Valores de calcio y de los marcadores bioquímicos de remodelamiento óseo en el momento del parto | Clínica e Investigación en Ginecología y Obstetricia

Article information

Resumen

Introducción

Durante el parto se producen dos situaciones que pueden afectar al metabolismo fosfocálcico como son las contracciones uterinas y el desprendimiento placentario. Ambos hechos suponen alteraciones que pueden modificar los valores de los marcadores de remodelamiento óseo.

PacientesyméTODO

Se determinan los niveles de calcio,fósforo,albúmina,parathormona,fosfatasa alcalina total y osteocalcina séricas,y de piridinolinas y su ratio con la creatinina en la orina,en 38 embarazadas normales en el momento del parto.

Resultados

El calcio total presenta valores significativamente inferiores a los observados durante el embarazo (p < 0,01),mientras que la albúmina,la fosfatasa alcalina,la parathormona y la osteocalcina no presentan diferencias significativas. Las piridinolinas urinarias presentan,de forma aislada,unos valores elevados,aunque se normalizan si se analizan en relación con la creatinina.

Discusión

Las modificaciones de los marcadores de remodelamiento óseo durante el parto son producto más del propio proceso del parto que de cambios del metabolismo fosfocálcico.

Summary

Introduction

During delivery two situations are produced which can affect phosphocalcic metabolism, uterine contractions and placentary detachment. Both acts cause alterations, which can modify levels of bone remodelling markers.

Patients and methods

During delivery 38 women with normal pregnancies had their levels of calcium, phosphorous, albumin and parathormone (PTH) measured, also total alkaline phosphatase, serum osteocalcine, and pyridolines and their ratio with urinary creatinine.

Results

Total calcium levels were significantly inferior to those observed during pregnancy (p < 001), whilst albumin, alkaline phosphatase, PTH, and os-teocalcine did not have significant differences. The urinary pyridolines, exceptionally, had elevated values although these normalized if they were analysed in relation to creatinine.

Discussion

The modifications of bone remodelling markers during delivery are produced more by the process of delivery than by changes in phosphocalcium metabolism.

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http://dx.doi.org/10.3168/jds.S0022-0302(76)84160-4 | Medline