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"en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Abdominal phase: A) Creation of the jejunal tube after dissection of the mesentery; B) Optimal perfusion of the jejunum is confirmed with indocyanine green fluorescence imaging prior to completing the abdominal phase.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Andrés Navarrete, Roberto Humeres" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Andrés" "apellidos" => "Navarrete" ] 1 => array:2 [ "nombre" => "Roberto" "apellidos" => "Humeres" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0009739X20303079" "doi" => "10.1016/j.ciresp.2020.09.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0009739X20303079?idApp=UINPBA00004N" ] ] 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"autores" => array:5 [ 0 => array:4 [ "nombre" => "Sergio" "apellidos" => "Cerrato Delgado" "email" => array:1 [ 0 => "sergio_0892@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Amparo" "apellidos" => "Valverde Martinez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Tatiana" "apellidos" => "Gómez Sánchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Alberto" "apellidos" => "Fierro Aguilar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Jose Manuel" "apellidos" => "Pacheco García" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Médico Residente de Cirugía General y Digestiva, Servicio de Cirugía General y Digestiva, Hospital Universitario Puerta del Mar, Cádiz, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "FEA de Cirugía General y Digestiva, Servicio de Cirugía General y Digestiva, Hospital Universitario Puerta del Mar, Cádiz, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Jefe de Servicio, Servicio de Cirugía General y Digestiva, Hospital Universitario Puerta del Mar, Cádiz, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "<span class="elsevierStyleItalic">Step-up approach</span> en pancreatitis necrosante grave: combinación de desbridamiento retroperitoneal videoasistido y necrosectomía endoscópica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 3683 "Ancho" => 2174 "Tamanyo" => 811694 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Diagram of the video-assisted retroperitoneal necrosectomy on the right side.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Walled-off pancreatic necrosis is one of the most feared complications of severe acute pancreatitis. Although most cases evolve favorably with conservative management, up to one-quarter of patients will require interventional techniques<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a>. The management of peripancreatic collections has evolved in recent years, and the benefits of the step-up approach have been widely demonstrated<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3–5</span></a>. The current debate in this field focuses on demonstrating the superiority of endoscopic necrosectomy (EN) over video-assisted retroperitoneal debridement (VARD), or vice versa<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>. We present the case of a patient with severe acute pancreatitis and large walled-off necrosis that required the combined use of EN and VARD for its resolution.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient is a 69-year-old man with arterial hypertension and hyperuricemia, who came to the emergency room due to sudden and intense abdominal pain in the epigastrium. We observed notable impairment of his general condition and signs of peripheral hypoperfusion. Blood pressure was 153/95 mmHg; heart rate 86 bpm. He maintained an oxygen saturation of 89%–92%, with an inspired oxygen fraction of 21%. Intra-abdominal pressure was 27 mmHg, measured indirectly. His abdomen was very distended, with generalized tenderness and muscle guarding. Lab work-up showed normal renal function and ions, alanine aminotransferase 256 U/L, aspartate aminotransferase 518 U/L, total bilirubin 1.63 mg/dL (direct 0.96 mg/dL), amylase 6.396 U/L, lipase 21 200 U/L, C-reactive protein 51 mg/dL, leukocytes 262 900 μL (80% neutrophils) and coagulation in normal ranges. Abdominal computed tomography (CT) scan was performed 48 h after admission, showing images compatible with pancreatitis, with focal areas of necrosis and gallstones (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). During the first month of hospitalization in the Intensive Care Unit, he presented multiple organ failure and required non-invasive mechanical ventilation, hemofiltration, and high doses of vasoactive drugs. Due to suspected superinfection of the collection, empirical antibiotic therapy was started with piperacillin/tazobactam 4/0.5 every 8 h. The patient then presented an episode of upper gastrointestinal bleeding and endoscopy was performed, during which a large clot was observed with no other observable findings. An abdominal CT scan showed hemorrhage from the left gastric artery, which was embolized. The CT scan 22 days after admission also revealed a necrosis of more than 80% of the pancreatic parenchyma and a peripancreatic necrotic collection (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). We then decided to insert a percutaneous pigtail catheter under CT guidance. <span class="elsevierStyleItalic">Klebsiella pneumoniae</span> was isolated in the fluid culture, which was treated with 1 g ceftriaxone every 24 h according to the antibiogram. During the next 30 days of hospitalization, the patient continued to present a torpid evolution (improvement after the placement of the drain tube and progressive worsening afterwards). The drains were changed twice for others with a larger diameter, but the evolution was similar (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C and D). Orotracheal intubation was required as a consequence of nosocomial pneumonia.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">After 62 days, the follow-up CT scan showed an increase in the peripancreatic collection. We decided to carry out EN. A metallic diabolo stent was placed, and a double pigtail catheter was inserted through it. Two successive sessions of EN were carried out with an infusion of 0.3% hydrogen peroxide. In the 3rd session, a 7 Fr nasocystic catheter was inserted, through which saline lavages were carried out. During the 4th session, the stent was accidentally moved, which required replacement. Evolution continued to be torpid. Radiologically, the part of the collection located around the head of the pancreas continued to grow, extending to the right paracolic gutter. We decided to perform VARD (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The collection was accessed by following the pigtail catheter in place. Through a 12 mmHg trocar, 6−8 mmHg retro-pneumoperitoneum was created, and an auxiliary 5 mmHg trocar was inserted. The purulent contents were aspirated, and the necrotic material was removed. Aspiration lavage of the cavity was done with saline and povidone iodine. A grooved 19 Fr Blake silicone drain was placed inside the cavity, which was washed out with saline and urokinase every 12 h.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The patient progressed favorably. The pigtail catheter was removed on the 10th day and the Blake drain on the 16th day. On the 20th postoperative day, the patient was transferred to the hospital ward, and after 190 days of total hospital stay, he was discharged. The gastric prosthesis was removed 9 months later, after having verified that the collections had resolved correctly (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The patient is currently asymptomatic and under treatment for pancreatic insufficiency.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">An important factor in the management of patients with severe acute pancreatitis is the correct characterization of pancreatic collections. It is recommended to wait until the definitive conformation of the wall (generally 4 weeks) before attempting any invasive technique<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8</span></a> (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A–C). Within the step-up approach, there are different accepted routes to perform necrosectomy. One of them is the VARD technique. This involves stepwise management, since radioguided placement of a catheter inside the collection is necessary beforehand. There are many studies that have demonstrated a reduction in complications and mortality compared to open surgery<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,9</span></a>. In addition, EN is also evolving as a safe technique within stepwise management. The advent of lumen-apposing metal stents seems to reduce the number of complications, especially migration, as in our patient<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>. The TENSION study (multicenter, controlled and randomized) found no differences in terms of morbidity and mortality between the two techniques, although it did demonstrate superiority of the endoscopic technique in terms of reducing pancreatic fistula and hospital stay compared to VARD<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>. In our case, however, both techniques used in conjunction for the correct resolution of the symptoms. Thus, EN was more suitable for retrogastric collections, and VARD was more useful in the paracolic gutters.</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion, the combination of different necrosectomy techniques should be considered a tool for the management of severe pancreatitis and should be considered part of the multidisciplinary management of patients in hospitals with extensive experience.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Cerrato Delgado S, Valverde Martinez A, Gómez Sánchez T, Fierro Aguilar A, Pacheco García JM. <span class="elsevierStyleItalic">Step-up approach</span> en pancreatitis necrosante grave: combinación de desbridamiento retroperitoneal videoasistido y necrosectomía endoscópica. Cir Esp. 2022;100:52–55.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1827 "Ancho" => 3167 "Tamanyo" => 652941 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) abdominal CT scan at admission; (B) abdominal CT after 15 days of hospitalization; (C) abdominal CT after 29 days of hospitalization; (D) 3 percutaneous drain tubes placed under abdominal CT guidance successively for the drainage of the collection (marked with arrows).</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 3683 "Ancho" => 2174 "Tamanyo" => 811694 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Diagram of the video-assisted retroperitoneal necrosectomy on the right side.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1455 "Ancho" => 3340 "Tamanyo" => 383584 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Follow-up CT scan in the outpatient clinic 6 months after discharge, before withdrawal of the gastric stent (white arrow: atrophic pancreas; blue arrow: gastric stent).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of conservative treatment, without necrosectomy, for infected pancreatic necrosis: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "V.P. 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Year/Month | Html | Total | |
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2024 November | 11 | 0 | 11 |
2024 October | 67 | 7 | 74 |
2024 September | 83 | 24 | 107 |
2024 August | 60 | 21 | 81 |
2024 July | 33 | 12 | 45 |
2024 June | 41 | 18 | 59 |
2024 May | 32 | 13 | 45 |
2024 April | 27 | 2 | 29 |
2024 March | 65 | 9 | 74 |
2024 February | 109 | 14 | 123 |
2024 January | 133 | 8 | 141 |
2023 December | 71 | 5 | 76 |
2023 November | 121 | 7 | 128 |
2023 October | 134 | 11 | 145 |
2023 September | 57 | 11 | 68 |
2023 August | 28 | 6 | 34 |
2023 July | 26 | 7 | 33 |
2023 June | 12 | 6 | 18 |
2023 May | 16 | 14 | 30 |
2023 April | 12 | 12 | 24 |
2023 March | 10 | 7 | 17 |
2023 February | 5 | 6 | 11 |
2023 January | 5 | 0 | 5 |