Scientific letter
Superior mesenteric vein thrombosis as the only manifestation of SARS-CoV-2 infection
Trombosis de la vena mesentérica superior como única manifestación de la infección por SARS-CoV-2
Sergio Navarro-Martínez
, José Ángel Diez Ares, Nuria Peris Tomás, Paula Gonzálvez Guardiola, Álvaro Pérez-Rubio
Corresponding author
Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Doctor Peset, Valencia, Spain
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"Superior mesenteric vein thrombosis as the only manifestation of SARS-CoV-2 infection" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "244" "paginaFinal" => "246" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Sergio Navarro-Martínez, José Ángel Diez Ares, Nuria Peris Tomás, Paula Gonzálvez Guardiola, Álvaro Pérez-Rubio" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Sergio" "apellidos" => "Navarro-Martínez" "email" => array:1 [ 0 => "na.mar.sergio@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "José Ángel" "apellidos" => "Diez Ares" ] 2 => array:2 [ "nombre" => "Nuria" "apellidos" => "Peris Tomás" ] 3 => array:2 [ "nombre" => "Paula" "apellidos" => "Gonzálvez Guardiola" ] 4 => array:2 [ "nombre" => "Álvaro" "apellidos" => "Pérez-Rubio" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Doctor Peset, Valencia, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author</span>." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Trombosis de la vena mesentérica superior como única manifestación de la infección por SARS-CoV-2" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1116 "Ancho" => 2332 "Tamanyo" => 292140 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Coronal and axial computed tomography images showing the thrombus in the superior mesenteric vein in the confluence of the mesenteric-portal axis (arrow).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In December 2019, the SARS-CoV-2 coronavirus was detected for the first time in the Chinese city of Wuhan<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>. This virus is the cause of the pandemic that has resulted in nearly one million deaths to date, while saturating healthcare systems around the world and modifying surgical activity in our country<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a>. Despite being a respiratory virus, numerous non-respiratory complications have been reported triggered by SARS-CoV-2 infection and derived from its treatment<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a>. An increase in venous and arterial thromboembolic events has been demonstrated in these patients, as well as damage to the microvascularization. It has been suggested that endothelial damage is the main factor causing hypercoagulability in coronavirus disease 2019 (COVID-19)<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7</span></a>.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We present the case of a 40-year-old man with no history of interest who came to the emergency room due to abdominal pain in the epigastrium that had progressed over several days, with no other associated symptoms. Physical examination was anodyne, and laboratory tests showed: D-dimer 446 ng/mL, fibrinogen 742 mg/dL, and slightly prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT). SARS-CoV-2 screening was done with a polymerase chain reaction (PCR) test of a nasopharyngeal exudate sample as part of the hospital protocol, and the patient was discharged with a diagnosis of nonspecific abdominal pain. The next day, the patient received a positive PCR result for SARS-CoV-2. After 12 days of home isolation, the patient returned to the emergency room due to worsening abdominal pain and general malaise. He presented a diffusely tender abdomen with guarding and signs of peritoneal irritation in the epigastrium and mesogastrium. He did not present respiratory symptoms. Laboratory tests revealed increased acute-phase reactants. PT and aPTT remained long, fibrinogen elevated, and D-dimer increased to 947 ng/mL. Chest X-ray showed no pathological findings. A computed tomography (CT) scan was requested, which revealed a thrombus in the superior mesenteric vein originating from the confluence of the mesenteric-portal axis and a section of approximately 50 cm of dilated proximal jejunum with a thickened wall due to submucosal edema with low contrast uptake (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). No intestinal pneumatosis, pneumoperitoneum or free fluid were observed. Given these findings, we decided to admit the patient in isolation for anticoagulant treatment and close monitoring. The patient had a good evolution, with a progressive decrease in abdominal pain, and was discharged on the sixth day after two negative nasopharyngeal exudate PCR. At discharge, a CT scan showed the resolution of the loop edema and the persistence of the thrombus. Oral anticoagulation was prescribed for six months. Four months later, a coagulopathy study revealed antithrombin III deficiency.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">SARS-CoV-2 infection causes predominantly respiratory symptoms. However, since the appearance of this new disease, numerous cases of thromboembolic events have been described in patients with COVID-19. Nevertheless, in our review of the literature, we have not found any cases of isolated thrombosis of the superior mesenteric vein as the first and only symptom associated with SARS-CoV-2 infection, as in our case. The pathogenesis of this hypercoagulable state is not fully understood. It seems that endothelial injury plays a major role in the higher incidence of thromboembolic events in these patients. This is due to the fact that the virus enters the organism through the union of its surface protein to the angiotensin converting enzyme 2 (ACE2)<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>. Other associated factors are the presence of high levels of circulating prothrombotic factors such as fibrinogen or factor VIII and venostasis secondary to less mobilization in hospitalized and/or isolated patients. The most common coagulation abnormalities on lab tests are, as in the present case, a normal or slightly prolonged PT or aPTT, normal or slightly increased platelet count, and an elevated D-dimer<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>. The most frequent thromboembolic manifestations in these patients are deep vein thrombosis (DVT) and pulmonary embolism (PE)<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>, and it has even been suggested that many PE are primary thromboses of the pulmonary arteries secondary to endotheliitis. Thromboses of the mesenteric territory associated with SARS-CoV-2 infection are rare and occur mainly in the small vessels. The involvement of the large abdominal vessels is predominantly arterial and in hospitalized patients, while there have been few reported cases of mesenteric venous thrombosis, mostly associated with arterial thrombosis<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In this second ‘wave’ of COVID-19 with more than 30 000 daily diagnoses in Spain, the number of asymptomatic infections or those with mild symptoms represent the majority of new positives. This is because more diagnostic tests are being performed and asymptomatic contacts traced. As a consequence, more and more forms of presentation and non-respiratory symptoms are being recorded in patients with active SARS-CoV-24 infection<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>. We have yet to resolve many unknown factors about the pathophysiology of this disease and its consequences in the medium and long term. Given the current healthcare situation and the constant increase in cases, we should include COVID-19 in the differential diagnoses of patients with abdominal thromboembolic events, especially in young patients with no previous pathology or risk factors. Likewise, we should highlight the need for thrombophilia studies in these patients, where COVID-19 can act as a precipitating factor for thromboembolic events in patients with undiagnosed coagulopathies.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0025" class="elsevierStylePara elsevierViewall">This study has received no funding of any kind.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interests</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interests" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Navarro-Martínez S, Diez Ares JÁ, Peris Tomás N, Gonzálvez Guardiola P, Pérez-Rubio Á. Trombosis de la vena mesentérica superior como única manifestación de la infección por SARS-CoV-2. Cir Esp. 2022;100:245–247.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1116 "Ancho" => 2332 "Tamanyo" => 292140 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Coronal and axial computed tomography images showing the thrombus in the superior mesenteric vein in the confluence of the mesenteric-portal axis (arrow).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A Novel Coronavirus from Patients with Pneumonia in China, 2019" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 0 | 8 |
| 2024 October | 24 | 2 | 26 |
| 2024 September | 47 | 2 | 49 |
| 2024 August | 41 | 7 | 48 |
| 2024 July | 32 | 3 | 35 |
| 2024 June | 27 | 0 | 27 |
| 2024 May | 22 | 2 | 24 |
| 2024 April | 30 | 21 | 51 |
| 2024 March | 40 | 3 | 43 |
| 2024 February | 55 | 6 | 61 |
| 2024 January | 60 | 2 | 62 |
| 2023 December | 54 | 2 | 56 |
| 2023 November | 51 | 1 | 52 |
| 2023 October | 61 | 1 | 62 |
| 2023 September | 38 | 1 | 39 |
| 2023 August | 31 | 1 | 32 |
| 2023 July | 62 | 6 | 68 |
| 2023 June | 69 | 3 | 72 |
| 2023 May | 106 | 1 | 107 |
| 2023 April | 59 | 2 | 61 |
| 2023 March | 29 | 0 | 29 |
| 2023 February | 21 | 0 | 21 |
| 2023 January | 18 | 2 | 20 |
| 2022 December | 19 | 0 | 19 |
| 2022 November | 17 | 0 | 17 |
| 2022 October | 13 | 0 | 13 |
| 2022 September | 23 | 3 | 26 |
| 2022 August | 13 | 0 | 13 |
| 2022 July | 4 | 0 | 4 |
| 2022 June | 9 | 0 | 9 |
| 2022 May | 17 | 0 | 17 |
| 2022 April | 0 | 1 | 1 |
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