Selective effect of laparoscopic Roux-en-Y gastric bypass on lipid metabolism | Clínica e Investigación en Arteriosclerosis (English Edition)

array:22 ["pii" => "S2529912322000201" "issn" => "25299123" "doi" => "10.1016/j.artere.2022.04.005" "estado" => "S300" "fechaPublicacion" => "2022-03-01" "aid" => "6140" "copyrightAnyo" => "2022" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Clin Investig Arterioscler. 2022;34:68-74" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S2529912322000134" "issn" => "25299123" "doi" => "10.1016/j.artere.2022.04.002" "estado" => "S300" "fechaPublicacion" => "2022-03-01" "aid" => "620" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Clin Investig Arterioscler. 2022;34:75-85" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Is serum Osteopontin a predictor of carotid atherosclerosis severity among prevalent hemodialysis patients?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "75" "paginaFinal" => "85" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Es la osteopontina sérica un factor predictivo de la gravedad de la aterosclerosis carotídea en los pacientes prevalentes en hemodiálisis?" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 2114 "Ancho" => 2167 "Tamanyo" => 160070 ] ] "descripcion" => array:1 [ "en" => "ROC curve analysis showing the diagnostic performance of OPN to detect carotid Atheroma (AUC=0.767, p<0.001)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Maha A. Behairy, Sahar Shawky, Reham Hamed, Somia Bawady, Hoda A. Abdelsattar, Walid Bichari" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Maha A." "apellidos" => "Behairy" ] 1 => array:2 [ "nombre" => "Sahar" "apellidos" => "Shawky" ] 2 => array:2 [ "nombre" => "Reham" "apellidos" => "Hamed" ] 3 => array:2 [ "nombre" => "Somia" "apellidos" => "Bawady" ] 4 => array:2 [ "nombre" => "Hoda A." "apellidos" => "Abdelsattar" ] 5 => array:2 [ "nombre" => "Walid" "apellidos" => "Bichari" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0214916821001583" "doi" => "10.1016/j.arteri.2021.11.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0214916821001583?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529912322000134?idApp=UINPBA00004N" "url" => "/25299123/0000003400000002/v1_202205120709/S2529912322000134/v1_202205120709/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2529912322000109" "issn" => "25299123" "doi" => "10.1016/j.artere.2022.03.001" "estado" => "S300" "fechaPublicacion" => "2022-03-01" "aid" => "613" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Clin Investig Arterioscler. 2022;34:57-67" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Bempedoic acid as a PPARα activator: New perspectives for hepatic steatosis treatment in a female rat experimental model" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "57" "paginaFinal" => "67" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El ácido bempedoico como activador PPARα: Nuevas perspectivas para el tratamiento de la esteatosis hepática en un modelo experimental de rata hembra" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2274 "Ancho" => 2600 "Tamanyo" => 187711 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Drink and food consumption, total calorie intake and animal weights. (A) Area under the curve (AUC) of drink consumption per rat during 90 days, expressed in ml (ml/90d/rat). (B) Area under the curve (AUC) of solid food consumption per rat during 90 days, expressed in g (g/90d/rat). (C) Area under the curve (AUC) of total calorie intake per rat during 90 days, expressed in kcal (kcal/90d/rat). (D) Bodyweight of the animals at the end of treatment, expressed in g. Results expressed as an average  ± SD for n = 8 animals/group. Bpda: group fed with HF-FR and treated with bempedoic acid; CT: control group; HF-FR: group fed with a high-fat diet and supplemented with fructose in the drinking water. *P < .05, **P < .01, ***P < .001 vs. the CT group. #P < .05, ##P < .01 vs. HF-FR group." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Roger Bentanachs, Ana Magdalena Velázquez, Rosa María Sánchez, Marta Alegret, Juan Carlos Laguna, Núria Roglans" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Roger" "apellidos" => "Bentanachs" ] 1 => array:2 [ "nombre" => "Ana Magdalena" "apellidos" => "Velázquez" ] 2 => array:2 [ "nombre" => "Rosa María" "apellidos" => "Sánchez" ] 3 => array:2 [ "nombre" => "Marta" "apellidos" => "Alegret" ] 4 => array:2 [ "nombre" => "Juan Carlos" "apellidos" => "Laguna" ] 5 => array:2 [ "nombre" => "Núria" "apellidos" => "Roglans" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0214916821001376" "doi" => "10.1016/j.arteri.2021.09.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0214916821001376?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529912322000109?idApp=UINPBA00004N" "url" => "/25299123/0000003400000002/v1_202205120709/S2529912322000109/v1_202205120709/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Selective effect of laparoscopic Roux-en-Y gastric bypass on lipid metabolism" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "68" "paginaFinal" => "74" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Marianela Ackerman, Edgardo Serra, Pablo Flecha, Juan Patricio Nogueira" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Marianela" "apellidos" => "Ackerman" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "Edgardo" "apellidos" => "Serra" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "Pablo" "apellidos" => "Flecha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] ] ] 3 => array:4 [ "nombre" => "Juan Patricio" "apellidos" => "Nogueira" "email" => array:1 [ 0 => "nogueirajuanpatricio@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "e" "identificador" => "aff0025" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Cátedra de Medicina Interna, Facultad de Medicina Universidad Nacional del Nordeste (UNNE), Corrientes, Argentina" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Nutrición y Diabetes, Centro de Endocrinología y Nutrición (CIEN), Corrientes, Argentina" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Cirugía Bariátrica y Metabólica, Centro de Endocrinología y Nutrición (CIEN), Corrientes, Argentina" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Instituto Modelo de Gastroenterología, Formosa, Argentina" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Centro de Investigación en Nutrición, Endocrinología y Metabolismo (CIENM), Facultad de Ciencias de la Salud, Universidad Nacional de Formosa, Formosa, Argentina" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efecto selectivo de bypass gástrico laparoscópico en Y de Roux sobre el metabolismo lipídico" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1473 "Ancho" => 2508 "Tamanyo" => 110346 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "TG levels 18 months after LRYGP vs. LSG. *P < .05 between groups." ] ] ] "textoCompleto" => "IntroductionObesity is a public health problem in the whole world, and it is associated with comorbidities such as: type 2 diabetes mellitus (DM2) and cardiovascular diseases (CVD).<a class="elsevierStyleCrossRef" href="#bib0005">1</a> The increasing prevalence of obesity is accompanied by a higher prevalence of DM2. Obesity does not only increase the risk of developing DM2, as it also aggravates the risks of the same for health and makes managing it more complex.<a class="elsevierStyleCrossRef" href="#bib0010">2</a>CVD is the main cause of morbidity and mortality in patients with obesity and DM2.<a class="elsevierStyleCrossRef" href="#bib0015">3</a> High levels of cholesterol in plasma with low density lipoproteins (C-LDL) are the main cardiovascular lipid risk factor.<a class="elsevierStyleCrossRef" href="#bib0020">4</a> Nevertheless, atherogenic dyslipidaemia (AD) as seen in states of insulin resistance (IR), such as obesity and DM2, is a decisive factor in cardiovascular risk. AD is chiefly characterized by high levels of fasting and post-prandial triglyceride-rich lipoproteins (TRL) in plasma, small and dense low density lipoproteins (LDL) and low levels of cholesterol carried in high density lipoproteins (HDL-C).<a class="elsevierStyleCrossRef" href="#bib0025">5</a>Bariatric surgery (BS) is currently the most effective treatment to induce weight loss in obese patients. It leads to the complete or partial remission of DM2 and improves cardiovascular risk factors such as arterial hypertension and lipid alterations in a significant proportion of patients.<a class="elsevierStyleCrossRef" href="#bib0030">6</a>The most common BS procedures used worldwide are laparoscopic sleeve gastrectomy (LSG), a restrictive technique, and the laparoscopic Roux-en-Y gastric bypass (LRYGP), which is a combined restrictive and malabsorptive technique. As there is no strict recommendation regarding when to perform a LSG or a LRYGP, differences in the resulting glycosidic and lipid parameters may be highly useful when selecting the best surgical technique for a patient.<a class="elsevierStyleCrossRef" href="#bib0035">7</a>Of the factors which are associated with a good prognosis, reducing TG and total cholesterol have been shown in multivariate analysis to be early markers of a reduction in cardiovascular events.<a class="elsevierStyleCrossRef" href="#bib0040">8</a>Many of the random controlled clinical trials published do not evaluate lipid parameters in their initial end points. Many studies do not report on the percentage of patients who had been subjected to previous or subsequent lipid lowering treatments, or the class or dose of the lipid lowering drugs used.This study evaluates lipid parameters after an 18 month follow-up of patients operated using LRYGP vs. LSG.Material and methodsA total of 168 obese patients evaluated in the Department of Nutrition and Bariatric Surgery of the Nutrition, Endocrinology and Metabolism Centre (CIEN), Corrientes, Argentina, and the Instituto Modelo de Gastroenterología (IMG), Formosa, Argentina, were recruited for this study.All of the patients were evaluated by a multidisciplinary team composed of an endocrinologist, a bariatric surgeon, a psychiatrist and a nutritionist during at least six months prior to surgery. All of the subjects fulfilled the criteria for bariatric surgery.<a class="elsevierStyleCrossRef" href="#bib0045">9</a>The surgical techniques used included LRYGP and LSG. Follow-up after surgery was restricted to 18 months. Patients with kidney failure were excluded (glomerular filtration ≤60 mL/min/1.73 m2), as were minors and those older than 65 years, pregnant women and subjects with a severe disease that determined their survival. Patients whose follow-up was incomplete, lacked data or who had been subjected to surgery due to weight gain were excluded from this study. Clinical and analytical data corresponding to all of the patients were gathered after review of their computerized clinical histories. This study was undertaken according to the Helsinki Declaration and approved by the bioethics committee of the IMG, and all of the patients gave their informed consent in writing.The diet of each subject was evaluated by a nutritionist, using a self-administered diary recording consumption over three days. Their weight, fasting biochemical parameters, body composition and energy intake were measured one month before surgery (T0) and at six months (T6), 12 months (T12) and 18 months (T18) after surgery. Our study was not designed to compare the efficacy of both surgical procedures, LRYGP vs LSG.Blood samples were taken after nocturnal fasting. The plasma was immediately separated by centrifuging at 2000 rpm during 15 min at 4 C. TG in plasma, total cholesterol, HDL-C and LDL-C were measured using an enzymatic colorimetric kit (Cobas 6000 c 501 analyser; Roche Diagnostics, Mannheim, Germany). Glucose in plasma was analysed using the hexokinase method (Cobas 6000c, 501 analyser). Concentrations of insulin in plasma were determined using the electrochemiluminescence method (Cobas Analyser 6000 and 601). Insulin resistance was estimated using the homeostasis model of assessment (HOMA-IR): fasting insulin (mUI/L) × fasting glucose (mmol /L) /22.5.<a class="elsevierStyleCrossRef" href="#bib0050">10</a> HOMA-IR was not calculated for patients with diabetes to avoid the HOMA-IR calculation error due to the antidiabetic drugs taken by these patients.Concentrations in plasma were determined for apoB and apoA-I by immunonephelometry (Roche Diagnostics) using a BN ProSpec analyser (Siemens Healthineers, Erlangen, Germany). Resting energy expenditure (REE) was measured by indirect calorimetry (Quark-RMR-Cosmed, Rome, Italy). Body composition was evaluated by dual-energy x-ray absorptiometry (DEXA) (Lunar iDXA and enCORE 2007 version software, GE Healthcare, Chalfont St Giles, United Kingdom).Statistical analysisData were expressed as an average ± standard deviation for continuous variables. Categorical variables were shown as percentages. The normal distribution of variables was confirmed by the Kolmogorov- Smirnov test. Comparisons between groups were made by the X2 test for categorical variables, as well as the Student’s t-test and ANOVA for continuous variables. The relationship between continuous variables was examined by multiple regression analysis. All statistical analysis was performed using the IBM SPSS Statistics 25.0 programme (IBM Inc., NY). Tests were bilateral, and P < .05 was considered to be statistically significant.ResultsPatients’ basal characteristics are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>, without significant differences. The average follow-up time was 1.5 years. Treatment prior to BS is shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>. No significant differences were found in terms of sex, energy expenditure, fat mass, glucose, lipids or apolipoproteins between the laparoscopic Roux-en-Y gastric bypass (LRYGP) group and the laparoscopic sleeve gastrectomy (LSG) group. The evolution of anthropometric and metabolic parameters after months’ follow-up after surgery are shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>. A fall in weight, body mass index (BMI), fasting glucose in plasma, HOMA-IR, energy intake and fat mass was detected after surgery in both groups during the months of follow-up.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia>A fall in apoB and a rise in apoA-1 was observed at six months, as was a fall in TG and a rise in HDL in both groups (LRYGP and LSG) after six months, while on the other hand a fall in LDL and CT after 12 and 18 months only occurred in the LRYGP group (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1–4</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia>Finally, step-by-step multiple lineal regression analysis showed that the fall in HOMA-IR independently predicted the reduction in LDL at 18 months, explaining 72% of this fall (R2 = 0.720) (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>).<elsevierMultimedia ident="tbl0020"></elsevierMultimedia>DiscussionThis study showed that LRYGP is superior in terms of reducing LDL and CT at 12 and 18 months of follow-up.BS reduces cardiovascular mortality.<a class="elsevierStyleCrossRef" href="#bib0055">11</a> This fall has been attributed in part to a reduction in plasmatic lipids, through unknown mechanisms. This study shows that the clinically important improvements in plasmatic lipids after LRYGP surgery arise in the final postoperative period, with substantial weight loss. The possible underlying mechanism for the improvement or resolution of the dyslipidaemia after bariatric surgery may be associated with weight loss. Weight loss is expected to improve insulin sensitivity, which in turn may reduce TG levels and increase the levels of HDL-C. This curve is similar to the weight loss curve after LRYGP and LSG.<a class="elsevierStyleCrossRefs" href="#bib0060">12,13</a>Levels of total cholesterol and LDL-c fall at 12 and 18 months, which supports the hypothesis that these changes are a direct consequence of surgery rather than absolute weight loss. The intestine plays a crucial role in cholesterol metabolism and participates in the absorption of cholesterol (from foods and bile) as well as in trans-intestinal cholesterol excretion. It has been known for a long time that an ileac bypass (which creates poor absorption, without closing the stomach as occurs in bariatric surgery) reduces cholesterol levels and cardiovascular diseases.<a class="elsevierStyleCrossRef" href="#bib0030">6</a> Curiously, all of the studies which compare the different effects of LSG and LRYGP on concentrations of cholesterol in plasma show a constant 20%–30% reduction in cholesterol after LRYGP, which is maintained at five years.<a class="elsevierStyleCrossRef" href="#bib0070">14</a>Contrary to the previous finding, cholesterol levels do not change after LSG.<a class="elsevierStyleCrossRef" href="#bib0075">15</a> The 20%–30% reduction in cholesterol after LRYGP is equivalent to the fall that is obtained with an average dose of statins. The malabsorption technique of LRYGP significantly alters the flow of nutrients in the intestine, and the metabolic changes observed after this technique are in part independent of weight loss. These changes are multifactorial and complex, and they constitute a broad field for exploration.Characterizing the factors which cause the constant 20%–30% fall in cholesterol after LRYGP may make it possible to identify new components of intestinal cholesterol metabolism and new therapeutic targets to reduce cholesterol. The potential factors which may be involved in reducing LDL after LRYGP are: (i) changes in cholesterol metabolism (a reduction in intestinal absorption, an increase in intestinal excretion, an increase in hepatic catabolism or a fall in hepatic synthesis), (ii) an increase in the intestinal conversion of cholesterol into coprostanol (an inactive type of sterol that is neither absorbed nor eliminated in the faeces), (iii) changes in the metabolism of the biliary acids (which are critical factors in intestinal cholesterol metabolism), (iii) changes in the intestinal hormones, and (iv) changes in the intestinal microbial ecosystem (microbiota).<a class="elsevierStyleCrossRefs" href="#bib0080">16,17</a>Statins may affect this mechanism, as they inhibit the synthesis of cholesterol in the liver, which leads to the activation of the LDL receptors and increasing hepatic capture of HDL from the circulation. The 20%–30% fall in cholesterol after LRYGP is equivalent to the reduction caused by an average dose of low-intensity statins.<a class="elsevierStyleCrossRef" href="#bib0090">18</a> The administration of low therapeutic intensity statins is associated with average falls in total cholesterol, LDL-c and TG of 20%, 28% and 13%, respectively, with a 5% increase in HDL-c.<a class="elsevierStyleCrossRefs" href="#bib0090">18,19</a> In long-term cohort studies of patients treated with statins, for every 1% fall in LDL-C, there is a ∼1% reduction in the relative risk of major cardiovascular events, in a lineal relationship.<a class="elsevierStyleCrossRef" href="#bib0095">19</a>A 69% negative association was found in the multivariate analysis between the HOMA-IR index and LDL levels. This may be explained by the fact that insulin regulates the expression of the LDL receptor, so that within the context of increased insulin sensitivity the catabolism of LDL would improve.<a class="elsevierStyleCrossRef" href="#bib0100">20</a>The fall in TG levels and the increase in HDL with both BS techniques may be associated with weight loss and reduced IR. In a recent work on the kinetics of triglyceride-rich lipoproteins (TRL) with a hepatic and intestinal origin, BS led to a lower production of B-100 apoproteins (apo) by the liver and lower production of apoB-48 by the intestine.<a class="elsevierStyleCrossRef" href="#bib0105">21</a> This characteristic fall in TG and rise in HDL are not only due a reduction in the plasma content of apoC-III, as there is also redistribution of apo-CIII at six and 12 months after surgery, from the TRL fraction to the HDL fraction.<a class="elsevierStyleCrossRef" href="#bib0110">22</a>Cholesterol synthesis increases when there is obesity, and it is associated with a fall in HDL-c, while weight loss reduces cholesterol synthesis.<a class="elsevierStyleCrossRef" href="#bib0085">17</a> The increase in HDL-c after LRYGP is compatible with the secondary benefit of weight loss, perhaps through the altered absorption and reduced synthesis of cholesterol.ConclusionBoth BS techniques have been shown to reduce cardiovascular mortality and to improve dyslipidaemia and atherogenisis. Only LRYGP improves LDL levels, and this may mean that this technique has an additional benefit that should be taken into account when selecting the surgical technique to use for patients with previous hypercholesterolaemia.FinancingThe authors declare that they received no financing.Conflict of interestsThe authors have no conflict of interests to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:3 [ "identificador" => "xres1708264" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1511016" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1708263" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1511015" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Material and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Statistical analysis" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Results" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Discussion" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conclusion" ] 10 => array:2 [ "identificador" => "sec0035" "titulo" => "Financing" ] 11 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflict of interests" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1511016" "palabras" => array:4 [ 0 => "Obesity bariatric surgery" 1 => "TG" 2 => "LDL-C" 3 => "Cholesterol" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1511015" "palabras" => array:6 [ 0 => "Obesidad mórbida" 1 => "Cirugía bariátrica" 2 => "TG" 3 => "C-LDL" 4 => "Colesterol" 5 => "Insulino-resistencia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "IntroductionBariatric surgery (BS) has shown to reduce cardiovascular morbidity and mortality in obesity. The BS has improved the dyslipidemia of the insulin resistant patient, our objective was to evaluate if there was a difference in the lipid profile between the laparoscopic roux-en-Y gastric bypass (RYGB) technique vs. the sleeve gastrectomy (SG) technique at 18 months of follow-up. MethodsAn observational, open, prospective study of morbidly obese patients who underwent bariatric surgery at 18-month follow-up. Anthropometric analysis, body composition, energy expenditure at rest, glucose, insulin, Hba1c, LDL, HDL, TG and CT were performed. ResultsAbsence baseline differences were found in the proportion of patients with hypertension, diabetes, steatosis, and sex between the RYGB vs SG groups. A reduction of TG was observed at 6 months in favor of RYGB vs SG: 108.60 ± 34.86 vs. 124.59 ± 44.58, P = 0.044), however, a decrease in both LDL levels was found at 12 and 18 months in favor of the RYGB vs. SG group: 96.23 ± 24.33 vs. 107.83 ± 28.88, P = 0.025; 90.98 ± 20.62 vs 106.22 ± 31.48, P = 0.003; the decrease in CT was observed only at 18 months in favor of the RYGB vs. SG group: 171.39 ± 25.058 vs. 186.89 ± 31.81, P = 0.005. ConclusionRYBG has shown to be more effective in reducing LDL and CT levels compared to SG, which provides an additional benefit of RYGB in relation to the lipid profile of the patient." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "IntroducciónLa cirugía bariátrica (CB) ha mostrado reducir la morbilidad y mortalidad cardiovascular en obesidad mórbida. La CB ha mejorado la dislipemia del paciente insulino-resistente (IR). El objetivo de nuestro trabajo fue evaluar si existe diferencia en el perfil lipídico entre la técnica de bypass gástrico laparoscópico en Y de Roux (BGYRL) vs la técnica de la gastrectomía tubular laparoscópica (GTL) a 18 meses de seguimiento. MétodosEstudio observacional, abierto, prospectivo, de pacientes con obesidad mórbida sometidos que realizaron a cirugía bariátrica a 18 meses seguimiento. Se realizo análisis antropométricos, composición corporal, gasto energético de reposo, de glucosa, insulina, Hba1c, LDL, HDL, TG y CT. ResultadosNo se encontraron diferencias basales de la proporción de pacientes con hipertensión arterial, diabetes de tipo 2, esteatosis y de sexo entre los grupos de BGYRL (91) vs GTL (77). Se observo reducción de TG a los 6 meses a favor de BGYRL vs GTL: 108,60 ± 34,86 vs 124,59 ± 44,58; P = 0,044), en cambio se encontró disminución tanto de niveles de LDL a los 12 y 18 meses a favor del grupo BGYRL vs GTL: 96,23 ± 24,33 vs 107,83 ± 28,88, P = 0,025; 90,98 ± 20,62 vs 106,22 ± 31,48, P = 0,003; la disminución de CT se observó solo a los 18 meses a favor del grupo BGYRL vs GTL: 171,39 ± 25,058 vs 186,89 ± 31,81, P = 0,005. ConclusiónEl BGYRL ha mostrado ser más eficaz para reducir LDL y CT en comparación con GTL, lo cual otorga un beneficio adicional del BGYRL en relación al perfil lipídico del paciente." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusión" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "⋆" "nota" => "Please cite this article as: Ackerman M, Serra E, Flecha P, Nogueira JP, Efecto selectivo de bypass gástrico laparoscópico en Y de Roux sobre el metabolismo lipídico, Clin Investig Arterioscler. 2022;34:68–74." ] ] "multimedia" => array:8 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1494 "Ancho" => 2508 "Tamanyo" => 113774 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Cholesterol levels 18 months after LRYGP vs. LSG. *P < .05 between groups." ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1625 "Ancho" => 2500 "Tamanyo" => 108858 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "LDL levels 18 months after LRYGP vs. LSG. *P < .05 between groups." ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1473 "Ancho" => 2508 "Tamanyo" => 110346 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "TG levels 18 months after LRYGP vs. LSG. *P < .05 between groups." ] ] 3 => array:8 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1626 "Ancho" => 2508 "Tamanyo" => 95970 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "HDL levels 18 months after LRYGP vs. LSG. *P < .05 between groups." ] ] 4 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "Data expressed as an average ± standard deviation or a percentage.REE, Resting Energy Expenditure." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LSG (n = 77) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LRYGP (n = 91) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44.80 ± 12.49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45.88 ± 10.23 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sex (male) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35.40% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.20% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI (kg/m2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43.64 ± 7.71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44.96 ± 7.13 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diabetes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17.50% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.60% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hypertension \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60.40% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">55.70% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Steatosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70.80% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">73.80% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Glycaemia (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">98.24 ± 23.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100.17 ± 12.33 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Insulin mUI/l \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20.35 ± 39.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.42 ± 18.04 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HOMA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.09 ± 4.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.06 ± 3.21 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LDL (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">123.50 ± 34.85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">124.10 ± 33.24 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HDL (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51.69 ± 10.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.04 ± 16.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TG (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">161.31 ± 83.57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">173.49 ± 79.61 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CT (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">194.96 ± 44.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">199.02 ± 34.21 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ApoB (g/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.96 ± 0.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.95 ± .20 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ApoA-1(g/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.49 ± 0.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.45 ± .26 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fat mass (kg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50.9 ± 5.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50.4 ± 4.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">REE (kc/day) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2115 ± 778 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2208 ± 813 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2901044.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Basal clinical and metabolic characteristics of the population." ] ] 5 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0030" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LRYGP \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LSG \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Oral antidiabetics \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Insulin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Statins \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Statins + ezetimibe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fibrates \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2901043.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Antidiabetic drugs and lipid lowering treatments in obese patients prior to surgery (T0)." ] ] 6 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0035" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "Data expressed as an average ± standard deviation or a percentage.LRYGP, Laparoscopic Roux-en-Y gastric bypass; LSG, laparoscopic sleeve gastrectomy." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">T0 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">T6 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">T12 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">T18 \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI-LSG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43.64 ± 7.71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32.59 ± 6.54<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29.4 ± 5.32<a class="elsevierStyleCrossRef" href="#tblfn0010">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28.58 ± 4.45 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI-LRYGP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44.96 ± 7.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32.13 ± 4.87<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28.87 ± 5.39<a class="elsevierStyleCrossRef" href="#tblfn0010">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28.376 ± 4.46 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Insulin-LSG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20.35 ± 39.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.74 ± 1.23<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.46 ± 2.66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.30 ± 1.67 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Insulin-LRYGP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.42 ± 18.04 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.50 ± 1.19<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.58 ± 1.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.24 ± 0.94 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Glycaemia-LSG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">98.24 ± 23.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88.12 ± 2.99<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">85.74 ± 1.48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">83.14 ± 1.38 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Glycaemia-LRYGP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100.17 ± 12.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">87.36 ± 1.79<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">83.32 ± 1.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">84.60 ± 1.12 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HOMA-IR-LSG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.92 ± 1.39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.85 ± 0.10<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.60 ± 0.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.28 ± 0.90 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HOMA-IR-LRYGP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.03 ± 1.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.10 ± 0.80<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.53 ± 0.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.32 ± 0.70 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CT-LSG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">194.96 ± 44.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">184.85 ± 31.05<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">185.83 ± 32.85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">186.89 ± 31.12 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CT-LRYGP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">199.02 ± 34.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">174.82 ± 32.4<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">174.39 ± 28.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">171.39 ± 29.18<a class="elsevierStyleCrossRef" href="#tblfn0025">*****</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LDL-LSG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">123.50 ± 34.85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">115.18 ± 30.37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">107.83 ± 28.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">106.22 ± 31.48 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LDL-LRYGP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">124.10 ± 33.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">110.52 ± 28.1<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">96.23 ± 24.33<a class="elsevierStyleCrossRefs" href="#tblfn0010">**,****</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">90.98 ± 20.62<a class="elsevierStyleCrossRef" href="#tblfn0025">*****</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HDL-LSG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51.69 ± 10.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54.04 ± 15.51<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61.50 ± 11.08<a class="elsevierStyleCrossRef" href="#tblfn0010">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">58.15 ± 10.91 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HDL-LRYGP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.04 ± 16.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">55.08 ± 18.55<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">58.50 ± 12.08<a class="elsevierStyleCrossRef" href="#tblfn0010">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60.47 ± 9.12 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TG-LSG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">161.31 ± 83.57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">124.59 ± 44.57<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">118.38 ± 42.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">101.5 ± 29.20 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TG-LRYGP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">173.49 ± 79.61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">108.60 ± 34.86<a class="elsevierStyleCrossRefs" href="#tblfn0005">*,***</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">107.12 ± 36.77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">108.23 ± 33.21 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2901045.png" ] ] ] "notaPie" => array:5 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "*" "nota" => "P < .05 from T6-T0 intragroup." ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "**" "nota" => "P < .05 from T12-T6 intragroup; & P < .05 from T18-T12 intragroup." ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "***" "nota" => "P < .05 from T6-T0 intergroup." ] 3 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "****" "nota" => "P < .05 from T12-T6 intragroup." ] 4 => array:3 [ "identificador" => "tblfn0025" "etiqueta" => "*****" "nota" => "P < .05 from T18-T12 intragroup." ] ] ] "descripcion" => array:1 [ "en" => "Clinical and metabolic characteristics at six, 12 and 18 months of follow-up." ] ] 7 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0040" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "The complete model was calculated for all of the obese subjects in the cohort, T18-T0 for BMI, apoB, apoA-I, fasting glucose and HOMA-IR (final adjusted model R2 = 0.72)." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Regression coefficient \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Confidence interval \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HOMA-IR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.12 to .40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><.01 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Constant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2901042.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Multiple lineal regression models which predict the evolution of LDL T18-T0 (final model after step-by-step selection with an exclusion threshold at P < .05)." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity, insulin resistance, and cardiovascular disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Reaven" 1 => "F. Abbasi" 2 => "T. McLaughlin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/rp.59.1.207" "Revista" => array:6 [ "tituloSerie" => "Recent Prog Horm Res." "fecha" => "2004" "volumen" => "59" "paginaInicial" => "207" "paginaFinal" => "223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14749503" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dynamics of diabetes and obesity: epidemiological perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Boles" 1 => "R. Kandimalla" 2 => "P.H. Reddy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bbadis.2017.01.016" "Revista" => array:7 [ "tituloSerie" => "Biochim Biophys Acta Mol Basis Dis." "fecha" => "2017" "volumen" => "1863" "numero" => "5" "paginaInicial" => "1026" "paginaFinal" => "1036" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28130199" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Type-2 diabetes mellitus and cardiovascular disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.J. Henning" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2217/fca-2018-0045" "Revista" => array:7 [ "tituloSerie" => "Future Cardiol." "fecha" => "2018" "volumen" => "14" "numero" => "6" "paginaInicial" => "491" "paginaFinal" => "509" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30409037" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiology of diabetic dyslipidaemia: where are we?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. Vergès" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00125-015-3525-8" "Revista" => array:7 [ "tituloSerie" => "Diabetologia." "fecha" => "2015" "volumen" => "58" "numero" => "5" "paginaInicial" => "886" "paginaFinal" => "899" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25725623" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of the gut in diabetic dyslipidemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Stahel" 1 => "C. Xiao" 2 => "A. Nahmias" 3 => "G.F. Lewis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3389/fendo.2020.00116" "Revista" => array:5 [ "tituloSerie" => "Front Endocrinol (Lausanne)." "fecha" => "2020" "volumen" => "11" "paginaInicial" => "116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32231641" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bariatric surgery: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Buchwald" 1 => "Y. Avidor" 2 => "E. Braunwald" 3 => "M.D. Jensen" 4 => "W. Pories" 5 => "K. Fahrbach" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.292.14.1724" "Revista" => array:7 [ "tituloSerie" => "JAMA." "fecha" => "2004" "volumen" => "292" "numero" => "14" "paginaInicial" => "1724" "paginaFinal" => "1737" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15479938" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morbid obesity and dyslipidaemia: the impact of bariatric surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Climent" 1 => "D. Benaiges" 2 => "A. Goday" 3 => "M. Villatoro" 4 => "H. Julià" 5 => "J.M. Ramón" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arteri.2019.11.001" "Revista" => array:7 [ "tituloSerie" => "Clin Investig Arterioscler." "fecha" => "2020" "volumen" => "32" "numero" => "2" "paginaInicial" => "79" "paginaFinal" => "86" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31973950" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of bariatric surgery on mortality in Swedish obese subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Sjöström" 1 => "K. Narbro" 2 => "C.D. Sjöström" 3 => "K. Karason" 4 => "B. Larsson" 5 => "H. Wedel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa066254" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med." "fecha" => "2007" "volumen" => "357" "numero" => "8" "paginaInicial" => "741" "paginaFinal" => "752" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17715408" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical practice guidelines of the European Association for Endoscopic Surgery (EAES) on bariatric surgery: update 2020 endorsed by IFSO-EC, EASO and ESPCOP" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Di Lorenzo" 1 => "S.A. Antoniou" 2 => "R.L. Batterham" 3 => "L. Busetto" 4 => "D. Godoroja" 5 => "A. Iossa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00464-020-07555-y" "Revista" => array:7 [ "tituloSerie" => "Surg Endosc." "fecha" => "2020" "volumen" => "34" "numero" => "6" "paginaInicial" => "2332" "paginaFinal" => "2358" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32328827" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.R. Matthews" 1 => "J.P. Hosker" 2 => "A.S. Rudenski" 3 => "B.A. Naylor" 4 => "D.F. Treacher" 5 => "R.C. Turner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/BF00280883" "Revista" => array:7 [ "tituloSerie" => "Diabetologia." "fecha" => "1985" "volumen" => "28" "numero" => "7" "paginaInicial" => "412" "paginaFinal" => "419" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3899825" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgery decreases long-term mortality, morbidity, and health care use in morbidly obese patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.V. Christou" 1 => "J.S. Sampalis" 2 => "M. Liberman" 3 => "D. Look" 4 => "S. Auger" 5 => "A.P.H. McLean" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.sla.0000137343.63376.19" "Revista" => array:7 [ "tituloSerie" => "Ann Surg." "fecha" => "2004" "volumen" => "240" "numero" => "3" "paginaInicial" => "416" "paginaFinal" => "423" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15319713" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early improvement of postprandial lipemia after bariatric surgery in obese type 2 diabetic patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Griffo" 1 => "G. Nosso" 2 => "R. Lupoli" 3 => "M. Cotugno" 4 => "G. Saldalamacchia" 5 => "G. Vitolo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11695-013-1148-z" "Revista" => array:7 [ "tituloSerie" => "Obes Surg." "fecha" => "2014" "volumen" => "24" "numero" => "5" "paginaInicial" => "765" "paginaFinal" => "770" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24374941" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resolution of hyperlipidemia after laparoscopic Roux-en-Y gastric bypass" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N.T. Nguyen" 1 => "E. Varela" 2 => "A. Sabio" 3 => "C.-L. Tran" 4 => "M. Stamos" 5 => "S.E. Wilson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jamcollsurg.2006.03.019" "Revista" => array:7 [ "tituloSerie" => "J Am Coll Surg." "fecha" => "2006" "volumen" => "203" "numero" => "1" "paginaInicial" => "24" "paginaFinal" => "29" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16798484" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laparoscopic Roux-en-Y gastric bypass improves lipid profile and decreases cardiovascular risk: a 5-year longitudinal cohort study of 1048 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D. Gero" 1 => "L. Favre" 2 => "P. Allemann" 3 => "P. Fournier" 4 => "N. Demartines" 5 => "M. Suter" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11695-017-2938-5" "Revista" => array:7 [ "tituloSerie" => "Obes Surg." "fecha" => "2018" "volumen" => "28" "numero" => "3" "paginaInicial" => "805" "paginaFinal" => "811" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28971303" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in lipid profile of obese patients following contemporary bariatric surgery: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.P. Heffron" 1 => "A. Parikh" 2 => "A. Volodarskiy" 3 => "C. Ren-Fielding" 4 => "A. Schwartzbard" 5 => "J. Nicholson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjmed.2016.02.004" "Revista" => array:7 [ "tituloSerie" => "Am J Med." "fecha" => "2016" "volumen" => "129" "numero" => "9" "paginaInicial" => "952" "paginaFinal" => "959" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26899751" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cholesterol metabolism after bariatric surgery in grade 3 obesity: differences between malabsorptive and restrictive procedures" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Benetti" 1 => "M. Del Puppo" 2 => "A. Crosignani" 3 => "A. Veronelli" 4 => "E. Masci" 5 => "F. Frigè" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2337/dc12-1737" "Revista" => array:7 [ "tituloSerie" => "Diabetes Care." "fecha" => "2013" "volumen" => "36" "numero" => "6" "paginaInicial" => "1443" "paginaFinal" => "1447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23275360" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of changes in human cholesterol metabolism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.A. Miettinen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ann Clin Res." "fecha" => "1970" "volumen" => "2" "numero" => "4" "paginaInicial" => "300" "paginaFinal" => "320" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5493461" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "AT 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.J. Stone" 1 => "J.G. Robinson" 2 => "A.H. Lichtenstein" 3 => "C.N. Bairey Merz" 4 => "C.B. Blum" 5 => "R.H. Eckel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.cir.0000437738.63853.7a" "Revista" => array:7 [ "tituloSerie" => "Circulation." "fecha" => "2014" "volumen" => "129" "numero" => "25 Suppl 2" "paginaInicial" => "S1" "paginaFinal" => "45" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24222016" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.C. LaRosa" 1 => "J. He" 2 => "S. Vupputuri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.282.24.2340" "Revista" => array:7 [ "tituloSerie" => "JAMA." "fecha" => "1999" "volumen" => "282" "numero" => "24" "paginaInicial" => "2340" "paginaFinal" => "2346" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10612322" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Co-incubation of native and oxidized low-density lipoproteins: potentiation of relaxation impairment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Perségol" 1 => "V. Sementa" 2 => "A. Athias" 3 => "J. Lecerf" 4 => "C. Lallemant" 5 => "P. Gambert" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0014-2999(00)00696-8" "Revista" => array:7 [ "tituloSerie" => "Eur J Pharmacol." "fecha" => "2000" "volumen" => "406" "numero" => "3" "paginaInicial" => "429" "paginaFinal" => "437" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11040350" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of bariatric surgery on hepatic and intestinal lipoprotein particle metabolism in obese, nondiabetic humans" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Padilla" 1 => "M. Maraninchi" 2 => "S. Béliard" 3 => "B. Berthet" 4 => "J.-P. Nogueira" 5 => "E. Wolff" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/ATVBAHA.114.303849" "Revista" => array:7 [ "tituloSerie" => "Arterioscler Thromb Vasc Biol." "fecha" => "2014" "volumen" => "34" "numero" => "10" "paginaInicial" => "2330" "paginaFinal" => "2337" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25104797" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of bariatric surgery on apolipoprotein C-III levels and lipoprotein distribution in obese human subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Maraninchi" 1 => "N. Padilla" 2 => "S. Béliard" 3 => "B. Berthet" 4 => "J.-P. Nogueira" 5 => "J. Dupont-Roussel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacl.2017.02.012" "Revista" => array:6 [ "tituloSerie" => "J Clin Lipidol." "fecha" => "2017" "volumen" => "11" "numero" => "2" "paginaInicial" => "495" "paginaFinal" => "506" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/25299123/0000003400000002/v1_202205120709/S2529912322000201/v1_202205120709/en/main.assets" "Apartado" => array:4 [ "identificador" => "63721" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/25299123/0000003400000002/v1_202205120709/S2529912322000201/v1_202205120709/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529912322000201?idApp=UINPBA00004N"]

Statistics

Original article

Selective effect of laparoscopic Roux-en-Y gastric bypass on lipid metabolism

Efecto selectivo de bypass gástrico laparoscópico en Y de Roux sobre el metabolismo lipídico

Marianela Ackermana,b, Edgardo Serrac, Pablo Flechad, Juan Patricio Nogueirae,

Corresponding author

nogueirajuanpatricio@gmail.com

Corresponding author.

a Cátedra de Medicina Interna, Facultad de Medicina Universidad Nacional del Nordeste (UNNE), Corrientes, Argentina

b Departamento de Nutrición y Diabetes, Centro de Endocrinología y Nutrición (CIEN), Corrientes, Argentina

c Departamento de Cirugía Bariátrica y Metabólica, Centro de Endocrinología y Nutrición (CIEN), Corrientes, Argentina

d Instituto Modelo de Gastroenterología, Formosa, Argentina

e Centro de Investigación en Nutrición, Endocrinología y Metabolismo (CIENM), Facultad de Ciencias de la Salud, Universidad Nacional de Formosa, Formosa, Argentina

Read

259

Times
was read the article

Total PDF

200

Total HTML

Share statistics

 array:22 [
  "pii" => "S2529912322000201"
  "issn" => "25299123"
  "doi" => "10.1016/j.artere.2022.04.005"
  "estado" => "S300"
  "fechaPublicacion" => "2022-03-01"
  "aid" => "6140"
  "copyrightAnyo" => "2022"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Clin Investig Arterioscler. 2022;34:68-74"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2529912322000134"
    "issn" => "25299123"
    "doi" => "10.1016/j.artere.2022.04.002"
    "estado" => "S300"
    "fechaPublicacion" => "2022-03-01"
    "aid" => "620"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Clin Investig Arterioscler. 2022;34:75-85"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Is serum Osteopontin a predictor of carotid atherosclerosis severity among prevalent hemodialysis patients&#63;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "75"
          "paginaFinal" => "85"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "&#191;Es la osteopontina s&#233;rica un factor predictivo de la gravedad de la aterosclerosis carot&#237;dea en los pacientes prevalentes en hemodi&#225;lisis&#63;"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0020"
          "etiqueta" => "Figure 4"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr4.jpeg"
              "Alto" => 2114
              "Ancho" => 2167
              "Tamanyo" => 160070
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">ROC curve analysis showing the diagnostic performance of OPN to detect carotid Atheroma &#40;AUC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;767&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Maha A&#46; Behairy, Sahar Shawky, Reham Hamed, Somia Bawady, Hoda A&#46; Abdelsattar, Walid Bichari"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Maha A&#46;"
              "apellidos" => "Behairy"
            ]
            1 => array:2 [
              "nombre" => "Sahar"
              "apellidos" => "Shawky"
            ]
            2 => array:2 [
              "nombre" => "Reham"
              "apellidos" => "Hamed"
            ]
            3 => array:2 [
              "nombre" => "Somia"
              "apellidos" => "Bawady"
            ]
            4 => array:2 [
              "nombre" => "Hoda A&#46;"
              "apellidos" => "Abdelsattar"
            ]
            5 => array:2 [
              "nombre" => "Walid"
              "apellidos" => "Bichari"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0214916821001583"
        "doi" => "10.1016/j.arteri.2021.11.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0214916821001583?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529912322000134?idApp=UINPBA00004N"
    "url" => "/25299123/0000003400000002/v1_202205120709/S2529912322000134/v1_202205120709/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S2529912322000109"
    "issn" => "25299123"
    "doi" => "10.1016/j.artere.2022.03.001"
    "estado" => "S300"
    "fechaPublicacion" => "2022-03-01"
    "aid" => "613"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Clin Investig Arterioscler. 2022;34:57-67"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Bempedoic acid as a PPAR&#945; activator&#58; New perspectives for hepatic steatosis treatment in a female rat experimental model"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "57"
          "paginaFinal" => "67"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "El &#225;cido bempedoico como activador PPAR&#945;&#58; Nuevas perspectivas para el tratamiento de la esteatosis hep&#225;tica en un modelo experimental de rata hembra"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2274
              "Ancho" => 2600
              "Tamanyo" => 187711
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Drink and food consumption&#44; total calorie intake and animal weights&#46; &#40;A&#41; Area under the curve &#40;AUC&#41; of drink consumption per rat during 90 days&#44; expressed in ml &#40;ml&#47;90d&#47;rat&#41;&#46; &#40;B&#41; Area under the curve &#40;AUC&#41; of solid food consumption per rat during 90 days&#44; expressed in g &#40;g&#47;90d&#47;rat&#41;&#46; &#40;C&#41; Area under the curve &#40;AUC&#41; of total calorie intake per rat during 90 days&#44; expressed in kcal &#40;kcal&#47;90d&#47;rat&#41;&#46; &#40;D&#41; Bodyweight of the animals at the end of treatment&#44; expressed in g&#46; Results expressed as an average &#8239;&#177;&#8239;SD for n&#8239;&#61;&#8239;8 animals&#47;group&#46; Bpda&#58; group fed with HF-FR and treated with bempedoic acid&#59; CT&#58; control group&#59; HF-FR&#58; group fed with a high-fat diet and supplemented with fructose in the drinking water&#46; &#42;<span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;05&#44; &#42;&#42;<span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;01&#44; &#42;&#42;&#42;<span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;001 vs&#46; the CT group&#46; <span class="elsevierStyleSup">&#35;</span><span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;05&#44; <span class="elsevierStyleSup">&#35;&#35;</span><span class="elsevierStyleItalic">P</span>&#8239;&#60;&#8239;&#46;01 vs&#46; HF-FR group&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Roger Bentanachs, Ana Magdalena Vel&#225;zquez, Rosa Mar&#237;a S&#225;nchez, Marta Alegret, Juan Carlos Laguna, N&#250;ria Roglans"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Roger"
              "apellidos" => "Bentanachs"
            ]
            1 => array:2 [
              "nombre" => "Ana Magdalena"
              "apellidos" => "Vel&#225;zquez"
            ]
            2 => array:2 [
              "nombre" => "Rosa Mar&#237;a"
              "apellidos" => "S&#225;nchez"
            ]
            3 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Alegret"
            ]
            4 => array:2 [
              "nombre" => "Juan Carlos"
              "apellidos" => "Laguna"
            ]
            5 => array:2 [
              "nombre" => "N&#250;ria"
              "apellidos" => "Roglans"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0214916821001376"
        "doi" => "10.1016/j.arteri.2021.09.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0214916821001376?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529912322000109?idApp=UINPBA00004N"
    "url" => "/25299123/0000003400000002/v1_202205120709/S2529912322000109/v1_202205120709/en/main.assets"
  ]
  "en" => array:18 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Selective effect of laparoscopic Roux-en-Y gastric bypass on lipid metabolism"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "68"
        "paginaFinal" => "74"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Marianela Ackerman, Edgardo Serra, Pablo Flecha, Juan Patricio Nogueira"
        "autores" => array:4 [
          0 => array:3 [
            "nombre" => "Marianela"
            "apellidos" => "Ackerman"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Edgardo"
            "apellidos" => "Serra"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Pablo"
            "apellidos" => "Flecha"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          3 => array:4 [
            "nombre" => "Juan Patricio"
            "apellidos" => "Nogueira"
            "email" => array:1 [
              0 => "nogueirajuanpatricio@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:5 [
          0 => array:3 [
            "entidad" => "C&#225;tedra de Medicina Interna&#44; Facultad de Medicina Universidad Nacional del Nordeste &#40;UNNE&#41;&#44; Corrientes&#44; Argentina"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Nutrici&#243;n y Diabetes&#44; Centro de Endocrinolog&#237;a y Nutrici&#243;n &#40;CIEN&#41;&#44; Corrientes&#44; Argentina"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Departamento de Cirug&#237;a Bari&#225;trica y Metab&#243;lica&#44; Centro de Endocrinolog&#237;a y Nutrici&#243;n &#40;CIEN&#41;&#44; Corrientes&#44; Argentina"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Instituto Modelo de Gastroenterolog&#237;a&#44; Formosa&#44; Argentina"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Centro de Investigaci&#243;n en Nutrici&#243;n&#44; Endocrinolog&#237;a y Metabolismo &#40;CIENM&#41;&#44; Facultad de Ciencias de la Salud&#44; Universidad Nacional de Formosa&#44; Formosa&#44; Argentina"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Efecto selectivo de <span class="elsevierStyleItalic">bypass</span> g&#225;strico laparosc&#243;pico en Y de Roux sobre el metabolismo lip&#237;dico"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1473
            "Ancho" => 2508
            "Tamanyo" => 110346
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">TG levels 18 months after LRYGP vs&#46; LSG&#46; &#42;<span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05 between groups&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Obesity is a public health problem in the whole world&#44; and it is associated with comorbidities such as&#58; type 2 diabetes mellitus &#40;DM2&#41; and cardiovascular diseases &#40;CVD&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The increasing prevalence of obesity is accompanied by a higher prevalence of DM2&#46; Obesity does not only increase the risk of developing DM2&#44; as it also aggravates the risks of the same for health and makes managing it more complex&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">CVD is the main cause of morbidity and mortality in patients with obesity and DM2&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> High levels of cholesterol in plasma with low density lipoproteins &#40;<span class="elsevierStyleSmallCaps">C</span>-LDL&#41; are the main cardiovascular lipid risk factor&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Nevertheless&#44; atherogenic dyslipidaemia &#40;AD&#41; as seen in states of insulin resistance &#40;IR&#41;&#44; such as obesity and DM2&#44; is a decisive factor in cardiovascular risk&#46; AD is chiefly characterized by high levels of fasting and post-prandial triglyceride-rich lipoproteins &#40;TRL&#41; in plasma&#44; small and dense low density lipoproteins &#40;LDL&#41; and low levels of cholesterol carried in high density lipoproteins &#40;HDL-C&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Bariatric surgery &#40;BS&#41; is currently the most effective treatment to induce weight loss in obese patients&#46; It leads to the complete or partial remission of DM2 and improves cardiovascular risk factors such as arterial hypertension and lipid alterations in a significant proportion of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The most common BS procedures used worldwide are laparoscopic sleeve gastrectomy &#40;LSG&#41;&#44; a restrictive technique&#44; and the laparoscopic Roux-en-Y gastric bypass &#40;LRYGP&#41;&#44; which is a combined restrictive and malabsorptive technique&#46; As there is no strict recommendation regarding when to perform a LSG or a LRYGP&#44; differences in the resulting glycosidic and lipid parameters may be highly useful when selecting the best surgical technique for a patient&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Of the factors which are associated with a good prognosis&#44; reducing TG and total cholesterol have been shown in multivariate analysis to be early markers of a reduction in cardiovascular events&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Many of the random controlled clinical trials published do not evaluate lipid parameters in their initial end points&#46; Many studies do not report on the percentage of patients who had been subjected to previous or subsequent lipid lowering treatments&#44; or the class or dose of the lipid lowering drugs used&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">This study evaluates lipid parameters after an 18 month follow-up of patients operated using LRYGP vs&#46; LSG&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">A total of 168 obese patients evaluated in the Department of Nutrition and Bariatric Surgery of the Nutrition&#44; Endocrinology and Metabolism Centre &#40;CIEN&#41;&#44; Corrientes&#44; Argentina&#44; and the <span class="elsevierStyleItalic">Instituto Modelo de Gastroenterolog&#237;a</span> &#40;IMG&#41;&#44; Formosa&#44; Argentina&#44; were recruited for this study&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">All of the patients were evaluated by a multidisciplinary team composed of an endocrinologist&#44; a bariatric surgeon&#44; a psychiatrist and a nutritionist during at least six months prior to surgery&#46; All of the subjects fulfilled the criteria for bariatric surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The surgical techniques used included LRYGP and LSG&#46; Follow-up after surgery was restricted to 18 months&#46; Patients with kidney failure were excluded &#40;glomerular filtration &#8804;60&#8201;mL&#47;min&#47;1&#46;73&#8201;m<span class="elsevierStyleSup">2</span>&#41;&#44; as were minors and those older than 65 years&#44; pregnant women and subjects with a severe disease that determined their survival&#46; Patients whose follow-up was incomplete&#44; lacked data or who had been subjected to surgery due to weight gain were excluded from this study&#46; Clinical and analytical data corresponding to all of the patients were gathered after review of their computerized clinical histories&#46; This study was undertaken according to the Helsinki Declaration and approved by the bioethics committee of the IMG&#44; and all of the patients gave their informed consent in writing&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The diet of each subject was evaluated by a nutritionist&#44; using a self-administered diary recording consumption over three days&#46; Their weight&#44; fasting biochemical parameters&#44; body composition and energy intake were measured one month before surgery &#40;T0&#41; and at six months &#40;T6&#41;&#44; 12 months &#40;T12&#41; and 18 months &#40;T18&#41; after surgery&#46; Our study was not designed to compare the efficacy of both surgical procedures&#44; LRYGP vs LSG&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Blood samples were taken after nocturnal fasting&#46; The plasma was immediately separated by centrifuging at 2000&#8201;rpm during 15&#8201;min at 4 C&#46; TG in plasma&#44; total cholesterol&#44; HDL-C and LDL-C were measured using an enzymatic colorimetric kit &#40;Cobas 6000 c 501 analyser&#59; Roche Diagnostics&#44; Mannheim&#44; Germany&#41;&#46; Glucose in plasma was analysed using the hexokinase method &#40;Cobas 6000c&#44; 501 analyser&#41;&#46; Concentrations of insulin in plasma were determined using the electrochemiluminescence method &#40;Cobas Analyser 6000 and 601&#41;&#46; Insulin resistance was estimated using the homeostasis model of assessment &#40;HOMA-IR&#41;&#58; fasting insulin &#40;mUI&#47;L&#41; &#215; fasting glucose &#40;mmol &#47;L&#41; &#47;22&#46;5&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> HOMA-IR was not calculated for patients with diabetes to avoid the HOMA-IR calculation error due to the antidiabetic drugs taken by these patients&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Concentrations in plasma were determined for apoB and apoA-I by immunonephelometry &#40;Roche Diagnostics&#41; using a BN ProSpec analyser &#40;Siemens Healthineers&#44; Erlangen&#44; Germany&#41;&#46; Resting energy expenditure &#40;REE&#41; was measured by indirect calorimetry &#40;Quark-RMR-Cosmed&#44; Rome&#44; Italy&#41;&#46; Body composition was evaluated by dual-energy x-ray absorptiometry &#40;DEXA&#41; &#40;Lunar iDXA and enCORE 2007 version software&#44; GE Healthcare&#44; Chalfont St Giles&#44; United Kingdom&#41;&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Statistical analysis</span><p id="par0070" class="elsevierStylePara elsevierViewall">Data were expressed as an average&#8201;&#177;&#8201;standard deviation for continuous variables&#46; Categorical variables were shown as percentages&#46; The normal distribution of variables was confirmed by the Kolmogorov- Smirnov test&#46; Comparisons between groups were made by the <span class="elsevierStyleItalic">X</span><span class="elsevierStyleSup">2</span> test for categorical variables&#44; as well as the Student&#8217;s t-test and ANOVA for continuous variables&#46; The relationship between continuous variables was examined by multiple regression analysis&#46; All statistical analysis was performed using the IBM SPSS Statistics 25&#46;0 programme &#40;IBM Inc&#46;&#44; NY&#41;&#46; Tests were bilateral&#44; and <span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05 was considered to be statistically significant&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0075" class="elsevierStylePara elsevierViewall">Patients&#8217; basal characteristics are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; without significant differences&#46; The average follow-up time was 1&#46;5 years&#46; Treatment prior to BS is shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; No significant differences were found in terms of sex&#44; energy expenditure&#44; fat mass&#44; glucose&#44; lipids or apolipoproteins between the laparoscopic Roux-en-Y gastric bypass &#40;LRYGP&#41; group and the laparoscopic sleeve gastrectomy &#40;LSG&#41; group&#46; The evolution of anthropometric and metabolic parameters after months&#8217; follow-up after surgery are shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46; A fall in weight&#44; body mass index &#40;BMI&#41;&#44; fasting glucose in plasma&#44; HOMA-IR&#44; energy intake and fat mass was detected after surgery in both groups during the months of follow-up&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">A fall in apoB and a rise in apoA-1 was observed at six months&#44; as was a fall in TG and a rise in HDL in both groups &#40;LRYGP and LSG&#41; after six months&#44; while on the other hand a fall in LDL and CT after 12 and 18 months only occurred in the LRYGP group &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1&#8211;4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Finally&#44; step-by-step multiple lineal regression analysis showed that the fall in HOMA-IR independently predicted the reduction in LDL at 18 months&#44; explaining 72&#37; of this fall &#40;R2&#8201;&#61;&#8201;0&#46;720&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">This study showed that LRYGP is superior in terms of reducing LDL and CT at 12 and 18 months of follow-up&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">BS reduces cardiovascular mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> This fall has been attributed in part to a reduction in plasmatic lipids&#44; through unknown mechanisms&#46; This study shows that the clinically important improvements in plasmatic lipids after LRYGP surgery arise in the final postoperative period&#44; with substantial weight loss&#46; The possible underlying mechanism for the improvement or resolution of the dyslipidaemia after bariatric surgery may be associated with weight loss&#46; Weight loss is expected to improve insulin sensitivity&#44; which in turn may reduce TG levels and increase the levels of HDL-C&#46; This curve is similar to the weight loss curve after LRYGP and LSG&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Levels of total cholesterol and LDL-c fall at 12 and 18 months&#44; which supports the hypothesis that these changes are a direct consequence of surgery rather than absolute weight loss&#46; The intestine plays a crucial role in cholesterol metabolism and participates in the absorption of cholesterol &#40;from foods and bile&#41; as well as in trans-intestinal cholesterol excretion&#46; It has been known for a long time that an ileac bypass &#40;which creates poor absorption&#44; without closing the stomach as occurs in bariatric surgery&#41; reduces cholesterol levels and cardiovascular diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Curiously&#44; all of the studies which compare the different effects of LSG and LRYGP on concentrations of cholesterol in plasma show a constant 20&#37;&#8211;30&#37; reduction in cholesterol after LRYGP&#44; which is maintained at five years&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Contrary to the previous finding&#44; cholesterol levels do not change after LSG&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> The 20&#37;&#8211;30&#37; reduction in cholesterol after LRYGP is equivalent to the fall that is obtained with an average dose of statins&#46; The malabsorption technique of LRYGP significantly alters the flow of nutrients in the intestine&#44; and the metabolic changes observed after this technique are in part independent of weight loss&#46; These changes are multifactorial and complex&#44; and they constitute a broad field for exploration&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Characterizing the factors which cause the constant 20&#37;&#8211;30&#37; fall in cholesterol after LRYGP may make it possible to identify new components of intestinal cholesterol metabolism and new therapeutic targets to reduce cholesterol&#46; The potential factors which may be involved in reducing LDL after LRYGP are&#58; &#40;i&#41; changes in cholesterol metabolism &#40;a reduction in intestinal absorption&#44; an increase in intestinal excretion&#44; an increase in hepatic catabolism or a fall in hepatic synthesis&#41;&#44; &#40;ii&#41; an increase in the intestinal conversion of cholesterol into coprostanol &#40;an inactive type of sterol that is neither absorbed nor eliminated in the faeces&#41;&#44; &#40;iii&#41; changes in the metabolism of the biliary acids &#40;which are critical factors in intestinal cholesterol metabolism&#41;&#44; &#40;iii&#41; changes in the intestinal hormones&#44; and &#40;iv&#41; changes in the intestinal microbial ecosystem &#40;microbiota&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;17</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Statins may affect this mechanism&#44; as they inhibit the synthesis of cholesterol in the liver&#44; which leads to the activation of the LDL receptors and increasing hepatic capture of HDL from the circulation&#46; The 20&#37;&#8211;30&#37; fall in cholesterol after LRYGP is equivalent to the reduction caused by an average dose of low-intensity statins&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> The administration of low therapeutic intensity statins is associated with average falls in total cholesterol&#44; LDL-c and TG of 20&#37;&#44; 28&#37; and 13&#37;&#44; respectively&#44; with a 5&#37; increase in HDL-c&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;19</span></a> In long-term cohort studies of patients treated with statins&#44; for every 1&#37; fall in LDL-C&#44; there is a &#8764;1&#37; reduction in the relative risk of major cardiovascular events&#44; in a lineal relationship&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">A 69&#37; negative association was found in the multivariate analysis between the HOMA-IR index and LDL levels&#46; This may be explained by the fact that insulin regulates the expression of the LDL receptor&#44; so that within the context of increased insulin sensitivity the catabolism of LDL would improve&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">The fall in TG levels and the increase in HDL with both BS techniques may be associated with weight loss and reduced IR&#46; In a recent work on the kinetics of triglyceride-rich lipoproteins &#40;TRL&#41; with a hepatic and intestinal origin&#44; BS led to a lower production of B-100 apoproteins &#40;apo&#41; by the liver and lower production of apoB-48 by the intestine&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> This characteristic fall in TG and rise in HDL are not only due a reduction in the plasma content of apoC-III&#44; as there is also redistribution of apo-CIII at six and 12 months after surgery&#44; from the TRL fraction to the HDL fraction&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Cholesterol synthesis increases when there is obesity&#44; and it is associated with a fall in HDL-c&#44; while weight loss reduces cholesterol synthesis&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> The increase in HDL-c after LRYGP is compatible with the secondary benefit of weight loss&#44; perhaps through the altered absorption and reduced synthesis of cholesterol&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusion</span><p id="par0135" class="elsevierStylePara elsevierViewall">Both BS techniques have been shown to reduce cardiovascular mortality and to improve dyslipidaemia and atherogenisis&#46; Only LRYGP improves LDL levels&#44; and this may mean that this technique has an additional benefit that should be taken into account when selecting the surgical technique to use for patients with previous hypercholesterolaemia&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Financing</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors declare that they received no financing&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of interests</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:13 [
        0 => array:3 [
          "identificador" => "xres1708264"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introduction"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1511016"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1708263"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Introducci&#243;n"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusi&#243;n"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1511015"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Material and methods"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Statistical analysis"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Results"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Discussion"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Conclusion"
        ]
        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Financing"
        ]
        11 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Conflict of interests"
        ]
        12 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1511016"
          "palabras" => array:4 [
            0 => "Obesity bariatric surgery"
            1 => "TG"
            2 => "LDL-C"
            3 => "Cholesterol"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1511015"
          "palabras" => array:6 [
            0 => "Obesidad m&#243;rbida"
            1 => "Cirug&#237;a bari&#225;trica"
            2 => "TG"
            3 => "C-LDL"
            4 => "Colesterol"
            5 => "Insulino-resistencia"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Bariatric surgery &#40;BS&#41; has shown to reduce cardiovascular morbidity and mortality in obesity&#46; The BS has improved the dyslipidemia of the insulin resistant patient&#44; our objective was to evaluate if there was a difference in the lipid profile between the laparoscopic roux-en-Y gastric bypass &#40;RYGB&#41; technique vs&#46; the sleeve gastrectomy &#40;SG&#41; technique at 18 months of follow-up&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">An observational&#44; open&#44; prospective study of morbidly obese patients who underwent bariatric surgery at 18-month follow-up&#46; Anthropometric analysis&#44; body composition&#44; energy expenditure at rest&#44; glucose&#44; insulin&#44; Hba1c&#44; LDL&#44; HDL&#44; TG and CT were performed&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Absence baseline differences were found in the proportion of patients with hypertension&#44; diabetes&#44; steatosis&#44; and sex between the RYGB vs SG groups&#46; A reduction of TG was observed at 6 months in favor of RYGB vs SG&#58; 108&#46;60&#8201;&#177;&#8201;34&#46;86 vs&#46; 124&#46;59&#8201;&#177;&#8201;44&#46;58&#44; P&#8201;&#61;&#8201;0&#46;044&#41;&#44; however&#44; a decrease in both LDL levels was found at 12 and 18 months in favor of the RYGB vs&#46; SG group&#58; 96&#46;23&#8201;&#177;&#8201;24&#46;33 vs&#46; 107&#46;83&#8201;&#177;&#8201;28&#46;88&#44; P&#8201;&#61;&#8201;0&#46;025&#59; 90&#46;98&#8201;&#177;&#8201;20&#46;62 vs 106&#46;22&#8201;&#177;&#8201;31&#46;48&#44; P&#8201;&#61;&#8201;0&#46;003&#59; the decrease in CT was observed only at 18 months in favor of the RYGB vs&#46; SG group&#58; 171&#46;39&#8201;&#177;&#8201;25&#46;058 vs&#46; 186&#46;89&#8201;&#177;&#8201;31&#46;81&#44; P&#8201;&#61;&#8201;0&#46;005&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">RYBG has shown to be more effective in reducing LDL and CT levels compared to SG&#44; which provides an additional benefit of RYGB in relation to the lipid profile of the patient&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">La cirug&#237;a bari&#225;trica &#40;CB&#41; ha mostrado reducir la morbilidad y mortalidad cardiovascular en obesidad m&#243;rbida&#46; La CB ha mejorado la dislipemia del paciente insulino-resistente &#40;IR&#41;&#46; El objetivo de nuestro trabajo fue evaluar si existe diferencia en el perfil lip&#237;dico entre la t&#233;cnica de bypass g&#225;strico laparosc&#243;pico en Y de Roux &#40;BGYRL&#41; vs la t&#233;cnica de la gastrectom&#237;a tubular laparosc&#243;pica &#40;GTL&#41; a 18 meses de seguimiento&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional&#44; abierto&#44; prospectivo&#44; de pacientes con obesidad m&#243;rbida sometidos que realizaron a cirug&#237;a bari&#225;trica a 18 meses seguimiento&#46; Se realizo an&#225;lisis antropom&#233;tricos&#44; composici&#243;n corporal&#44; gasto energ&#233;tico de reposo&#44; de glucosa&#44; insulina&#44; Hba1c&#44; LDL&#44; HDL&#44; TG y CT&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">No se encontraron diferencias basales de la proporci&#243;n de pacientes con hipertensi&#243;n arterial&#44; diabetes de tipo 2&#44; esteatosis y de sexo entre los grupos de BGYRL &#40;91&#41; vs GTL &#40;77&#41;&#46; Se observo reducci&#243;n de TG a los 6 meses a favor de BGYRL vs GTL&#58; 108&#44;60&#8201;&#177;&#8201;34&#44;86 vs 124&#44;59&#8201;&#177;&#8201;44&#44;58&#59; <span class="elsevierStyleItalic">P</span>&#8201;&#61;&#8201;0&#44;044&#41;&#44; en cambio se encontr&#243; disminuci&#243;n tanto de niveles de LDL a los 12 y 18 meses a favor del grupo BGYRL vs GTL&#58; 96&#44;23&#8201;&#177;&#8201;24&#44;33 vs 107&#44;83&#8201;&#177;&#8201;28&#44;88&#44; <span class="elsevierStyleItalic">P</span>&#8201;&#61;&#8201;0&#44;025&#59; 90&#44;98&#8201;&#177;&#8201;20&#44;62 vs 106&#44;22&#8201;&#177;&#8201;31&#44;48&#44; <span class="elsevierStyleItalic">P</span>&#8201;&#61;&#8201;0&#44;003&#59; la disminuci&#243;n de CT se observ&#243; solo a los 18 meses a favor del grupo BGYRL vs GTL&#58; 171&#44;39&#8201;&#177;&#8201;25&#44;058 vs 186&#44;89&#8201;&#177;&#8201;31&#44;81&#44; <span class="elsevierStyleItalic">P</span>&#8201;&#61;&#8201;0&#44;005&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">El BGYRL ha mostrado ser m&#225;s eficaz para reducir LDL y CT en comparaci&#243;n con GTL&#44; lo cual otorga un beneficio adicional del BGYRL en relaci&#243;n al perfil lip&#237;dico del paciente&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#8902;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Please cite this article as&#58; Ackerman M&#44; Serra E&#44; Flecha P&#44; Nogueira JP&#44; Efecto selectivo de bypass g&#225;strico laparosc&#243;pico en Y de Roux sobre el metabolismo lip&#237;dico&#44; Clin Investig Arterioscler&#46; 2022&#59;34&#58;68&#8211;74&#46;</p>"
      ]
    ]
    "multimedia" => array:8 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1494
            "Ancho" => 2508
            "Tamanyo" => 113774
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cholesterol levels 18 months after LRYGP vs&#46; LSG&#46; &#42;<span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05 between groups&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1625
            "Ancho" => 2500
            "Tamanyo" => 108858
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">LDL levels 18 months after LRYGP vs&#46; LSG&#46; &#42;<span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05 between groups&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1473
            "Ancho" => 2508
            "Tamanyo" => 110346
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">TG levels 18 months after LRYGP vs&#46; LSG&#46; &#42;<span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05 between groups&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1626
            "Ancho" => 2508
            "Tamanyo" => 95970
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0020"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">HDL levels 18 months after LRYGP vs&#46; LSG&#46; &#42;<span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05 between groups&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0025"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Data expressed as an average&#8201;&#177;&#8201;standard deviation or a percentage&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">REE&#44; Resting Energy Expenditure&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LSG &#40;n&#8201;&#61;&#8201;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LRYGP &#40;n&#8201;&#61;&#8201;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#46;80&#8201;&#177;&#8201;12&#46;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#46;88&#8201;&#177;&#8201;10&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sex &#40;male&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&#46;40&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;20&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#46;64&#8201;&#177;&#8201;7&#46;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#46;96&#8201;&#177;&#8201;7&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;50&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;60&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypertension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#46;40&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#46;70&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Steatosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&#46;80&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#46;80&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glycaemia &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&#46;24&#8201;&#177;&#8201;23&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;17&#8201;&#177;&#8201;12&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Insulin mUI&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;35&#8201;&#177;&#8201;39&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;42&#8201;&#177;&#8201;18&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HOMA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;09&#8201;&#177;&#8201;4&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;06&#8201;&#177;&#8201;3&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LDL &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">123&#46;50&#8201;&#177;&#8201;34&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124&#46;10&#8201;&#177;&#8201;33&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HDL &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#46;69&#8201;&#177;&#8201;10&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#46;04&#8201;&#177;&#8201;16&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TG &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">161&#46;31&#8201;&#177;&#8201;83&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">173&#46;49&#8201;&#177;&#8201;79&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CT &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">194&#46;96&#8201;&#177;&#8201;44&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">199&#46;02&#8201;&#177;&#8201;34&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ApoB &#40;g&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;96&#8201;&#177;&#8201;0&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;95&#8201;&#177;&#8201;&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ApoA-1&#40;g&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;49&#8201;&#177;&#8201;0&#46;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;45&#8201;&#177;&#8201;&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fat mass &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;9&#8201;&#177;&#8201;5&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;4&#8201;&#177;&#8201;4&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">REE &#40;kc&#47;day&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2115&#8201;&#177;&#8201;778&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2208&#8201;&#177;&#8201;813&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2901044.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Basal clinical and metabolic characteristics of the population&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0030"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LRYGP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">LSG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Oral antidiabetics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Insulin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Statins&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Statins&#8201;&#43;&#8201;ezetimibe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fibrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2901043.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Antidiabetic drugs and lipid lowering treatments in obese patients prior to surgery &#40;T0&#41;&#46;</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0035"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Data expressed as an average&#8201;&#177;&#8201;standard deviation or a percentage&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">LRYGP&#44; Laparoscopic Roux-en-Y gastric bypass&#59; LSG&#44; laparoscopic sleeve gastrectomy&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">T0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">T6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">T12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">T18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BMI-LSG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#46;64&#8201;&#177;&#8201;7&#46;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#46;59&#8201;&#177;&#8201;6&#46;54<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#46;4&#8201;&#177;&#8201;5&#46;32<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#46;58&#8201;&#177;&#8201;4&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BMI-LRYGP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#46;96&#8201;&#177;&#8201;7&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#46;13&#8201;&#177;&#8201;4&#46;87<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#46;87&#8201;&#177;&#8201;5&#46;39<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#46;376&#8201;&#177;&#8201;4&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Insulin-LSG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;35&#8201;&#177;&#8201;39&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;74&#8201;&#177;&#8201;1&#46;23<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;46&#8201;&#177;&#8201;2&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;30&#8201;&#177;&#8201;1&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Insulin-LRYGP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;42&#8201;&#177;&#8201;18&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;50&#8201;&#177;&#8201;1&#46;19<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;58&#8201;&#177;&#8201;1&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;24&#8201;&#177;&#8201;0&#46;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glycaemia-LSG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&#46;24&#8201;&#177;&#8201;23&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&#46;12&#8201;&#177;&#8201;2&#46;99<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&#46;74&#8201;&#177;&#8201;1&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#46;14&#8201;&#177;&#8201;1&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glycaemia-LRYGP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#46;17&#8201;&#177;&#8201;12&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#46;36&#8201;&#177;&#8201;1&#46;79<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#46;32&#8201;&#177;&#8201;1&#46;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&#46;60&#8201;&#177;&#8201;1&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HOMA-IR-LSG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;92&#8201;&#177;&#8201;1&#46;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;85&#8201;&#177;&#8201;0&#46;10<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;60&#8201;&#177;&#8201;0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;28&#8201;&#177;&#8201;0&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HOMA-IR-LRYGP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;03&#8201;&#177;&#8201;1&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;10&#8201;&#177;&#8201;0&#46;80<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;53&#8201;&#177;&#8201;0&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;32&#8201;&#177;&#8201;0&#46;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CT-LSG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">194&#46;96&#8201;&#177;&#8201;44&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">184&#46;85&#8201;&#177;&#8201;31&#46;05<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185&#46;83&#8201;&#177;&#8201;32&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">186&#46;89&#8201;&#177;&#8201;31&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CT-LRYGP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">199&#46;02&#8201;&#177;&#8201;34&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">174&#46;82&#8201;&#177;&#8201;32&#46;4<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">174&#46;39&#8201;&#177;&#8201;28&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">171&#46;39&#8201;&#177;&#8201;29&#46;18<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;&#42;&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LDL-LSG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">123&#46;50&#8201;&#177;&#8201;34&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">115&#46;18&#8201;&#177;&#8201;30&#46;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">107&#46;83&#8201;&#177;&#8201;28&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">106&#46;22&#8201;&#177;&#8201;31&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LDL-LRYGP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124&#46;10&#8201;&#177;&#8201;33&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">110&#46;52&#8201;&#177;&#8201;28&#46;1<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&#46;23&#8201;&#177;&#8201;24&#46;33<a class="elsevierStyleCrossRefs" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;&#44;&#42;&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&#46;98&#8201;&#177;&#8201;20&#46;62<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;&#42;&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HDL-LSG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#46;69&#8201;&#177;&#8201;10&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#46;04&#8201;&#177;&#8201;15&#46;51<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#46;50&#8201;&#177;&#8201;11&#46;08<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&#46;15&#8201;&#177;&#8201;10&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HDL-LRYGP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#46;04&#8201;&#177;&#8201;16&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#46;08&#8201;&#177;&#8201;18&#46;55<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&#46;50&#8201;&#177;&#8201;12&#46;08<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#46;47&#8201;&#177;&#8201;9&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TG-LSG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">161&#46;31&#8201;&#177;&#8201;83&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124&#46;59&#8201;&#177;&#8201;44&#46;57<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">118&#46;38&#8201;&#177;&#8201;42&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">101&#46;5&#8201;&#177;&#8201;29&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TG-LRYGP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">173&#46;49&#8201;&#177;&#8201;79&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">108&#46;60&#8201;&#177;&#8201;34&#46;86<a class="elsevierStyleCrossRefs" href="#tblfn0005"><span class="elsevierStyleSup">&#42;&#44;&#42;&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">107&#46;12&#8201;&#177;&#8201;36&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">108&#46;23&#8201;&#177;&#8201;33&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2901045.png"
              ]
            ]
          ]
          "notaPie" => array:5 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005"><span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05 from T6-T0 intragroup&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010"><span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05 from T12-T6 intragroup&#59; &#38; <span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05 from T18-T12 intragroup&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "&#42;&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015"><span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05 from T6-T0 intergroup&#46;</p>"
            ]
            3 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "&#42;&#42;&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020"><span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05 from T12-T6 intragroup&#46;</p>"
            ]
            4 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "&#42;&#42;&#42;&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025"><span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05 from T18-T12 intragroup&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Clinical and metabolic characteristics at six&#44; 12 and 18 months of follow-up&#46;</p>"
        ]
      ]
      7 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0040"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">The complete model was calculated for all of the obese subjects in the cohort&#44; T18-T0 for BMI&#44; apoB&#44; apoA-I&#44; fasting glucose and HOMA-IR &#40;final adjusted model R2&#8201;&#61;&#8201;0&#46;72&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Regression coefficient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Confidence interval&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HOMA-IR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;12 to &#46;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Constant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2901042.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Multiple lineal regression models which predict the evolution of LDL T18-T0 &#40;final model after step-by-step selection with an exclusion threshold at <span class="elsevierStyleItalic">P</span>&#8201;&#60;&#8201;&#46;05&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:22 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity&#44; insulin resistance&#44; and cardiovascular disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Reaven"
                            1 => "F&#46; Abbasi"
                            2 => "T&#46; McLaughlin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/rp.59.1.207"
                      "Revista" => array:6 [
                        "tituloSerie" => "Recent Prog Horm Res&#46;"
                        "fecha" => "2004"
                        "volumen" => "59"
                        "paginaInicial" => "207"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14749503"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dynamics of diabetes and obesity&#58; epidemiological perspective"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Boles"
                            1 => "R&#46; Kandimalla"
                            2 => "P&#46;H&#46; Reddy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bbadis.2017.01.016"
                      "Revista" => array:7 [
                        "tituloSerie" => "Biochim Biophys Acta Mol Basis Dis&#46;"
                        "fecha" => "2017"
                        "volumen" => "1863"
                        "numero" => "5"
                        "paginaInicial" => "1026"
                        "paginaFinal" => "1036"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28130199"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Type-2 diabetes mellitus and cardiovascular disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;J&#46; Henning"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2217/fca-2018-0045"
                      "Revista" => array:7 [
                        "tituloSerie" => "Future Cardiol&#46;"
                        "fecha" => "2018"
                        "volumen" => "14"
                        "numero" => "6"
                        "paginaInicial" => "491"
                        "paginaFinal" => "509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30409037"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathophysiology of diabetic dyslipidaemia&#58; where are we&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46; Verg&#232;s"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00125-015-3525-8"
                      "Revista" => array:7 [
                        "tituloSerie" => "Diabetologia&#46;"
                        "fecha" => "2015"
                        "volumen" => "58"
                        "numero" => "5"
                        "paginaInicial" => "886"
                        "paginaFinal" => "899"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25725623"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of the gut in diabetic dyslipidemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Stahel"
                            1 => "C&#46; Xiao"
                            2 => "A&#46; Nahmias"
                            3 => "G&#46;F&#46; Lewis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fendo.2020.00116"
                      "Revista" => array:5 [
                        "tituloSerie" => "Front Endocrinol &#40;Lausanne&#41;&#46;"
                        "fecha" => "2020"
                        "volumen" => "11"
                        "paginaInicial" => "116"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32231641"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bariatric surgery&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Buchwald"
                            1 => "Y&#46; Avidor"
                            2 => "E&#46; Braunwald"
                            3 => "M&#46;D&#46; Jensen"
                            4 => "W&#46; Pories"
                            5 => "K&#46; Fahrbach"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.292.14.1724"
                      "Revista" => array:7 [
                        "tituloSerie" => "JAMA&#46;"
                        "fecha" => "2004"
                        "volumen" => "292"
                        "numero" => "14"
                        "paginaInicial" => "1724"
                        "paginaFinal" => "1737"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15479938"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Morbid obesity and dyslipidaemia&#58; the impact of bariatric surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Climent"
                            1 => "D&#46; Benaiges"
                            2 => "A&#46; Goday"
                            3 => "M&#46; Villatoro"
                            4 => "H&#46; Juli&#224;"
                            5 => "J&#46;M&#46; Ram&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arteri.2019.11.001"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Investig Arterioscler&#46;"
                        "fecha" => "2020"
                        "volumen" => "32"
                        "numero" => "2"
                        "paginaInicial" => "79"
                        "paginaFinal" => "86"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31973950"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of bariatric surgery on mortality in Swedish obese subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Sj&#246;str&#246;m"
                            1 => "K&#46; Narbro"
                            2 => "C&#46;D&#46; Sj&#246;str&#246;m"
                            3 => "K&#46; Karason"
                            4 => "B&#46; Larsson"
                            5 => "H&#46; Wedel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa066254"
                      "Revista" => array:7 [
                        "tituloSerie" => "N Engl J Med&#46;"
                        "fecha" => "2007"
                        "volumen" => "357"
                        "numero" => "8"
                        "paginaInicial" => "741"
                        "paginaFinal" => "752"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17715408"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical practice guidelines of the European Association for Endoscopic Surgery &#40;EAES&#41; on bariatric surgery&#58; update 2020 endorsed by IFSO-EC&#44; EASO and ESPCOP"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Di Lorenzo"
                            1 => "S&#46;A&#46; Antoniou"
                            2 => "R&#46;L&#46; Batterham"
                            3 => "L&#46; Busetto"
                            4 => "D&#46; Godoroja"
                            5 => "A&#46; Iossa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00464-020-07555-y"
                      "Revista" => array:7 [
                        "tituloSerie" => "Surg Endosc&#46;"
                        "fecha" => "2020"
                        "volumen" => "34"
                        "numero" => "6"
                        "paginaInicial" => "2332"
                        "paginaFinal" => "2358"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32328827"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Homeostasis model assessment&#58; insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46;R&#46; Matthews"
                            1 => "J&#46;P&#46; Hosker"
                            2 => "A&#46;S&#46; Rudenski"
                            3 => "B&#46;A&#46; Naylor"
                            4 => "D&#46;F&#46; Treacher"
                            5 => "R&#46;C&#46; Turner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF00280883"
                      "Revista" => array:7 [
                        "tituloSerie" => "Diabetologia&#46;"
                        "fecha" => "1985"
                        "volumen" => "28"
                        "numero" => "7"
                        "paginaInicial" => "412"
                        "paginaFinal" => "419"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3899825"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Surgery decreases long-term mortality&#44; morbidity&#44; and health care use in morbidly obese patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;V&#46; Christou"
                            1 => "J&#46;S&#46; Sampalis"
                            2 => "M&#46; Liberman"
                            3 => "D&#46; Look"
                            4 => "S&#46; Auger"
                            5 => "A&#46;P&#46;H&#46; McLean"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.sla.0000137343.63376.19"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Surg&#46;"
                        "fecha" => "2004"
                        "volumen" => "240"
                        "numero" => "3"
                        "paginaInicial" => "416"
                        "paginaFinal" => "423"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15319713"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early improvement of postprandial lipemia after bariatric surgery in obese type 2 diabetic patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Griffo"
                            1 => "G&#46; Nosso"
                            2 => "R&#46; Lupoli"
                            3 => "M&#46; Cotugno"
                            4 => "G&#46; Saldalamacchia"
                            5 => "G&#46; Vitolo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-013-1148-z"
                      "Revista" => array:7 [
                        "tituloSerie" => "Obes Surg&#46;"
                        "fecha" => "2014"
                        "volumen" => "24"
                        "numero" => "5"
                        "paginaInicial" => "765"
                        "paginaFinal" => "770"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24374941"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Resolution of hyperlipidemia after laparoscopic Roux-en-Y gastric bypass"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46;T&#46; Nguyen"
                            1 => "E&#46; Varela"
                            2 => "A&#46; Sabio"
                            3 => "C&#46;-L&#46; Tran"
                            4 => "M&#46; Stamos"
                            5 => "S&#46;E&#46; Wilson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jamcollsurg.2006.03.019"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Coll Surg&#46;"
                        "fecha" => "2006"
                        "volumen" => "203"
                        "numero" => "1"
                        "paginaInicial" => "24"
                        "paginaFinal" => "29"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16798484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Laparoscopic Roux-en-Y gastric bypass improves lipid profile and decreases cardiovascular risk&#58; a 5-year longitudinal cohort study of 1048 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46; Gero"
                            1 => "L&#46; Favre"
                            2 => "P&#46; Allemann"
                            3 => "P&#46; Fournier"
                            4 => "N&#46; Demartines"
                            5 => "M&#46; Suter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11695-017-2938-5"
                      "Revista" => array:7 [
                        "tituloSerie" => "Obes Surg&#46;"
                        "fecha" => "2018"
                        "volumen" => "28"
                        "numero" => "3"
                        "paginaInicial" => "805"
                        "paginaFinal" => "811"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28971303"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in lipid profile of obese patients following contemporary bariatric surgery&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;P&#46; Heffron"
                            1 => "A&#46; Parikh"
                            2 => "A&#46; Volodarskiy"
                            3 => "C&#46; Ren-Fielding"
                            4 => "A&#46; Schwartzbard"
                            5 => "J&#46; Nicholson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjmed.2016.02.004"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Med&#46;"
                        "fecha" => "2016"
                        "volumen" => "129"
                        "numero" => "9"
                        "paginaInicial" => "952"
                        "paginaFinal" => "959"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26899751"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cholesterol metabolism after bariatric surgery in grade 3 obesity&#58; differences between malabsorptive and restrictive procedures"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Benetti"
                            1 => "M&#46; Del Puppo"
                            2 => "A&#46; Crosignani"
                            3 => "A&#46; Veronelli"
                            4 => "E&#46; Masci"
                            5 => "F&#46; Frig&#232;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2337/dc12-1737"
                      "Revista" => array:7 [
                        "tituloSerie" => "Diabetes Care&#46;"
                        "fecha" => "2013"
                        "volumen" => "36"
                        "numero" => "6"
                        "paginaInicial" => "1443"
                        "paginaFinal" => "1447"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23275360"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detection of changes in human cholesterol metabolism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46;A&#46; Miettinen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Clin Res&#46;"
                        "fecha" => "1970"
                        "volumen" => "2"
                        "numero" => "4"
                        "paginaInicial" => "300"
                        "paginaFinal" => "320"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5493461"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "AT 2013 ACC&#47;AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults&#58; a report of the American College of Cardiology&#47;American Heart Association Task Force on Practice Guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;J&#46; Stone"
                            1 => "J&#46;G&#46; Robinson"
                            2 => "A&#46;H&#46; Lichtenstein"
                            3 => "C&#46;N&#46; Bairey Merz"
                            4 => "C&#46;B&#46; Blum"
                            5 => "R&#46;H&#46; Eckel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.cir.0000437738.63853.7a"
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation&#46;"
                        "fecha" => "2014"
                        "volumen" => "129"
                        "numero" => "25 Suppl 2"
                        "paginaInicial" => "S1"
                        "paginaFinal" => "45"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24222016"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of statins on risk of coronary disease&#58; a meta-analysis of randomized controlled trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;C&#46; LaRosa"
                            1 => "J&#46; He"
                            2 => "S&#46; Vupputuri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.282.24.2340"
                      "Revista" => array:7 [
                        "tituloSerie" => "JAMA&#46;"
                        "fecha" => "1999"
                        "volumen" => "282"
                        "numero" => "24"
                        "paginaInicial" => "2340"
                        "paginaFinal" => "2346"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10612322"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Co-incubation of native and oxidized low-density lipoproteins&#58; potentiation of relaxation impairment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Pers&#233;gol"
                            1 => "V&#46; Sementa"
                            2 => "A&#46; Athias"
                            3 => "J&#46; Lecerf"
                            4 => "C&#46; Lallemant"
                            5 => "P&#46; Gambert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0014-2999(00)00696-8"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Pharmacol&#46;"
                        "fecha" => "2000"
                        "volumen" => "406"
                        "numero" => "3"
                        "paginaInicial" => "429"
                        "paginaFinal" => "437"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11040350"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of bariatric surgery on hepatic and intestinal lipoprotein particle metabolism in obese&#44; nondiabetic humans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Padilla"
                            1 => "M&#46; Maraninchi"
                            2 => "S&#46; B&#233;liard"
                            3 => "B&#46; Berthet"
                            4 => "J&#46;-P&#46; Nogueira"
                            5 => "E&#46; Wolff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/ATVBAHA.114.303849"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arterioscler Thromb Vasc Biol&#46;"
                        "fecha" => "2014"
                        "volumen" => "34"
                        "numero" => "10"
                        "paginaInicial" => "2330"
                        "paginaFinal" => "2337"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25104797"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of bariatric surgery on apolipoprotein C-III levels and lipoprotein distribution in obese human subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Maraninchi"
                            1 => "N&#46; Padilla"
                            2 => "S&#46; B&#233;liard"
                            3 => "B&#46; Berthet"
                            4 => "J&#46;-P&#46; Nogueira"
                            5 => "J&#46; Dupont-Roussel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacl.2017.02.012"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Lipidol&#46;"
                        "fecha" => "2017"
                        "volumen" => "11"
                        "numero" => "2"
                        "paginaInicial" => "495"
                        "paginaFinal" => "506"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/25299123/0000003400000002/v1_202205120709/S2529912322000201/v1_202205120709/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "63721"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/25299123/0000003400000002/v1_202205120709/S2529912322000201/v1_202205120709/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529912322000201?idApp=UINPBA00004N"
]

Article information

ISSN: 25299123
Original language: English

DOI:10.1016/j.artere.2022.04.005

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	4	0	4
2024 October	12	4	16
2024 September	11	3	14
2024 August	17	4	21
2024 July	11	7	18
2024 June	8	2	10
2024 May	11	1	12
2024 April	6	2	8
2024 March	10	3	13
2024 February	6	3	9
2024 January	8	1	9
2023 December	17	1	18
2023 November	10	4	14
2023 October	28	1	29
2023 September	9	2	11
2023 August	7	1	8
2023 July	3	17	20
2023 June	5	0	5
2023 May	8	2	10
2023 April	3	0	3
2023 March	6	1	7

Show all

Indexed in:

Follow us:

Subscribe:

Statistics

Indexed in:

Follow us:

Subscribe:

Statistics

Subscribe to our newsletter