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Warthin-like, a Rare Variant of Papillary Thyroid Warthin-like, a rare variant of papillary thyroid cancer
Warthin-like, una variante infrecuente del carcinoma papilar de tiroides
Francisco Villalba Ferrera,
Corresponding author
flvferrer@hotmail.com

Corresponding author.
, María José García Coreta, Alberto Ríos Agudoa, Gara Alcalá García del Ríoa, Ana Villalba Segarrab
a Servicio de Cirugía General y Digestivo, Unidad de Cirugía Endocrina, Hospital General Universitario de Valencia, Valencia, Spain
b Universidad CEU Cardenal Herrera, Alfara del Patriarca, Valencia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Papillary thyroid carcinoma &#40;PTC&#41; is the most common malignancy of the thyroid gland&#46; Currently&#44; in addition to the classic PTC variant&#44; 14 other histopathological variants can be distinguished&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The Warthin-like variant of papillary thyroid carcinoma &#40;PTC-WL&#41; is rare &#40;1&#46;9&#37;&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> as only 164 cases have been described&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and there are no specific recommendations regarding its prognosis and treatment&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We present a case of the PTC-WL variant and comment on the most relevant aspects of this type of tumor given its rarity&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A 59-year-old woman with no medical history consulted for a nodule in the left thyroid lobe that was well defined&#44; non-adherent&#44; measured 2<span class="elsevierStyleHsp" style=""></span>cm&#44; with no palpable lymphadenopathies&#46; Analytically&#44; the patient was euthyroid with elevated anti-TPO antibodies &#40;1500<span class="elsevierStyleHsp" style=""></span>IU&#47;mL&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Ultrasound revealed a solid&#44; hypoechoic nodule measuring 17<span class="elsevierStyleHsp" style=""></span>mm&#215;21<span class="elsevierStyleHsp" style=""></span>mm&#215;16<span class="elsevierStyleHsp" style=""></span>mm with no halo&#44; scarce intranodular vascularization and a poorly defined surface &#40;TIRADS 4C&#41;&#46; FNA was performed on 2 occasions&#44; reported as Bethesda II&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Left hemithyroidectomy was indicated&#46; The pathology study reported a PTC-WL variant measuring 2<span class="elsevierStyleHsp" style=""></span>cm&#44; no capsular infiltration&#44; mutated BRAF V600E biomarker and associated thyroiditis &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The patient was reoperated with right hemithyroidectomy and prophylactic left lymph node dissection&#44; with definitive histology of thyroiditis and no lymph node involvement&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Radioiodine &#40;100<span class="elsevierStyleHsp" style=""></span>mCi&#41; was administered&#44; and after 18 months of follow-up the patient is disease-free with thyroglobulin 0&#46;1<span class="elsevierStyleHsp" style=""></span>ng&#47;mL and anti-thyroglobulin antibodies 0&#46;1<span class="elsevierStyleHsp" style=""></span>IU&#47;mL&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The PTC-WL variant mainly affects women &#40;W&#58;M&#61;8&#58;1&#41; in the fifth decade of life&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Its name is due to the histological similarity with salivary gland tumors<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and its behavior is similar to the classic PTC variant&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> which is currently considered different from the oncocytic variant due to histological and prognostic differences&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The size is variable &#40;0&#46;5&#8211;6&#46;0<span class="elsevierStyleHsp" style=""></span>cm&#41;&#44; presentation is usually unifocal &#40;88&#37;&#41; and lymph node involvement is seen in up to 45&#37; of cases&#44; similar to the classic variant&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> On ultrasound&#44; they are usually seen as solid-cystic nodules&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Diagnosis by FNA biopsy is complicated because it is difficult to differentiate the lesion from the classic variant or other lesions such as thyroiditis&#44; and the definitive diagnosis is sometimes established with the surgical specimen&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In the case described&#44; the cytology result was Bethesda II on 2 occasions&#44; with no diagnosis of thyroiditis or carcinoma&#46; This established the surgical indication together with the high suspicion of malignancy on ultrasound&#44; and the definitive diagnosis was reached based on the surgical specimen&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The histological diagnosis stands out because of a papillary structure with fibrovascular stalks infiltrated by lymphatic tissue and covered by tumor cells with oncocytic change and nuclear characteristics of papillary carcinoma&#46; Oncocytic or H&#252;rthle cells may be seen interspersed in the lymphatic infiltrate&#46; The healthy parenchyma is also usually accompanied by lymphatic infiltrate&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Proper diagnosis is important since the prognosis and treatment may be different for each histological variant&#46; The differential diagnosis will be mainly with H&#252;rthle cell carcinoma&#44; as well as the tall cell and oncocytic variants of papillary carcinoma&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The PTC-WL variant is associated with Hashimoto&#39;s thyroiditis in 80&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Some authors consider this a good prognostic factor since the tumor is less aggressive and survival is higher when this association exists&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> In the case described&#44; this association was found in the surgical specimen&#44; but not in the preoperative cytological study&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The BRAF &#40;proto-oncogene B-raf&#41; V600E mutation presented by the patient has been implicated in the pathogenesis of papillary thyroid carcinoma&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> being detected in more than 80&#37; of patients with the classic PTC variant<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and up to 65&#37; of patients with the PTC-WL variant&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Since there are few published cases&#44; the prognosis and treatment are not clear&#46; Based on the bibliography consulted&#44; it appears to be a carcinoma with a good prognosis similar to the classic PTC variant&#44; so the prognosis and treatment of the PTC-WL variant are currently considered the same&#46; However&#44; published studies include few cases&#44; with short follow-up times and poorly documented histopathological and clinical characteristics&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Regarding tumor behavior&#44; the study by Yeo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> is the only article that compares the PTC-WL and classic variants&#44; finding that the former is associated more with Hashimoto&#39;s thyroiditis and less with the BRAF V600E mutation&#44; with similar demographic&#44; clinical and pathological characteristics&#44; especially when associated with Hashimoto&#39;s thyroiditis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">The BRAF V600E mutation has been associated with a worse prognosis&#44; associated with more extensive disease and a higher recurrence rate&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Therefore&#44; we decided to use prophylactic central homolateral node dissection in the case described&#46; However&#44; Yeo et al&#46; did not find a correlation between the BRAF mutation and the clinical&#8211;pathological characteristics among patients with the PTC-WL variant&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">The medical literature has reported lymphatic involvement in up to 45&#37; of cases&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> 3 cases of recurrence &#40;1&#46;8&#37;&#41;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;9</span></a> and 2 cases &#40;1&#46;2&#37;&#41; associated with undifferentiated areas&#44; one of which progressed to anaplastic disease&#44; distant metastasis and death within 18 months of surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">The patient described presented an association with Hashimoto&#39;s thyroiditis and BRAF V600E mutation&#46; After excellent response to treatment&#44; she is currently disease-free&#46;</p></span>"
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