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Utilidad de la ECMO veno-venosa" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 689 "Ancho" => 2095 "Tamanyo" => 124798 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A) Computed tomography (CT) scan upon admission to the Intensive Care Unit; B) CT scan 16 h after admission, coinciding with severe hypoxemia.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María A. 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"autoresLista" => "Alfredo Vivas López, Cristina Narvaez Chavez, Alberto Marcacuzco Quinto, Ana Teijo Quintáns, Iago Justo Alonso" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Alfredo" "apellidos" => "Vivas López" "email" => array:1 [ 0 => "alfv7@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Cristina" "apellidos" => "Narvaez Chavez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Alberto" "apellidos" => "Marcacuzco Quinto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Ana" "apellidos" => "Teijo Quintáns" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Iago" "apellidos" => "Justo Alonso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Cirugía General y del Aparato Digestivo, Hospital 12 de Octubre, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital 12 de Octubre, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Metástasis en vesícula biliar de carcinoma epidermoide de cabeza y cuello: presentación atípica de metástasis de vía aérea" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 633 "Ancho" => 2167 "Tamanyo" => 520389 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemistry of the surgical piece: A) Positive immunohistochemistry for CK 5-6; B) Positive immunohistochemistry for p63.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Of all the malignant neoplasms of the digestive tract, gallbladder cancer ranks fifth in order of frequency<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>. More than 95% of these are primary neoplasms, and metastases from other carcinomas are extremely rare<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 69-year-old male smoker and drinker. His medical history included a T4N2M1 oral cavity squamous cell carcinoma at the age of 55 that had been treated with hemiglossectomy, functional cervical dissection and forearm flap, although follow-up in the outpatient consultation had been inadequate due to lack of patient compliance. Ten years later, he presented recurrence at the cervical and pulmonary level and was treated with immunotherapy and chemotherapy (C19D1 MK-3475-048 maintenance with pembrolizumab) with a sustained partial response. Months later, he underwent left cervical dissection, and several areas were identified of intracapsular metastasis of squamous cell carcinoma. Two months after this surgery, a PET/CT scan showed no evidence of local tumor recurrence of the pharyngeal neoplasm, but a hypermetabolic lesion was identified in the fundus of the gallbladder (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), and he was therefore referred to us for surgery. Abdominal MRI demonstrated focal thickening of the gallbladder wall that was 7 mm thick and 27 mm in maximum diameter, with indeterminate enhancement, meaning that the malignant nature of the lesion could not be ruled out (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Tumor markers were negative. With suspected metastasis of the oral squamous cell carcinoma, the digestive tumor committee decided on a surgical approach that included surgical resection and radical cholecystectomy, with laparoscopic resection of 2-3 cm of the liver parenchyma. A combination of the electroscalpel and the laparoscopic ultrasonic surgical aspirator (CUSA©) was implemented for the dissection of the liver parenchyma with cirrhotic characteristics. There were no incidents during surgery, and the patient was discharged from hospital on the fifth postoperative day, without complications. The pathological anatomy study identified the lesion as squamous cell carcinoma, with positive immunohistochemistry for squamous tumor markers CK 5-6 and p63 (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>), poorly differentiated, with a solid pattern, no glandular component, and images of lymphovascular and perineural invasion; positive presence of human papillomavirus (HPV) DNA was detected by polymerase chain reaction (PCR) technique. No lymph node involvement was found, and margins were free.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Almost all distant metastases of head and neck squamous cell carcinomas (HNSCC) occur in the lungs (77%), bones (19%), mediastinum/other lymph nodes (4%), as well as the brain, liver and skin. The appearance of metastases of HNSCC in other locations is extremely rare<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>. In turn, metastases from other neoplasms that are deposited in the gallbladder are very rare, and these patients have a very short survival after diagnosis (8.4 months on average)<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>. Within this group of gallbladder metastases, the most common primary malignant tumors are melanoma<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> and gastric cancer<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>. There are no reports of gallbladder metastasis from airway carcinomas in the literature. The patient in this case report presented advanced-stage squamous cell neoplasm of the airway (T4N2M1) with histologically confirmed cervical recurrence and a lesion in the gallbladder that was purely squamous. This poses the differential diagnosis with a squamous cell carcinoma of the gallbladder, which is very rare and has an incidence of 4% among gallbladder tumors<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>. In this case, the presence of a primary airway neoplasm and the confirmed presence of HPV DNA in the resected lesion (knowing that HPV is responsible for up to 65% of epidermoid tumors of the oral cavity<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>), leads us to conclude that it is a metastatic lesion of an airway squamous cell carcinoma, making this one of the first reported cases of this type of metastasis in the gallbladder.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Vivas López A, Narvaez Chavez C, Marcacuzco Quinto A, Teijo Quintáns A, Justo Alonso I. Metástasis en vesícula biliar de carcinoma epidermoide de cabeza y cuello: presentación atípica de metástasis de vía aérea. Cir Esp. 2021;99:688–690.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3080 "Ancho" => 2500 "Tamanyo" => 417304 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">MRI and PET/CT prior to surgery.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 633 "Ancho" => 2167 "Tamanyo" => 520389 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Immunohistochemistry of the surgical piece: A) Positive immunohistochemistry for CK 5-6; B) Positive immunohistochemistry for p63.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathology of upper gastrointestinal malignancies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. 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Year/Month | Html | Total | |
---|---|---|---|
2024 October | 14 | 2 | 16 |
2024 September | 54 | 6 | 60 |
2024 August | 43 | 9 | 52 |
2024 July | 47 | 1 | 48 |
2024 June | 25 | 3 | 28 |
2024 May | 24 | 5 | 29 |
2024 April | 30 | 6 | 36 |
2024 March | 39 | 3 | 42 |
2024 February | 62 | 2 | 64 |
2024 January | 50 | 1 | 51 |
2023 December | 54 | 2 | 56 |
2023 November | 37 | 2 | 39 |
2023 October | 70 | 4 | 74 |
2023 September | 33 | 2 | 35 |
2023 August | 21 | 0 | 21 |
2023 July | 26 | 1 | 27 |
2023 June | 29 | 2 | 31 |
2023 May | 51 | 2 | 53 |
2023 April | 40 | 0 | 40 |
2023 March | 31 | 3 | 34 |
2023 February | 19 | 2 | 21 |
2023 January | 13 | 3 | 16 |
2022 December | 7 | 5 | 12 |
2022 November | 20 | 9 | 29 |