&#47;0043&#47;0019</span>&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0180">Conflict of interest</span><p id="par0270" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To estimate the prevalence and incidence of self-reported diabetes and to study its association with medium- and long-term mortality from all causes in persons &#8805;65 years&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0015">Design</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A population-based cohort study begun in 1993&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0020">Setting</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">&#8220;Envejecer en Legan&#233;s&#8221; cohort &#40;Madrid&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0025">Participants</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A random sample of persons &#8805;65 years &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1277 in the 1993 baseline sample&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0030">Methods</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Participants were classified as having diabetes if they so reported and had consulted a physician for this reason within the last year&#46; Diabetes history was categorized in &#60;10 and &#8805;10 years in 1993&#46; Incidence density was calculated in 2-year periods in non-diabetic individuals &#40;1965 persons&#47;2 years&#41;&#46; Vital status was recorded on 31 December 2011&#46; The association between diabetes history &#8805;10 years and mortality at 6 and 18 years follow-up was studied by the Kaplan&#8211;Meier and Cox regression analyses after adjusting for age&#44; sex&#44; heart disease and comorbidity&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0035">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The prevalence of self-reported diabetes rose from 10&#46;3&#37; in 1993 to 16&#46;1&#37; in 1999 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and was higher in women than men &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Total incidence density was 2&#46;6 cases&#47;100 persons&#47;2 years &#40;95&#37; CI&#58; 2&#46;0&#8211;3&#46;3&#41;&#46; Medium- and long-term mortality was higher in persons with diabetes history &#8805;10 years than in non-diabetic individuals &#40;HR&#58; 2&#46;0&#59; 95&#37; CI&#58; 1&#46;2&#8211;3&#46;3 and HR&#58; 1&#46;7&#59; 95&#37; CI&#58; 1&#46;1&#8211;2&#46;5&#44; respectively&#41;&#46; In diabetics with history &#60;10 years the HR was 1&#46;3 &#40;95&#37; CI&#58; 0&#46;9&#8211;1&#46;9&#41; and HR&#58; 1&#46;5 &#40;95&#37; CI&#58; 1&#46;2&#8211;1&#46;9&#44; respectively&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Although diabetes is clearly associated with increased risk of mortality&#44; it is significant only for patients with &#8805;10 years&#8217; history of diabetes&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0050">Objetivos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Calcular la prevalencia y la incidencia de diabetes autorreferida y analizar su asociaci&#243;n con la mortalidad general a medio y a largo plazo en personas &#8805;<span class="elsevierStyleHsp" style=""></span>65<span class="elsevierStyleHsp" style=""></span>a&#241;os&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0055">Dise&#241;o</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Estudio de cohortes de base poblacional iniciado en 1993&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0060">Emplazamiento</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Cohorte &#171;Envejecer en Legan&#233;s&#187; &#40;Madrid&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0065">Participantes</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Muestra aleatoria de los &#8805;<span class="elsevierStyleHsp" style=""></span>65<span class="elsevierStyleHsp" style=""></span>a&#241;os &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;277 en 1993&#41;&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0070">Mediciones principales</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Diab&#233;tico&#58; autorreferido y haber visitado al m&#233;dico por este motivo el &#250;ltimo a&#241;o&#46; Antig&#252;edad de diabetes&#58; m&#225;s y menos de 10<span class="elsevierStyleHsp" style=""></span>a&#241;os en 1993&#46; Prevalencia en 1993&#44; 1995&#44; 1997 y 1999&#46; Densidad de incidencia calculada para periodos bianuales &#40;1&#46;965<span class="elsevierStyleHsp" style=""></span>personas&#47;2<span class="elsevierStyleHsp" style=""></span>a&#241;os&#41;&#46; Estado vital registrado a 31 de diciembre de 2011&#46; La asociaci&#243;n entre diabetes y mortalidad a 6 y 18<span class="elsevierStyleHsp" style=""></span>a&#241;os se estudi&#243; mediante Kaplan-Meier y regresi&#243;n de Cox&#44; ajustando por edad&#44; sexo&#44; enfermedades del coraz&#243;n y comorbilidad&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de diabetes autorreferida aument&#243; desde el 10&#44;3&#37; &#40;1993&#41; hasta el 16&#44;1&#37; &#40;1999&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; siendo superior en mujeres &#40;p<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; La incidencia de diabetes fue de 2&#44;66<span class="elsevierStyleHsp" style=""></span>casos por 100<span class="elsevierStyleHsp" style=""></span>personas&#47;2<span class="elsevierStyleHsp" style=""></span>a&#241;os &#40;IC 95&#37;&#58; 1&#44;9-3&#44;3&#41;&#46; La mortalidad a medio y a largo plazo fue mayor en diab&#233;ticos con &#8805;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>a&#241;os que en no diab&#233;ticos &#40;HR&#58; 2&#44;0&#59; IC 95&#37;&#58; 1&#44;2-3&#44;3&#44; y HR&#58; 1&#44;7&#59; IC 95&#37;&#58; 1&#44;1-2&#44;5&#44; respectivamente&#41;&#46; En diab&#233;ticos &#60;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>a&#241;os el HR para mortalidad fue 1&#44;3 &#40;IC 95&#37;&#58; 0&#44;9-1&#44;9&#41; y 1&#44;5 &#40;IC 95&#37;&#58; 1&#44;2-1&#44;9&#41;&#44; respectivamente&#46;</p> <span class="elsevierStyleSectionTitle" id="sect0080">Conclusiones</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Aunque padecer diabetes se asocia a un aumento de la mortalidad&#44; esta asociaci&#243;n es significativa solo para los pacientes con historia de diabetes igual o superior a 10<span class="elsevierStyleHsp" style=""></span>a&#241;os&#46;</p>"
      ]
    ]
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      0 => array:3 [
        "etiqueta" => "1"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0040">Both&#44; the first &#40;MSM&#41; and second &#40;AB&#41; authors&#44; have contributed equally to the paper&#46;</p>"
        "identificador" => "fn1"
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    "multimedia" => array:7 [
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        "identificador" => "fig0010"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
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        "figura" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Medium- and long-term survival of diabetic patients and non-diabetic patients adjusted for age and sex&#44; heart disease and comorbidity&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Men &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>644&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Women &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>633&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Total &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1277&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#91;mean &#40;SD&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#46;6 &#40;8&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#46;9 &#40;8&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#46;8 &#40;8&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Body mass index &#40;BMI&#41; &#91;mean &#40;SD&#41;&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;3 &#40;3&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#46;0 &#40;4&#46;8&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#46;1 &#40;4&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Self-rated health fair&#44; poor or very poor &#91;<span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">357 &#40;55&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">432 &#40;68&#46;2&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">789 &#40;61&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetic patients &#91;<span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;11&#46;8&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">122 &#40;9&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patients with 10 or more years history of diabetes &#91;<span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;0&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;4&#46;4&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33 &#40;2&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Heart disease &#91;<span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">163 &#40;25&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">139 &#40;22&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">302 &#40;23&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Comorbidity &#40;&#8805;4 diseases&#41; &#91;<span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">285 &#40;44&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">388 &#40;61&#46;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">673 &#40;52&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Distribution of variables in the baseline Legan&#233;s cohort &#40;1993&#41;&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1993 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1277&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1995 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>939&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1997 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>743&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1999 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>519&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#37; &#91;95&#37; CI&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#37; &#91;95&#37; CI&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&#37; &#91;95&#37; CI&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&#37; &#91;95&#37; CI&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Men&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Women&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;2<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;</span></a> &#91;10&#46;0&#8211;18&#46;4&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16&#46;2 &#91;11&#46;7&#8211;20&#46;8&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;5 &#91;12&#46;5&#8211;22&#46;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;126&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Age-specific prevalence of diagnosed diabetes by sex from 1993 to 1999&#46;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a></p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Percentage&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">95&#37; confidence interval&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;6&#8211;3&#46;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;3&#8211;4&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Men&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;9&#8211;4&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Women&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">3&#46;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;8&#8211;4&#46;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#8805;75</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8&#8211;2&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Men&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;2&#8211;3&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Women&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5&#8211;2&#46;8&nbsp;\t\t\t\t\t\t\n
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Medium-term mortality &#40;1993&#8211;1999&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">HR&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">95&#37; CI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HR&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">95&#37; CI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Crude data</span><a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">a</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Less than 10 years of diabetes in 1993&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8&#8211;1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;394&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;1&#8211;1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>10 or more years of diabetes in 1993&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0&#8211;2&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;051&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9&#8211;2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;096&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Adjusted for age and sex</span><a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">a</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Less than 10 years of diabetes in 1993&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0&#8211;2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;056&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;3&#8211;2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>10 or more years of diabetes in 1993&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;3&#8211;3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;2&#8211;2&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="7" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Additionally adjusted for heart disease</span><a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">a</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Less than 10 years of diabetes in 1993&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9&#8211;1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;095&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;2&#8211;2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>10 or more years of diabetes in 1993&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;2&#8211;3&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Additionally adjusted for comorbidity</span><a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">a</span></a></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Less than 10 years of diabetes in 1993&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;9&#8211;1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;141&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;2&#8211;1&#46;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>10 or more years of diabetes in 1993&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;009&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;009&nbsp;\t\t\t\t\t\t\n
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                  """
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          "en" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Association of diabetes with all-cause mortality &#40;Cox regression Hazard Model&#41;&#46;<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">a</span></a></p>"
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          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">General outline of the study</span>&#58;</p>"
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      6 => array:5 [
        "identificador" => "tb0005"
        "tipo" => "MULTIMEDIATEXTO"
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        "texto" => array:1 [
          "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">What is known about the topic</span><p id="par0220" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0225" class="elsevierStylePara elsevierViewall">Diabetes mellitus is a chronic disease with major impact on health&#44; and its prevalence and incidence are increasing&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0230" class="elsevierStylePara elsevierViewall">Because diabetes is a silent disease&#44; with no sudden or exact date of onset&#44; it is difficult to design studies of disease incidence&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0235" class="elsevierStylePara elsevierViewall">It is known that mortality is higher in diabetics than in non-diabetics&#44; and diabetes in the elderly is responsible for a significant morbidity and mortality&#46;</p></li></ul></p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">What brings the study</span><p id="par0240" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0245" class="elsevierStylePara elsevierViewall">The article analyzes the prevalence of self-reported diabetes in Spain in a base population cohort of people over 65 years &#40;Aging in Leganes cohort&#41;&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">The prevalence of diabetes increased progressively over time&#44; from 10&#46;3&#37; in 1993 to 16&#46;1&#37; in 1999&#46; Women had a significantly higher prevalence than men&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0255" class="elsevierStylePara elsevierViewall">The diabetes incidence in this population during the study period &#40;1993&#8211;1999&#41; was 13&#46;1 cases per 1000 person-years &#40;2&#46;6 cases per 100 persons&#47;2 years of follow-up&#41;&#46; No differences were found between sexes neither between the age group 65&#8211;74 years and people over 75 years&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0260" class="elsevierStylePara elsevierViewall">Although diabetes is clearly associated with increased risk of mortality&#44; it is significant only for patients with &#8805;10 years history of diabetes&#46; Mortality for persons with 10 or more years of history of diabetes is almost 70&#37; higher than people without diabetes&#46;</p></li></ul></p></span></span>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:35 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ethnicity and sex affect diabetes incidence and outcomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;A&#46; Khan"
                            1 => "H&#46; Wang"
                            2 => "S&#46; Anand"
                            3 => "Y&#46; Jin"
                            4 => "N&#46;R&#46; Campbell"
                            5 => "L&#46; Pilote"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2337/dc10-0865"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2011"
                        "volumen" => "34"
                        "paginaInicial" => "96"
                        "paginaFinal" => "101"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20978094"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "IDF Diabetes Atlas&#46; Fifth edition&#59; 2011&#46; <a id="intr0005" class="elsevierStyleInterRef" href="http://www.idf.org/diabetesatlas/news/fifth-edition-relese">http&#58;&#47;&#47;www&#46;idf&#46;org&#47;diabetesatlas&#47;news&#47;fifth-edition-relese</a> &#91;accessed 20&#46;08&#46;12&#93;&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
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        "texto" => "<p id="par0275" class="elsevierStylePara elsevierViewall">We would like to thank the elderly people of Legan&#233;s for their generous participation in this study during many years as well as professors Jos&#233; Ram&#243;n Banegas and Juan Jos&#233; de la Cruz for their help in preparing the article&#46;</p>"
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Article information

ISSN: 02126567
Original language: English

DOI:10.1016/j.aprim.2013.12.004

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Year/Month	Html	Pdf	Total

2024 October	11	2	13
2024 September	46	3	49
2024 August	20	2	22
2024 July	38	7	45
2024 June	30	2	32
2024 May	26	1	27
2024 April	28	4	32
2024 March	48	3	51
2024 February	68	5	73
2024 January	42	7	49
2023 December	35	13	48
2023 November	31	4	35
2023 October	46	7	53
2023 September	16	3	19
2023 August	10	2	12
2023 July	18	6	24
2023 June	28	9	37
2023 May	22	5	27
2023 April	14	3	17
2023 March	5	5	10
2023 February	15	4	19
2023 January	13	7	20
2022 December	17	9	26
2022 November	33	7	40
2022 October	22	15	37
2022 September	21	18	39
2022 August	20	8	28
2022 July	21	10	31
2022 June	19	13	32
2022 May	19	20	39
2022 April	22	10	32
2022 March	25	6	31
2022 February	9	7	16
2022 January	10	16	26
2021 December	39	15	54
2021 November	34	8	42
2021 October	30	12	42
2021 September	14	12	26
2021 August	11	9	20
2021 July	19	15	34
2021 June	24	6	30
2021 May	16	6	22
2021 April	19	19	38
2021 March	69	27	96
2021 February	47	9	56
2021 January	26	11	37
2020 December	26	13	39
2020 November	24	11	35
2020 October	23	10	33
2020 September	25	11	36
2020 August	29	8	37
2020 July	27	9	36
2020 June	30	17	47
2020 May	23	17	40
2020 April	34	4	38
2020 March	32	13	45
2020 February	38	18	56
2020 January	36	10	46
2019 December	51	12	63
2019 November	43	20	63
2019 October	36	17	53
2019 September	58	19	77
2019 August	29	7	36
2019 July	47	15	62
2019 June	64	12	76
2019 May	113	18	131
2019 April	47	13	60
2019 March	50	21	71
2019 February	45	16	61
2019 January	39	18	57
2018 December	35	10	45
2018 November	36	9	45
2018 October	41	10	51
2018 September	41	7	48
2018 August	62	1	63
2018 July	33	3	36
2018 June	25	1	26
2018 May	27	3	30
2018 April	210	4	214
2018 March	4	0	4
2018 February	8	2	10
2018 January	8	7	15
2017 December	10	3	13
2017 November	7	1	8
2017 October	11	3	14
2017 September	15	4	19
2017 August	30	8	38
2017 July	7	1	8
2017 June	18	6	24
2017 May	23	5	28
2017 April	15	2	17
2017 March	23	3	26
2017 February	20	1	21
2017 January	18	4	22
2016 December	17	7	24
2016 November	32	2	34
2016 October	61	13	74
2016 September	45	13	58
2016 August	21	7	28
2016 July	15	3	18
2016 June	35	7	42
2016 May	19	10	29
2016 April	12	9	21
2016 March	17	8	25
2016 February	23	4	27
2016 January	12	5	17
2015 December	26	8	34
2015 November	17	4	21
2015 October	18	12	30
2015 September	27	17	44
2015 August	17	4	21
2015 July	19	6	25
2015 June	15	6	21
2015 May	38	22	60
2015 April	21	16	37
2015 March	25	8	33
2015 February	29	10	39
2015 January	34	13	47
2014 December	34	18	52
2014 November	42	16	58
2014 October	78	45	123
2014 September	169	213	382

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