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Original article
Association of carotid atheroma plaque with IL-18 levels and with polymorphisms in the IL-18 receptor gene in a Mediterranean population
Asociación de la placa de ateroma carotídea con los niveles plasmáticos de IL-18 y con polimorfismos en el gen del receptor de la IL-18 en la población mediterránea
Ana Palancaa,b, Amparo Bartual-Rodrigoa, Carolina Cuencab, Oscar D. Mayo-Lópezb, F. Javier Ampudia-Blascoa,b,d,e, Herminia González-Navarrob,c,d, Juan F. Ascasob,e, Ana Bárbara García-Garcíab,d,f, F. Javier Chavesb,d,f, José T. Reala,b,d,e, Sergio Martínez-Hervása,b,d,e,
Corresponding author
smartinezhervas@hotmail.com

Corresponding author.
a Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valencia, Valencia, Spain
b INCLIVA, Instituto de Investigación Sanitaria, Valencia, Spain
c Departamento de Bioquímica y Biología Molecular, Universitat de València, Valencia, Spain
d CIBER de Diabetes y Enfermedades Metabólicas asociadas, Instituto de Salud Carlos III, Madrid, Spain
e Departament de Medicina, Universitat de València, Valencia, Spain
f Unidad de Genómica y Diabetes, INCLIVA, Instituto de Investigación Sanitaria, Valencia, Spain
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            "entidad" => "CIBER de Diabetes y Enfermedades Metab&#243;licas asociadas&#44; Instituto de Salud Carlos III&#44; Madrid&#44; Spain"
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      "es" => array:1 [
        "titulo" => "Asociaci&#243;n de la placa de ateroma carot&#237;dea con los niveles plasm&#225;ticos de IL-18 y con polimorfismos en el gen del receptor de la IL-18 en la poblaci&#243;n mediterr&#225;nea"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Atherosclerosis is an chronic inflammatory disease&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Studies in experimental animals have demonstrated the importance of different inflammatory mediators in both the onset and development of atherosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Multiple studies in humans have shown the close association between inflammatory markers and the development of cardiovascular disease&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Furthermore&#44; it has recently been shown that the use of drugs capable of reducing the inflammatory state&#44; without modifying other cardiovascular risk factors&#44; reduces the incidence of cardiovascular disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The degree of inflammation&#44; as well as the development of atherosclerosis and subsequent cardiovascular disease&#44; are modulated by both environmental and genetic factors&#46; The regulation of the inflammatory process by genetic factors could explain the great variability in the inflammatory response&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> However&#44; the genetic contribution to both the development of inflammation and atherosclerosis remains a partially unknown factor&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">One of the inflammatory molecules that has been linked to the development of atherosclerosis is interleukin 18 &#40;IL-18&#41;&#46; In animal models&#44; it has been observed that plasma levels of IL-18 play an important role in both the formation and development of atheromatous plaque&#44; in addition to its stability and severity<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Similar outcomes have also been observed in humans&#46; Different studies have demonstrated the association between IL-18 levels and the development of cardiovascular disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a> Furthermore&#44; some studies have identified the influence of some genetic variations in the genes involved in the IL-18 system on cardiovascular disease and its severity&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;12</span></a> although there is less data on Single Nucleotide Polymorphisms &#40;SNPs&#41; located in IL-18 receptor 1 &#40;IL18R1&#41; and IL-18 receptor accessory protein &#40;IL18RAP&#41;&#46;However&#44; outcomes are contradictory and their effect on atheromatous plaque has not been evaluated&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Our hypothesis was therefore that plasma levels of IL-18 are associated with the presence of atherosclerosis and genetic variations may exist that could influence the development of atheromatous plaque&#46; The objective of our study was to evaluate the possible relationship between IL-18 plasma levels and the presence of atherosclerosis evaluated at the carotid level&#44; and also to analyse the possible influence of different polymorphisms in the IL18R1 and IL18RAP genes in a Mediterranean population&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Subjects</span><p id="par0025" class="elsevierStylePara elsevierViewall">Seven hundred and forty-six patients from the VALencian CArdiovascular Risk &#40;VALCAR&#41; study were included&#46; This was a cross-sectional study designed to evaluate the prevalence of cardiovascular risk factors in an urban population&#44; and their association with the presence of atherosclerosis evaluated by carotid ultrasound&#46; The participating individuals were included for two years by consecutive opportunistic sampling from among those who attended different consultations of our health department in a metropolitan area of &#8203;&#8203;Valencia&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The exclusion criteria for our study were&#58; patients with chronic inflammatory diseases &#40;both digestive and rheumatic&#41;&#44; the presence of plasma levels of high-sensitivity C-reactive protein &#40;hsCRP&#41;&#62;10&#8239;mg&#47;l and having had an infectious or inflammatory episode in the previous 2 weeks&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The study was approved by the Ethics Committee of our centre&#46; All participants provided written consent to participate in the study&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Clinical parameters</span><p id="par0040" class="elsevierStylePara elsevierViewall">An anamnesis was taken for all participants in which special interest was paid to the use of drugs for regular or occasional consumption during the study period&#44; smoking habits &#40;number of cigarettes&#47;day&#41; and alcohol consumption &#40;grams of alcohol&#47;day&#41;&#46; A history of cardiovascular disease prior to the date of inclusion in the study was also collected&#46; Blood pressure was determined after 10&#8239;min of supine position&#44; using the average value of 3 measurements separated by 5&#8239;min&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Anthropometric parameters</span><p id="par0045" class="elsevierStylePara elsevierViewall">The parameters evaluated were&#58; weight in kilograms &#40;kg&#41;&#59; height in meters &#40;m&#41;&#59; body mass index &#40;BMI&#41; in kg&#47;m<span class="elsevierStyleSup">2</span>&#44; and waist circumference in centimetres &#40;cm&#41;&#44; measured at the midpoint between the anterior superior iliac spine and the lower costal margin&#44; with the subject standing and the arms in an anatomical position&#46; The measurement was obtained with a tape measure graduated in cm&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Biochemical parameters</span><p id="par0050" class="elsevierStylePara elsevierViewall">A blood sample was drawn after a 12&#8239;h overnight fast&#46; The methodology was similar to that previously described&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Specifically&#44; plasma levels of total cholesterol &#40;TC&#41;&#44; triglycerides &#40;TG&#41; and glucose were determined by enzymatic methods&#46; HDL cholesterol &#40;HDL-c&#41; after precipitation with phosphotungstic acid magnesium chloride&#46; LDL cholesterol &#40;LDL-C&#41; was calculated by the Friedewald formula&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Plasma levels of IL-18 were determined by the ELISA technique with &#8220;Human IL-18 ELISA Kit&#8221; &#40;Medical &#949;t BIologicalLaboratories Co&#46; Ltd&#46;&#41; and quantified by absorbance measurement with the GloMax&#174;-Multi&#8239;&#43;&#8239;Detection System apparatus &#40;Promega&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Carotid ultrasound</span><p id="par0060" class="elsevierStylePara elsevierViewall">The ultrasound was performed using a Siemens Sonoline G40 device&#44; with a high-resolution linear transducer of 8&#8239;MHz frequency&#46; The examination was performed with the subjects in the supine position with the head turned at 45&#176; to the opposite side of the side being explored&#46; Three predetermined segments were evaluated on both sides&#58; common carotid &#40;1&#8239;cm proximal to the carotid bulb&#41;&#44; carotid bulb &#40;1&#8211;2&#8239;cm&#41; and internal carotid &#40;1&#8239;cm distal to the bifurcation&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Six measurements were made at regular intervals bilaterally in 3 different projections &#40;ACCD&#58; 90&#8211;120 and 150&#176;&#59; ACCI&#58; 210&#44; 240 and 270&#176;&#41;&#46; All measurements were used for statistical analysis&#46; The intima-media thickness &#40;IMT&#41;&#44; defined as the distance between the carotid-intima lumen interface and the media-adventitia interface of the distal wall&#44; was determined in longitudinal sections in the region prior to the bifurcation of the common carotid artery &#40;1&#8239;cm&#41;&#46; Carotid plaque was considered a focal thickening of more than 50&#37; of the surrounding vessel wall&#44; or a IMT greater than 1&#46;5&#8239;mm that protruded into the adjacent lumen&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">All examinations were performed by a single investigator &#40;SM-H&#41; trained in performing carotid ultrasounds and always following the same protocol previously described&#46; The coefficient of variability was studied in 20 subjects&#44; and was 5&#46;2&#37; for the mean IMT of both common carotids&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">SNP selection and genotyping</span><p id="par0070" class="elsevierStylePara elsevierViewall">Genomic DNA was obtained from blood cells of venous blood&#44; using the Chemagic&#174; system &#40;Chemagen&#44; Baesweiler&#44; Germany&#41;&#46; The DNA was quantified and diluted to a final concentration of 100&#8239;ng&#47;&#956;l&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The IL-18 receptor SNPs for genotyping were selected based on a conjunction of different parameters&#58; heterozygosity &#40;&#62;10&#37; for the lowest frequency allele&#41; in the Caucasian population&#44; position and spacing along the gene and possible effect functional &#40;<a href="http://www.ensembl.org/index.html">http&#58;&#47;&#47;www&#46;ensembl&#46;org&#47;index&#46;html</a>&#41;&#46; Four of them were finally selected&#58; rs2270297 and rs2287037 located in IL18R1&#59; rs2293224 and rs7559479 located in IL18RAP&#46; SNPs were genotyped using a SNPlex&#174; assay &#40;Applied Biosystems&#44; Foster City&#44; CA&#44; USA&#41; following the manufacturer&#39;s recommendations&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Statistical methods</span><p id="par0080" class="elsevierStylePara elsevierViewall">Quantitative variables were expressed as mean&#8239;&#177;&#8239;standard deviation and the qualitative variables as percentages and&#47;or total number&#46; To compare quantitative variables between groups&#44; the Student&#8217;s t test and the ANOVA test &#40;2 or more variables&#44; respectively&#41; were used for normally distributed variables&#46; For non-normally distributed variables&#44; the Mann-Whitney test and the Kruskal-Wallis test were used &#40;2 or more variables&#44; respectively&#41;&#46; To correct confounding factors in some comparison studies&#44; ANCOVA analysis was used&#46; To compare the qualitative variables between groups&#44; the Chi-square test was used&#44; or the Fisher test when the number was under 5&#46; The bivariate correlations between variables were studied with the Pearson test for variables with a normal distribution and Spearman test for variables without normal distribution&#46; To evaluate the factors associated with carotid IMT and the presence of atheromatous plaque&#44; linear and logistic regression analyses were performed&#44; respectively&#46; Differences were considered statistically significant if the p value was less than &#46;05&#46; The statistical package SPSS&#174; for Windows version 15&#46;0 &#40;SPSS&#174;&#44; Chicago&#44; IL&#44; USA&#41; was used&#46; Allele and genotype frequencies were calculated for each SNP using SPSS&#174; and y SNPstats &#40;<a href="http://bioinfo.iconcologia.net/index.php">http&#58;&#47;&#47;bioinfo&#46;iconcologia&#46;net&#47;index&#46;php</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> Hardy-Weinberg equilibrium &#40;HWE&#41; was calculated by the Chi-square test with one degree of freedom using the SNPstat software&#46; Linkage disequilibrium was calculated using the R2 statistic&#46; The association between the polymorphisms and IL-18 levels was analysed using a co-dominant inheritance model using SPSS&#174; and SNPstat&#46; For the comparison of quantitative variables between genotypes&#44; the ANOVA test was used&#46; Age and sex&#44; as 2 potential confounders&#44; were used as covariates&#46; Differences were considered statistically significant if the p value was less than &#46;05&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Results</span><p id="par0085" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> contains the general characteristics of the population studied&#46; Statistically significant differences were found between both genders in BMI&#59; abdominal circumference&#59; systolic and diastolic blood pressure&#59; parameters of carbohydrate metabolism&#44; as well as in HDL-c and plasma triglycerides&#46; Likewise&#44; the levels of IL-18 &#40;472&#46;7&#8239;&#177;&#8239;205&#46;5 vs&#46; 389&#46;4&#8239;&#177;&#8239;185&#46;5&#8239;pg&#47;ml&#41; and carotid IMT &#40;&#46;599&#8239;&#177;&#8239;&#46;185 vs&#46; &#46;542&#8239;&#177;&#8239;&#46;174&#8239;mm&#41; were significantly higher in men&#46; There was also a higher frequency of atheromatous plaques in men compared to women&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the characteristics of the population divided according to the quartiles of plasma IL-18 levels&#46; It is observed that as IL-18 levels increase&#44; the levels of parameters associated with the presence of insulin resistance&#44; as well as carotid IMT&#44; increase significantly&#46; The prevalence of atheromatous plaques was significantly lower in the subjects included in the quartile with the lowest levels of IL-18&#44; compared to the other 3&#44; with no significant differences between the other 3 groups&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">When analysing the association of IL-18 with other parameters &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#44; significant correlations were observed with the parameters associated with the presence of insulin resistance&#44; as well as with the components included in the definition of metabolic syndrome and&#44; in addition&#44; with carotid IMT and with the presence of atheromatous plaque&#46; There was no significant correlation between the SNPs studied and IL-18 levels&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Furthermore&#44; the possible association between the presence of alterations at the carotid level and the polymorphisms analysed was analysed &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; Hardy-Weinberg equilibrium was maintained for all polymorphisms analysed&#46; Carriers of the minor allele of rs2287037 presented an increased risk of developing atheromatous plaque&#44; while carriers of the minor allele of rs2293224 presented a significant reduction in said risk&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Finally&#44; regression analyses were performed&#46; Using linear regression&#44; the factors associated with the increase in carotid IMT were evaluated&#44; observing a significant correlation only with age and cholesterol levels &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>&#41;&#46; Using logistic regression&#44; the factors associated with the presence of atheromatous plaque were evaluated&#44; observing a significant association with age&#44; gender and one of the SNPs evaluated&#44; rs2287037 &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">Table 6</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><elsevierMultimedia ident="tbl0030"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Discussion</span><p id="par0110" class="elsevierStylePara elsevierViewall">This study demonstrates that patients with higher IL-18 plasma levels have associated cardiovascular risk factors&#46; Furthermore&#44; elevated levels of IL-18 were significantly associated with increased carotid IMT and the presence of atheromatous plaques&#46; This association appears to be influenced by genetic factors&#44; as demonstrated by the associations found between SNPs in the IL-18 receptor gene and the presence of atheromatous plaque&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Atherosclerosis is a chronic disease&#44; the pathogenesis of which involves different inflammatory molecules&#46; Among these&#44; IL-18 is a cytokine that plays an important role in the development of the inflammatory process&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> In fact&#44; it is considered that&#44; together with IL-1&#946;&#44; it is one of the 2 most prominent inflammatory cytokines of the inflammasome that promote the development of atherosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> However&#44; in relation to this finding there seem to be contradictory data&#46; Fan et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> in a meta-analysis&#44; applying Mendelian randomisation methodology&#44; found no relationship between IL-18 levels and the risk of cardiovascular disease&#46; Therefore&#44; knowledge of the role of IL-18&#44; as well as the possible mechanisms involved in the modulation of the atherosclerotic process&#44; is of great interest&#44; particularly because it could be a possible way to help reduce the risk of developing atherosclerosis and cardiovascular disease&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">In our study&#44; patients with higher levels of IL-18 had higher carotid IMT&#44; as well as a greater association with other cardiovascular risk factors&#46; Furthermore&#44; those with lower levels of IL-18 had a lower proportion of atheroma plaques &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; These findings are in line with previous studies in which it was observed that IL-18 had a proatherogenic role&#46; Thus&#44; plasma levels of IL-18 proved to be a good predictor of both the development of cardiovascular disease and mortality from this cause&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;23</span></a> In contrast&#44; animal models deficient in IL-18 have a lower presence of atherosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Furthermore&#44; experimental data indicate that the IL-18 signalling pathway is involved in plaque instability&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25&#44;26</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">However&#44; there is great variability in the development of atherosclerosis and cardiovascular disease among patients with elevated levels of IL-18&#46; The presence of different genetic variations could explain this&#44; at least in part&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> Previous studies have shown that polymorphisms in the IL-18 gene are associated with the development of coronary heart disease and its severity&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;12</span></a> although there are contradictory data&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;28</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">L-18 signalling is induced by the binding of this cytokine to a heterodimeric receptor called IL-18R&#46; This is made up of 2 chains&#44; IL-18R1 &#40;with binding function&#41; and IL18RAP &#40;receptor accessory protein&#44; with signal transduction function&#41;&#46; The interaction of both IL-18R chains is necessary to induce IL-18 signaling&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">29&#44;30</span></a> In our study we analysed 2 SNPs of IL-18R1 &#40;rs2270297 and rs2287037&#41; and 2 SNPs of IL-18RAP &#40;rs2293224 and rs7559479&#41;&#46; We observed that the genotype with the A allele of the SNP rs2287037 of IL-18R1 is associated with a higher prevalence of carotid atheromatous plaque&#46; Due to the location&#44; this SNP could be functional&#46; Furthermore&#44; in the regression analysis&#44; this SNPs was significantly associated with the presence of atheromatous plaque&#46; On the contrary&#44; the genotype with the C allele of the IL-18RAP SNP rs2293224 is associated with a lower prevalence of atheromatous plaque&#46; However&#44; there are no previous studies relating variations in these SNPs with the presence of atherosclerosis&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">There are several limitations to this study&#46; Firstly&#44; it is a cross-sectional study&#46; Therefore&#44; it is not possible to establish causal relationships&#46; Furthermore&#44; the results have not been replicated in another population&#46; Finally&#44; there is no data in this study on the presence of atheromatous plaques at the femoral level&#46; Nor has it been evaluated whether there is an association between the characteristics of the atheroma plaque or the number of affected vascular territories and the levels of IL-18 and the genetic variations studied&#46; However&#44; the findings support the participation of IL-18 in the development of atherosclerosis&#44; as well as its possible regulation&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">To conclude&#44; this study carried out in a Mediterranean population suggests that plasma levels of IL-18 are related to other cardiovascular risk factors&#44; especially those related to the presence of insulin resistance&#46; Furthermore&#44; higher levels of IL-18 are related to the presence of atheromatous plaques&#44; and there are genetic variations in the IL-18 receptor gene that could be associated with the development of said atheromatous plaques&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Funding</span><p id="par0145" class="elsevierStylePara elsevierViewall">Biomedical Research Networking Centre Consortium &#40;CIBER for its initials in Spanish&#41; CB07&#47;08&#47;0018&#44; Carlos III Health Institute&#44; Ministry of Science and Innovation and European Union &#40;European Regional Development Funds&#41;&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">AP is the recipient of a Sara Borrell postdoctoral contract from the Carlos III Health Institute &#40;CD22&#47;00012&#41;&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflict of interests</span><p id="par0155" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
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          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Funding"
        ]
        9 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Conflict of interests"
        ]
        10 => array:2 [
          "identificador" => "xack762595"
          "titulo" => "Acknowledgements"
        ]
        11 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2023-11-11"
    "fechaAceptado" => "2023-12-15"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1855211"
          "palabras" => array:5 [
            0 => "IL-18"
            1 => "Atherosclerosis"
            2 => "Inflammation"
            3 => "Polymorphism"
            4 => "Atheroma plaque"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1855210"
          "palabras" => array:5 [
            0 => "IL-18"
            1 => "Arteriosclerosis"
            2 => "Inflamaci&#243;n"
            3 => "Polimorfismo"
            4 => "Placa de ateroma"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Atherosclerosis is an inflammatory disease&#46; Interleukin 18 &#40;IL-18&#41; is an inflammatory molecule that has been linked to the development of atherosclerosis and cardiovascular disease&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">To evaluate the possible relationship between plasma levels of IL-18 and the presence of atherosclerosis evaluated at the carotid level&#44; as well as to analyze the possible modulation by different polymorphisms in a Mediterranean population&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material and methods</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">746 individuals from the metropolitan area of &#8203;&#8203;Valencia were included&#44; recruited over a period of 2 years&#46; Hydrocarbon and lipid metabolism parameters were determined using standard methodology and IL-18 using ELISA&#46; In addition&#44; carotid ultrasound was performed and the genotype of 4 SNPs related to the IL-18 signaling pathway was analyzed&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Patients with higher plasma levels of IL-18 had other associated cardiovascular risk factors&#46; Elevated IL-18 levels were significantly associated with higher carotid IMT and the presence of atheromatous plaques&#46; The genotype with the A allele of the SNP rs2287037 was associated with a higher prevalence of carotid atheromatous plaque&#46; On the contrary&#44; the genotype with the C allele of the SNP rs2293224 was associated with a lower prevalence of atheromatous plaque&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">High levels of IL-18 were significantly associated with a higher carotid IMT and the presence of atheromatous plaques&#44; which appear to be influenced by genetic factors&#44; as evidenced by associations between SNPs in the IL-18 receptor gene and the presence of atheroma plaque&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material and methods"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
          ]
          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Antecedentes</span><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">La arteriosclerosis es una enfermedad inflamatoria&#46; La interleucina 18 &#40;IL-18&#41; es una mol&#233;cula inflamatoria que se ha relacionado con el desarrollo de arteriosclerosis y enfermedad cardiovascular&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Evaluar la posible relaci&#243;n entre los niveles plasm&#225;ticos de IL-18 y la presencia de arteriosclerosis evaluada a nivel carot&#237;deo&#44; as&#237; como analizar la posible modulaci&#243;n por diferentes polimorfismos en una poblaci&#243;n mediterr&#225;nea&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Material y m&#233;todos</span><p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 746 individuos procedentes del &#225;rea metropolitana de Valencia&#44; reclutados durante un per&#237;odo de 2 a&#241;os&#46; Se determinaron par&#225;metros del metabolismo hidrocarbonado y lip&#237;dico mediante metodolog&#237;a est&#225;ndar e IL-18 mediante ELISA&#46; Adem&#225;s&#44; se realiz&#243; ecograf&#237;a carot&#237;dea y se analiz&#243; el genotipo de 4 SNPs relacionados con la v&#237;a de se&#241;alizaci&#243;n de IL-18&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con niveles plasm&#225;ticos m&#225;s elevados de IL-18 presentaron otros factores de riesgo cardiovascular asociados&#46; Los niveles elevados de IL-18 se asociaron de forma significativa con un mayor GIM carot&#237;deo y con la presencia de placas de ateroma&#46; El genotipo con el alelo A del SNP rs2287037 se asoci&#243; con mayor prevalencia de placa de ateroma carot&#237;dea&#46; Por el contrario&#44; el genotipo con el alelo C del SNP rs2293224 se asoci&#243; con una menor prevalencia de placa de ateroma&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">Los niveles elevados de IL-18 se asociaron de forma significativa con un mayor GIM carot&#237;deo y con la presencia de placas de ateroma&#44; que parecen estar influenciados por factores gen&#233;ticos&#44; como lo demuestran las asociaciones entre los SNPs en el gen del receptor de IL-18 y la presencia de placa de ateroma&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Antecedentes"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Material y m&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "multimedia" => array:6 [
      0 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Table "
            "rol" => "short"
          ]
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Data are presented as mean&#8239;&#177;&#8239;standard deviation&#59; p value between women and men&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">BMI&#58; body mass index&#59; DBP&#58; diastolic blood pressure&#59; HDL-c&#58; HDL cholesterol&#59; IL-18&#58; interleukin&#59; IMT&#58; intima-media thickness&#59; LDL-c&#58; LDL cholesterol&#59; SBP&#58; systolic blood pressure&#59; TC&#58; total cholesterol&#59; TG&#58; triglycerides&#59; WC&#58; waist circumference&#46;</p>"
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Complete group&#40;<span class="elsevierStyleItalic">n</span>&#8239;&#61;&#8239;746&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Women&#40;<span class="elsevierStyleItalic">n</span>&#8239;&#61;&#8239;384&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Men&#40;<span class="elsevierStyleItalic">n</span>&#8239;&#61;&#8239;362&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p value&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">45&#46;3&#8239;&#177;&#8239;14&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">45&#46;9&#8239;&#177;&#8239;15&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">44&#46;7&#8239;&#177;&#8239;13&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;267&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">27&#46;4&#8239;&#177;&#8239;4&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;7&#8239;&#177;&#8239;5&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#46;1&#8239;&#177;&#8239;4&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">WC &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">91&#46;7&#8239;&#177;&#8239;13&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#46;2&#8239;&#177;&#8239;13&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&#46;5&#8239;&#177;&#8239;11&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">125&#46;4&#8239;&#177;&#8239;16&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121&#46;9&#8239;&#177;&#8239;17&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129&#46;3&#8239;&#177;&#8239;14&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">77&#46;3&#8239;&#177;&#8239;1&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#46;9&#8239;&#177;&#8239;11&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&#46;8&#8239;&#177;&#8239;9&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glucose &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">99&#46;1&#8239;&#177;&#8239;24&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95&#46;6&#8239;&#177;&#8239;20&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">102&#46;7&#8239;&#177;&#8239;28&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Insulin &#40;mcU&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;3&#8239;&#177;&#8239;7&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;7&#8239;&#177;&#8239;7&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;0&#8239;&#177;&#8239;7&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  """
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        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Data are presented as mean&#177;standard deviation&#59; p value between women and men&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">BMI&#58; body mass index&#59; DBP&#58; diastolic blood pressure&#59; HDL-c&#58; HDL cholesterol&#59; IL-18&#58; interleukin 18&#59; IMT&#58; intima-media thickness&#59; LDL-c&#58; LDL cholesterol&#59; SBP&#58; systolic blood pressure&#59; TC&#58; total cholesterol&#59; TG&#58; triglycerides&#59; WC&#58; waist circumference&#46;</p>"
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">50&#46;3&#8239;&#177;&#8239;13&#46;6<a class="elsevierStyleCrossRefs" href="#tblfn0005">&#42;&#44;&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">WC &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&#46;1&#8239;&#177;&#8239;11&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&#46;1&#8239;&#177;&#8239;13&#46;2<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&#46;0&#8239;&#177;&#8239;13&#46;3<a class="elsevierStyleCrossRefs" href="#tblfn0005">&#42;&#44;&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&#46;8&#8239;&#177;&#8239;12&#46;9<a class="elsevierStyleCrossRefs" href="#tblfn0005">&#42;&#44;&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">120&#46;9&#8239;&#177;&#8239;15&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124&#46;6&#8239;&#177;&#8239;16&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">126&#46;4&#8239;&#177;&#8239;15&#46;9<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129&#46;6&#8239;&#177;&#8239;16&#46;6<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">74&#46;8&#8239;&#177;&#8239;10&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&#46;9&#8239;&#177;&#8239;10&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&#46;2&#8239;&#177;&#8239;9&#46;5<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#46;1&#8239;&#177;&#8239;9&#46;9<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Glucose &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91&#46;9&#8239;&#177;&#8239;13&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#46;5&#8239;&#177;&#8239;25&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#46;3&#8239;&#177;&#8239;19&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">107&#46;4&#8239;&#177;&#8239;32&#46;3<a class="elsevierStyleCrossRefs" href="#tblfn0005">&#42;&#44;&#42;&#42;&#44;&#42;&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Insulin &#40;mcU&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;8&#8239;&#177;&#8239;5&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;6&#8239;&#177;&#8239;6&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#46;6&#8239;&#177;&#8239;6&#46;8<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;6&#8239;&#177;&#8239;12&#46;8<a class="elsevierStyleCrossRefs" href="#tblfn0005">&#42;&#44;&#42;&#42;&#44;&#42;&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HOMA index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;1&#8239;&#177;&#8239;1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;7&#8239;&#177;&#8239;2&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;8&#8239;&#177;&#8239;2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;5&#8239;&#177;&#8239;4&#46;6<a class="elsevierStyleCrossRefs" href="#tblfn0005">&#42;&#44;&#42;&#42;&#44;&#42;&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TC &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">222&#46;3&#8239;&#177;&#8239;59&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">224&#46;8&#8239;&#177;&#8239;61&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">223&#46;9&#8239;&#177;&#8239;65&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">229&#46;5&#8239;&#177;&#8239;66&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HDL-c &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&#46;7&#8239;&#177;&#8239;13&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#46;1&#8239;&#177;&#8239;15&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;7&#8239;&#177;&#8239;12&#46;9<a class="elsevierStyleCrossRefs" href="#tblfn0005">&#42;&#44;&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#46;0&#8239;&#177;&#8239;14&#46;2<a class="elsevierStyleCrossRefs" href="#tblfn0005">&#42;&#44;&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LDL-c &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">140&#46;4&#8239;&#177;&#8239;50&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">142&#46;9&#8239;&#177;&#8239;54&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">141&#46;3&#8239;&#177;&#8239;50&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">148&#46;5&#8239;&#177;&#8239;65&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TG &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">105&#46;2&#8239;&#177;&#8239;69&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129&#46;3&#8239;&#177;&#8239;95&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">160&#46;8&#8239;&#177;&#8239;146&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">236&#46;8&#8239;&#177;&#8239;490&#46;6<a class="elsevierStyleCrossRefs" href="#tblfn0005">&#42;&#44;&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carotid IMP &#40;mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;510&#8239;&#177;&#8239;&#46;139&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;556&#8239;&#177;&#8239;&#46;205&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;588&#8239;&#177;&#8239;&#46;173<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;629&#8239;&#177;&#8239;&#46;175<a class="elsevierStyleCrossRefs" href="#tblfn0005">&#42;&#44;&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Carotid atheroma plaque &#40;n&#44; &#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;20&#46;9&#37;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;23&#46;1&#37;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44 &#40;23&#46;6&#37;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">BMI&#58; body mass index&#59; DBP&#58; diastolic blood pressure&#59; HDL-c&#58; HDL cholesterol&#59; IL-18&#58; interleukin 18&#59; IMT&#58; intima-media thickness&#59; LDL-c&#58; LDL cholesterol&#59; SBP&#58; systolic blood pressure&#59; TC&#58; total cholesterol&#59; TG&#58; triglycerides&#59; WC&#58; waist circumference&#46;</p>"
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">dbSNP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Genotype&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">N&#46;&#186;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Plaque</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Odds ratio &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Yes &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">rs2270297&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HWE&#58; <span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;&#46;12&#59; MAF&#58; &#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GG&#8239;&#43;&#8239;GA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">592&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;918&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;96&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;8&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;4 &#40;&#46;08&#8211;1&#46;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">rs2287037&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HWE&#58; <span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;&#46;26&#59; MAF&#58; &#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">266&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;44&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;27&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;&#46;0052&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GA&#8239;&#43;&#8239;AA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">371&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;55&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;73&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">2&#46;46 &#40;1&#46;28&#8211;4&#46;73&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">rs2293224&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HWE&#58; <span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;&#46;074&#59; MAF&#58; &#46;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">171&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;25&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;38&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;&#46;0069&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TC&#8239;&#43;&#8239;CC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">453&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;74&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;61&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#46;41 &#40;&#46;21&#8211;&#46;78&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">rs7559479&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Non standardised coefficient&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#46;680&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">TC &#40;mg&#47;dl&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;0005&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;147&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">IL-18 &#40;pg&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
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                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Ther Med"
                        "fecha" => "2019"
                        "volumen" => "18"
                        "paginaInicial" => "517"
                        "paginaFinal" => "522"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31281442"
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              "identificador" => "bib0045"
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                    0 => array:2 [
                      "titulo" => "Interleukin 18 and coronary heart disease&#58; prospective study and systematic review"
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                          "etal" => true
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                            2 => "C&#46;G&#46; Owen"
                            3 => "S&#46;G&#46; Wannamethee"
                            4 => "S&#46;E&#46; Humphries"
                            5 => "M&#46; Woodward"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.atherosclerosis.2011.03.015"
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                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "2011"
                        "volumen" => "217"
                        "paginaInicial" => "227"
                        "paginaFinal" => "233"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21481392"
                            "web" => "Medline"
                          ]
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                ]
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            9 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-18 and the risk of coronary heart disease in European men&#58; the Prospective Epidemiological Study of Myocardial Infarction &#40;PRIME&#41;"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Blankenberg"
                            1 => "G&#46; Luc"
                            2 => "P&#46; Ducimeti&#232;re"
                            3 => "D&#46; Arveiler"
                            4 => "J&#46; Ferri&#232;res"
                            5 => "P&#46; Amouyel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.CIR.0000099509.76044.A2"
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                        "tituloSerie" => "Circulation"
                        "fecha" => "2003"
                        "volumen" => "108"
                        "paginaInicial" => "2453"
                        "paginaFinal" => "2459"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14581397"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            10 => array:3 [
              "identificador" => "bib0055"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-18 and the risk of future cardiovascular disease among initially healthy women"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46;M&#46; Everett"
                            1 => "S&#46; Bansal"
                            2 => "N&#46; Rifai"
                            3 => "J&#46;E&#46; Buring"
                            4 => "P&#46;M&#46; Ridker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.atherosclerosis.2008.04.015"
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                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "2009"
                        "volumen" => "202"
                        "paginaInicial" => "282"
                        "paginaFinal" => "288"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18514203"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between polymorphisms in interleukin-18 promoter and risk of coronary artery disease&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "S&#46;-F&#46; Li"
                            2 => "Y&#46;-X&#46; Cui"
                            3 => "M&#46;-Y&#46; Wu"
                            4 => "L&#46;-N&#46; Su"
                            5 => "D&#46; Hu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1042/BSR20192721"
                      "Revista" => array:3 [
                        "tituloSerie" => "Biosci Rep"
                        "fecha" => "2019"
                        "volumen" => "39"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL18-family genes polymorphism is associated with the risk of myocardial infarction and IL18 concentration in patients with coronary artery disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;V&#46; Ponasenko"
                            1 => "A&#46;V&#46; Tsepokina"
                            2 => "M&#46;V&#46; Khutornaya"
                            3 => "M&#46;Y&#46; Sinitsky"
                            4 => "O&#46;L&#46; Barbarash"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/08820139.2021.1876085"
                      "Revista" => array:6 [
                        "tituloSerie" => "Immunol Invest"
                        "fecha" => "2022"
                        "volumen" => "51"
                        "paginaInicial" => "802"
                        "paginaFinal" => "816"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33522333"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk&#58; the MORGAM Project"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;-L&#46; Grisoni"
                            1 => "C&#46; Proust"
                            2 => "M&#46; Alanne"
                            3 => "M&#46; Desuremain"
                            4 => "V&#46; Salomaa"
                            5 => "K&#46; Kuulasmaa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2350-10-44"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Med Genet"
                        "fecha" => "2009"
                        "volumen" => "10"
                        "paginaInicial" => "44"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19473509"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Los niveles plasm&#225;ticos de IL-18 se relacionan con la insulinemia y est&#225;n modulados por polimorfismos del gen de IL-18"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Martinez-Hervas"
                            1 => "V&#46; Mart&#237;nez-Barquero"
                            2 => "E&#46; Nu&#241;ez Savall"
                            3 => "V&#46; Lend&#237;nez"
                            4 => "L&#46; Olivares"
                            5 => "E&#46; Benito"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arteri.2015.04.004"
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                        "tituloSerie" => "Clin Investig Arterioscler&#46;"
                        "fecha" => "2015"
                        "volumen" => "27"
                        "paginaInicial" => "265"
                        "paginaFinal" => "271"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26205090"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mannheim intima-media thickness consensus"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;-J&#46; Touboul"
                            1 => "M&#46;G&#46; Hennerici"
                            2 => "S&#46; Meairs"
                            3 => "H&#46; Adams"
                            4 => "P&#46; Amarenco"
                            5 => "M&#46; Desvarieux"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000081812"
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                        "tituloSerie" => "Cerebrovasc Dis"
                        "fecha" => "2004"
                        "volumen" => "18"
                        "paginaInicial" => "346"
                        "paginaFinal" => "349"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15523176"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "SEA 2022 Standards for Global Control of Cardiovascular Risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Mostaza"
                            1 => "X&#46; Pint&#243;"
                            2 => "P&#46; Armario"
                            3 => "L&#46; Masana"
                            4 => "J&#46;T&#46; Real"
                            5 => "P&#46; Valdivielso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arteri.2021.11.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Investig Arterioscler"
                        "fecha" => "2022"
                        "volumen" => "34"
                        "paginaInicial" => "130"
                        "paginaFinal" => "179"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35090775"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "SNPStats&#58; a web tool for the analysis of association studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "X&#46; Sol&#233;"
                            1 => "E&#46; Guin&#243;"
                            2 => "J&#46; Valls"
                            3 => "R&#46; Iniesta"
                            4 => "V&#46; Moreno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/bioinformatics/btl268"
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                        "tituloSerie" => "Bioinformatics"
                        "fecha" => "2006"
                        "volumen" => "22"
                        "paginaInicial" => "1928"
                        "paginaFinal" => "1929"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16720584"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-18"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;A&#46; Gracie"
                            1 => "S&#46;E&#46; Robertson"
                            2 => "IB&#46; McInnes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "J Leukoc Biol"
                        "fecha" => "2003"
                        "volumen" => "73"
                        "paginaInicial" => "213"
                        "paginaFinal" => "224"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12554798"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Impact of Cytokines in Coronary Atherosclerotic Plaque&#58; Current Therapeutic Approaches"
                      "autores" => array:1 [
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                          "etal" => false
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                            1 => "P&#46; Theofilis"
                            2 => "K&#46; Tsioufis"
                            3 => "D&#46; Tousoulis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:3 [
                        "tituloSerie" => "Int J Mol Sci"
                        "fecha" => "2022"
                        "volumen" => "23"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "No association between interleukin-18 levels and risk of cardiovascular disease&#58; A Mendelian randomization study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Fan"
                            1 => "P&#46; He"
                            2 => "J&#46; Guan"
                            3 => "W&#46; Song"
                            4 => "H&#46; Zhi"
                            5 => "L&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s41065-020-00121-5"
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                        "tituloSerie" => "Hereditas"
                        "fecha" => "2020"
                        "volumen" => "157"
                        "paginaInicial" => "12"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32264954"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Role of Interleukin-18 in the Development and Progression of Atherosclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Bahrami"
                            1 => "T&#46; Sathyapalan"
                            2 => "A&#46; Sahebkar"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Med Chem"
                        "fecha" => "2021"
                        "volumen" => "28"
                        "paginaInicial" => "1757"
                        "paginaFinal" => "1774"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32338205"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Blankenberg"
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                            2 => "C&#46; Bickel"
                            3 => "D&#46; Peetz"
                            4 => "F&#46; Cambien"
                            5 => "J&#46; Meyer"
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                        ]
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                    ]
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                    0 => array:2 [
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                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "volumen" => "106"
                        "paginaInicial" => "24"
                        "paginaFinal" => "30"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12093765"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0120"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Elhage"
                            1 => "J&#46; Jawien"
                            2 => "M&#46; Rudling"
                            3 => "H&#46;-G&#46; Ljunggren"
                            4 => "K&#46; Takeda"
                            5 => "S&#46; Akira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0008-6363(03)00343-2"
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                        "tituloSerie" => "Cardiovasc Res"
                        "fecha" => "2003"
                        "volumen" => "59"
                        "paginaInicial" => "234"
                        "paginaFinal" => "240"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12829194"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Z&#46; Mallat"
                            1 => "A&#46; Corbaz"
                            2 => "A&#46; Scoazec"
                            3 => "S&#46; Besnard"
                            4 => "G&#46; Les&#232;che"
                            5 => "Y&#46; Chvatchko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/hc3901.096721"
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2001"
                        "volumen" => "104"
                        "paginaInicial" => "1598"
                        "paginaFinal" => "1603"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11581135"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-18&#47;interleukin-18 binding protein signaling modulates atherosclerotic lesion development and stability"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "A&#46; Corbaz"
                            2 => "A&#46; Scoazec"
                            3 => "P&#46; Graber"
                            4 => "S&#46; Alouani"
                            5 => "B&#46; Esposito"
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                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1161/hh1901.098735"
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                        "tituloSerie" => "Circ Res"
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                        "volumen" => "89"
                        "paginaInicial" => "E41"
                        "paginaFinal" => "E45"
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                          0 => array:2 [
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              ]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Tiret"
                            1 => "T&#46; Godefroy"
                            2 => "E&#46; Lubos"
                            3 => "V&#46; Nicaud"
                            4 => "D&#46;-A&#46; Tregouet"
                            5 => "S&#46; Barbaux"
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                      ]
                    ]
                  ]
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                    0 => array:2 [
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                        "tituloSerie" => "Circulation"
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                        "volumen" => "112"
                        "paginaInicial" => "643"
                        "paginaFinal" => "650"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16043644"
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                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of Risk Genes Associated with Myocardial Infarction-Big Data Analysis and Literature Review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "H&#46; Moldovan"
                            3 => "A&#46; Scafa-Udriste"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3390/ijms232315008"
                      "Revista" => array:3 [
                        "tituloSerie" => "Int J Mol Sci"
                        "fecha" => "2022"
                        "volumen" => "23"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The structure and binding mode of interleukin-18"
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                          "autores" => array:6 [
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                            4 => "I&#46; Ohki"
                            5 => "H&#46; Ohnishi"
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                    ]
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                    0 => array:2 [
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                        "tituloSerie" => "Nat Struct Biol"
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                        "volumen" => "10"
                        "paginaInicial" => "966"
                        "paginaFinal" => "971"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14528293"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "IL-1 and IL-18 receptors&#44; and their extended family"
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                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;E&#46; Sims"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0952-7915(01)00306-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Immunol"
                        "fecha" => "2002"
                        "volumen" => "14"
                        "paginaInicial" => "117"
                        "paginaFinal" => "122"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11790541"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
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