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Liver Function Tests and Common Biliopancreatic Channel Kinetics - Biliopancreatic Reflux" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "326" "paginaFinal" => "333" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Manuel Planells Roig, Úrsula Ponce Villar, Fabián Peiró Monzó, Alba Coret Franco, Natalia Orozco Gil, Ángela Bañuls Matoses, Eugenio Sanchez Aparisi, Lidia Marti Gonzalez, Federico Caro Martínez" "autores" => array:9 [ 0 => array:4 [ "nombre" => "Manuel" "apellidos" => "Planells Roig" "email" => array:1 [ 0 => "planells.mvi@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Úrsula" "apellidos" => "Ponce Villar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Fabián" "apellidos" => "Peiró Monzó" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Alba" "apellidos" => "Coret Franco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Natalia" "apellidos" => "Orozco Gil" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Ángela" "apellidos" => "Bañuls Matoses" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 6 => array:3 [ "nombre" => "Eugenio" "apellidos" => "Sanchez Aparisi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 7 => array:3 [ "nombre" => "Lidia" "apellidos" => "Marti Gonzalez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 8 => array:3 [ "nombre" => "Federico" "apellidos" => "Caro Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Unidad de Cirugía Hepatobiliopancreática, Servicio de Cirugía, Hospital Francisco de Borja, Gandía, Valencia, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Cirugía, Hospital Francisco de Borja, Gandía, Valencia, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Radiología, Hospital Francisco de Borja, Gandía, Valencia, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Gastroenterología, Hospital Francisco de Borja, Gandía, Valencia, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicio de Cirugía General y Aparato Digestivo, Hospital Francisco de Borja, Gandía, Valencia, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pancreatitis biliar. Cinética de pruebas funcionales hepáticas y canal común biliopancreático - reflujo biliopancreático" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Biliary pancreatitis (BP) is triggered by the onset of biliopancreatic reflux (BPR) secondary to transient lithiasic obstruction of the opening of the common bile duct and the Wirsung duct at the papilla of Vater. This combined mouth or biliopancreatic common channel (BPCC) occurs in 67% the patients<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> while an independent opening of the ducts occurs in the rest of the population.</p><p id="par0010" class="elsevierStylePara elsevierViewall">BPR demonstration and therefore the existence of BPCC through intraoperative cholangiography (IOC) or trans-Kehr intraoperative cholangiography<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> occurs in 7%–50% of the patients who undergo a cholangiography<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> with an increase in the prevalence of BP up to 87%.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">BPCC allows the gallstones of small size (microlithiasis) to produce a transient ampullary obstruction, which is initially mechanical and subsequently inflammatory, and at the same time, generates BPR causing BP,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> without the need of the existence of choledocian occupation maintained for BP development or maintenance.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Our study had two purposes. First, to assess the incidence of BPR and BPCC in patients with BP who undergo cholecystectomy and routine IOC, in order to analyze the possible differences attributable to its presence in patients with BP translated in terms of alterations in the liver function tests (LFT) and assess the possible importance of its existence. Secondly, to analyze the kinetics of LFT alterations in order to establish a selective indication of preoperative explorations before cholecystectomy in patients with BP.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and Methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">Retrospective case study of patients with a diagnosis of BP and subsequent scheduled cholecystectomy subject to IOC. The study included 107 patients with BP as the first episode during a period of 48 months. Exclusion criteria were the following: recurrent BP, pancreatitis post-endoscopic retrograde cholangiopancreatography (ERCP), chronic alcoholism, hypertriglyceridemia, hypercalcaemia or use of pancreatitis associated drugs. BP was diagnosed in patients with abdominal pain and elevated amylase greater than 3 times the standard level (amylase >380). Liver function tests at the time of admission (LFTA) were performed in all patients, including the urgent laboratory test at admission, and after 48<span class="elsevierStyleHsp" style=""></span>h, in order to establish the Ransom-Inrie criteria.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Patients who were subject to ERCP and sphincterotomy (ERCP-ES) and those who presented severe BP with necrosis, abscess, pseudocyst or organ failure were excluded.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Urgent abdominal ultrasound was performed in all cases as well as abdominal CT with contrast in selected cases. The presence of bile duct dilatation (BDD) by ultrasonography was established according to Bachar parameters in relation to the age ranges.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">All patients received initial medical treatment and, after a variable period, they underwent scheduled surgery, either at admission or later on, prior preoperative laboratory test with complete liver profile (PLFT).</p><p id="par0040" class="elsevierStylePara elsevierViewall">A series of 80 patients were used as a control group (CG) and were submitted to elective cholecystectomy and IOC, for uncomplicated symptomatic cholelithiasis; such patients were randomized during the study period and underwent surgery in the same week as BP cases.</p><p id="par0045" class="elsevierStylePara elsevierViewall">IOC was reviewed by 2 of the authors (Planells Roig and Peiró Monzó), excluding from the study the cases where there was no consistency between them as to the existence of BPR. Biliopancreatic reflux/Biliopancreatic common channel (BPR-BPCC) was defined as the existence of retrograde filling of the Wirsung duct during IOC secondary to BPCC (length >2.5<span class="elsevierStyleHsp" style=""></span>mm in cholangiographies). Findings of BPR and odditis (BPR-BPCC-O) were defined when there was BPR-BPCC and absence of contrast in the duodenum without choledocholithiasis, after the bile duct instrumental exploration. The diagnosis of choledocholithiasis (CBDS) was considered when confirmed by bile duct instrumental exploration.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The study of the laboratory values included the admission exam (LFTA) and the pre-surgical exam (PLFT). The following values were considered as pathological values: bilirubin >1.5<span class="elsevierStyleHsp" style=""></span>mg/dl, ALP >140<span class="elsevierStyleHsp" style=""></span>mg/dl, SGOT >65<span class="elsevierStyleHsp" style=""></span>U/l, SGPT >77 U/l, GGT >70.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Since the biochemical data does not follow a normal distribution,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> the statistical study is presented as the mean and the Mann Whitney test is used to compare group of patients in the continuous variables. Paired Wilcoxon test was used to compare the differences within each group. Chi-square test with Yates correction was used in discrete variables. A result with <span class="elsevierStyleItalic">P</span><.05 was considered significant. The analysis of OV/MNV ratio (observed value/maximum normal value) was used to compare the variations of the different function tests (increases of the reference value), which allows to contrast the maximum independent enzyme impact regardless of the type of analytic determination.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">No significant differences were found with respect to the distribution by age and gender. The average age was 59.9 (14.3) in the group of BP vs 55.9 (13.5) in the CG, <span class="elsevierStyleItalic">P</span>=.059 (−8.070; 0.150) although the difference in ages was significant when CBDS cases were excluded in both groups, 55.5 (13.8) in the CG compared to 59.7 (14.5) in the BP group (<span class="elsevierStyleItalic">P</span>=.035–8.605; 0.157). Distribution by gender was of 17 men (21.3%) and 63 women in the CG vs 35 men (32.7%) and 72 women in the BP group (Chi S 2.955, <span class="elsevierStyleItalic">P</span>=.058 F). In the BP group without CBDS, the average age of patients with BPR-BPCC-O was 58.8 (13.9) compared to the group without BPR 60.6 (15.2) (<span class="elsevierStyleItalic">P</span>=.536). There were no differences in the distribution by gender, and the BPR-BPCC-O incidence was 57.6% in men and 47.8% in women.</p><p id="par0065" class="elsevierStylePara elsevierViewall">From the 107 patients with BP, 74 underwent surgery in an interval of 8 weeks after the acute episode. The interval admission/intervention (<span class="elsevierStyleSmallCaps">III</span>) in this group was of 2.2 (1.3) weeks in 59 cases and 6.0 (1.1) weeks in 10 cases. There were 22 cases (29.7%) of readmission due to BP in this group. In patients who underwent surgery after 8 weeks (No.=33), the readmission rate was of 5 cases (15.2%) where surgery was performed at an interval lower than 12 weeks 7 and greater than 12 weeks 26.</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Cholangiographic Findings</span><p id="par0070" class="elsevierStylePara elsevierViewall">IOC was performed in all patients, it was normal in 105 cases, 78.8% of the patients of the CG and 39.3% of the BP group (Chi S 29.004; <span class="elsevierStyleItalic">P</span>=.000). It failed in 4 cases, 2 in each group (2.1% of the whole series). Incidence of BPR-BPCC was 38.3% in the BP group and only 5.0% in the CG group (Chi S 27.8; <span class="elsevierStyleItalic">P</span>=.000). On the other hand, the incidence of BPR-BPCC-O was 48.6% in the BP group compared to the CG group (0 cases) (Chi S 41.476; <span class="elsevierStyleItalic">P</span>=.000). All cases of odditis<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> occurred in the BP group (12.1%). CBDS rate confirmed by the bile duct instrumental exploration was of 14 cases (14/187) similar in both groups, 8.8 in the CG and 6.5 in the BP group (Chi S 0.322; <span class="elsevierStyleItalic">P</span>=.857), and it did not associate any case to BPR-BPCC-O. There were 4 (2.1%) IOC false positive cases and one CBDS false negative case.</p><p id="par0075" class="elsevierStylePara elsevierViewall">BPR-BPCC incidence was of 50.0% in patients who underwent surgery in an interval of 4 weeks, 53.8% in patients operated between 4 and 8 weeks, 50% in patients operated between 8 and 2 weeks and 41.7% in patients operated further after 12 weeks in the BP group.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Odditis</span><p id="par0080" class="elsevierStylePara elsevierViewall">Incidence of odditis was 75% in patients who underwent surgery during the first 4 weeks and 25% after this interval, always associated to BPR-BPCC, which suggests more irritation post-BP than morphological alteration, unlike BPR-BPCC, whose temporary distribution does not show any differences based on the surgical interval as described in the previous paragraph.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ultrasound Findings</span><p id="par0085" class="elsevierStylePara elsevierViewall">Microlithiasis incidence was greater in the BP group (9.7% vs 2.5%) Chi S 3.819 (<span class="elsevierStyleItalic">P</span>=.045 F). There was evidence of gallbladder wall thickening (chronic cholecystitis) in 22.5% of the control group and 19.4% in the BP group. In 2.9% of the patients with BP there was evidence of scleroatrophic gallbladder. In the BP group, the ultrasound showed BDD in 11 cases (10.3%) where none of them presented CBDS with a BPR-BPCC-O incidence of 7 cases (63.6%).</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Laboratory Tests Alteration in Patients With Choledocholithiasis. Biochemical Markers of Choledocholithiasis</span><p id="par0090" class="elsevierStylePara elsevierViewall">In the BP group, incidence of CBDS was of 6 cases in the first 4 weeks and of one case in the following weeks. The analysis of the LFTA and PLFT showed no differences in (TBil, SGOT, SGPT) among patients with and without CBDS, with significant differences only in the case of alkaline phosphatase and in the preoperative exam 203.6 (103.1) in patients with CBDS vs 118.6 (93.4) (<span class="elsevierStyleItalic">P</span>=.017) in patients without CBDS. Differences in the preoperative GGT 280.3 (352.1) vs 112.5 (108.3) did not reach statistical significance.</p><p id="par0095" class="elsevierStylePara elsevierViewall">In the CG, a significant difference was evidenced in the preoperative TBil 2.4 (5.0) in patients with CBDS compared to those who did not present CBDS 0.5 (0.3), <span class="elsevierStyleItalic">P</span>=.002 (0.7374; 3.0471) without differences in the rest of the SGOT, SGPT variables although both ALP and GGT showed greater values but without any significance.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Bilirubin was dichotomized at admission in the BP group with a cut-off of 5<span class="elsevierStyleHsp" style=""></span>mg/dl (indicative values of clear bile obstruction) without evidence of any relation with the BPR-BPCC-O or CBDS existence (in patients with CBDS, 5 of 7 cases presented bilirubin values lower than 5<span class="elsevierStyleHsp" style=""></span>mg/dl); therefore, its usefulness in CBDS prediction was low.</p><p id="par0105" class="elsevierStylePara elsevierViewall">Likewise, TBil was dichotomized at the preoperative laboratory tests with a cut-off of 1.5<span class="elsevierStyleHsp" style=""></span>mg/dl, not allowing to detect 5 of the 7 cases of CBDS, neither showing correlation with the incidence of BPR-BPCC nor BPR-BPCC-O.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Ranson's Criteria and Biliopancreatic Reflux/Biliopancreatic Common Channel</span><p id="par0110" class="elsevierStylePara elsevierViewall">Patients meeting 3 or more Ranson's criteria (No.=41; 38.3%) showed amylase levels at admission greater than 2431.0 (1329.6) vs 1657.4 (1171.4) compared to those meeting less than 3 criteria (No.=66), <span class="elsevierStyleItalic">P</span>=.002 (CI 287.0; 1260.2). In the 10 patients who required admission in the ICU, Ranson's score was of 3.2 (1.3) compared to 2.0 (1.5) in those who did not require admission [<span class="elsevierStyleItalic">P</span>=.015 (0.2024; 2.1151)]. There were no differences in Ranson's score among patients who suffered recurrence/re-admission after the acute outbreak of BP (No.=27).</p><p id="par0115" class="elsevierStylePara elsevierViewall">Incidence of BPR-BPCC-O showed no relation with Ranson's score, 19 cases (46.3%) in patients meeting 3 or more criteria compared to 33 cases (50.0) in patients meeting less than 3 criteria and the score was similar in patients with or without BPR-BPCC-O 1.9 (1.4) vs 2.3 (1.6) (<span class="elsevierStyleItalic">P</span>=.338).</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Severe Biliary Pancreatitis and Biliopancreatic Reflux/Biliopancreatic Common Channel-O</span><p id="par0120" class="elsevierStylePara elsevierViewall">Incidence of BPR-BPCC-O was greater in patients who required admission in the ICU (13.7%) compared to those who did not present it (4.1%), although not reaching a statistical significance but the need for urgent surgery due to cholangitis was significantly greater in patients with BPR-BPCC-O (12.5%) compared to those patients without BPR-BPCC-O (1.7%), Chi S 4.994; <span class="elsevierStyleItalic">P</span>=.036 (F).</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Admission Laboratory Tests (Liver Function Tests) and Biliopancreatic Reflux/Biliopancreatic Common Channel-O</span><p id="par0125" class="elsevierStylePara elsevierViewall">LFTA from patients with BP, excluding the cases of associated CBDS, by virtue of the existence of BPR-BPCC-O in the IOC, showed no evidence of significant differences.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Preoperative Laboratory Tests. Control Group vs Biliary Pancreatitis</span><p id="par0130" class="elsevierStylePara elsevierViewall">Preoperative liver function tests between CG and BP group, excluding patients with CBDS, showed significant differences between both groups as shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Due to such difference, the interval influence between the BP acute episode and the surgical intervention was analyzed, (<span class="elsevierStyleSmallCaps">III</span>) as regards the laboratory alterations of the BP group depending on the week of intervention, showing a tendency towards analytical normalization by week 4. Therefore, the cohort value was used to assess PLFT alterations.</p><p id="par0140" class="elsevierStylePara elsevierViewall">Patients who underwent surgery in an interval of 4 weeks were submitted to surgery 1.9 (1.3) weeks after such interval. Incidence of BPR-BPCC-O was similar based on <span class="elsevierStyleSmallCaps">III</span>, and were 52.9% and 43.5%, respectively. In any of the 2 intervals (>0–4 weeks) LFTs show significant differences in the BP group based on <span class="elsevierStyleSmallCaps">III</span> with the CG (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>), the greater as well as the lower the interval (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>), which generates a clear uncertainty in the assessment of the possibility of CBDS since in patients with BP, the laboratory alteration persists significantly with a biochemical pattern suggesting a potential existence of CBDS, though such alteration diminishes with time.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0145" class="elsevierStylePara elsevierViewall">The analysis of OV/MNV ratio (observed value/maximum normal value) (maximum normal value/determined value ratio) which allows to evidence the variation with respect to the normal value and therefore the comparison of the variations of the different function tests between them showed no significant differences between patients who underwent surgery in an interval >0<4 weeks and the existence of BPR-BPCC-O (Mann Whitney) when LFTA and PLFT were analyzed.</p><p id="par0150" class="elsevierStylePara elsevierViewall">Differences in LFT were not only evidenced between the CG and BP groups but also in the BP group based on <span class="elsevierStyleSmallCaps">III</span> (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). These analyses evidenced differences in the LFT, although they were only significant in the case of SGOT, SGPT and GGT. This fact suggested a residual inflammatory alteration or a different analytical behaviour based on the existence of BPR-BPCC-O. The hypothesis that the PLFT alterations were secondary to BPR-BPCC-O was initially ruled out when analysing the same compared to the incidence of BPR-BPCC, as it was similar in both intervals (intervention >0<4 weeks) (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>) not showing significant differences in the PLFTs. At this point, the conclusion derived from the kinetic analysis of the PLFTs alterations should be the BPR-BPCC-O has no analytical translation and that analytical alterations should be attributed to other factors secondary to BP.</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0155" class="elsevierStylePara elsevierViewall">However, when analysing the differences between LFTA and PLFT (Wilcoxon) within the same groups based on the interval to the intervention and the existence of BPR-BPCC-O, excluding patients with CBDS, both in absolute values as with the OV/MNV ratio (<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>), it was evidenced that in patients with BPR-BPCC-O, decrease (normalization) in LFT values between the acute episode and intervention was significant in all variables except from ALP and GGT, both in patients who underwent surgery during the first 4 weeks as well as in patients who belatedly underwent surgery. Even more, when analysing OV/MNV ratio in patients with BPR-BPCC-O, the decrease in LFT was not significant in ALP and GGT, both markers of cholestasis both at 4 weeks and in an greater interval, and it was significant in the group without BPR-BPCC-O, which would indicate that the existence of BPR-BPCC produces a higher degree of cholestasis, persistent in time, and that the existence of alterations in the PLFT may indicate the existence of BPR-BPCC-O or its biochemical consequence in the absence of CBDS.</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0160" class="elsevierStylePara elsevierViewall">In 1976, studies on gallstones in stool of patients with BP<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> generated the “migratory stone” theory, revealing that the CBDS rate was<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10,11</span></a> 63%–75% (at 48<span class="elsevierStyleHsp" style=""></span>h after admission), decreasing to 5% when the acute episode had finished. Recent studies (ERCP) confirm that the incidence of CBDS in the first 48<span class="elsevierStyleHsp" style=""></span>h is 70%<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> reaffirming the pathogenesis of the BP by transient occlusion of the ampulla of Vater by biliary sludge or gallstones<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> that, in most of the patients, spontaneously pass into the duodenum.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">BPCC-BPR determined by IOC occurs in 7%–50% of patients undergoing cholecystectomy<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> increasing in BP up to 87%,<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and is 5% in patients with uncomplicated symptomatic cholelithiasis<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,10,15–18</span></a>; it has no relationship with the pressure applied to contrast material during IOC.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> In our country, the reported incidence is 6%–48.1%,<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20,21</span></a> achieving in our series a 51.0% in BP in contrast to 14.6 of CG.</p><p id="par0170" class="elsevierStylePara elsevierViewall">The BPCC-BPR is not related to choledocian obstruction.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18,19</span></a> In patients with CBDS and BPR the trans Kher IOC does not evidence disappearance of the BPR,<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10,21–23</span></a> which indicates absence of relation between BPR, choledocholithiasis and the choledochus diameter.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Furthermore, the ampullary cholangio-manometry in patients with BP shows a reduced diameter of the BPCC originating either primary or secondary BPR.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> Finally, in patients with BP and choledochotomy on a T-tube, an elevation of trypsinogen and an increase of amylase in choledochal drainage have been shown reflecting the functional obstruction of the sphincter of Oddi and the existence of retrograde reflux through the BPCC in the absence of CBDS.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">Patients with microlithiasis (<3<span class="elsevierStyleHsp" style=""></span>mm) are more likely to develop BP while acute cholecystitis is more common in larger gallstones.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,21</span></a> The BDD is normal in patients with BP without CBDS (10.3% in our series). In this group, gallstones are usually 3–7<span class="elsevierStyleHsp" style=""></span>mm sized in diameter<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,21</span></a> and the BDD is secondary to the distal transient obstruction originating retrograde biliary pressure increase,<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> and its morphological translation is the BD dilation by ultrasonography and the cholangiographic BPR as in our study, where the existence of BDD is associated with a high incidence of BPR-BPCC-O in the absence of CBDS.</p><p id="par0180" class="elsevierStylePara elsevierViewall">The high incidence of BPCC (67%–80%), though not absolute in BP, could demonstrate that the BPCC is transient in relation to the passage of the gallstone and subsequent inflammatory papillary oedema<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25,26,32,33</span></a> with following functional normalization by reversing the BPR. On the contrary, our study shows that the prevalence of BPR is similar in patients who underwent surgery before and after 4 weeks, remaining constant throughout different time intervals considered for surgery, which points to an anatomical rather than transient functional alteration.</p><p id="par0185" class="elsevierStylePara elsevierViewall">Odditis is related to repeated episodes of lithiasic migration in patients with BP and its incidence is high in patients who suffered BP, being its translation uncertain as it could be assumed either as a morphological substrate of the BP aetiology or a morphological consequence of the biliopancreatic confluent “irritation”.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> In our series, odditis seems to be more an “irritative” process since it concentrates in 75% of cases surgically treated during the first 4 weeks, as opposed to the existence of BPR-BPCC that remains constant over time.</p><p id="par0190" class="elsevierStylePara elsevierViewall">The incidence of CBDS in BP and early ERCP reaches 55.9%.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27,28</span></a> However, routine IOC in patients with previous BP without BD dilation and LFT normalization shows a much lower incidence of CBDS, of 8.5%,<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> and a 5.1% residual lithiasis rate which decreases to 2.8% when no IOC is performed.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> This disparity in the incidence of CBDS depending on the admission-intervention interval points to the necessity to establish an indication of time interval for ERCP-MRCP or LC practice based on the estimation of probability of associated CBDS.</p><p id="par0195" class="elsevierStylePara elsevierViewall">Although BP has been considered as a clinical indicator of CBDS, its PPV is low (0.26).<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> In general, elevations in TBil, ALP and SGPT along with the existence of BDD are considered CBDS markers.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> However, in BP, the low specificity of ultrasound and biochemical markers can cause unnecessary ERCP,<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27,31</span></a> since both ALP and GGT have low PPV and NPV. Moreover, SGOT, SGPT and bilirubin in the early phase of the BP are not useful in the prediction of CBDS.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> Transient elevation of transaminases is related to biliary aetiology of pancreatitis, mainly SGPT (PPV 80%–90%),<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> by transient occlusion of the ampulla of Vater<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> whose biochemical translation is the bilirubin and SGOT/SGPT elevation, and stabilises after the disimpaction.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> Moreover, the initial rising of the LFT in the BP follows a proven kinetics of normalization<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> or increase<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> and bilirubin<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> follows a crescendo-decrescendo pattern<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> in relation to whether papillary obstruction is transient (mechanical by the passage of sludge or gallstone or inflammatory by papillary oedema) or prolonged, being the interval of biochemical normalization essential for the indication of complementary examinations of the BD as MRCP<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> or ERCP as well as to define the timing of cholecystectomy.</p><p id="par0200" class="elsevierStylePara elsevierViewall">The LFTs alteration (in particular ALP and TBil) causes uncertainty in the prediction of CBDS and does not allow to discriminate cases with CBDS or absolute values, or with the determination of the OV/MNV ratio of the LFTs.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> If we also consider that ultrasound parameters as diagnosis of CBDS and/or BDD, which in the acute phase can occur in 9% and 31% of BP patients respectively, show a low PPV and NPV,<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27,31,37</span></a> uncertainty in the estimation of probability of CBDS will provoke an excess of preoperative explorations, such as ERCP or MRCP and would seek the presence of other generating mechanisms of laboratory alterations observed in PB in the absence of CBDS<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> as the existence of BPR-BPCC.</p><p id="par0205" class="elsevierStylePara elsevierViewall">In our study, as well as in that of Fumino,<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> there are no evident statistically significant differences in the LFTs at admission among patients with BP based on the existence of BPR-BPCC. Conversely, analysis of LFTA and PLFT variations evidences significant differences in TBil, SGOT, and SGPT both in patients either with or without BPR-BPCC, but not in ALP and GGT. The analysis of the OV/MNV ratio at admission and preoperative stage confirms that the variations are not significant in the BPR-BPCC group in ALP and GGT, i.e., there is no substantial normalization between the values at admission and the preoperative values, thus it can be concluded that, in patients with BPR-BPCC, there would be a greater biliary evacuation difficulty translated into a greater degree of cholestasis, an absence of major differences between the 2 points of analytical determination and therefore a lower normalization or a crescendo pattern in this group. In consequence, the existence of alterations in the PLFT must not be taken as a single value, but comparatively analyzed with the values at admission to estimate their degree of normalization and thus be attributed to BPR-BPCC or CBDS.</p><p id="par0210" class="elsevierStylePara elsevierViewall">Thus, in patients with a decrescendo pattern of the LFTs and defined as high ultrasound risk of CBDS (suspected CBDS or BDD), the preoperative study of BD should be restricted to MRCP that would also allow to exclude the IOC during the LC, while in patients with a crescendo pattern without normalization of the LFTs, in which the presence of BPCC-BPR could explain the non-analytic normalization or incomplete normalization, MRCP should precede ERCP<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> and not be indicated as a first line exploration of the bile duct. In either case, the indication for ERCP must be restricted to MRCP findings regarding false positives and negatives resulting from biochemical markers and US of CBDS in BP, and should not be considered as first line scan.</p><p id="par0215" class="elsevierStylePara elsevierViewall">The main contribution of our study, although limited by its retrospective nature, has been the determination of the kinetics of laboratory alterations in patients with BP depending on the interval to the intervention and the existence of BPCC-BPR-O, which allows to demonstrate that there is a greater cholestatic pattern responsible for the over-indication of complementary examinations in patients with BPCC for the uncertainty that it creates in relation to the existence of bile duct occupation. In addition, even though the sample is reduced, we have evidenced an association between serious BP requiring the admission in ICU and the existence of BPR-BPCC, which could be secondary to the greater degree of cholestasis in these patients and, therefore, the greater probability of cholangitis. On the other hand, our study identifies odditis as an irritant process with its frequency diminished in time as opposed to the BPR-BPCC which is stable over time. We have proved a high prevalence of BPR-BPCC in patients with BP in addition to demonstrating persistent laboratory alterations after the acute episode of BP with progressive normalization as from week 4. Laboratory alterations in the LFTs after the acute episode of BP generate that preoperative CBDS exclusion cannot be based on liver profile but that it will require complementary imaging studies, such as MRCP. The ERCP-ES must be indicated only after image scans with MRCP. Intraoperative IOC in patients with previous BP should be performed only in a selective manner and not routinely when MRCP is uncertain, or after ERCP-ES. The implementation of a prospective study to calculate the reduction or normalization estimated in the LFTs depending on the presence of BPR-BPCC would allow identification of patients with normalization or absence of LFT without risk of associated CBDS.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflict of Interest</span><p id="par0220" class="elsevierStylePara elsevierViewall">The authors declare that there are no conflicts of interests.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres483543" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec505627" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres483544" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec505626" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Material and Methods" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Results" "secciones" => array:8 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Cholangiographic Findings" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Odditis" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Ultrasound Findings" ] 3 => array:2 [ "identificador" => "sec0035" "titulo" => "Laboratory Tests Alteration in Patients With Choledocholithiasis. Biochemical Markers of Choledocholithiasis" ] 4 => array:2 [ "identificador" => "sec0040" "titulo" => "Ranson's Criteria and Biliopancreatic Reflux/Biliopancreatic Common Channel" ] 5 => array:2 [ "identificador" => "sec0045" "titulo" => "Severe Biliary Pancreatitis and Biliopancreatic Reflux/Biliopancreatic Common Channel-O" ] 6 => array:2 [ "identificador" => "sec0050" "titulo" => "Admission Laboratory Tests (Liver Function Tests) and Biliopancreatic Reflux/Biliopancreatic Common Channel-O" ] 7 => array:2 [ "identificador" => "sec0055" "titulo" => "Preoperative Laboratory Tests. Control Group vs Biliary Pancreatitis" ] ] ] 7 => array:2 [ "identificador" => "sec0060" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0065" "titulo" => "Conflict of Interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-08-27" "fechaAceptado" => "2013-04-09" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec505627" "palabras" => array:3 [ 0 => "Billiary pancreatitis" 1 => "Biliopancreatic reflux" 2 => "Liver function tests" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec505626" "palabras" => array:3 [ 0 => "Pancreatitis biliar" 1 => "Reflujo biliopancreático" 2 => "Pruebas funcionales hepáticas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine the prevalence of biliopancreatic reflux (BPR) in patients with biliary pancreatitis (BP) undergoing elective cholecystectomy with intraoperative cholangiography (IOC) in comparison with a control group of symptomatic cholelithiasis (CG).</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Retrospective review of 107 consecutive BP cases. BPR was determined by IOC and liver function tests (LFT) were recorded at admission (A), 48<span class="elsevierStyleHsp" style=""></span>h, and preoperative examination (P). LFT analysis between A and P were analyzed between groups with respect to BPR, time interval to cholecystectomy within the same group and by determination of observed value/maximum normal value ratio (OV/MNV).</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">BPR incidence was 38.3% in BP in comparison with 5% in CG (<span class="elsevierStyleItalic">P</span>=.0001) it was independent from interval time to cholecystectomy, in contrast with Odditis, suggesting an anatomical condition for CCBP and a functional one for Odditis. LFT analysis showed no differences in relation to BPR incidence. LFT excluding AP and GGT returned to normal values with significant differences in OV/MNV when BPR was present which points to an increased cholestasis in BPR group. US dilatation of CBD was noted in 10.3% and was associated to CCBP.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">BPR in BP increases cholestasis and contributes to confusion in the estimation of common bile duct stones increasing ERCP-EE rates. US and biochemical markers of CBDS show a low specificity due to BPR-CCBP which suggests that MRI-cholangiography is a mandatory exploration before ERCP-EE examination.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Estudio de la prevalencia de reflujo biliopancreático (RBP)/canal común biliopancreático (CCBP) en pacientes con pancreatitis biliar (PB) sometidos a colecistetomía (CST) y colangiografía intraoperatoria (CIO) y análisis de la cinética de pruebas funcionales hepáticas (PFH) en comparación con un grupo control (GC) de colelitiasis sintomática.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de 107 pacientes consecutivos con PB. Se determinó la existencia de RBP-CCBP en la CIO y se analizaron las PFH al ingreso (AI), a las 48 horas y en el examen preoperatorio (AP). La variación analítica se analizó entre grupos según existencia de RBP-CCBP y entre el AI y AP, según intervalo ingreso-intervención (<span class="elsevierStyleSmallCaps">III</span>) y dentro del mismo grupo mediante determinación de la ratio valor observado-valor máximo normal (VO/VMN).</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La incidencia de CCBP fue de 38,3% en PB vs 5,0 en GC (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,0001) y fue independiente del <span class="elsevierStyleSmallCaps">III</span> a diferencia de la odditis apuntando a una alteración anatómica para la primera y funcional para la segunda. Las variaciones analíticas no muestran diferencias entre grupos en función de la existencia de CCBP, pero con ausencia de diferencias al analizar la ratio VO/VMN en FA y GGT, lo que indica un mayor grado de colestasis en los pacientes con RBP-CCBP. La incidencia de dilatación de vía biliar US fue del 10,3% asociándose a CCBP.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El RBP-CCBP en PB genera un mayor grado de colestasis e incertidumbre en la estimación de coledocolitiasis asociada y excesiva sobreindicación de ERCP-EE. Los marcadores US y bioquímicos de coledocolitiasis tienen una baja especificidad en PB por la existencia de CCBP lo que obliga a incluir a la colangiografía por RMN como exploración previa a la ERCP-EE.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as: Planells Roig M, Ponce Villar Ú, Peiró Monzó F, Coret Franco A, Orozco Gil N, Bañuls Matoses Á, et al. Pancreatitis biliar. Cinética de pruebas funcionales hepáticas y canal común biliopancreático - reflujo biliopancreático. Cir Esp. 2015;93:326–333.</p>" ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">CS: elective cholecystectomy by uncomplicated symptomatic cholelithiasis without associated choledocholithiasis; BP: biliary pancreatitis without associated choledocholithiasis.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">CS 70 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">BP 100 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Mann–Whitney \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">TBil \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.5 (0.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.9 (1.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−0.6375; −0.559 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SGOT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.6 (20.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">44.3 (66.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−37.051; −4.408 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SGPT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33.7 (41.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">88.1 (114.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−83.014; −25.846 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">AL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">125.8 (77.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">118.6 (93.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.226 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−22.166; 36.554 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">GGT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">60.5 (91.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">112.5 (108.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−88.133; −15.865 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab765070.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Preoperative Laboratory Tests (PLFT) in Patients of the Control Group vs PB Group Excluding the Cases With CBDS.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">CG-CBDS: control group excluding patients with choledocholithiasis.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">CG (69) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">BP Interval >4 (42)<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">MW \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">95% CI \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">BP Interval 4 (51)<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">MW \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">95% CI \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">TBil \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.5 (0.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.6 (0.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.074 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−0.1915; 0.0264 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.1 (1.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−0.9104; −0.1663 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SGOT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.6 (20.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28.9 (21.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.088 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−13.396; 2.764 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56.5 (85.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−53.965; −11.924 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SGPT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33.7 (41.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52.5 (51.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.028 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−36.614; −1.016 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">115.0 (140.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−116.5; −46.116 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ALP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">125.8 (77.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">97.7 (53.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.036 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−2.899; 59.088 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">133.9 (112.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.914 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−44.794; 28.597 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">GGT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">60.5 (91.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">76.5 (75.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.096 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−55.236; 23.287 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">143.2 (122.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−127.3; −38.193 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab765071.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">BP acute outbreak interval/intervention >4 weeks.</p>" ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">BP acute outbreak interval/intervention ≤4 weeks.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Preoperative Laboratory Variations (PLFT) Between the Control Group (CG) and the Biliary Pancreatitis Group Without CBDS According to the Intervention Interval.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Interval ≤4 weeks \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Interval <4 weeks \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">MW \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Amylase \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">327.2 (777.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">108.1 (106.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.333 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−70.895; 508.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">TBil \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.1 (1.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.6 (0.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.194 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−0.0498; 0.9614 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SGOT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56.5 (85.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28.9 (21.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.015 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.304; 51.953 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SGPT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">115.0 (140.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52.5 (51.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">20.854; 104.134 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ALP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">133.9 (112.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">97.7 (53.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.104 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−3.972; 76.359 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">GGT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">143.2 (122.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">76.5 (75.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14.291; 119.214 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab765074.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Preoperative Laboratory Variations (PLFT) Biliary Pancreatitis/Intervention Interval (<span class="elsevierStyleSmallCaps">III</span>).</p>" ] ] 3 => array:7 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:2 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Interval <4 weeks \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">BPR-BPCC-O+ (19) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">BPR-BPCC-O− (23) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">MW \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">TBil \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.6 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.7 (0.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.528 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−0.2018; 0.2088 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SGOT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33.0 (26.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25.5 (16.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.535 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−5.930; 20.975 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SGPT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">55.2 (57.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50.6 (47.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.691 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−28.936; 38.159 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ALP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">93.3 (29.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">100.7 (65.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.849 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−48.659; 33.992 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">GGT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51.1 (39.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">92.0 (88.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.106 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−99.429; 17.610 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab765075.png" ] ] 1 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Interval ≤4 weeks \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">BPR-BPCC-O+ \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">BPR-BPCC-O− \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">MW \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">TBil \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.1 (1.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.0 (0.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.122 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−0.7841; 0.9508 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SGOT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">58.2 (94.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">54.4 (74.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.681 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−43.806; 51.455 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">SGPT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">92.7 (130.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">140.0 (148.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.107 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">124.279; 29.707 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ALP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">134.7 (92.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">132.9 (136.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.773 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−70.754; 74.256 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">GGT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">141.5 (112.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">144.9 (134.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.986 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">−90.364; 83.541 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab765072.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Preoperative Laboratory Variations in Biliary Pancreatitis, Intervention Interval and BPR-BPCC-O.</p>" ] ] 4 => array:7 [ "identificador" => "tbl0025" "etiqueta" => "Table 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSmallCaps">A</span>: admission; P: preoperative; Ratio OV/MNV: ratio between the obtained value and the maximum normal value in the liver function test performed.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Amylase A-P \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Bil A-P \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SGOT A-P \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SGPT A-P \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">ALP A-P \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">GGT A-P \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleItalic">Absolute value</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Interval 4 BPR+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NS \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Interval 4 BPR− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.019 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Interval >4 BPR+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.028 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Interval >4 BPR− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.006 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleItalic">Ratio OV/MNV</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Interval 4 BPR+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NS \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Interval 4 BPR− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.035 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.012 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Interval >4 BPR+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NS \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Interval >4 BPR− \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.020 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.015 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab765073.png" ] ] ] ] 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Year/Month | Html | Total | |
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2024 October | 32 | 6 | 38 |
2024 September | 76 | 11 | 87 |
2024 August | 47 | 7 | 54 |
2024 July | 45 | 5 | 50 |
2024 June | 46 | 5 | 51 |
2024 May | 37 | 5 | 42 |
2024 April | 40 | 10 | 50 |
2024 March | 54 | 5 | 59 |
2024 February | 70 | 5 | 75 |
2024 January | 88 | 3 | 91 |
2023 December | 74 | 3 | 77 |
2023 November | 99 | 7 | 106 |
2023 October | 91 | 11 | 102 |
2023 September | 53 | 0 | 53 |
2023 August | 69 | 2 | 71 |
2023 July | 104 | 7 | 111 |
2023 June | 78 | 4 | 82 |
2023 May | 86 | 7 | 93 |
2023 April | 83 | 2 | 85 |
2023 March | 86 | 8 | 94 |
2023 February | 70 | 13 | 83 |
2023 January | 84 | 9 | 93 |
2022 December | 88 | 8 | 96 |
2022 November | 109 | 16 | 125 |
2022 October | 69 | 24 | 93 |
2022 September | 78 | 15 | 93 |
2022 August | 78 | 9 | 87 |
2022 July | 62 | 6 | 68 |
2022 June | 69 | 8 | 77 |
2022 May | 45 | 9 | 54 |
2022 April | 83 | 5 | 88 |
2022 March | 146 | 18 | 164 |
2022 February | 147 | 7 | 154 |
2022 January | 107 | 16 | 123 |
2021 December | 87 | 13 | 100 |
2021 November | 86 | 12 | 98 |
2021 October | 43 | 16 | 59 |
2021 September | 41 | 14 | 55 |
2021 August | 88 | 6 | 94 |
2021 July | 36 | 11 | 47 |
2021 June | 38 | 9 | 47 |
2021 May | 96 | 12 | 108 |
2021 April | 169 | 26 | 195 |
2021 March | 64 | 6 | 70 |
2021 February | 46 | 7 | 53 |
2021 January | 39 | 13 | 52 |
2020 December | 38 | 10 | 48 |
2020 November | 45 | 5 | 50 |
2020 October | 36 | 7 | 43 |
2020 September | 30 | 9 | 39 |
2020 August | 40 | 4 | 44 |
2020 July | 28 | 6 | 34 |
2020 June | 40 | 6 | 46 |
2020 May | 34 | 11 | 45 |
2020 April | 18 | 4 | 22 |
2020 March | 21 | 5 | 26 |
2020 February | 27 | 6 | 33 |
2020 January | 26 | 12 | 38 |
2019 December | 65 | 6 | 71 |
2019 November | 26 | 9 | 35 |
2019 October | 24 | 10 | 34 |
2019 September | 37 | 8 | 45 |
2019 August | 25 | 13 | 38 |
2019 July | 26 | 22 | 48 |
2019 June | 70 | 23 | 93 |
2019 May | 184 | 50 | 234 |
2019 April | 85 | 10 | 95 |
2019 March | 12 | 8 | 20 |
2019 February | 27 | 5 | 32 |
2019 January | 13 | 4 | 17 |
2018 December | 17 | 2 | 19 |
2018 November | 24 | 7 | 31 |
2018 October | 13 | 4 | 17 |
2018 September | 9 | 2 | 11 |
2018 August | 10 | 1 | 11 |
2018 July | 18 | 2 | 20 |
2018 June | 11 | 2 | 13 |
2018 May | 13 | 5 | 18 |
2018 April | 22 | 2 | 24 |
2018 March | 17 | 1 | 18 |
2018 February | 7 | 0 | 7 |
2018 January | 11 | 3 | 14 |
2017 December | 9 | 6 | 15 |
2017 November | 12 | 2 | 14 |
2017 October | 13 | 3 | 16 |
2017 September | 24 | 8 | 32 |
2017 August | 17 | 5 | 22 |
2017 July | 18 | 2 | 20 |
2017 June | 31 | 4 | 35 |
2017 May | 24 | 4 | 28 |
2017 April | 26 | 3 | 29 |
2017 March | 27 | 26 | 53 |
2017 February | 19 | 23 | 42 |
2017 January | 19 | 6 | 25 |
2016 December | 25 | 8 | 33 |
2016 November | 20 | 6 | 26 |
2016 October | 39 | 8 | 47 |
2016 September | 36 | 7 | 43 |
2016 August | 20 | 7 | 27 |
2016 July | 30 | 4 | 34 |
2016 June | 37 | 10 | 47 |
2016 May | 21 | 6 | 27 |
2016 April | 10 | 13 | 23 |
2016 March | 26 | 14 | 40 |
2016 February | 21 | 8 | 29 |
2016 January | 21 | 5 | 26 |
2015 December | 41 | 8 | 49 |
2015 November | 28 | 6 | 34 |
2015 October | 37 | 11 | 48 |
2015 September | 43 | 5 | 48 |
2015 August | 10 | 5 | 15 |
2015 July | 1 | 1 | 2 |
2015 June | 0 | 3 | 3 |
2015 May | 1 | 2 | 3 |