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Scientific letter
Primary Adenocarcinoma of the Navel: An Uncommon Entity
Adenocarcinoma primario del ombligo: una entidad poco frecuente
Beatriz Febreroa,
Corresponding author
beatrizfebrero@hotmail.com

Corresponding author.
, David Ruiz de Anguloa, M. Ángeles Ortiza, M. José Lópezb, Pascual Parrillaa
a Servicio de Cirugía General, Hospital Universitario Virgen de la Arrixaca, Murcia, España, Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBEREHD)
b Servicio de Anatomía Patológica, Hospital Universitario Virgen de la Arrixaca, Murcia, España, Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBEREHD)
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Malignant tumors in the umbilical region are uncommon&#44; although they represent more than 10&#37; of malignant neoplasms that affect the skin of the anterior wall of the abdomen&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> This anatomical region is home to numerous vascular and embryological connections with the abdominal organs&#44; which favors the appearance of metastases derived from different visceral tumors&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a> Nonetheless&#44; primary umbilical tumors make up only 20&#37; of the malignant tumors in that location&#44; and very few cases have been reported to date&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the diagnostic&#47;therapeutic sequence followed in a patient with a primary adenocarcinoma in the umbilical region&#44; and also review the limited related scientific literature&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 60-year-old male who presented with a painless non-reducible nodule in the umbilical region that had been progressively growing over the course of the previous year&#46; Upon physical examination&#44; we observed a round tumor formation that was attached to deep planes and measured some 3<span class="elsevierStyleHsp" style=""></span>cm in diameter&#46; Abdominal ultrasound revealed a solid umbilical mass measuring 3<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>cm affecting the left anterior rectus&#46; The fine needle aspiration &#40;FNA&#41; sample was compatible with adenocarcinoma&#46; The cytology report&#44; including immunohistochemistry study&#44; showed a possible biliopancreatic origin as the first option and proposed that the lesion could possibly be a primary umbilical adenocarcinoma if no other origin was found &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The patient underwent gastroscopy&#44; colonoscopy&#44; thoracic and abdominal computed axial tomography &#40;CT&#41; scans &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; magnetic resonance cholangiopancreatography and even positron-emission tomography &#40;PET&#41; with the intention to rule out the presence of a primary tumor in another location&#46; All of the tests came back normal&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">We performed a midline laparotomy with <span class="elsevierStyleItalic">en bloc</span> resection of the navel&#44; tumor and a portion of the left anterior rectus muscle that was affected&#46; We explored the rest of the abdominal cavity&#44; with normal findings&#46; Postoperative recovery was favorable&#44; and the patient was discharged from the hospital 48<span class="elsevierStyleHsp" style=""></span>h after the intervention&#46; The pathology study reported findings compatible with well-differentiated infiltrating adenocarcinoma &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; As no internal adenocarcinoma was found&#44; it was concluded that the mass was a primary umbilical adenocarcinoma arising from the urachus&#46; Seven months after the intervention&#44; the patient is asymptomatic&#44; with normal tumor marker levels and no evidence of locoregional or distant disease&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The navel region can be a host to a large variety of benign tumors&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;6</span></a> Malignant tumors&#44; which are much less frequent&#44; are mostly metastases of an abdominal neoplasm and&#44; to a lesser degree&#44; they can be primary umbilical tumors&#44; representing only 20&#37; of malignant tumors of the navel&#46; They are mainly adenocarcinomas although other histologic types&#44; such as sarcomas and melanomas&#44; have also been described&#46; The glandular epithelium is normally not present in the umbilical area&#44; but it can appear derived from the metaplasia of the squamous epithelium or embryological remains of the omphalomesenteric duct or the urachus&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3&#44;6&#8211;8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Therefore&#44; given an umbilical nodule with histological characteristics of adenocarcinoma in an FNA sample&#44; the main problem is determining the origin&#46; Immunohistochemistry can guide the diagnosis&#44; but it is essential to complete a series of tests to rule out the existence of an extra-umbilical primary tumor &#40;thyroid ultrasound&#44; abdominal ultrasound&#44; abdominal CT scan&#44; colonoscopy&#44; chest radiography&#44; etc&#46;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> In our case&#44; we also carried out a PET and a gastroscopy&#44; since gastric adenocarcinoma is the tumor that most frequently metastasizes in the navel&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Metastases of other tumors in the navel are known as &#8220;Sister Mary Joseph nodules&#8221; and are found in from 1 to 3&#37; of digestive tumors&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;10</span></a> The embryological connection between this region and the abdominal organs&#44; as well as the extensive lymphatic network that connects the navel with the inguinal and axillary areas&#44; explains this predisposition&#46; The primary tumor is usually found in the gastro-intestinal tract &#40;stomach&#44; pancreas&#44; intestine&#44; cecal appendix&#44; etc&#46;&#41; although they may also be gynecological tumors&#44; sarcomas and other neoplasms originating outside the abdominal cavity &#40;breast&#44; lung&#44; penis&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3&#44;5&#44;6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Treatment of primary tumors of the navel is radical resection&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> During surgery&#44; all the abdominal organs should be examined&#44; as in our case&#44; in order to rule out the existence of a primary tumor that had not been detected previously&#46; Besides complete resection of the tumor&#44; it is necessary to follow-up these patients since relapse in the umbilical area has been reported in the literature<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> as well as the later appearance of liver metastases<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and lymphadenopathies in the inguinal region<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> in the mid- and long-terms&#46; This could indicate the need for adjuvant treatment with chemotherapy or radiotherapy in certain patients&#46; Because of their poor prognosis&#44; the treatment of metastatic umbilical tumors is more controversial&#44; and radiotherapy is the treatment of choice in many cases&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; tumors in the umbilical region require a differential diagnosis in which it is essential to carry out a series of tests to rule out the existence of an extra-umbilical primary tumor&#44; which can vary the therapy to be followed&#46; There are few cases described in the literature of primary malignant neoplasms affecting the umbilicus&#44; and it is therefore necessary to study each case in detail and to closely follow up the patients after they have been treated surgically since the prognosis is still not well defined&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Febrero B&#44; Ruiz de Angulo D&#44; Ortiz M&#193;&#44; L&#243;pez MJ&#44; Parrilla P&#46; Adenocarcinoma primario del ombligo&#58; una entidad poco frecuente&#46; Cir Esp&#46; 2014&#59;92&#40;6&#41;&#58;436&#8211;438&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Results of fine-needle aspiration&#58; &#40;a&#41; hematoxylin&#8211;eosin stain &#40;HE&#44; 400&#215;&#41;&#59; &#40;b&#41; immunohistochemistry study ruling out expression of cytokeratin 20&#59; &#40;c&#41; confirmed expression of cytokeratin 19&#59; &#40;d&#41; confirmed expression of cytokeratin 7&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Abdominal computed tomography showing a mass in the left anterior rectus muscle measuring 3<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>2&#46;7<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>cm &#40;CC<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>AP<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>T&#41; with heterogenous contrast uptake&#44; compatible with a tumor process &#40;arrow&#41;&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Microscopic study of the surgical specimen&#58; &#40;a&#41; a neoplasm is observed composed of glandular structures with a tendency toward cystification without significant signs of complexity&#44; covered for the most part by a cuboidal&#44; cylindrical or &#40;less frequently&#41; flat epithelial monolayer&#46; The cells show mild cytological atypia with a limited number of mitoses&#46; In the lumen of the glands&#44; there is presence of a material with proteinaceous content &#40;asterisk&#41;&#46; The stroma surrounding the gland structures is intensely desmoplastic &#40;arrow&#41;&#44; and some lymphocytic inflammatory infiltrate is also observed&#44; sometimes with formation of clear centers &#40;two arrows&#41; &#40;HE&#44; 50&#215;&#41;&#59; &#40;b&#41; the proliferation rate &#40;ki-67&#41; was approximately 30&#37;&#46;</p>"
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Article information
ISSN: 21735077
Original language: English
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2024 March 47 9 56
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2024 January 52 2 54
2023 December 49 5 54
2023 November 57 3 60
2023 October 52 2 54
2023 September 44 1 45
2023 August 41 1 42
2023 July 81 6 87
2023 June 64 3 67
2023 May 63 2 65
2023 April 56 2 58
2023 March 74 3 77
2023 February 81 6 87
2023 January 68 19 87
2022 December 48 6 54
2022 November 37 8 45
2022 October 47 7 54
2022 September 47 10 57
2022 August 56 13 69
2022 July 43 11 54
2022 June 41 10 51
2022 May 34 7 41
2022 April 32 14 46
2022 March 37 6 43
2022 February 45 7 52
2022 January 68 8 76
2021 December 92 6 98
2021 November 74 15 89
2021 October 77 8 85
2021 September 69 11 80
2021 August 61 16 77
2021 July 59 11 70
2021 June 41 12 53
2021 May 39 9 48
2021 April 136 11 147
2021 March 55 8 63
2021 February 58 9 67
2021 January 83 20 103
2020 December 38 8 46
2020 November 98 11 109
2020 October 35 8 43
2020 September 43 12 55
2020 August 23 7 30
2020 July 35 6 41
2020 June 23 11 34
2020 May 32 17 49
2020 April 25 6 31
2020 March 25 5 30
2020 February 33 8 41
2020 January 29 7 36
2019 December 50 8 58
2019 November 40 3 43
2019 October 36 4 40
2019 September 30 6 36
2019 August 27 5 32
2019 July 41 14 55
2019 June 52 16 68
2019 May 152 67 219
2019 April 66 10 76
2019 March 14 4 18
2019 February 19 8 27
2019 January 12 4 16
2018 December 10 1 11
2018 November 15 4 19
2018 October 15 5 20
2018 September 6 0 6
2018 August 5 1 6
2018 July 10 3 13
2018 June 5 1 6
2018 May 6 1 7
2018 April 2 1 3
2018 March 7 1 8
2018 February 3 1 4
2018 January 17 9 26
2017 December 5 0 5
2017 November 17 4 21
2017 October 6 6 12
2017 September 13 5 18
2017 August 23 1 24
2017 July 14 1 15
2017 June 24 15 39
2017 May 20 3 23
2017 April 24 4 28
2017 March 45 51 96
2017 February 22 3 25
2017 January 21 4 25
2016 December 16 9 25
2016 November 23 14 37
2016 October 32 7 39
2016 September 49 7 56
2016 August 37 10 47
2016 July 18 2 20
2016 June 21 10 31
2016 May 25 10 35
2016 April 31 13 44
2016 March 26 27 53
2016 February 16 14 30
2016 January 14 14 28
2015 December 17 16 33
2015 November 17 11 28
2015 October 19 7 26
2015 September 30 3 33
2015 August 19 4 23
2015 July 12 4 16
2015 June 9 0 9
2015 May 12 1 13
2015 April 23 8 31
2015 March 14 7 21
2015 February 31 6 37
2015 January 29 4 33
2014 December 25 13 38
2014 November 57 9 66
2014 October 62 20 82
2014 September 15 8 23
2014 July 0 1 1
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos