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Scientific Letter
Cholecystocutaneous Fistula as a First Sign of Presentation of a Gallbladder Adenocarcinoma
Fístula colecistocutánea como forma de presentación del adenocarcinoma de vesícula biliar
Paúl Ugalde Serrano
Corresponding author
pugalde13@gmail.com

Corresponding author.
, Lorena Solar García, Alberto Miyar de León, Ignacio González-Pinto Arrillaga, Juan González González
Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Central de Asturias, Oviedo, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cholecysto-cutaneous fistulas are a rare surgical entity&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> They are associated with complications of cholecystitis&#44; empyema&#44; gallbladder carcinoma with local extension&#44; or after surgery&#46; We present the case of a cholecysto-cutaneous fistula as a form of presentation of gallbladder adenocarcinoma&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was an 83-year-old male with no prior history except for a previous episode of acute cholecystitis 2 years earlier&#44; which had been treated conservatively with antibiotics and fluid therapy at another hospital&#46; He came to the Emergency Department of our hospital complaining of abdominal pain in the right upper quadrant associated with the oozing of hematic-purulent content through an orifice in the abdominal wall located in the right hypochondrium&#46; Abdominal examination revealed a mass in this region&#46; The patient presented important anemia in the blood work-up &#40;Hb 6<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#41;&#44; although he was hemodynamically stable&#46; Abdominal CT demonstrated a collection measuring 98<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>78<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>90<span class="elsevierStyleHsp" style=""></span>mm that was located predominantly in the extraperitoneal region&#44; with hematic content in its interior&#44; extending from the gallbladder bed to the subcutaneous tissue that fistulized through the skin &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; A right subcostal laparotomy was performed&#59; a large hematoma situated in the gallbladder bed was evacuated&#44; the gallbladder and the fistulous tract from the gallbladder fundus to the abdominal wall were removed&#46; The cutaneous fistula orifice was excised with the associated cholecystectomy&#46; The pathology study reported moderately differentiated papillary adenocarcinoma&#44; with infiltration of the cystic duct and abdominal wall &#40;T3N0M0&#41;&#46; The patient was discharged after an uneventful postoperative recovery&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Neoplasms of the bile duct are uncommon and are associated with a poor prognosis&#46; Gallbladder carcinoma &#40;GBC&#41; represents 3&#37; of malignant tumors and is fifth in the order of frequency within the group of gastrointestinal malignant neoplasms&#46; The annual incidence of GBC ranges between 2 and 13&#47;100 000 inhabitants&#46; The most common age of presentation is between 65 and 75&#46; In 95&#37; of cases&#44; the most frequent histologic type is adenocarcinoma&#44; and there seems to be a clear association with cholelithiasis&#44; porcelain gallbladder&#44; repeated gallbladder infections&#44; bile duct anomalies and benign gallbladder tumors&#44; among others&#46; Gallstones are the main associated factor&#59; some studies have found that the risk for developing GBC in patients with gallstones is 1&#37;&#8211;3&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> As for the pathogenesis of this entity&#44; chronic inflammation due to several stimuli has been implicated&#44; and it is thought that the adenoma&#8211;carcinoma sequence is present in many cases of GBC&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Early-stage GBC presents with non-specific symptoms that are similar to cholelithiasis&#44; while in advanced cancer more significant symptoms can appear&#44; such as weight loss&#44; jaundice&#44; anorexia&#44; ascites and palpable mass in the right hypochondrium&#44; associated with a poorer prognosis and tumor irresectability&#46; Because of this presentation&#44; less than 50&#37; of GBC cases are diagnosed preoperatively&#59; many are incidental findings after cholecystectomies due to cholecystitis or biliary colic&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5</span></a> In these cases and depending on the pTNM&#44; re-laparotomy is often necessary for radical cholecystectomy &#40;resection of segments <span class="elsevierStyleSmallCaps">iv</span>b and <span class="elsevierStyleSmallCaps">v</span> as well as hilar lymphadenectomy&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The mortality of this disease is related to the degree of locoregional tumor dissemination&#46; Most GBC cases are diagnosed in late stages&#44; with a 5-year survival rate of only 5&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;6&#44;7</span></a> Currently&#44; some groups have reported 5-year survival rates between 61&#37;&#8211;80&#37; and 30&#37;&#8211;45&#37; in stages T2 and T3&#44; respectively&#44; after extensive radical cholecystectomy&#44; suggesting that adequate surgical management with R0 resections can improve the results in patients with GBC&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In this patient in particular&#44; a second procedure for radical surgery was ruled out given the patient&#39;s age&#44; general state and advanced disease&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Despite not being a common form of presentation&#44; isolated cases have been described of spontaneous cholecysto-cutaneous fistula due to gallbladder carcinoma&#46; Spontaneous cholecysto-cutaneous fistula is a rare surgical entity that was first described by Thilesus in 1670&#46; It is becoming a less and less common disease due to the early diagnosis and surgical management of biliary lithiasis&#44; and 226 cases have been published to date&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> This disease presents fundamentally as a complication of a lithiasic inflammatory process&#44; and corresponds with the spontaneous evolution of untreated gallbladder empyema&#44; although there have been cases described of fistulas secondary to acalculous cholecystitis or gallbladder carcinoma&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The gallbladder perforation generally occurs in the fundus and&#44; once this happens&#44; the gallbladder is able to freely drain into the abdominal cavity or adhere to neighboring structures&#44; causing internal fistulas or&#44; less frequently&#44; toward the abdominal wall as external fistulas&#46; The presentation of the fistula may be evident by observing the discharge of bile or calculi to the abdominal wall&#46; In more difficult situations&#44; there may be drainage of pus&#44; leading one to consider pathologies such as infected epidermal cyst&#44; tuberculoma&#44; pyogenic granuloma&#44; metastatic carcinoma or chronic costal osteomyelitis within the differential diagnosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5&#44;8</span></a></p></span>"
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