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Narrative review" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1393 "Ancho" => 900 "Tamanyo" => 251537 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Secciones transversales secuenciales de ADC intramural evolucionado de glándulas anales A) del 1/3 medio del canal anal y cercano a margen radial, y B) de la parte distal del canal anal con infiltración de musculatura perianal.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Manuel Ferrer Márquez, Francisco Javier Velasco Albendea, Ricardo Belda Lozano, María del Mar Berenguel Ibáñez, Ángel Reina Duarte" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Manuel" "apellidos" => "Ferrer Márquez" ] 1 => array:2 [ "nombre" => "Francisco Javier" "apellidos" => "Velasco Albendea" ] 2 => array:2 [ "nombre" => "Ricardo" "apellidos" => "Belda Lozano" ] 3 => array:2 [ "nombre" => "María del Mar" "apellidos" => "Berenguel Ibáñez" ] 4 => array:2 [ "nombre" => "Ángel" "apellidos" => "Reina Duarte" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173507713001671" "doi" => "10.1016/j.cireng.2013.10.017" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173507713001671?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0009739X13000602?idApp=UINPBA00004N" "url" => "/0009739X/0000009100000005/v1_201305021703/S0009739X13000602/v1_201305021703/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173507713001695" "issn" => "21735077" "doi" => "10.1016/j.cireng.2013.10.019" "estado" => "S300" "fechaPublicacion" => "2013-05-01" "aid" => "812" "copyright" => "AEC" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Cir Esp. 2013;91:287-93" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1790 "formatos" => array:3 [ "EPUB" => 12 "HTML" => 1338 "PDF" => 440 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Special Article</span>" "titulo" => "Is the Claiming of Costs Justifiable in Jehovah's Witness Surgical Patients After Healthcare That is not Part of the Public Health System?" 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Narrative Review" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "281" "paginaFinal" => "286" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Manuel Ferrer Márquez, Francisco Javier Velasco Albendea, Ricardo Belda Lozano, María del Mar Berenguel Ibáñez, Ángel Reina Duarte" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Manuel" "apellidos" => "Ferrer Márquez" "email" => array:1 [ 0 => "Manuferrer78@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Francisco Javier" "apellidos" => "Velasco Albendea" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Ricardo" "apellidos" => "Belda Lozano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "María del Mar" "apellidos" => "Berenguel Ibáñez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Ángel" "apellidos" => "Reina Duarte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Cirugía General y del Aparato Digestivo, Hospital Torrecárdenas, Almería, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Torrecárdenas, Almería, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Adenocarcinoma del canal anal. Revisión de conjunto" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 675 "Ancho" => 901 "Tamanyo" => 212948 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Disorganized and infiltrative tubular gland proliferation underlying non-neoplastic squamous anal mucosa on the endoscopic biopsy of an ADC of the anal glands (hematoxylin and eosin ×10).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The anal canal is the terminal part of the large intestine; it is a tubular structure measuring 3–4<span class="elsevierStyleHsp" style=""></span>cm that extends from the perianal skin up to the end of the rectum. The superior portion is covered with rectal mucosa, the middle part (coinciding with the pectineal line) with transitional mucosa and the inferior portion with mucosa with stratified squamous epithelium.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Carcinomas in this region are classified as anal canal cancer and the patterns of differentiation are, mainly, basaloid (basically squamous in nature, similar to its homonym in the upper respiratory/digestive tract), epidermoid, analogous to skin tumors, and those with a line of differentiation toward adenocarcinoma.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The objective of this article is to review the literature on the histopathology, symptoms, diagnosis and treatment of adenocarcinoma of the anal canal.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Methodology</span><p id="par0020" class="elsevierStylePara elsevierViewall">We reviewed the literature published in the MEDLINE/Pubmed and Ovid databases from 1997 to 2012, using the following keywords “anal adenocarcinoma”, “anal neoplasm”, “anal gland carcinoma”, “anal duct carcinoma”, “anal canal”, “immunohistochemistry”, “chemoradiotherapy” and “radical surgery”.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Histopathology</span><p id="par0025" class="elsevierStylePara elsevierViewall">Although the anal canal is short in length, it can present a great variety of tumors, which reflects the anatomic, embryologic and histologic complexities of this structure. Tumor localization and the interpretation of morphologic findings are both controversial and, occasionally, very difficult.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Adenocarcinoma (ADC) of the anal canal is a rare entity. Most cases of ADC have a colorectal phenotype and represent tumors derived from the upper part of the anal canal or cells with glandular characteristics from the transitional zone. Distinguishing between true anal canal ADC and lower rectal ADC with extension to the anal canal can be extremely difficult. According to the World Health Organization (WHO), three types of ADC can be distinguished, mainly determined by their origin: those that originate in the superior part of the anal canal, those that are derived from anal ducts or glands and those associated with chronic anorectal fistulae<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a>:</p><p id="par0035" class="elsevierStylePara elsevierViewall">Tumors that originate in the mucosa of the superior portion of the anal canal are the most common (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) and present with a colorectal phenotype. In evolved stages, it is extremely difficult to differentiate them from distal rectal ADC. Their main clinical implication is based on their capacity for local extension, owing to the double lymphatic drainage toward the inguinal and femoral chains. The usual immunohistochemical phenotype coincides with the immunohistochemical profile of ADC of the lower rectal segment, consisting in CK20+, CK7− and CDX2+. CK7 is occasionally positive, as can also occur exceptionally in rectal ADC, but it would similarly and characteristically co-express CK20.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,4,5</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">ADC that develops in the duct or glands of the anal canal (anal ductal ADC or anal gland ADC) is extremely rare. It corresponds with a specific intramural subtype of anal canal ADC (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A and B). Its diagnosis is sometimes done by exclusion, since histologically detecting normal gland elements and associated ducts, or extension of ADC, generally occurs in very early stages. The recent definition of anal gland ADC by Hobbs et al.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> does not require demonstrating this continuity with the anal canal glands. In addition to the morphological characteristics of the neoplasia, what has acquired greater protagonism in the diagnosis is that no intraluminal growth is observed (the normal glands of the anal canal are distributed in the submucosal layer, penetrating the sphincter musculature and even reaching the perianal fat). Furthermore, this tumor subtype is not associated with dysplasia of the mucosal surface (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>) and is not generally related to pre-existing fistulae. These tumors may produce small quantities of mucin and their immunochemical profile is CK20−, CK7+ and CDX2− (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>), comparable to the immunohistochemical profile of normal glands of the anal canal and similar to the profile of the transitional epithelium of the anal canal.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,4–8</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">Finally, ADC associated with chronic colorectal fistulae (congenital or acquired, with a long-term evolution of 10–20 years) is usually secondary to chronic inflammatory processes such as Crohn's disease or other evolved benign perianal diseases. Sometimes, fistulae are secondary to dilatations of the anal canal glands or ducts, and the morphology and immunohistochemistry of the tumor would be identical to that of anal gland/duct ADC. Jones and Morson<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> have suggested that some of these carcinomas associated with fistulae originate in congenital duplications in the distal end of the hindgut. Generally, they adopt a well-differentiated mucinous ADC pattern, but the exact histogenetic origin is often impossible to demonstrate and may belong to any of the anterior subtypes. In addition, they must be differentiated from mucin-producing adenocarcinoma of the lower rectum. In this context, the immunohistochemical study (CK20, CK7 and CDX2) can be variable, and only by combining morphological, immunophenotypic and clinical-evolutive characteristics are we able to propose one origin or another.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,4,5,7–9</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Epidemiology</span><p id="par0050" class="elsevierStylePara elsevierViewall">Anal tumors are rare neoplasms of the digestive tube that represent 5% of all anorectal neoplasms and 1.5% of gastrointestinal tumors. The key microscopic aspects in anal canal tumors have progressively changed over the years. The increased experience and support of immunohistochemical techniques and molecular studies have brought about numerous changes in the nomenclature. The most frequent lesion (70%–80% of tumors) in both the anal canal as well as the perianal skin is squamous carcinoma.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10–13</span></a> Around 10% of all malignant anal lesions are anal ADC (5%–19%), which present a more aggressive natural history than squamous carcinoma, with shorter survival times and higher rates of local as well as distant relapse.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,6,10,13–15</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Although good results have been reported in patients with neoplasms detected in early evolutive phases, the clinical similarity with other benign diseases and the lower expression of the tumor component in the mucosa are usually reasons that delay diagnosis and, therefore, make for a poorer prognosis.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> A greater percentage of patients with anal canal ADC present with advanced disease, distant metastasis and, consequently, shorter overall survival compared with squamous carcinoma. Data from the National Cancer Data Base (NCDB) reveal that, at the time of presentation, 9.8% of patients with anal ADC are stage <span class="elsevierStyleSmallCaps">iv,</span> compared with 5% of squamous carcinomas. Likewise, distant lesions occur in 28.1% of patients with ADC compared with 11.8% of squamous cancers. The 5-year survival rate in patients with ADC is poorer in all the stages than in patients with epidermoid carcinoma, with the greatest difference observed in stage <span class="elsevierStyleSmallCaps">iv</span> (13% for patients with ADC and 29% for those with epidermoid cancer).<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The age of presentation is around the sixth decade of life, with equal distribution between the sexes.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,14</span></a> Multiple risk factors have been proposed, such as HPV and HIV, smoking and immunosuppression.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10,17</span></a> The presence of chronic perianal fistulae, either with or without associated Crohn's disease, represents an important risk factor, especially with a history of 10 or more years of disease.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17,18</span></a><span class="elsevierStyleItalic">Lymphogranuloma venereum</span> (LGV), as a cause of proctitis, can cause stenosis and perianal fistulae and is also associated with increased risk for rectal ADC.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Symptoms and diagnosis</span><p id="par0065" class="elsevierStylePara elsevierViewall">The clinical manifestations are usually nonspecific. Patients may present pain, indurations, abscesses, fistulae or palpable masses. Other symptoms include bleeding, pruritus, spotting, prolapse and weight loss.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,13</span></a> In the series by Kline et al.,<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> 15% of the patients were asymptomatic. Typical symptoms include the presence of perianal fistula for more than 10 years or the existence of recurring fistulae, even after surgery.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Early diagnostic suspicion is crucial in order to avoid any delays in diagnosis or treatment. Although the clinical characteristics can lead us to suspect this type of tumor, the definitive diagnosis can only be established with biopsy and histological studies. In cases of advanced fistulous disease, it is not clear whether the biopsy should be taken from the anal canal close to the internal orifice or by curettage of the external orifice.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Furthermore, inguinal lymphadenopathies should be explored because, as it has been explained previously, these are aggressive lesions with a high capacity for both local and distant invasion. Local dissemination tends to be greater in those tumors that originate in the glands of the anal canal or fistulous tracts since, as they are located outside the intestinal wall, the dissemination is initiated from a more advanced position.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Other diagnostic methods used to study local and distant extension include endoanal ultrasound, pelvic magnetic resonance and computed tomography.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17,18</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Treatment</span><p id="par0085" class="elsevierStylePara elsevierViewall">The limited number of cases published of anal canal ADC does not allow a thoroughly proven therapeutic approach.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Until the 1990s, most authors recommended radical surgery (abdomino-perineal amputation [APA]) as the treatment of choice for anal canal ADC.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21–23</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">In a retrospective analysis of 192 patients with anal canal cancer treated at the University of Minnesota, Klas et al.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> reported their experience with 36 patients diagnosed with ADC. Twenty-two (61%) were treated with surgery alone (6 APA and 16 local resections) and 14 (39%) with surgery followed by chemoradiotherapy (CRT). 5-year survival and local recurrence were 63% and 21%, respectively. The authors did not compare the two therapeutic methods due to the insufficient number of patients. They attributed the good results to the fact that the majority of the lesions (78%) were smaller than 5<span class="elsevierStyleHsp" style=""></span>cm, and they propose treatment with pre- or postoperative CRT for larger lesions (>5<span class="elsevierStyleHsp" style=""></span>cm).</p><p id="par0095" class="elsevierStylePara elsevierViewall">A multicenter retrospective study that included 82 patients diagnosed with anal ADC treated in different European centers<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> recommended combined CRT as the best treatment, while reserving radical surgery (APA) only for rescue therapy. In this study, the patients were managed with combined CRT, radiotherapy (RT) plus surgery or surgery alone. Overall survival and disease-free interval were higher in those patients with CRT, compared with those with RT plus surgery or surgery alone. The multivariate analysis showed that the T and N stages, histologic grade and therapeutic method were independent prognostic factors for survival. Nevertheless, this study has several shortcomings: neoadjuvant therapy was not used in any of the groups, adjuvant chemotherapy was not used after surgery, the patients who were included in the RT plus surgery group were significantly older than the patients in the combined CRT group, and in 75% of the surgical patients local resection was performed. These factors could be responsible for the high level of local and distant recurrence of the group with RT plus surgery.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Papagikos et al.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> studied 16 patients with anal ADC who were treated with RT either with or without chemotherapy with curative intent. The results of this treatment were compared with a group of patients with epidermoid carcinoma who were treated with CRT. Mean follow-up was 45 months for patients with ADC and 44 for those with epidermoid cancer. Although the patients with epidermoid carcinoma presented more advanced primary tumors, the local and distant recurrences were significantly higher in patients with ADC. Moreover, 5-year disease-free survival after CRT was 19% in patients with ADC compared with 77% of those with epidermoid carcinoma. This study concluded that treatment with definitive CRT, which has been demonstrated to be useful in epidermoid tumors, presents poor local control and a high level of distant recurrences in patients with ADC. They recommend preoperative CRT followed by APA to maximize the pelvic control of the disease. Adjuvant chemotherapy should be considered for micrometastatic disease.</p><p id="par0105" class="elsevierStylePara elsevierViewall">A retrospective study by Li et al.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> that included 49 patients with anal canal ADC concluded that APA together with CRT is the recommended treatment. Five-year survival in patients with APA alone, CRT, APA plus CRT, and with no treatment was 34.4%, 0%, 37.5% and 0%, respectively.</p><p id="par0110" class="elsevierStylePara elsevierViewall">Chang et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> published a series with more than 20 years of experience including 34 patients. The patients, who were considered potentially curable, were treated with local surgery followed by RT or CRT, or radical surgical treatment (APA) plus pre- or postoperative CRT. The disease-free survival was 13 months after local resection and 32 months after radical surgery, and overall 5-year survival was 43% for local treatment and 63% for patients treated with radical surgery (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">Patients with inguinal lymphadenopathies at disease presentation have poorer prognoses due to the higher percentage of distant disease.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15,18</span></a> According to some authors,<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,6,26</span></a> the inguinal dose of RT should vary in correlation with the existence of inguinal affectation and the therapeutic modality. Therefore, it is recommended to use doses above 54–55<span class="elsevierStyleHsp" style=""></span>Gy when initial CRT is used, while, in cases where only RT was used, the corresponding dose should be increased to 60–66<span class="elsevierStyleHsp" style=""></span>Gy. In patients with no known inguinal node invasion who receive treatment with CRT either with or without associated surgery, the recommended prophylactic dose is 45<span class="elsevierStyleHsp" style=""></span>Gy. Due to the poor prognosis of patients who present with inguinal lymphadenopathies, Papagikos et al.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> prioritize the use of initial CRT (with doses above 55<span class="elsevierStyleHsp" style=""></span>Gy) and additional systemic chemotherapy, with surgical resection used selectively or for isolated local relapse.</p><p id="par0120" class="elsevierStylePara elsevierViewall">Currently, most authors advocate maximizing the local control of the disease, avoiding transanal resection (which has had a negative impact on survival in some series),<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,27</span></a> and diminishing the risk of metastasis with the use of intensive chemotherapy.</p><p id="par0125" class="elsevierStylePara elsevierViewall">Given the fact that the anal glands are histologically and embryologically different from the anal squamous epithelium, the recommended chemotherapy regime does not usually include mitomycin. What is generally used are classic rectal AC regimes based on 5-fluorouracil, either with or without associated oxaliplatin.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7,15</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusions</span><p id="par0130" class="elsevierStylePara elsevierViewall">Anal canal adenocarcinoma is a rare entity that is occasionally difficult to distinguish from adenocarcinoma of the lower rectum with extension to the anal canal. Due to its aggressive behavior, early suspicion is crucial to avoid delayed diagnosis and treatment. Although there is no standardized protocol for the treatment of anal canal ADC, the current recommended approach is preoperative CRT followed by radical surgery (APA), with subsequent adjuvant therapy for the prevention of micrometastasis. CRT used alone should be reserved for those patients who would not tolerate radical surgery and, according to some authors, when there are proven inguinal lymph node metastases.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflict of interests</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:2 [ "identificador" => "xres293526" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec277466" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres293527" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec277467" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Methodology" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Histopathology" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Epidemiology" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Symptoms and diagnosis" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Treatment" ] 10 => array:2 [ "identificador" => "sec0035" "titulo" => "Conclusions" ] 11 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflict of interests" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-11-23" "fechaAceptado" => "2013-01-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec277466" "palabras" => array:4 [ 0 => "Anal adenocarcinoma" 1 => "Anal neoplasm" 2 => "Chemoradiotherapy" 3 => "Radical surgery" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec277467" "palabras" => array:4 [ 0 => "Adenocarcinoma anal" 1 => "Neoplasia anal" 2 => "Quimiorradioterapia" 3 => "Cirugía radical" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Adenocarcinoma (ADC) of the anal canal is a rare disease comprising only 5% of all anorectal neoplasias and 1.5% of all gastrointestinal tumors. The World Health Organization classifies anal ADC into 3 types: the first may arise from the mucosa of the transitional zone in the upper canal, the second from the anal glands (ducts) and the last can develop in the environment of a chronic anorectal fistula. Patients with ADC of the anal canal have high rates of pelvic failure, distant metastasis, and lower overall survival than patients with epidermoid carcinoma. Because of limited case reports about this neoplasia, management strategies have not been well established. Most authors of related studies recommend preoperative chemoradiotherapy (CRT) followed by radical surgery. The aim of the present study is to review clinicopathology features and management of anal canal ADC.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El adenocarcinoma (ADC) del canal anal es una entidad rara que representa el 5% de todas las neoplasias anorrectales y un 1,5% de los tumores gastrointestinales. De acuerdo con la Organización Mundial de la Salud se pueden distinguir 3 tipos: el primero tiene su origen en la mucosa de transición del canal superior, el segundo deriva de las glándulas (ductos) anales, y el último deriva de una fístula perianal crónica. Los pacientes con ADC del canal anal presentan mayor porcentaje de enfermedad avanzada, de metástasis a distancia y menor supervivencia global que aquellos con carcinoma escamoso. La escasa casuística publicada sobre esta neoplasia implica que no existe un esquema terapéutico plenamente comprobado. La mayoría de los autores abogan por un tratamiento con quimiorradioterapia (QRT) neoadyuvante seguido de cirugía radical. El objetivo de este artículo es realizar una revisión de la literatura existente sobre las características clinicopatológicas y el manejo del ADC del canal anal.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Ferrer Márquez M, Velasco Albendea FJ, Belda Lozano R, Berenguel Ibáñez MM, Reina Duarte Á. Adenocarcinoma del canal anal. Revisión de conjunto. Cir Esp. 2013;91:281–286.</p>" ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 671 "Ancho" => 950 "Tamanyo" => 169766 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional surface of an adenocarcinoma (ADC) originated in the mucosa of the superior portion of the anal canal with circumferential and endoluminal growth.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1393 "Ancho" => 900 "Tamanyo" => 272084 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Sequential cross-sections of intramural ADC evolved from the anal glands: (A) from the middle third of the anal canal, close to the radial margin; and (B) from the distal part of the anal canal with infiltration of the perianal musculature.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 675 "Ancho" => 901 "Tamanyo" => 212948 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Disorganized and infiltrative tubular gland proliferation underlying non-neoplastic squamous anal mucosa on the endoscopic biopsy of an ADC of the anal glands (hematoxylin and eosin ×10).</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1201 "Ancho" => 1599 "Tamanyo" => 613049 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">(A) Submucosal neoplastic gland component in ADC of the anal glands (hematoxylin and eosin ×20); (B) ADC of the anal glands with positive immunoexpression in the glands for CK7 (cytokeratin 7×10); (C) ADC of the anal glands negative for CK20 (cytokeratin 20×10); (D) ADC of the anal glands negative for CDX2 (CDX 2×10).</p>" ] ] 4 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">CRT, chemoradiotherapy; DFS, disease-free survival; RT, radiotherapy; SV, survival; Tx, treatment.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Author \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Study year \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">No. of patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Treatment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Results \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Belkacémi et al.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2003 (retrospective comparative) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- CRT- Radiotherapy<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>surgery- Surgery alone \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5-year DFS:- 54% (CRT)- 25% (RT+ surgery)- 22% (surgery alone) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Klas et al.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1999 (retrospective descriptive) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Surgery alone- Surgery<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span> CRT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5-year SV and local recurrence were 63% and 21%, respectively \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Papagikos et al.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2003 (retrospective comparative between ADC and epidermoid) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">RT<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>CT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5-year DFS after CRT:- 19% in anal ADC- 77% in epidermoid \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Li et al.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2006 (retrospective comparative) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Only surgery- CRT- Surgery<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>CRT- No Tx \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5-year SV:- 34.4% (only surgery)- 0% (CRT)- 37.5% (surgery<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>CRT)- 0% (no Tx) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Chang et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2009 (retrospective comparative) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">- Local surgery<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>CRT- Radical surgery<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>CRT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5-year SV:- 42% (local surgery)- 63% (radical surgery) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab427244.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Studies About the Treatment of Anal ADC.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ 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2024 May | 177 | 19 | 196 |
2024 April | 146 | 16 | 162 |
2024 March | 182 | 17 | 199 |
2024 February | 165 | 7 | 172 |
2024 January | 173 | 6 | 179 |
2023 December | 198 | 20 | 218 |
2023 November | 216 | 9 | 225 |
2023 October | 233 | 25 | 258 |
2023 September | 130 | 10 | 140 |
2023 August | 98 | 7 | 105 |
2023 July | 179 | 6 | 185 |
2023 June | 162 | 9 | 171 |
2023 May | 200 | 6 | 206 |
2023 April | 170 | 4 | 174 |
2023 March | 154 | 21 | 175 |
2023 February | 128 | 16 | 144 |
2023 January | 129 | 9 | 138 |
2022 December | 93 | 17 | 110 |
2022 November | 129 | 12 | 141 |
2022 October | 104 | 15 | 119 |
2022 September | 122 | 10 | 132 |
2022 August | 170 | 23 | 193 |
2022 July | 109 | 20 | 129 |
2022 June | 120 | 11 | 131 |
2022 May | 129 | 30 | 159 |
2022 April | 161 | 17 | 178 |
2022 March | 183 | 16 | 199 |
2022 February | 248 | 13 | 261 |
2022 January | 202 | 16 | 218 |
2021 December | 120 | 15 | 135 |
2021 November | 173 | 24 | 197 |
2021 October | 171 | 13 | 184 |
2021 September | 177 | 27 | 204 |
2021 August | 176 | 24 | 200 |
2021 July | 151 | 39 | 190 |
2021 June | 167 | 19 | 186 |
2021 May | 140 | 31 | 171 |
2021 April | 239 | 47 | 286 |
2021 March | 128 | 20 | 148 |
2021 February | 117 | 24 | 141 |
2021 January | 117 | 19 | 136 |
2020 December | 121 | 23 | 144 |
2020 November | 102 | 16 | 118 |
2020 October | 107 | 10 | 117 |
2020 September | 107 | 12 | 119 |
2020 August | 153 | 22 | 175 |
2020 July | 80 | 17 | 97 |
2020 June | 89 | 31 | 120 |
2020 May | 67 | 28 | 95 |
2020 April | 80 | 12 | 92 |
2020 March | 96 | 5 | 101 |
2020 February | 92 | 18 | 110 |
2020 January | 149 | 21 | 170 |
2019 December | 106 | 16 | 122 |
2019 November | 134 | 24 | 158 |
2019 October | 156 | 16 | 172 |
2019 September | 180 | 26 | 206 |
2019 August | 159 | 10 | 169 |
2019 July | 150 | 18 | 168 |
2019 June | 197 | 27 | 224 |
2019 May | 321 | 56 | 377 |
2019 April | 192 | 23 | 215 |
2019 March | 74 | 12 | 86 |
2019 February | 72 | 12 | 84 |
2019 January | 64 | 9 | 73 |
2018 December | 39 | 16 | 55 |
2018 November | 71 | 13 | 84 |
2018 October | 128 | 7 | 135 |
2018 September | 93 | 9 | 102 |
2018 August | 32 | 1 | 33 |
2018 July | 48 | 2 | 50 |
2018 June | 26 | 4 | 30 |
2018 May | 36 | 1 | 37 |
2018 April | 44 | 6 | 50 |
2018 March | 24 | 2 | 26 |
2018 February | 25 | 0 | 25 |
2018 January | 48 | 0 | 48 |
2017 December | 25 | 0 | 25 |
2017 November | 23 | 0 | 23 |
2017 October | 38 | 9 | 47 |
2017 September | 53 | 4 | 57 |
2017 August | 52 | 1 | 53 |
2017 July | 63 | 4 | 67 |
2017 June | 63 | 2 | 65 |
2017 May | 121 | 9 | 130 |
2017 April | 51 | 3 | 54 |
2017 March | 50 | 34 | 84 |
2017 February | 130 | 2 | 132 |
2017 January | 56 | 5 | 61 |
2016 December | 55 | 4 | 59 |
2016 November | 63 | 4 | 67 |
2016 October | 101 | 10 | 111 |
2016 September | 207 | 14 | 221 |
2016 August | 88 | 6 | 94 |
2016 July | 58 | 3 | 61 |
2016 June | 53 | 4 | 57 |
2016 May | 44 | 4 | 48 |
2016 April | 36 | 18 | 54 |
2016 March | 42 | 13 | 55 |
2016 February | 32 | 9 | 41 |
2016 January | 24 | 10 | 34 |
2015 December | 41 | 7 | 48 |
2015 November | 28 | 5 | 33 |
2015 October | 48 | 6 | 54 |
2015 September | 39 | 8 | 47 |
2015 August | 53 | 7 | 60 |
2015 July | 45 | 6 | 51 |
2015 June | 25 | 2 | 27 |
2015 May | 48 | 6 | 54 |
2015 April | 54 | 12 | 66 |
2015 March | 30 | 7 | 37 |
2015 February | 18 | 6 | 24 |
2015 January | 54 | 9 | 63 |
2014 December | 80 | 13 | 93 |
2014 November | 54 | 7 | 61 |
2014 October | 24 | 6 | 30 |
2014 September | 17 | 5 | 22 |
2014 August | 23 | 7 | 30 |
2014 July | 24 | 10 | 34 |
2014 June | 22 | 5 | 27 |
2014 May | 38 | 5 | 43 |
2014 April | 13 | 6 | 19 |
2014 March | 18 | 6 | 24 |
2014 February | 15 | 7 | 22 |
2014 January | 19 | 8 | 27 |
2013 December | 17 | 3 | 20 |
2013 November | 4 | 8 | 12 |