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Role of Computed Tomography in the Diagnosis of Brunner Gland Hamartoma
Papel de la tomografía computarizada en el diagnóstico del hamartoma de las glándulas de Brunner
José Andrés García-Marína,
Corresponding author
joseandresgarciamarin@gmail.com

Corresponding author.
, Ramón José Lirón-Ruiza, Enrique Luis Girela-Baenab, José Luis Aguayo-Albasinia
a Servicio de Cirugía General y Aparato Digestivo, Hospital Universitario Morales Meseguer, Murcia, Spain
b Servicio de Radiodiagnóstico, Hospital Universitario Morales Meseguer, Murcia, Spain
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when the melenas had begun&#46; The patient was haemodynamically stable&#44; and the abdomen was soft and non-painful&#46; Lab workup showed haemoglobin 10&#46;3<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#44; HCT 29&#46;6&#37;&#44; 13<span class="elsevierStyleHsp" style=""></span>400 leukocytes and 81&#37; PMN&#59; the remaining haemogram and biochemistry levels were normal&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Gastroscopy revealed a polypoid lesion in the superior duodenal knee&#59; gastrointestinal stromal tumour was ruled out&#44; and no signs of previous bleeding were observed&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We requested an abdominal CT&#46; The results reported the mass was a polypoid lesion measuring 3<span class="elsevierStyleHsp" style=""></span>cm&#215;2&#46;6<span class="elsevierStyleHsp" style=""></span>cm in the second portion of the duodenum&#44; which had a 3<span class="elsevierStyleHsp" style=""></span>cm pedicle that was implanted in the posterior side of the duodenal bulb&#46; The lesion presented heterogenous uptake&#44; with a peculiar presence of areas of fatty density in its interior&#44; which provided a probable diagnosis of Brunner gland hamartoma &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">We performed gastroscopy with polypectomy and haemostatic control of the pedicle with adrenalin and endoclips&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The pathology study defined the lesion as a mucosal&#8211;submucosal mass of hyperplastic Brunner glands and observed proliferated hyperplastic glandular lobules with cystic dilatations&#44; separated by fibrous tissue&#44; adipocytes and smooth muscle fibres&#46; These findings were compatible with Brunner gland hamartoma&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The patient was discharged&#46; He continues to be asymptomatic&#44; and endoscopic follow-up studies have shown good progress&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The Brunner glands are acinar structures that are mainly situated in the first portion of the duodenum&#44; which diminish in number distally&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Their function seems to be related with gastric acid&#44; as their secretions inactivate the acidity of gastric juices&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Since their discovery in 1688&#44; the nomenclature of the lesions associated with their growth has gone through different stages&#46; Currently&#44; the lesions are considered hamartomas given the abnormal proliferation of morphologically normal tissues &#40;without atypia&#41; within the lesion&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">It is a rare tumour with a reported approximate incidence of 1&#37; of small bowel tumours and 5&#37; of duodenal tumours&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> They are most frequently diagnosed between the 5th and 6th decades of life&#44; with a slightly greater prevalence in men&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">The aetiology is not clear&#46; Initially&#44; it was proposed that their growth could possibly be a consequence of hyperchlorhydria&#44; based on their function as an acid buffer&#44; but this possibility was ruled out since the lesions are not more frequent in cases of Zollinger&#8211;Ellison syndrome&#46; Furthermore&#44; they do not recede with antisecretory treatment&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">There seems to be a certain correlation with recurring pancreatitis episodes that lead to chronic pancreatitis&#44; possibly as a mechanism for adapting to the exocrine insufficiency caused by these conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Clinically&#44; most published case reports to date are based on the diagnosis as a consequence of upper gastrointestinal bleeding<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> or intestinal obstruction&#46; Indeed&#44; it seems that what is most common is that the lesion&#44; especially when it reaches a certain size &#40;larger than 1<span class="elsevierStyleHsp" style=""></span>cm&#41;&#44; debuts with symptoms of upper gastrointestinal bleeding&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;5&#8211;7</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">On other occasions&#44; the diagnosis can be incidental or due to symptoms of duodenal&#47;intestinal obstruction&#44; intussusception&#44; non-painful jaundice or pancreatitis&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The diagnosis is histological&#46; Endoscopic biopsy generally does not reach planes beyond the mucosa&#44; which provides for visualisation of the hamartomatous tissue&#46; Endoscopic ultrasound is useful for the diagnosis&#46; And in most cases&#44; a well-defined heterogenous hypoechoic submucosal nodule is observed&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">In our case&#44; it was not necessary to recur to endoscopic ultrasound because the CT scan was diagnostic&#46; Hur et al&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> described the radiological&#8211;pathological association of Brunner gland hamartomas studied by CT&#46; In general&#44; the lesions are observed to be nodules in the first duodenal portion that are hypoattenuated compared to the pancreatic parenchyma and heterogeneous&#46; The heterogeneity corresponds to the areas of adipose tissue and smooth muscle proliferation&#46; On other occasions&#44; where there is less amount of mesenchymal tissue&#44; the lesion can be described as homogeneously hypoattenuated&#44; but this is less frequent&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The differential diagnosis should include adenomatous polyps&#44; gastrointestinal stromal tumours&#44; lymphomas&#44; carcinoid tumours and tumours of the pancreatic and periampullary areas&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">The clinical approach should be endoscopic and is recommended when symptoms arise&#46; Surgery by means of duodenotomy or segmental resection should be reserved for cases that cannot be treated with endoscopy&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">The prognosis is excellent&#46; Although cases of malignant degeneration of hamartomas have been described&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> these may actually be focal adenocarcinomas over a non-dysplastic Brunner hamartoma&#46;</p></span>"
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