Corresponding author at: Doctores 102 Col. El Marqués, 76047 Querétaro, Querétaro, México. Tel.: +52 01 44 2223 6904.
was read the article
array:25 [ "pii" => "S2444050715000340" "issn" => "24440507" "doi" => "10.1016/j.circen.2015.08.008" "estado" => "S300" "fechaPublicacion" => "2015-03-01" "aid" => "26" "copyright" => "Academia Mexicana de Cirugía A.C." "copyrightAnyo" => "2015" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Cir Cir. 2015;83:129-34" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2078 "formatos" => array:3 [ "EPUB" => 42 "HTML" => 1544 "PDF" => 492 ] ] "Traduccion" => array:1 [ "es" => array:20 [ "pii" => "S0009741115000092" "issn" => "00097411" "doi" => "10.1016/j.circir.2015.04.008" "estado" => "S300" "fechaPublicacion" => "2015-03-01" "aid" => "8" "copyright" => "Academia Mexicana de Cirugía A.C." "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Cir Cir. 2015;83:129-34" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3645 "formatos" => array:3 [ "EPUB" => 55 "HTML" => 2712 "PDF" => 878 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artículo original</span>" "titulo" => "Melanoma maligno primario del sistema nervioso central: un reto diagnóstico" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "129" "paginaFinal" => "134" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Primary malignant melanoma of the central nervous system: A diagnostic challenge" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figura 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1418 "Ancho" => 950 "Tamanyo" => 191151 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Nidos de células epitelioides, con melanina citoplasmática, núcleos pleomórficos y prominentes nucléolos, con figuras mitóticas atípicas.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Javier Quillo-Olvera, Juan Salvador Uribe-Olalde, Leopoldo Alberto Alcántara-Gómez, Jorge Dax Rejón-Pérez, Héctor Guillermo Palomera-Gómez" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Javier" "apellidos" => "Quillo-Olvera" ] 1 => array:2 [ "nombre" => "Juan Salvador" "apellidos" => "Uribe-Olalde" ] 2 => array:2 [ "nombre" => "Leopoldo Alberto" "apellidos" => "Alcántara-Gómez" ] 3 => array:2 [ "nombre" => "Jorge Dax" "apellidos" => "Rejón-Pérez" ] 4 => array:2 [ "nombre" => "Héctor Guillermo" "apellidos" => "Palomera-Gómez" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2444050715000340" "doi" => "10.1016/j.circen.2015.08.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444050715000340?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0009741115000092?idApp=UINPBA00004N" "url" => "/00097411/0000008300000002/v1_201506190028/S0009741115000092/v1_201506190028/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2444050715000352" "issn" => "24440507" "doi" => "10.1016/j.circen.2015.08.009" "estado" => "S300" "fechaPublicacion" => "2015-03-01" "aid" => "27" "copyright" => "Academia Mexicana de Cirugía A.C." "documento" => "simple-article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "crp" "cita" => "Cir Cir. 2015;83:135-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2777 "formatos" => array:3 [ "EPUB" => 67 "HTML" => 2255 "PDF" => 455 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical case</span>" "titulo" => "Traumatic occipitocervical and atlantoaxial dislocation with clivus fracture in a child. Case report" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "135" "paginaFinal" => "140" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Luxación traumática occipitocervical y atlantoaxial con fractura del clivus en un paciente pediátrico. Reporte de un caso" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1958 "Ancho" => 981 "Tamanyo" => 137385 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">(A) Preoperative image showing clivus fracture. (B) Preoperative reconstruction with coronal view of clivus fracture. (C) Preoperative reconstruction with sagittal view showing occipitocervical and atlantoaxial dislocation and clivus fracture.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Tenoch Herrada-Pineda, Mauro Loyo-Varela, Francisco Revilla-Pacheco, Monika Uribe-Leitz, Salvador Manrique-Guzmán" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Tenoch" "apellidos" => "Herrada-Pineda" ] 1 => array:2 [ "nombre" => "Mauro" "apellidos" => "Loyo-Varela" ] 2 => array:2 [ "nombre" => "Francisco" "apellidos" => "Revilla-Pacheco" ] 3 => array:2 [ "nombre" => "Monika" "apellidos" => "Uribe-Leitz" ] 4 => array:2 [ "nombre" => "Salvador" "apellidos" => "Manrique-Guzmán" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0009741115000109" "doi" => "10.1016/j.circir.2015.04.009" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0009741115000109?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444050715000352?idApp=UINPBA00004N" "url" => "/24440507/0000008300000002/v1_201510070233/S2444050715000352/v1_201510070233/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2444050715000339" "issn" => "24440507" "doi" => "10.1016/j.circen.2015.08.007" "estado" => "S300" "fechaPublicacion" => "2015-03-01" "aid" => "25" "copyright" => "Academia Mexicana de Cirugía A.C." "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Cir Cir. 2015;83:124-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2096 "formatos" => array:3 [ "EPUB" => 50 "HTML" => 1564 "PDF" => 482 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Modification to stapled mucosectomy technique with PPH. Experience of a surgical group" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "124" "paginaFinal" => "128" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Modificación a la técnica de mucosectomía con engrapadora PPH. Experiencia de un grupo quirúrgico" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 551 "Ancho" => 2000 "Tamanyo" => 185871 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Modification to stapled mucosectomy technique with PPH, cont. (a) Modification of the anorectal angle to facilitate the introduction of the stapler. (b) Suture is tied around the axis. (c) Stapler is closed and there is a waiting time of 1<span class="elsevierStyleHsp" style=""></span>min. Stapler is activated and again there is a waiting time of 1<span class="elsevierStyleHsp" style=""></span>min. (d) The circumferential strip of redundant tissue is removed.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Edgar Agustín González-Macedo, Carlos Cosme-Reyes, Carlos Belmonte-Montes" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Edgar Agustín" "apellidos" => "González-Macedo" ] 1 => array:2 [ "nombre" => "Carlos" "apellidos" => "Cosme-Reyes" ] 2 => array:2 [ "nombre" => "Carlos" "apellidos" => "Belmonte-Montes" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0009741115000080" "doi" => "10.1016/j.circir.2015.04.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0009741115000080?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444050715000339?idApp=UINPBA00004N" "url" => "/24440507/0000008300000002/v1_201510070233/S2444050715000339/v1_201510070233/en/main.assets" ] "en" => array:21 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Primary malignant melanoma of the central nervous system: A diagnostic challenge" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "129" "paginaFinal" => "134" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Javier Quillo-Olvera, Juan Salvador Uribe-Olalde, Leopoldo Alberto Alcántara-Gómez, Jorge Dax Rejón-Pérez, Héctor Guillermo Palomera-Gómez" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Javier" "apellidos" => "Quillo-Olvera" "email" => array:1 [ 0 => "a_i_o_n@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Juan Salvador" "apellidos" => "Uribe-Olalde" ] 2 => array:2 [ "nombre" => "Leopoldo Alberto" "apellidos" => "Alcántara-Gómez" ] 3 => array:2 [ "nombre" => "Jorge Dax" "apellidos" => "Rejón-Pérez" ] 4 => array:2 [ "nombre" => "Héctor Guillermo" "apellidos" => "Palomera-Gómez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neurocirugía, Hospital Regional Valentín Gómez Farías, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Zapopan, Jalisco, Mexico" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author at: Doctores 102 Col. El Marqués, 76047 Querétaro, Querétaro, México. Tel.: +52 01 44 2223 6904." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Melanoma maligno primario del sistema nervioso central: un reto diagnóstico" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1039 "Ancho" => 900 "Tamanyo" => 117108 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Hypointense lesion in axial T2 magnetic resonance.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Background</span><p id="par0005" class="elsevierStylePara elsevierViewall">Primary melanocytic tumours of the central nervous system are rare, histologically and clinically different from metastases from retinal or cutaneous malignant melanoma.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">1</span></a> They are classified into diffuse melanocytosis (diffuse melanosis) and meningeal melanomatosis, malignant melanoma and benign melanocytoma, with a small number of intermediate variants.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">1</span></a> This set of primary melanocytic neoplasms of the central nervous system have an extraordinary incidence, estimated at 0.9 per 10 million inhabitants.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">2</span></a> Of these, primary malignant melanoma of the central nervous system is even more unusual: it accounts for 1% of all cases of melanoma<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">3,4</span></a> and 0.7% of all primary tumours of the central nervous system.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">5</span></a> Its incidence is specifically 0.005 cases per 100,000 individuals.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">6</span></a> It presents in an age range from 35 to 50.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">7</span></a> Bhandari et al.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">2</span></a> state that it was Virchow who, in 1859, described the first case of primary diffuse intracranial melanoma, and Oogle reported in 1899 the first case of primary solitary intracranial melanoma.<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">7,8</span></a> These tumours arise from melanocytes present in the leptomeninges in the cerebral convexity, in the skull base, posterior fossa, cervical spinal canal, the pia mater covering vessels, reticular formation of the bridge and spinal cord, black substance and <span class="elsevierStyleItalic">locus coeruleus</span>.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">7</span></a> The most common sites within the central nervous system are: lobar (53.1%), posterior fossa (17.3%) and pineal region (13.6%).<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">2</span></a> The diagnosis of these tumours is difficult; it has to be carried out by exclusion, with primary melanocytic tumours of the central nervous system, primary tumours of the central nervous system with a certain degree of melanisation, and mainly with metastases from primary extracranial melanoma, the most common neoplasm causing cerebral metastases after lung cancer and breast cancer.<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">8,9</span></a> Although the prognosis of patients with primary malignant melanoma of the central nervous system is discouraging, especially in cases with leptomeningeal dissemination,<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">6,10</span></a> and this being the most direct prognosis factor,<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">11</span></a> it seems highly dependent on a full tumour resection.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">10,12</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A current review of PubMed literature on primary malignant melanoma of the central nervous system was carried out. Due to its low incidence, report cases and small series of cases were found. Also, it must be considered that in Mexico there is only one case of primary malignant melanoma of the central nervous system, reported in 2008 by Avilés-Aguilar et al.,<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">13</span></a> confirming the rare incidence of this tumour. In this article we document and present the radiological characteristics, macroscopic, histological and immunohistochemistry findings, and discuss the potential aetiological genotype, current management options and the prognosis of this infrequent entity. An illustrative case treated in our neurosurgery service is presented.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Clinical case</span><p id="par0015" class="elsevierStylePara elsevierViewall">This clinical case is of a female patient, 51 years of age, with no relevant history for her current condition. The symptoms described upon admission had one month of progression, with holocranial headache, mostly in the morning. Upon admission the patient mentioned intense holocranial headache, which ceased momentaneously with NSAID and was worsened with the Valsalva manoeuvre. She had difficulty in moving her left arm and leg, leading to ambulatory problems. In the physical examination we found: proper alertness, bradifrenia, 3/5 strength decrease in left arm and leg, and generalised hypertonia and hyperreflexia in the four limbs. Bilateral papillary oedema was observed in the ophthalmoscopy. The simple cranium axial tomography, carried out upon admission (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), showed a hyperdense, well-defined image, right temporoparietal, apparently intraventricular, with collapse of the right lateral ventricle, mainly the atrium, and severe expansive effect. The lesion presented heterogeneous areas of density. It extends up to the right parietal lobe. Its medial limits are the right fornix callosum region, extending along the occipital horn. Compression of the callosum body is evident, as well as the fornix cross-sectional area on the right side. The left ventricular system is perceived as permeable, with no compensatory dilation. A magnetic resonance imaging study was also performed. In the axial T1 weighted image (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>), the craneodorsal extension of the tumour was observed; the tumour was intraaxial and isointense in relation to the cerebral parenchyma, and intratumoural hyperintense areas, with suspected intratumoural microhaemorrages. The expansive effect over the body of the fornix, the fornix cross-sectional area, the bulb of the corpus callosum and the splenium of the corpus callosum on the right side was evident, in addition to the complete collapse of the body and atrium of the right ventricular system and apparent occupation of the ipsilateral occipital horn. In the T1 weighted image with contrast material, the same hyperintense lesion was observed, homogeneously enhanced by the gadolinium. In the axial T2 weighted image (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>) a hypointense lesion was observed.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In her first hospital stay, a loop diuretic was administered, steroid, anticonvulsant and semi-Fowler's position. Also, an elective surgical treatment was proposed. The presumptive diagnosis was meningioma, and a differential diagnosis was performed in the location between choroid plexus papilloma, metastases and glioma for ventricular atrium tumours, without taking into consideration primary malignant melanoma of the central nervous system. On the fourth day she presented sudden deterioration of alertness and consciousness, dilated right pupil and 2/5 tetraparesis, with accentuation of the superior motor neuron syndrome she had upon admission, and clinical signs of right uncal herniation were added. Therefore, an emergency decompressive right temporal craniectomy was performed. Pressure was released on the craniotomised temporal fossa. She was admitted into the intensive care unit in the postsurgical stage.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Afterwards, in better clinical condition and having improved the right pupillary diameter, on her first day in the intensive care unit, she went into surgery for a tumoral resection. A posterosuperior craniotomy was performed, as well as a superior intersulcal, right parietal approach. There was total resection of the tumour. The macroscopic characteristics of the tumour were soft neoplastic, aspirable, highly vascularised and bleeding, with vessel clusters, of low quality and difficult coagulation, parenquimatose and leptomeningeal infiltration. During surgery, an intraaxial lobar and extraventricular tumour was confirmed, with severe expansive effect on the right lateral ventricular system. The main characteristic of this tumour is that it was “black” in colour (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Two weeks after the surgery, a simple tomography of the head was taken, where midbrain was observed with no evidence of compression, an area of right temporoparietal encefalomalacia, secondary to the total tumour resection. The right lateral ventricular system with no collapse, permeable right occipital horn and atrium, with no transependimary communication, because the tumour was extraventricular and those structures were not injured during resection. The review of the histopathology sample revealed a highly cellular neoplasia, organised in nests of epithelial cells, with pleomorphic nuclei and a variable amount of cytoplasmic melanin, in addition to prominent nucleoli (<a class="elsevierStyleCrossRefs" href="#fig0025">Figs. 5 and 6</a>), and positive for HMB45 and S-100 protein. With the postsurgical findings mentioned and the previous immunohistochemistry, a directed anamnesis was performed, regarding the family history of skin neoplasms in the patient, which were denied. The case was formalised by the dermatology and ophthalmology service, and an exhaustive review was carried out to exclude mucotegumentary lesions and primary retinal neoplastic lesions.</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><elsevierMultimedia ident="fig0030"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Having ruled out metastatic tumours of the central nervous system with the use of negative tumour markers and scintigram, the final conclusion was a diagnosis of primary malignant melanoma of the central nervous system. The patient was discharged 9 days after her postsurgical status, the oncology service determined total cerebral radiotherapy with 3.000<span class="elsevierStyleHsp" style=""></span>centigray in 10 fractions, concomitant with temozolamide for 6 weeks. She is currently under oncology treatment.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">Melanosomic melanin is different from neuromelanin, which is only found on neurons.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">9</span></a> Leptomeningeal melanocytes are derived from the neural crest, consisting of a population of multipotential cells arising from the lateral margin of the neural tube during early embryo development, on day 22 of the embryogenesis, differentiating in leptomeningeal cells, glial cells, medullar adrenal cells and melanocytes.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> The higher concentration of melanocytes in the nervous system is in the pia mater, around the spinal cord and the high cervical cord.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">2,14</span></a> However, it is possible for the primary melanoma to arise from heterotopic masses of melanocytes in the central nervous system.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">2</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Several theories have been proposed, such as: (1) Mesodermal theory, stating that the cell pigment arises from the mesoderm and reaches the brain or spine through pial blood vessels. (2) Ectodermal theory, where only epithelial cells can produce pigment; therefore, the primary malignant melanoma of the central nervous system derive from aberrant embrionary ectodermal cells. (3) Neurogenic theory: pigmented cells are derived from the neural crest and may cause tumours.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">3</span></a> Chromosome abnormalities have also been reported, such as the deletion or rupture in the long and short arm of chromosome 6, with a potential loss in the function of tumour suppressor genes in primary malignant melanoma of the central nervous system,<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">15</span></a> and experimental models have been designed on mice showing the role of oncogenes<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">16,17</span></a> and the appearance of primary malignant melanoma of the central nervous system on mice when the oncogene NRAS is expressed in melanocytes during embryogenesis through an endogenous NRAS promoter.<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">18</span></a> It is known that this oncogene induces proliferation of melanocytes and congenital melanocytic lesions in humans. The acquisition of somatic mutations in the NRAS oncogene in melanocytes of the central nervous system is a risk factor predisposing to primary melanoma of the central nervous system in children.<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">16</span></a> Other somatic mutations, such as that of the GNAQ gen, at codon 209, are frequent events in primary melanocytic neoplasms of the central nervous system, with relevance in the future immunotherapy of these tumours.<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">17</span></a> Histopathology findings commonly found in the primary malignant melanoma of the central nervous system consist of pigmented tumour cells, cytologically atypical, with invasion to the central nervous system, pleomorphic nuclei; these are highly cellular neoplasms, organised in a syncytial pattern, epithelial, or irregular conglomerates of pigmented cells with leptomeningeal infiltration.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> However, a discouraging prognosis has been observed when these lesions are large, indurated, with deep invasion, epithelioid cellular pattern and marked mitotic activity.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">10,19</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The peak of incidence of primary malignant melanoma of the central nervous system is in the fourth and fifth decade of life, and has a preponderance in males.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">2,4</span></a> Presentation symptoms include intracranial hypertension and hydrocephalus (43.2%), focal neurologic deficit due to cerebral and spinal compression effect (34.6%), subarachnoid haemorrhage (17.3%) and convulsions (11.1%). It may be found as solitary or in the context of neurocutaneous melanosis,<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">12,20</span></a> and associations have been described between primary malignant melanoma and giant congenital nevo, although it is rare,<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">21</span></a> and transoperatory findings between leptomeningeal melanosis and primary melanoma of the central nervous system.<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">22</span></a> The beginning of symptoms may be acute, potentially associated to intratumoural haemorrhages, common in this tumour.<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">15</span></a> 70% of these lesions are black as surgical finding.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Typical radiologic characteristics in cranial computed tomography are those of a hyperdense lesion, in images with no contrast material.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">2</span></a> In the magnetic resonance we observe a hyperintense tumour in T1 and hypointense in T2.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">2</span></a> This is due to the paramagnetic effect of stable free radicals of melanin.<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">2,23</span></a> Odd electrons of melanin and protons of water produce a dipole-dipole interaction causing hyperintensity in T1 and hypointensity in T2.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">9</span></a> However, there are variants in relation to these findings: hypointensity in T1 and hyperintensity in T2, predominantly found in tumours with less than 10% of melanin in its cells,<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">23</span></a> and in tumours with intralesional haemorrhage.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">4</span></a> The only imaging sign for diagnosis is leptomeningeal dissemination.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">2</span></a> Other primary tumours must be taken into consideration in the differential diagnosis with the primary malignant melanoma of the central nervous system, such as meningioma, meduloblastoma, astrocytoma, melanotic schwannoma, pituitary tumours, choroid plexum papillomas.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">2</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">There is much controversy if upon diagnosis of a melanoma this is primary of the central nervous system or metastatic; however, Hayward<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">24</span></a> proposed in 1976 the following classifications: (1) Primary malignant melanoma of the central nervous system. (2) Secondary malignant melanoma of the central nervous system. (3) Variants of other intracranial tumours with melanin. For the purposes of classifying these tumours, the factors to look for are as follows: (a) with no finding of malignant melanoma outside the central nervous system; (b) cranial or spinal leptomeninges taken by the tumour; (c) intramedullary spinal lesions; (d) hydrocephalus; (e) tumour in the pineal or pituitary gland, and (f) solitary cerebral lesion.<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">24</span></a> These criteria are still relevant and used currently, because the immunohistochemical diagnosis or differential histological diagnosis between the primary and secondary malignant melanoma of the central nervous system is difficult.<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">25</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The final diagnosis has to be performed by a pathologist, taking into consideration the result of immunohistochemical markers used, such as the S100 protein (expressed in cells originated in the neural crest), HMB45 (detected in melanosomas) and Melan.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">2</span></a> Generally this tumour is negative for glial fibrillary acidic protein (GFAP) and epithelial membrane antigen (EMA).<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">26</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Surgical treatment is the main option.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">2</span></a> The use of combined chemotherapy, such as decarbazine together with 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl) 3-nitrosourea hydrochloride (ACNU) and vincristine with OK 432 (picibanil), has proven promising results in neoplasms of metastatic and primary origin.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">2</span></a> In 2011 the FDA approved new medication for malignant metastatic melanoma of the central nervous system; a new immunotherapy with ipilimumab and vemurafenib, blocker of mitogen-activated protein (MAP) kinase,<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">27</span></a> which may be used in cerebral primary malignant melanoma; however, there are still no clinical trials or clinical evidence to support its use as a sole therapy. Most authors agree that there is no defined therapy standard, and the efficacy of radiotherapy and chemotherapy on cerebral primary malignant melanoma is still controversial.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">28</span></a> The prognosis of cerebral primary malignant melanoma is better than that of metastatic malignant melanoma, especially with full resection,<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a> since, despite the aggressive multimodal management, in cerebral secondary malignant melanoma a survival of 3–6 months is reported,<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">15</span></a> compared to that of patients with diagnosis of solitary primary malignant melanoma of the central nervous system, which is 20.7 months.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conclusion</span><p id="par0075" class="elsevierStylePara elsevierViewall">The diagnosis of primary malignant melanoma of the central nervous system is a diagnosis by exclusion. However, it represents a challenge, since it first has to be suspected, and then try to exclude primary melanotic lesions with higher incidence and prevalence. The difficulty in establishing this diagnosis is secondary to the variants of behaviour presented in imaging studies of this tumour. In the case we presented, an intraventricular meningioma was suspected, and the signs observed in the magnetic resonance were not taken into consideration, in accordance with the malanotic pattern of iso/hyperintensity in T1 and hypointensity in T2.</p><p id="par0080" class="elsevierStylePara elsevierViewall">The extremely low incidence of this tumour has not allowed the development of management and diagnostic guidelines; therefore, the prognosis is still discouraging in general, only supported by the fact of a resection as extensive as possible of the lesion. It is necessary to perform a deep study of the genesis of primary melanoma of the central nervous system in order to use specific therapeutic approaches with immunotherapy, chemotherapy and radiotherapy. Further, the differential diagnosis between primary and metastatic malignant melanoma of the central nervous system continues to be complex. Hayward's criteria are used to perform the differential diagnosis between these two diseases.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">28</span></a> An extracranial lesion has to be ruled out scrupulously before making a diagnosis of primary melanoma of the central nervous system.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflict of interest</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that there are no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres566959" "titulo" => "Abstract" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Clinical case" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec584403" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres566958" "titulo" => "Resumen" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0020" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Caso clínico" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec584404" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Background" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Clinical case" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conclusion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflict of interest" ] 9 => array:2 [ "identificador" => "xack191430" "titulo" => "Acknowledgements" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2013-10-22" "fechaAceptado" => "2014-02-18" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec584403" "palabras" => array:4 [ 0 => "Primary malignant melanoma" 1 => "Central nervous system" 2 => "Melanoma" 3 => "Tumour" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec584404" "palabras" => array:4 [ 0 => "Melanoma maligno primario" 1 => "Sistema nervioso central" 2 => "Melanoma" 3 => "Tumor" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The rare incidence of primary malignant melanoma of the central nervous system and its ability to mimic other melanocytic tumours on images make it a diagnostic challenge for the neurosurgeon.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Clinical case</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A 51-year-old patient, with a tumour located in the right forniceal callosum area. Total surgical excision was performed. Histopathological result was consistent with the diagnosis of primary malignant melanoma of the central nervous system, after ruling out extracranial and extraspinal melanocytic lesions.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conclusions</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The primary malignant melanoma of the central nervous system is extremely rare. There are features in magnetic resonance imaging that increase the diagnostic suspicion; nevertheless there are other tumours with more prevalence that share some of these features through image. Since there is not an established therapeutic standard its prognosis is discouraging.</p></span>" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Clinical case" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Antecedentes</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La rara incidencia del melanoma maligno primario del sistema nervioso central y su capacidad de mimetizar por imagen otros tumores melanocíticos lo hacen ser un reto diagnóstico para el neurocirujano.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Caso clínico</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Presentamos el caso de una paciente femenina de 51 años de edad, con un tumor localizado en el área calloso forniceal derecha. Se realizó exéresis quirúrgica total, y el resultado histopatológico fue compatible con el diagnóstico de melanoma maligno primario del sistema nervioso central, habiéndose descartado lesiones extracraneales y extrarraquídeas mucotegumentarias melanocíticas.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusiones</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El melanoma maligno primario del sistema nervioso central es extremadamente raro. Existen características en imagen de resonancia magnética que incrementan la sospecha diagnóstica. Sin embargo, hay otros tumores más prevalentes que comparten algunas de esas características por imagen. No hay un estándar terapéutico establecido. Su pronóstico es desalentador.</p></span>" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0020" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Caso clínico" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Quillo-Olvera J, Uribe-Olalde JS, Alcántara-Gómez LA, Rejón-Pérez JD, Palomera-Gómez HG. Melanoma maligno primario del sistema nervioso central: un reto diagnóstico. Cir Cir. 2015; 83: 129–134.</p>" ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1000 "Ancho" => 850 "Tamanyo" => 69023 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Simple cranium axial tomography.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1011 "Ancho" => 900 "Tamanyo" => 91609 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Simple axial T1 magnetic resonance image.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1039 "Ancho" => 900 "Tamanyo" => 117108 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Hypointense lesion in axial T2 magnetic resonance.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1371 "Ancho" => 1583 "Tamanyo" => 418350 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">“Black” colour tumour, through transcortical access, highly vascularised, intraaxial.</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1418 "Ancho" => 950 "Tamanyo" => 191151 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Nests of epithelioid cells, with cytoplasmic melanin, pleomorphic nuclei and prominent nucleoli, with atypical mitotic figures.</p>" ] ] 5 => array:7 [ "identificador" => "fig0030" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 1188 "Ancho" => 1583 "Tamanyo" => 194168 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Epithelioid cell islands are observed, with high melanin content.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib0145" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary melanocytic lesions of the CNS: report of five cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D. Freudenstein" 1 => "A. Wagner" 2 => "A. Bornemann" 3 => "U. Ernemann" 4 => "T. Bauer" 5 => "F. Duffner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-2004-816266" "Revista" => array:6 [ "tituloSerie" => "Zentralbl Neurochir" "fecha" => "2004" "volumen" => "65" "paginaInicial" => "146" "paginaFinal" => "153" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15306980" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0150" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cerebellopontine angle melanoma: a case report and review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Bhandari" 1 => "J. Alapatt" 2 => "A. Govindan" 3 => "T. Sreekumar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5137/1019-5149.JTN.3632-10.2" "Revista" => array:6 [ "tituloSerie" => "Turk Neurosurg" "fecha" => "2012" "volumen" => "22" "paginaInicial" => "469" "paginaFinal" => "474" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22843468" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0155" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primitive cerebral melanoma: case report and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Greco Castro" 1 => "R. Soffietti" 2 => "G.B. Bradac" 3 => "R. Boldorini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Surg Neurol" "fecha" => "2001" "volumen" => "55" "paginaInicial" => "163" "paginaFinal" => "168" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11311915" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0160" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pigmented lesions of the central nervous system: radiologic-pathologic correlation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.B. Smith" 1 => "E.J. Rushing" 2 => "J.G. Smirniotopoulos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/rg.295095109" "Revista" => array:6 [ "tituloSerie" => "Radiographics" "fecha" => "2009" "volumen" => "29" "paginaInicial" => "1503" "paginaFinal" => "1524" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19755608" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0165" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of primary CNS melanoma with neuroimaging" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K.E. Somers" 1 => "J. Almast" 2 => "R.A. Biemiller" 3 => "H.J. Silberstein" 4 => "M.D. Johnson" 5 => "N.A. Mohile" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2012.41.6115" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2013" "volumen" => "31" "paginaInicial" => "e9" "paginaFinal" => "e11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23169522" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0170" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary pineal melanoma presenting with leptomeningeal spreading in a 22-year-old woman: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Azimi" 1 => "H.R. Mohmmadi" 2 => "M. Refiezadeh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1752-1947-6-165" "Revista" => array:5 [ "tituloSerie" => "J Med Case Rep" "fecha" => "2012" "volumen" => "6" "paginaInicial" => "165" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22738318" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0175" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant melanoma of the cerebello-pontine angle region" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.M. Braga" 1 => "O.I. Tella Júnior" 2 => "A. Ferreira" 3 => "C.F. Jordy" ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arq Neuropsiquiatr" "fecha" => "1989" "volumen" => "47" "paginaInicial" => "496" "paginaFinal" => "500" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2634393" "web" => "Medline" ] ] ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "http://www.scielo.br/pdf/anp/v47n4/20.pdf" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0180" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary malignant melanoma of the cerebellopontine angle" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Whinney" 1 => "N. Kitchen" 2 => "T. Revesz" 3 => "G. Brookes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Otol Neurotol" "fecha" => "2001" "volumen" => "22" "paginaInicial" => "218" "paginaFinal" => "222" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11300273" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0185" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imaging features of intraventricular melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Arbelaez" 1 => "M. Castillo" 2 => "D.M. Armao" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Neuroradiol" "fecha" => "1999" "volumen" => "20" "paginaInicial" => "691" "paginaFinal" => "693" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10319983" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0190" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary cerebello-pontine angle malignant melanoma: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Desai" 1 => "K. Dindorkar" 2 => "A. Goel" 3 => "A. Shenoy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurol India" "fecha" => "2001" "volumen" => "49" "paginaInicial" => "200" "paginaFinal" => "202" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11447448" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0195" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary solitary intracranial melanoma in the Sylvian fissure: MR demonstration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N. Kashiwagi" 1 => "N. Hirabuki" 2 => "H. Morino" 3 => "T. Taki" 4 => "W. Yoshida" 5 => "H. Nakamura" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00330-002-1372-8" "Revista" => array:7 [ "tituloSerie" => "Eur Radiol" "fecha" => "2002" "volumen" => "12" "numero" => "Suppl 3" "paginaInicial" => "S7" "paginaFinal" => "S10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12522592" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0200" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary melanocytic neoplasms of the central nervous system" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.V. Liubinas" 1 => "N. Maartens" 2 => "K.J. Drummond" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jocn.2010.01.017" "Revista" => array:6 [ "tituloSerie" => "J Clin Neurosci" "fecha" => "2010" "volumen" => "17" "paginaInicial" => "1227" "paginaFinal" => "1232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20558070" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0205" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Melanoma intraventricular primario" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Avilés-Aguilar" 1 => "A. Ibarra de la Torre" 2 => "M.I. Rivera-Salgado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Neurocien" "fecha" => "2008" "volumen" => "13" "paginaInicial" => "258" "paginaFinal" => "260" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0210" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The diagnostic dilema of primary central nervous system melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T. Wadasadawala" 1 => "S. Trivedi" 2 => "T. Gupta" 3 => "S. Epari" 4 => "R. Jalali" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jocn.2009.12.020" "Revista" => array:6 [ "tituloSerie" => "J Clin Neurosci" "fecha" => "2010" "volumen" => "17" "paginaInicial" => "1014" "paginaFinal" => "1017" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20627582" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0215" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An isochromosome 6p in a primary meningeal malignant melanoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Baudrier-Régnier" 1 => "C. Bodenant" 2 => "F. Proust" 3 => "T. Delangre" 4 => "J. Hemet" 5 => "A. Laquerrière" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Genet Cytogenet" "fecha" => "2000" "volumen" => "119" "paginaInicial" => "80" "paginaFinal" => "82" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10812178" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0220" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Pedersen" 1 => "H.V. Küsters-Vandevelde" 2 => "A. Viros" 3 => "P.J. Groenen" 4 => "B. Sanchez-Laorden" 5 => "J.H. Gilhuis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/2159-8290.CD-12-0464" "Revista" => array:6 [ "tituloSerie" => "Cancer Discov" "fecha" => "2013" "volumen" => "3" "paginaInicial" => "458" "paginaFinal" => "469" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23303902" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0225" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.V.N. Küsters-Vandevelde" 1 => "A. Klaasen" 2 => "B. Küsters" 3 => "P.J. Groenen" 4 => "I.A. van Engen-van Grunsven" 5 => "M.R. van Dijik" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00401-009-0611-3" "Revista" => array:6 [ "tituloSerie" => "Acta Neuropathol" "fecha" => "2009" "volumen" => "119" "paginaInicial" => "317" "paginaFinal" => "323" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19936769" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0230" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A model for primary melanoma of the CNS implicates NRAS" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C.A. Ciarlo" 1 => "L.I. Zon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/2159-8290.CD-13-0076" "Revista" => array:6 [ "tituloSerie" => "Cancer Discov" "fecha" => "2013" "volumen" => "3" "paginaInicial" => "382" "paginaFinal" => "383" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23580282" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0235" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary malignant melanoma of the optic nerve sheath: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Mohindra" 1 => "S. Mohindra" 2 => "A. Dhawan" 3 => "U. Saikia" 4 => "R.S. Mankoo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.surneu.2007.08.039" "Revista" => array:6 [ "tituloSerie" => "Surg Neurol" "fecha" => "2009" "volumen" => "71" "paginaInicial" => "372" "paginaFinal" => "375" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18207503" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0240" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary temporal melanoma without diffuse leptomeningeal involvement: a variant of neurocutaneous melanosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F.F. Eaves 3rd" 1 => "F.D. Burstein" 2 => "R. Hudgins" 3 => "S.R. Cohen" 4 => "M. Papciack" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Plast Reconstr Surg" "fecha" => "1995" "volumen" => "95" "paginaInicial" => "133" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7809226" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0245" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary central nervous malignant melanoma in the bathing trunk naevus syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.R. Salisbury" 1 => "P.E. Rose" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Postgrad Med J" "fecha" => "1989" "volumen" => "65" "paginaInicial" => "387" "paginaFinal" => "389" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2608580" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0250" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary intracranial malignant melanoma envolving from leptomeningeal melanosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y.J. Son" 1 => "K.C. Wang" 2 => "S.K. Kim" 3 => "B.K. Cho" 4 => "J.G. Chi" 5 => "Y.M. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Pediatr Oncol" "fecha" => "2003" "volumen" => "40" "paginaInicial" => "201" "paginaFinal" => "204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12518356" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0255" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary pineal malignant melanoma: case report and literature review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Arantes" 1 => "A.F. Castro" 2 => "H. Romão" 3 => "P. Meireles" 4 => "R. Garcia" 5 => "M. Honavar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clineuro.2010.08.003" "Revista" => array:6 [ "tituloSerie" => "Clin Neurol Neurosurg" "fecha" => "2011" "volumen" => "113" "paginaInicial" => "59" "paginaFinal" => "64" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20869806" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0260" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant melanoma and the central nervous system. A guide for classification based on the clinical findings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.D. Hayward" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "1976" "volumen" => "39" "paginaInicial" => "526" "paginaFinal" => "530" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/950562" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0265" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary malignant melanoma of the cerebellopontine angle: a diagnostic dilemma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.O. Oluigbo" 1 => "S.R. Cooke" 2 => "P.A. Flynn" 3 => "K.A. Choudhari" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1227/01.NEU.0000245613.86484.36" "Revista" => array:5 [ "tituloSerie" => "Neurosurgery" "fecha" => "2006" "volumen" => "59" "paginaInicial" => "E1336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17277669" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0270" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary malignant melanoma in the pineal region treated without chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Shinsato" 1 => "T. Hanada" 2 => "T. Kisanuki" 3 => "H. Yonezawa" 4 => "S. Yunoue" 5 => "T. Yoshioka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/2152-7806.102348" "Revista" => array:6 [ "tituloSerie" => "Surg Neurol Int" "fecha" => "2012" "volumen" => "3" "paginaInicial" => "123" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23226609" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0275" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastatic melanoma to the brain: surgery and radiation is still the standard of care" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Nicholas" 1 => "D. Mathios" 2 => "C. Jackson" 3 => "M. Lim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11864-013-0228-6" "Revista" => array:6 [ "tituloSerie" => "Curr Treat Options Oncol" "fecha" => "2013" "volumen" => "14" "paginaInicial" => "264" "paginaFinal" => "279" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23504304" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0280" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary central nervous system malignant melanoma: report of 5 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Mekni" 1 => "E. Braham" 2 => "K. Nouira" 3 => "K. Ben Hammouda" 4 => "K. Bellil" 5 => "S. Haouet" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pathologica" "fecha" => "2007" "volumen" => "99" "paginaInicial" => "71" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17987726" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack191430" "titulo" => "Acknowledgements" "texto" => "<p id="par0090" class="elsevierStylePara elsevierViewall">We thank Doctors Ernesto Gómez Limón and Eduardo Zambrano Velarde, both affiliated to the neurosurgery service, for their guidance and opinion which were very important to prepare this article.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/24440507/0000008300000002/v1_201510070233/S2444050715000340/v1_201510070233/en/main.assets" "Apartado" => array:4 [ "identificador" => "44602" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Clinical Cases" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/24440507/0000008300000002/v1_201510070233/S2444050715000340/v1_201510070233/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444050715000340?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 2 | 0 | 2 |
2024 October | 46 | 2 | 48 |
2024 September | 41 | 14 | 55 |
2024 August | 34 | 4 | 38 |
2024 July | 41 | 13 | 54 |
2024 June | 37 | 8 | 45 |
2024 May | 26 | 8 | 34 |
2024 April | 44 | 10 | 54 |
2024 March | 101 | 11 | 112 |
2024 February | 77 | 4 | 81 |
2024 January | 74 | 5 | 79 |
2023 December | 78 | 12 | 90 |
2023 November | 60 | 9 | 69 |
2023 October | 72 | 22 | 94 |
2023 September | 36 | 10 | 46 |
2023 August | 34 | 11 | 45 |
2023 July | 15 | 8 | 23 |
2023 June | 52 | 9 | 61 |
2023 May | 72 | 4 | 76 |
2023 April | 76 | 8 | 84 |
2023 March | 76 | 3 | 79 |
2023 February | 38 | 5 | 43 |
2023 January | 30 | 5 | 35 |
2022 December | 35 | 6 | 41 |
2022 November | 45 | 14 | 59 |
2022 October | 43 | 11 | 54 |
2022 September | 33 | 10 | 43 |
2022 August | 31 | 8 | 39 |
2022 July | 30 | 7 | 37 |
2022 June | 37 | 7 | 44 |
2022 May | 49 | 12 | 61 |
2022 April | 83 | 3 | 86 |
2022 March | 166 | 13 | 179 |
2022 February | 129 | 12 | 141 |
2022 January | 102 | 10 | 112 |
2021 December | 53 | 9 | 62 |
2021 November | 83 | 5 | 88 |
2021 October | 43 | 17 | 60 |
2021 September | 33 | 10 | 43 |
2021 August | 37 | 8 | 45 |
2021 July | 35 | 15 | 50 |
2021 June | 31 | 14 | 45 |
2021 May | 36 | 5 | 41 |
2021 April | 93 | 25 | 118 |
2021 March | 31 | 14 | 45 |
2021 February | 32 | 11 | 43 |
2021 January | 27 | 10 | 37 |
2020 December | 32 | 15 | 47 |
2020 November | 27 | 5 | 32 |
2020 October | 21 | 8 | 29 |
2020 September | 22 | 14 | 36 |
2020 August | 43 | 9 | 52 |
2020 July | 33 | 10 | 43 |
2020 June | 20 | 2 | 22 |
2020 May | 32 | 8 | 40 |
2020 April | 22 | 5 | 27 |
2020 March | 22 | 8 | 30 |
2020 February | 18 | 5 | 23 |
2020 January | 20 | 6 | 26 |
2019 December | 29 | 7 | 36 |
2019 November | 19 | 8 | 27 |
2019 October | 15 | 3 | 18 |
2019 September | 28 | 3 | 31 |
2019 August | 18 | 6 | 24 |
2019 July | 30 | 14 | 44 |
2019 June | 50 | 19 | 69 |
2019 May | 81 | 49 | 130 |
2019 April | 50 | 27 | 77 |
2019 March | 18 | 7 | 25 |
2019 February | 27 | 4 | 31 |
2019 January | 18 | 10 | 28 |
2018 December | 23 | 10 | 33 |
2018 November | 21 | 1 | 22 |
2018 October | 28 | 6 | 34 |
2018 September | 38 | 6 | 44 |
2018 August | 19 | 10 | 29 |
2018 July | 16 | 2 | 18 |
2018 June | 25 | 5 | 30 |
2018 May | 13 | 6 | 19 |
2018 April | 31 | 0 | 31 |
2018 March | 26 | 7 | 33 |
2018 February | 14 | 2 | 16 |
2018 January | 22 | 0 | 22 |
2017 December | 21 | 0 | 21 |
2017 November | 32 | 1 | 33 |
2017 October | 11 | 4 | 15 |
2017 September | 18 | 5 | 23 |
2017 August | 22 | 6 | 28 |
2017 July | 26 | 9 | 35 |
2017 June | 43 | 14 | 57 |
2017 May | 52 | 2 | 54 |
2017 April | 137 | 19 | 156 |
2017 March | 52 | 71 | 123 |
2017 February | 18 | 7 | 25 |
2017 January | 30 | 2 | 32 |
2016 December | 26 | 3 | 29 |
2016 November | 40 | 8 | 48 |
2016 October | 31 | 9 | 40 |
2016 September | 34 | 6 | 40 |
2016 August | 19 | 3 | 22 |
2016 July | 35 | 6 | 41 |
2016 June | 33 | 5 | 38 |
2016 May | 30 | 29 | 59 |
2016 April | 24 | 9 | 33 |
2016 March | 26 | 6 | 32 |
2016 February | 24 | 10 | 34 |
2016 January | 21 | 6 | 27 |
2015 December | 10 | 6 | 16 |
2015 November | 10 | 8 | 18 |
2015 October | 28 | 16 | 44 |