Corresponding author at: Eje 2A Sur (Dr. Balmis) No. 148, Cuauhtémoc, Doctores, C.P. 06726 México, D.F., Mexico. Tel.: +52 (55) 2789 2000.
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Tel.: +52 (55) 2789 2000." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Características clínicas del estrabismo en retraso psicomotor" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 887 "Ancho" => 1577 "Tamanyo" => 72049 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Refractive defect and type of strabismus</p> <p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">ET: esotropia; XT: exotropia; H: hypermetropia; CHA: compound hypermetropic astigmatism; SHA: simple hypermetropic astigmatism; M: myopia; CMA: compound myopic astigmatism; SMA: simple myopic astigmatism; MXA: mixed astigmatism.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Background</span><p id="par0005" class="elsevierStylePara elsevierViewall">The development of the brain and that of the eye are closely related, at both a morphological and molecular level. Therefore some eye disorders are accompanied by malformations of the central nervous system.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Psychomotor development is a dynamic and complex process which involves interrelated biological, psychological and social aspects, and is the basis of children's motor, intellectual, and subsequent relational skills.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> Psychomotor retardation is the abnormal development of an individual's mental, sensory or motor skills, and an alteration in the development of their skills, with an imbalance in the integrity of the central nervous and peripheral system, which means that the achievements of a paediatric patient appear in slow sequence or qualitatively altered for their age, especially in the first years of life, considered the plastic age in general neurological function.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">There are several elements which can alter a child's development in the first 3 years of life.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">3,4</span></a> According to Sweeney and Swanson,<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a> the risk factors associated with delayed psychomotor development can be biological (prenatal, natal and postnatal), psychosocial or environmental<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">4,5</span></a> (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The World Health Organisation considers that the frequency of high-risk pregnancies affects 3–5% of neonates.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> The high neurological risk in children is a public health problem in Mexico, and currently it is estimated that 7–8% of all live newborns are born prematurely (under 37 weeks), and that 1–2% are born weighing under 1500<span class="elsevierStyleHsp" style=""></span>g<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> and these children are more likely to develop motor problems because their nervous system is immature which makes it more susceptible to injuries to the motor system which is so fragile and vulnerable. It has been observed that the larger the injured area, the greater the motor impairment, and therefore, the damage to other neurological functions.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Cerebral palsy, defined as impaired control of movements and posture, is of early onset, secondary to central nervous system disease or dysfunction not resulting from progressive or degenerative brain disease. From 30% to 50% of patients with cerebral palsy have psychomotor retardation.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> They can present sensory deficits (atrophy of the optic nerve, deafness, lack of development of the visual cortex). From 50% to 90% of patients with cerebral palsy present neurological impairment, amblyopia, refractive errors, congenital cataracts, impaired ocular mobility; the latter include strabismus, oculomotor palsy, nystagmus, gaze palsy, and other supranuclear disorders.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Neurological disorders and psychomotor retardment are associated with strabismus in 50–80% of cases. The characteristics of this type of strabismus are generally similar to those of other types of strabismums in normal children, but a small percentage have differences which are sufficient to distinguish them. Children with neurological disorders, with horizontal type strabismus, have a high prevalence of constant exotropia and hyperfunction of the superior oblique muscles compared to healthy strabic children.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> The strabismus is usually horizontal and not paralytic. They commonly present vertical incomitance, with alphabetic syndrome “A”. Some studies show that esotropia is the most common type, however, in other studies, exotropia dominates.</p><p id="par0035" class="elsevierStylePara elsevierViewall">It has been demonstrated that variability is closely related to neurological instability and poor binocular vision, and that variable deviation is characteristic of patients with brain damage. Retardment is a major factor in the inadequate development of the binocular integration centres of the cortex, which is represented by the low fusion potential in these patients. This is probably one of the main causes of the high frequency of association with strabism. This variable or dyskinetic angle strabismus is very common and is characterised by ocular deviation, which goes from esotropia to exotropia; however, most are not associated with the accommodative reflex or attention.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The neurological status of these patients limits surgical treatment, and because it has comorbidity factors, this option is delayed. It is postponed in order not to interfere with neurological management, in order to avoid exposing the patient to deep general anaesthesia, and due to the association with other systemic disorders. Furthermore, it is not indicated as a first option for these patients, as patients with psychomotor retardment have an uncertain prognosis due to the greater presence of recurrent or consecutive strabismus. The reason for these poor results might be associated with a basic defect of binocular vision or to general muscle tone impairment.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Given the above, a study was undertaken to establish the most frequent type of strabismus and its characteristics, and establish the treatment prognosis for these types of patients.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material and methods</span><p id="par0050" class="elsevierStylePara elsevierViewall">A prospective, cross-sectional, descriptive and observational study was undertaken, in order to establish the type of strabismus and its characteristics in patients with psychomotor retardment, and the risk factors for developing the latter.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Patient with psychomotor retardment and strabismus of any age and sex, attending the Paediatric Ophthalmology and Strabismus clinic of the <span class="elsevierStyleItalic">Hospital General de México</span> for general consultation during the period between 15 March and 15 October 2012. Patients who were outside the enrolment range, patients with secondary strabismus and those who did not cooperate on strabological examination were excluded from the study.</p><p id="par0060" class="elsevierStylePara elsevierViewall">The following variables were analysed: age, gender, perinatal history divided into (<span class="elsevierStyleItalic">a</span>) prenatal (conception period [18–35]), course of pregnancy, perinatal control, vaginal or urinary tract infections; (<span class="elsevierStyleItalic">b</span>) natal: method of delivery, foetal distress, neonatal asphyxia, need for mechanical ventilation, hyperbilirubinaemia, gestational age and, birth weight; and (<span class="elsevierStyleItalic">c</span>) postnatal: seizures, meningitis, cranioencephalic trauma, and hydrocephalus. A full ophthalmological examination was performed. The following were analysed as strabological variables: type of strabismus (esotropia, exotropia), presence or otherwise of associated dissociated strabismus, presence or otherwise of vertical muscle hyperfunction, measurement of variability of deviation magnitude, and associated refractive defect.</p><p id="par0065" class="elsevierStylePara elsevierViewall">The data obtained were analysed by means of descriptive statistics, measured in percentages to evaluate frequencies.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0070" class="elsevierStylePara elsevierViewall">There were 49 patients with psychomotor retardment and strabismus, 53.1% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>26) were female and 46.9% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>23) male. Of the patients captured, 8 were placed in the age range newborn to one year of age, 30 were aged over one up to the age of 10, 10 were aged over 10 up to the age of 17, and there was only one adult patient.</p><p id="par0075" class="elsevierStylePara elsevierViewall">From the age of 18–35 was considered an appropriate conception period, pregnancies in women under or over this age being considered as high risk. It was found that 28.6% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>14) of the mothers were adolescents; most of the mothers, 53.1% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>26), had their children in an appropriate conception period, and 18.3% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>9) had them over the age of 35. The number of pregnancies of each patient was investigated and it was found that 20 patients were primigravida, 23 were multiparous, and only 6 were highly multiparous (having had 5 or more births).</p><p id="par0080" class="elsevierStylePara elsevierViewall">The most frequent deviation found was esotropia in 65.3% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>32), followed by exotropia at 32.7% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>16), and only 2% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1) presented nystagmus with no deviation towards the forehead. Of the patients with esotropia, 22 (68.75%) presented a variation in the magnitude of deviation, which varied from small (<<span class="elsevierStyleHsp" style=""></span>15 prismatic diopters [PD]) 31.8%, medium (16–45 PD) 59.1%, and large endotrophies (> 45 PD) 9.1%. It was found that 62.5% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>10) of the exotrophies had variability, small in 20%, and medium in 80% (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Only 4 patients with esotropia, and only 2 of the patients with exotropia presented dissociated vertical deviation. Another 3 patients had esotropia with inferior oblique muscle hyperfunction, of the 4 patients with exotropia, 2 had hyperfunction of both inferior oblique muscles and one of the superior oblique muscle. The mothers reported that 63% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>31) started to deviate from birth, 22.45% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>11) from 3 months to one year old, and 14.3% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>7) over the age of one. The type of refractive defect was investigated (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) for each type of deviation. The positive sphere range was +0.25 to +8.00, negative sphere from −1.00 to −3.00, and cylinder from −0.50 to −6.00.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">The following risk factors reported in the sample were as follows: with regard to gestational age, 55.1% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>27) were delivered at term, 40.8% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>20) were premature, and 4.1% post-term. The perinatal history was divided as follows: (<span class="elsevierStyleItalic">A</span>) prenatal: where it was found that 34.7% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>17) of the mothers presented urinary tract or vaginal infection, 22.4% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>11) threatened miscarriage, 10.2% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5) pre-eclampsia, and the remaining 32.4% did not specify the cause of their “abnormal” pregnancy. (<span class="elsevierStyleItalic">B</span>) Natal history: 22.4% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>11) had foetal distress, 40.8% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>20) neonatal asphyxia, 20.4% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>10) hyperbilirubinaemia, the remaining 16.4% of mothers did not know the birth conditions. And finally, (<span class="elsevierStyleItalic">C</span>) postnatal history: where 28.5% (14 patients) presented seizures, these were patients with exotropia in the majority (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">The reason for undertaking this study was to better establish the characteristics of strabismus which presents in children with psychomotor retardment, and thus establish a prognosis and find the most appropriate treatment for these patients. Understanding the development of the child from any area: cognitive, affective, motor or social, invariably brings us to its beginnings. Therefore, many studies have made it their objective to search for relationships between diseases of the newborn infant and their sequelae.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">There is no difference between genders in this study; the percentage was similar in females (54.5%), and males (45.5%). In terms of age range, most of the patients studied were aged between one and 10, and this was probably due to the age of diagnosis or confirmation of the psychomotor retardment or the neurological impairment, which was diagnosed in the majority over the age of one, this being the time that paediatricians undertake a full assessment, and then refer the patient to the appropriate department according to the problem that needs to be treated.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Esotropia was the most common type of strabismus at 65.3%, in the study sample, and the remaining 32.7% had exotropia. As mentioned in other studies, variability in magnitude of deviation is characteristic of strabismus in psychomotor retardment, especially esotropia. Variation is 10 PD or more from one moment to the next and can last from seconds to days. In general there is no alteration of the ductions, which is consistent with the study; 100% of the patients had no limitation of movement. From 50% to 80% of strabismus are related to psychomotor retardation; it is believed that 35% present variability, and that 50% of this variability corresponds to variable angle esotropia.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a> According to Díaz et al.,<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a> variability of medium magnitude (16–45 PD) is more common. Here variabilities of esotropia were analysed, medium esotropia presented in 70.45%, followed by small, and finally large esotropia. In our study similar results were obtained with a medium variable in 59.1%, small in 31.8% and large in 9–1%.</p><p id="par0105" class="elsevierStylePara elsevierViewall">Brodsky<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> mentions that children with neurological damage have a higher incidence of constant exotropia with superior oblique muscle hyperfunction, compared with strabic children without neurological damage. In this study a different percentage was encountered, as 62.5% of the exotropias presented variability, medium exotropia being the most common in 80%, and small in 20%. With regard to vertical muscle hyperfunction, only 2 patients had hyperfunction of the superior oblique muscles and 2 of the inferior oblique muscles, and therefore this is not a significant percentage.</p><p id="par0110" class="elsevierStylePara elsevierViewall">With regard to refractive defects in these patients, in line with other authors, most had a tendency towards hypermetropia, the maximum sphere being +8.00 in one patient; in addition to hypermetropia, the relationship with stigmatism was also significant: it was found that the most negative cylinder was −4.00. It is important to mention that in the esotropias compound hypermetropic astigmatism presented more frequently, whereas this was compound myopic astigmatism in the exotropias.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">12,13</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">It is mentioned that parity is associated with toxaemia or pre-eclampsia in pregnancy. Primiparous women are at most risk, 4–5 times higher than multiparous women. This data was corroborated in the study since 25% of the primigravidas (20 mothers) had pre-eclampsia; in this sample none of the multiparous women had pre-eclampsia.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> The percentage of mothers of the appropriate age for conception and giving birth (18–35) was 53.1%, followed by adolescent mothers (<<span class="elsevierStyleHsp" style=""></span>18) at 28.6%. This data draws attention as in previous studies it has been found that adolescent mothers are more at risk of difficult labours, premature births, and foetal distress.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Sánchez et al.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> performed a study with 307 patients and found that the main causes of neurological damage, in descending order were: neonatal asphyxia (53.7%), hyperbilirubinaemia (22.14%), foetal distress (18.24%), threatened miscarriage (11.7%), urinary tract infection (11.4%) and pre-eclampsia (9.7%). However in our study we only agree that neonatal asphyxia is the most common cause at 40.8%, followed by urinary tract infection at 34.7%, seizures 28.5%, foetal distress 22.4%, hyperbilirubinaemia 20.4%, and finally pre-eclampsia at 10.2%. Foetal distress encompasses perinatal asphyxia, which develops in utero, and neonatal asphyxia, which presents at birth, and is confirmed by metabolic alterations. It is one of the main causes of perinatal morbimortality with a frequency of 1.6–5.3 per hundred live newborns. The incidence of this condition varies with the gestational age, at 0.5% in infants born at term which contrasts with the 50% in infants born after less than 30 weeks gestation. However, in our sample there was no difference between the gestational ages.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> In their review, Castellanos et al.,<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> mention that around 4 in every 10 (43%) infants with a history of neurological risk, even if they had perinatal asphyxia, might have a neurological injury; 28% of our sample did not have a history of risk.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conclusions</span><p id="par0125" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0130" class="elsevierStylePara elsevierViewall">Esotropia is the most common type of strabismus in psychomotor retardation.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0135" class="elsevierStylePara elsevierViewall">Variability of the magnitude of deviation is a characteristic of strabismus in patients with psychomotor retardation.</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0140" class="elsevierStylePara elsevierViewall">Medium variability is the most frequent both in esotropias and in exotropias.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0145" class="elsevierStylePara elsevierViewall">The most common refractive defect is compound hypermetropic astigmatism in esotropias and myopic in exotropias.</p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of interests</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres611338" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Material and methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec625366" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres611337" "titulo" => "Resumen" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivo" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Material y métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec625365" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Background" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Material and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conclusions" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interests" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-01-18" "fechaAceptado" => "2015-05-14" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec625366" "palabras" => array:3 [ 0 => "Strabismus" 1 => "Psychomotor disorder" 2 => "Risk factors" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec625365" "palabras" => array:3 [ 0 => "Estrabismo" 1 => "Trastornos psicomotores" 2 => "Factores de riesgo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">In psychomotor retardation there is an abnormal development of mental, sensory and motor skills associated with ocular manifestations. There are biological and psychosocial risk factors that predispose an individual to neurological damage. From 50% to 80% of patients with strabismus retardation have special features that differentiate it from the rest of strabismus in healthy patients.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine the most common type of strabismus in patients with psychomotor retardation and their clinical features.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Patients with psychomotor retardation and strabismus were included. An ophthalmological examination was performed, as well as an evaluation of the characteristics of strabismus, including perinatal and post-natal history.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Esotropia was the most frequent squint with 65.3%, followed by exotropia with 32.7%. The variability in the squint magnitude was 60% in both types, and 6 patients had dissociated vertical deviation. Most of the patients started to present strabismus since they were born. The most frequent perinatal risk factors were threatened miscarriage, pre-eclampsia, foetal distress, and hypoxia.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Esotropia is the most common type of strabismus in psychomotor retardation. The variability of squint magnitude is a characteristic in these patients. The moderate variability is the most frequent in both esotropia and exotropia. The most common refractive error is hyperopic astigmatism in esotropia and the myopic kind in exotropia.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objective" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Material and methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Antecedentes</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En el retraso psicomotor hay desarrollo anormal de capacidades mentales, sensoriales o motoras, que se asocian con manifestaciones oculares. Existen factores de riesgo biológicos y psicosociales que predisponen a un individuo a daño neurológico. Del 50 al 80% de los pacientes con retraso psicomotor tienen estrabismo con características especiales, que lo diferencian del resto de los estrabismos en pacientes sanos.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Conocer el tipo más común de estrabismo en pacientes con retraso psicomotor, así como, sus características clínicas.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material y métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se incluyó a pacientes con retraso psicomotor y estrabismo. Se realizó exploración oftalmológica completa, valoración de las características del estrabismo y se indagó acerca de antecedentes perinatales y posnatales.</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La desviación más frecuente fue la endotropia con un 65.3%, seguida de la exotropia con 32.7%. La variabilidad de la magnitud de la desviación fue aproximadamente del 60% para ambos tipos de desviación; 6 pacientes presentaron desviación vertical disociada. La mayoría de los pacientes comenzaron a desviar desde el nacimiento. Como antecedente de importancia, los factores de riesgo perinatales más frecuentes fueron amenaza de aborto, preeclampsia, sufrimiento fetal y, asfixia neonatal.</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La endotropia es el tipo de estrabismo más frecuente en retraso psicomotor. La variabilidad de la magnitud de desviación es una característica del estrabismo en pacientes con retraso psicomotor. La variabilidad mediana es la más frecuente tanto en endotropias como en exotropias. El defecto refractivo más frecuente es el astigmatismo hipermetrópico compuesto en endotropias y miópico en exotropias.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivo" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Material y métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Arias-Cabello B, Arroyo-Yllanes ME, Pérez-Pérez JF, Fonte-Vázquez A. Características clínicas del estrabismo en retraso psicomotor. Cirugía y Cirujanos. 2016;84:9–14.</p>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 882 "Ancho" => 1470 "Tamanyo" => 88177 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Estrabismus and variability.</p> <p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">PD: prismatic diopters; ET: esotropia; XT: exotropia.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 887 "Ancho" => 1577 "Tamanyo" => 72049 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Refractive defect and type of strabismus</p> <p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">ET: esotropia; XT: exotropia; H: hypermetropia; CHA: compound hypermetropic astigmatism; SHA: simple hypermetropic astigmatism; M: myopia; CMA: compound myopic astigmatism; SMA: simple myopic astigmatism; MXA: mixed astigmatism.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 747 "Ancho" => 1579 "Tamanyo" => 45598 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Perinatal risk factors (prenatal, natal, postnatal).</p> <p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">UTI: urinary tract infection; TM: threatened miscarriage; Preec: pre-eclampsia; FD: foetal distress; NA: neonatal asphyxia; Hbil: hyperbilirubinaemia; S: seizures.</p>" ] ] 3 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:2 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Biological risks \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">• 1500<span class="elsevierStyleHsp" style=""></span>g or <<span class="elsevierStyleHsp" style=""></span>32 weeks of gestation• Infant of low birth weight for gestational age• Prenatal infection• Perinatal asphyxia• Mechanical ventilation for more than 24<span class="elsevierStyleHsp" style=""></span>h• Neonatal seizures• Postnatal sepsis, meningitis or encephalitis postnatal• Clinical or neuroimaging evidence of central nervous system disease which might affect development• Hyperbilirubinaemia which required exanguinotransfusion• Genetic, dysmorphic or metabolic disorders• Malformative syndrome with visual or hearing impairment• Inadequate nutrition \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1001501.png" ] ] 1 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Established risk \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Environmental risk \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">• Hydrocephalus• Microcephalus• Chromosome abnormalities• Skeletal muscle abnormalities• Multiple births• Myelodysplastic syndromes• Congenital myopathies and myotonic dystrophies• Inborn errors of metabolism• Brachial plexus injuries• HIV infections \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">• Social: single parent, adolescent• Drug addiction, maternal alcoholism• Ecological (lead)• Psychological (deprivation), poverty, no schooling• Parent with a major mental or emotional disorder including: drug addiction, depression and severe anxiety \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1001500.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Risk factors for neurological damage.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0080" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factores de riesgo y signos de alarma para daño neurológico en niños menores de un año de edad. Reporte de 307 casos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.E. Sánchez-Zúñiga" 1 => "G.C. Pérez-Madero" 2 => "M.L. Martín-López" 3 => "J.C. Pérez-Moreno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Mex Neuroci" "fecha" => "2009" "volumen" => "10" "numero" => "4" "paginaInicial" => "259" "paginaFinal" => "263" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0085" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluación y manejo del niño con retraso psicomotor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. Pérez-Olarte" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Integral" "fecha" => "2003" "volumen" => "7" "numero" => "8" "paginaInicial" => "557" "paginaFinal" => "566" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0090" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Terapia visual en niños con retraso psicomotor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Vidal-Pineda" 1 => "N.P. Pérez-García" 2 => "C.A. Hernández-Quezada" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Mex Oftalmol" "fecha" => "2009" "volumen" => "83" "numero" => "2" "paginaInicial" => "90" "paginaFinal" => "95" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0095" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Guías Diagnósticas de Física y Rehabilitación. N.° 8 Retraso psicomotor. Hospital General de México" ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2011" "paginaInicial" => "42" "paginaFinal" => "49" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0100" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neonatal care and follow-up for infants at neuromotor risk" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.K. Sweeney" 1 => "M.W. Swanson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Neurological rehabilitation" "paginaInicial" => "203" "paginaFinal" => "262" "edicion" => "3rd ed." "serieFecha" => "1990" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0105" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morbilidad neonatal en niños con factores de riesgo de daño neurológico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.E. Castellanos-Navarro" 1 => "J. Ruíz-Chávez" 2 => "G. Flores-Nava" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Mex Pediatr" "fecha" => "2010" "volumen" => "77" "numero" => "5" "paginaInicial" => "189" "paginaFinal" => "193" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0110" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A novel pattern of oculocerebral malformation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B.J. Clark" 1 => "W.R. Lee" 2 => "D. Doyle" 3 => "R. Arngrimsson" 4 => "J.L. Tolmie" 5 => "J.B. Stephenson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Br J Ophthal" "fecha" => "1997" "volumen" => "81" "paginaInicial" => "470" "paginaFinal" => "475" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0115" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Complex ocular motor disorder in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.M. Brodsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:6 [ "edicion" => "2nd ed." "titulo" => "Pediatric neuro-ophthalmology" "fecha" => "2010" "paginaInicial" => "309" "paginaFinal" => "311" "editorial" => "Springer Science & Business Media" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0120" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resultados con la aplicación de toxina botulínica en pacientes con endotropia y retraso psicomotor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.E. Arroyo-Yllanes" 1 => "J.F. Pérez-Pérez" 2 => "L. Murillo-Murillo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cir Ciruj" "fecha" => "2009" "volumen" => "77" "numero" => "1" "paginaInicial" => "9" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19228464" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0125" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio del comportamiento neonatal en el sufrimiento fetal agudo mediante la escala de Brazelton" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Jirón-Silva" 1 => "C. Costas-Moragas" 2 => "F. Botet-Mussons" 3 => "M. de Cáceres-Zurita" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "1998" "volumen" => "48" "numero" => "2" "paginaInicial" => "163" "paginaFinal" => "166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9577025" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0130" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endotropia de ángulo variable asociada a retraso psicomotor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Díaz-Castañeda" 1 => "M.C. Fuentes-Cataño" 2 => "J. Villaseñor-Solares" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Mex Oftalmol" "fecha" => "2009" "volumen" => "83" "numero" => "2" "paginaInicial" => "81" "paginaFinal" => "83" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0135" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Refractive errors in children with cerebral palsy, psychomotor retardation, and other non-cerebral palsy neuromotor disabilities" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Sobrado" 1 => "J. Suárez" 2 => "F.A. García-Sánchez" 3 => "E. Usón" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Dev Med Child Neurol" "fecha" => "1999" "volumen" => "41" "numero" => "6" "paginaInicial" => "396" "paginaFinal" => "403" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10400174" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0140" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Profile of refractive errors in cerebral palsy: impact of severity of motor impairment (GMFCS) and CP subtype on refractive outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.J. Saunders" 1 => "J.A. Little" 2 => "J.F. McClelland" 3 => "A.J. Jackson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1167/iovs.09-4670" "Revista" => array:8 [ "tituloSerie" => "Invest Ophthalmol Vis Sci" "fecha" => "2010" "volumen" => "51" "numero" => "6" "paginaInicial" => "2885" "paginaFinal" => "2890" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20107180" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1473309913701154" "estado" => "S300" "issn" => "14733099" ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0145" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factores de riesgo de mortalidad en el hijo de madre toxémica" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Gómez-Gómez" 1 => "C. Danglot-Banck" 2 => "G.S. García-de la Torre" 3 => "A. Antonio-Ocampo" 4 => "A. Fajardo-Gutiérrez" 5 => "M.L. Sánchez-García" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Gac Med Mex" "fecha" => "2004" "volumen" => "140" "numero" => "1" "paginaInicial" => "33" "paginaFinal" => "45" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15022886" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0150" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morbilidad y mortalidad perinatal en el embarazo precoz" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Vázquez-Márquez" 1 => "L.M. Pérez-Llorente" 2 => "C. Guerra-Verdecia" 3 => "Almirall-Chávez ÁM" 4 => "F. de la Cruz-Chávez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Cubana Obstet Ginecol" "fecha" => "1998" "volumen" => "24" "numero" => "3" "paginaInicial" => "137" "paginaFinal" => "144" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/24440507/0000008400000001/v1_201603020024/S2444050715001564/v1_201603020024/en/main.assets" "Apartado" => array:4 [ "identificador" => "44603" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/24440507/0000008400000001/v1_201603020024/S2444050715001564/v1_201603020024/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444050715001564?idApp=UINPBA00004N" ]
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2024 October | 37 | 4 | 41 |
2024 September | 29 | 6 | 35 |
2024 August | 30 | 2 | 32 |
2024 July | 25 | 3 | 28 |
2024 June | 19 | 12 | 31 |
2024 May | 30 | 4 | 34 |
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2023 November | 25 | 4 | 29 |
2023 October | 43 | 8 | 51 |
2023 September | 25 | 2 | 27 |
2023 August | 19 | 7 | 26 |
2023 July | 23 | 4 | 27 |
2023 June | 36 | 1 | 37 |
2023 May | 44 | 3 | 47 |
2023 April | 50 | 4 | 54 |
2023 March | 37 | 7 | 44 |
2023 February | 20 | 3 | 23 |
2023 January | 27 | 1 | 28 |
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2022 November | 31 | 9 | 40 |
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2022 September | 16 | 13 | 29 |
2022 August | 14 | 13 | 27 |
2022 July | 22 | 9 | 31 |
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2021 August | 29 | 7 | 36 |
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2021 April | 54 | 37 | 91 |
2021 March | 33 | 11 | 44 |
2021 February | 15 | 13 | 28 |
2021 January | 17 | 17 | 34 |
2020 December | 29 | 11 | 40 |
2020 November | 13 | 6 | 19 |
2020 October | 14 | 7 | 21 |
2020 September | 14 | 9 | 23 |
2020 August | 14 | 7 | 21 |
2020 July | 12 | 12 | 24 |
2020 June | 16 | 9 | 25 |
2020 May | 11 | 9 | 20 |
2020 April | 10 | 1 | 11 |
2020 March | 13 | 5 | 18 |
2020 February | 8 | 4 | 12 |
2020 January | 17 | 6 | 23 |
2019 December | 12 | 6 | 18 |
2019 November | 12 | 9 | 21 |
2019 October | 7 | 2 | 9 |
2019 September | 15 | 7 | 22 |
2019 August | 8 | 2 | 10 |
2019 July | 16 | 8 | 24 |
2019 June | 33 | 9 | 42 |
2019 May | 105 | 13 | 118 |
2019 April | 59 | 11 | 70 |
2019 March | 8 | 11 | 19 |
2019 February | 22 | 11 | 33 |
2019 January | 8 | 5 | 13 |
2018 December | 15 | 13 | 28 |
2018 November | 6 | 1 | 7 |
2018 October | 19 | 3 | 22 |
2018 September | 35 | 3 | 38 |
2018 August | 11 | 3 | 14 |
2018 July | 2 | 1 | 3 |
2018 June | 8 | 4 | 12 |
2018 May | 3 | 3 | 6 |
2018 April | 2 | 2 | 4 |
2018 March | 1 | 0 | 1 |
2018 February | 1 | 0 | 1 |
2018 January | 2 | 0 | 2 |
2017 November | 4 | 1 | 5 |
2017 October | 5 | 0 | 5 |
2017 September | 4 | 2 | 6 |
2017 August | 10 | 1 | 11 |
2017 July | 5 | 2 | 7 |
2017 June | 14 | 2 | 16 |
2017 May | 17 | 2 | 19 |
2017 April | 18 | 2 | 20 |
2017 March | 8 | 15 | 23 |
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2017 January | 10 | 0 | 10 |
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2016 July | 8 | 3 | 11 |
2016 June | 14 | 7 | 21 |
2016 May | 7 | 12 | 19 |
2016 April | 10 | 16 | 26 |
2016 March | 19 | 18 | 37 |