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Anesthesia for interventional neuroradiology
Anestesia en neuroradiología intervencionista
Chanhung Z. Lee
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clee4@anesthesia.ucsf.edu
Corresponding author at: 1001 Potrero Avenue, Building 10, Room 1206, San Francisco, CA 94110, United States.
Corresponding author at: 1001 Potrero Avenue, Building 10, Room 1206, San Francisco, CA 94110, United States.
Associate Professor of Anesthesiology, Department of Anesthesia and Perioperative Care, University of California, San Francisco, United States
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"apellidos" => "Lee" "email" => array:1 [ 0 => "clee4@anesthesia.ucsf.edu" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Associate Professor of Anesthesiology, Department of Anesthesia and Perioperative Care, University of California, San Francisco, United States" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "<span class="elsevierStyleItalic">Corresponding author at</span>: 1001 Potrero Avenue, Building 10, Room 1206, San Francisco, CA 94110, United States." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Anestesia en neuroradiología intervencionista" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The aim of this article is to present the author's critical review of the literature and interpretation of the roles of the Anesthesiologist in the management of patients undergoing invasive endovascular procedures to treat vascular diseases, primarily of the central nervous system, emphasizing perioperative and anesthetic management strategies to prevent complications and minimize their effects if they occur. This endovascular practice is usually termed Interventional Neuroradiology (INR) or endovascular neurosurgery. There are several particular anesthetic concerns for INR procedures, including: (1) maintaining immobility during the procedure to facilitate imaging; (2) rapid recovery from anesthesia to facilitate neurological examination and monitoring, or to provide for intermittent evaluation of neurological function during the procedure; (3) managing anticoagulation; (4) managing sudden unexpected procedure-specific complications during the intervention, i.e., hemorrhage or vascular occlusion, which may involve manipulating systemic blood pressures; (5) guiding the medical management of critical care patients during transport to and from the radiology suites; (6) self-protection issues related to radiation safety.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Pre-operative planning and patient preparation</span><p id="par0010" class="elsevierStylePara elsevierViewall">Baseline blood pressure and cardiovascular reserve should be assessed carefully because blood pressure manipulation is commonly required and treatment-related perturbations should be anticipated. A clear sense of the patient's baseline blood pressure range needs to be established. The concordance between blood pressure cuff and intra-arterial readings needs to be considered while decision is usually based on the individual cases. For procedures involving the blood supply to the CNS, beat-to-beat blood pressure monitoring is prudent. Pre-operative blood pressure range is likely to be known through blood pressure cuff values.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Secure intravenous (i.v.) access—with secure connections—should be established with adequate extension tubing to allow drug and fluid administration at maximal distance from the image intensifier during fluoroscopy. Infusions of primary anesthetics or vasoactive agents should be through proximal ports with minimal dead space.</p><p id="par0020" class="elsevierStylePara elsevierViewall">A pulse oximeter probe can be placed on the great toe of the leg that will receive the femoral introducer sheath, and may provide an early warning of femoral artery obstruction or distal thromboembolism, if there is concern about ischemia in high risk patients. Bladder catheters assist in fluid management as well as patient comfort, given that a significant volume of heparinized flush solution and radiographic contrast may be used.</p><p id="par0025" class="elsevierStylePara elsevierViewall">A fundamental knowledge of radiation safety is essential for working in an INR suite. Assume that the X-ray machine is always on. Exposure decreases proportionally to the inverse of the square of the distance from the source of radiation (inverse square law). Digital subtraction angiography (DSA) delivers considerably more radiation than fluoroscopy.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Optimal protection includes use of lead aprons, thyroid shields and radiation exposure badges. A recent study also highlighted the importance of eye-protection for anesthesiologists working significant time in the INR suite.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Movable lead glass screens may provide additional protection. With proper precautions, the anesthesia team should be exposed to far less than the annual recommended limit for health care workers.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Anesthetic technique</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Choice of anesthetic technique</span><p id="par0035" class="elsevierStylePara elsevierViewall">Most centers routinely use general endotracheal anesthesia for complex procedures or those of long duration. There is no clear superior method within well-described considerations for operative neuroanesthesia.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Specific anesthesia management concerns for common NIR procedures are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">General anesthesia</span><p id="par0040" class="elsevierStylePara elsevierViewall">General anesthesia minimizes motion artifacts which improves image quality. Intermittent apnea may be requested by the interventional team to even further reduce motion artifact during DSA. The specific choice of anesthesia may be guided primarily by other cardiac- and cerebrovascular considerations. Total intravenous anesthetic techniques, or a combination of low inspired concentrations of inhalational with intravenous agents may optimize rapid emergence.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Relative normocapnia or slight hypocapnia consistent with the safe conduct of positive pressure ventilation should be maintained unless intracranial pressure is a concern. If a patient has increased intracranial pressure, mild hypocapnia may be indicated prior to apnea during induction and to overcome any vapor-induced vasodilation during maintenance.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Intravenous sedation</span><p id="par0050" class="elsevierStylePara elsevierViewall">One major benefit of intravenous sedation is to allow continual assessment of neurological functions during the procedure. A variety of sedation regimens are available, and specific choices are based on the experience of the practitioner and the goals of anesthetic management. Common to all intravenous sedation techniques is the potential for upper airway obstruction. Placement of nasopharyngeal airways may cause troublesome bleeding in anticoagulated patients and is generally avoided. Dexmedetomidine should be used with care because of the tendency to cause relatively low blood pressure.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">12</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">For intravenous sedation cases, careful padding of pressure points and comfortable positioning may decrease the requirement for sedation, anxiolysis and analgesia. Evaluation of the potential ease of laryngoscopy in an emergent situation should take into account access to the airway when imaging is underway.</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Anticoagulation</span><p id="par0060" class="elsevierStylePara elsevierViewall">Careful management of coagulation prevents thromboembolic complications during and after the procedure. Generally, after a baseline activated clotting time (ACT) is obtained, intravenous heparin (70<span class="elsevierStyleHsp" style=""></span>units/kg) is given to a target prolongation of 2–3 times of baseline upon the request from the interventionists, especially if therapeutic procedures are planned. Then heparin often can either be given continuously or as an intermittent bolus with hourly monitoring of ACT as in typical therapeutic regimens.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Heparin-induced thrombocytopenia (HIT) is a rare but important adverse event for heparin anticoagulation. Development of heparin dependent antibodies after initial exposure leads to a prothrombotic syndrome. In high-risk patients, direct thrombin inhibitors can be applied and their effect can be monitored by either aPTT or ACT. Lepirudin and bivalirudin, synthetic derivatives, have half-lives of 40–120<span class="elsevierStyleHsp" style=""></span>min and about 25<span class="elsevierStyleHsp" style=""></span>min, respectively. Because these drugs undergo renal elimination, dose adjustments may be needed in patients with renal dysfunction. Argatroban is an alternative agent that undergoes primarily hepatic metabolism.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Antiplatelet agents (aspirin, the glycoprotein IIb/IIIa receptor antagonists and the thienopyridine derivatives) are increasingly being used for cerebrovascular disease management. Abciximab (Rheopro) has been used to treat thromboembolic complications. Abciximab, eptifibatide and tirofiban are glycoprotein IIb/IIIa receptor antagonists. The long duration and potent effect of Abciximab also increase the likelihood of major bleeding. The smaller molecule agents, eptifibatide and tirofiban, are competitive blockers and have a shorter half-life of about 2<span class="elsevierStyleHsp" style=""></span>h. Thienopyridine derivatives (ticlopidine and clopidogrel) bind to the platelet's ADP receptors and permanently alter the receptor; therefore, the duration of action is the life span of the platelet. The addition of clopidogrel to the antiplatelet regimen is commonly used for procedures that require placement of devices, such as stents, coiling or stent-assisted coiling, primarily in patients that have not had an acute event, such as unruptured aneurysms.</p><p id="par0075" class="elsevierStylePara elsevierViewall">At the end of the procedure or at occurrence of hemorrhagic complication, heparin may be reversed with protamine. Since there is no specific antidote for the direct thrombin inhibitors or the antiplatelet agents, the biological half-life is one of the major considerations in drug choice, and platelet transfusion is a non-specific therapy, should reversal be indicated. There is no currently available accurate test to measure platelet function in patients taking the newer antiplatelet drugs. Desmopressin (DDAVP) has been reported to shorten the prolonged bleeding time of individuals taking antiplatelet agents such as aspirin and ticlopidine. Specific clotting factors, including recombinant factor VIIa and factor IX complex, may be used to rescue severe life-threatening bleeding, including intracranial hemorrhage uncontrolled by standard transfusion therapy. The safety and efficacy of these coagulation factors remain to be investigated.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Deliberate hypertension</span><p id="par0080" class="elsevierStylePara elsevierViewall">During acute arterial occlusion or vasospasm, a practical way to increase collateral blood flow may be an augmentation of the collateral perfusion pressure by raising the systemic blood pressure. The Circle of Willis is a primary collateral pathway but may be incomplete in as many as more than 20% of otherwise normal subjects. There are also secondary collateral channels that bridge adjacent major vascular territories, most importantly for the long circumferential arteries that supply the hemispheric convexities. These pathways are known as the pial-to-pial collateral or leptomeningeal pathways.</p><p id="par0085" class="elsevierStylePara elsevierViewall">The extent to which the blood pressure has to be raised depends on the condition of the patient and the nature of the disease. Typically, during deliberate hypertension the systemic blood pressure is raised by 30–40% above the baseline in the absence of some direct outcome measure, such as resolution of ischemic symptoms or imaging evidence of improved perfusion. Phenylephrine is usually the first line agent for deliberate hypertension and is titrated to achieve the desired level of blood pressure. The EKG and ST segment monitor should be carefully inspected for signs of myocardial ischemia. Other pressors may be appropriate with excessive reflex bradycardia or baseline chronotropic medication or conduction delays. The effects of catecholamines on the cerebral circulation are not predictable, but in general, all of them are acceptable to achieve the target of adequate systemic pressure in the context of brain injury.</p><p id="par0090" class="elsevierStylePara elsevierViewall">The risk of causing hemorrhage into an ischemic area or rupturing an aneurysm must be weighed against the benefits of improving perfusion, but augmentation of blood pressure in the face of acute cerebral ischemia to promote collateral blood supply is probably protective in most settings. Clear communication with the interventional team is certainly crucial to determine the appropriate blood pressure goal and to monitor the effects of manipulation of cerebral perfusion.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Deliberate hypotension</span><p id="par0095" class="elsevierStylePara elsevierViewall">The two primary indications for induced hypotension are: (1) to test cerebrovascular reserve in patients undergoing carotid occlusion; and (2) to slow flow in a feeding artery of brain arterio-venous malformations before glue injection (sometimes termed “flow arrest”).<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">14</span></a> The most important factor in choosing a hypotensive agent is the ability to safely and expeditiously achieve the desired reduction in blood pressure while maintaining the patient physiologically stable, and if awake, not interfere with neurological assessment. It is important to realize that the population average lower limit of autoregulation is closer to 70<span class="elsevierStyleHsp" style=""></span>mmHg than the 50<span class="elsevierStyleHsp" style=""></span>mmHg frequently shown in text books.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">15</span></a> This may have important implications for use of deliberate hypotension, since ensuring adequate cerebral perfusion is critical for patient safety, especially if general anesthesia is used.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Management of neurological and procedural crises</span><p id="par0100" class="elsevierStylePara elsevierViewall">A well thought-out plan, coupled with rapid and effective communication between the anesthesia and radiology teams, is critical for good outcomes. The primary responsibility of the anesthesia team is to preserve gas exchange and, if needed, secure the airway and support systemic circulation. The anesthesiologist should communicate with the INR team and determine whether the problem is hemorrhagic or occlusive.</p><p id="par0105" class="elsevierStylePara elsevierViewall">In the setting of vascular occlusion, the goal is to increase distal perfusion by blood pressure augmentation with or without direct thrombolysis. If the problem is hemorrhagic, immediate cessation of heparin and reversal with protamine is indicated, after discussion with the interventional team. As an emergency reversal dose, 1<span class="elsevierStyleHsp" style=""></span>mg protamine can be given for each 100<span class="elsevierStyleHsp" style=""></span>units of initial heparin dosage that resulted in therapeutic anticoagulation. The ACT can then be used to fine-tune the final protamine dose. Complications of protamine administration include hypotension, true anaphylaxis and pulmonary hypertension. In the anesthetized or comatose patient, the sudden onset of bradycardia and hypertension (Cushing response) or the endovascular therapist's diagnosis of extravasation of contrast may be the only clues to a developing hemorrhage. Most cases of vascular rupture can be managed in the angiography suite. The INR team can attempt to seal the rupture site endovascularly and abort the procedure; a ventriculostomy catheter may be placed emergently in the angiography suite. Patients with suspected rupture will require emergent CT scan, but emergent craniotomy is usually not indicated.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Post-operative management</span><p id="par0110" class="elsevierStylePara elsevierViewall">Endovascular surgery patients pass the immediate post-operative period in a monitored setting such as a high dependency unit or intensive care unit to watch for signs of hemodynamic instability or neurologic deterioration. Control of blood pressure may be necessary during transport and post-operative recovery, e.g., induced hypertension, if indicated. In particular, patients undergoing treatment of extracranial carotid disease are prone to postprocedural hemodynamic instability, similar to post carotid endartectomy patients.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">16</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Abrupt restoration of normal systemic pressure to a chronically hypotensive (ischemic) vascular bed may overwhelm autoregulatory capacity and result in hemorrhage or swelling (normal perfusion pressure breakthrough, NPPB). The mechanism is unclear, but it is probably not simply a hemodynamic effect. Nonetheless, cerebral hyperemia is probably exacerbated by uncontrolled increases in systemic arterial blood pressure. In the absence of collateral perfusion pressure inadequacy, fastidious attention to preventing hypertension is warranted.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">17</span></a></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflicts of interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Funding</span><p id="par0125" class="elsevierStylePara elsevierViewall">None</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:15 [ 0 => array:3 [ "identificador" => "xres474609" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec496803" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres474608" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec496802" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Pre-operative planning and patient preparation" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Anesthetic technique" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Choice of anesthetic technique" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "General anesthesia" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Intravenous sedation" ] ] ] 7 => array:2 [ "identificador" => "sec0035" "titulo" => "Anticoagulation" ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Deliberate hypertension" ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Deliberate hypotension" ] 10 => array:2 [ "identificador" => "sec0050" "titulo" => "Management of neurological and procedural crises" ] 11 => array:2 [ "identificador" => "sec0055" "titulo" => "Post-operative management" ] 12 => array:2 [ "identificador" => "sec0060" "titulo" => "Conflicts of interest" ] 13 => array:2 [ "identificador" => "sec0065" "titulo" => "Funding" ] 14 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-11-05" "fechaAceptado" => "2014-11-06" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec496803" "palabras" => array:5 [ 0 => "Neurosurgical procedures" 1 => "Hemodynamics" 2 => "Anesthesia" 3 => "Endovascular procedures" 4 => "Central nervous system vascular malformations" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec496802" "palabras" => array:5 [ 0 => "Procedimientos Neuroquirúrgicos" 1 => "Hemodinámica" 2 => "Anestesia" 3 => "Procedimientos Endovasculares" 4 => "Malformaciones Vasculares del Sistema Nervioso Centra" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Interventional Neuroradiology</span> (INR) is firmly established in the management of cerebrovascular diseases. The aim of this manuscript is to present the author's critical review of the literature and interpretation emphasizing perioperative and anesthetic management strategies to prevent complications and minimize their effects if they occur. Planning the anesthetic and perioperative management is predicated on understanding the goals of the therapeutic intervention and anticipating potential problems.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La <span class="elsevierStyleItalic">Neuroradiología Intervencionista</span> (NRI) está firmemente establecida en el manejo de la patología cerebrovascular. El objetivo del presente manuscrito es presentar una revisión crítica de la literatura e interpretación por parte del autor, enfatizando las estrategias perioperatorias y anestésicas para prevenir complicaciones y minimizar sus efectos en caso de que estas se presenten. La planeación de la gestión anestésica y perioperatoria se fundamenta en comprender las metas de la intervención terapéutica y anticiparse a los problemas potenciales.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as: Lee CZ. Anestesia en neuroradiología intervencionista. Rev Colomb Anestesiol. 2015;43:151–155.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "Source: Author" "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Procedure \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Possible anesthetic considerations \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Therapeutic embolization of vascular malformation</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Intracranial AVMs \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Deliberate hypotension, post-procedure NPPB \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dural AVM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Existence of venous hypertension; deliberate hypercapnia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Extracranial AVMs \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Deliberate hypercapnia \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Carotid cavernous fistula (CCF) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Deliberate hypercapnia, post-procedure NPPB \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cerebral aneurysms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Aneurysmal rupture, blood pressure control<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Ethanol sclerotherapy of arteriovenous or venous malformations</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Brain swelling, airway swelling, hypoxemia, hypoglycemia, intoxication from ethanol, cardiorespiratory arrest \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Balloon angioplasty & stenting of occlusive cerebrovascular disease</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cerebral ischemia, deliberate hypertension, concomitant coronary artery disease, bradycadia, hypotension, NPPB \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Balloon angioplasty or pharmacological treatment of cerebral vasospasm secondary to aneurysmal SAH</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cerebral ischemia, blood pressure control<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Therapeutic carotid occlusion for giant aneurysms and skull base tumors</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cerebral ischemia, blood pressure control<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Thrombolysis of acute thromboembolic stroke</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Post-procedure ICH (NPPB), concomitant coronary artery disease, blood pressure control<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab745822.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Blood pressure control refers to deliberate hypo- or hypertension.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Interventional neuroradiologic procedures and primary anesthetic considerations.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">5–11</span></a></p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anesthetic considerations for interventional neuroradiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "W.L. Young" 1 => "J. Pile-Spellman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "1994" "volumen" => "80" "paginaInicial" => "427" "paginaFinal" => "456" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8311325" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Invasive neuroradiologic procedures for cerebrovascular abnormalities: anesthetic considerations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W.L. Young" 1 => "J. Pile-Spellman" 2 => "L. Hacein-Bey" 3 => "S. Joshi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Anesthesiol Clin North Am" "fecha" => "1997" "volumen" => "15" "paginaInicial" => "631" "paginaFinal" => "653" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiation exposure of the anesthesiologist in the neurointerventional suite" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Z.H. Anastasian" 1 => "D. Strozyk" 2 => "P.M. Meyers" 3 => "S. Wang" 4 => "M.F. Berman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ALN.0b013e31820c2b81" "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "2011" "volumen" => "114" "paginaInicial" => "512" "paginaFinal" => "520" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21285864" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anesthesia and sedation practices among neurointerventionalists during acute ischemic stroke endovascular therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.L. McDonagh" 1 => "D.M. Olson" 2 => "J.S. Kalia" 3 => "R. Gupta" 4 => "A. Abou-Chebl" 5 => "O.O. Zaidat" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3389/fneur.2010.00118" "Revista" => array:5 [ "tituloSerie" => "Front Neurol" "fecha" => "2010" "volumen" => "1" "paginaInicial" => "118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21188256" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0055" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraarterially administered verapamil as adjunct therapy for cerebral vasospasm: safety and 2-year experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "L. Feng" 1 => "B.F. Fitzsimmons" 2 => "W.L. Young" 3 => "M.F. Berman" 4 => "E. Lin" 5 => "B.D. Aagaard" 6 => "H. Duong" 7 => "J. Pile-Spellman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AJNR Am J Neuroradiol" "fecha" => "2002" "volumen" => "23" "paginaInicial" => "1284" "paginaFinal" => "1290" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12223366" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0060" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain AVM embolization with Onyx" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.J. van Rooij" 1 => "M. Sluzewski" 2 => "G.N. Beute" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AJNR Am J Neuroradiol" "fecha" => "2007" "volumen" => "28" "paginaInicial" => "172" "paginaFinal" => "177" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17213451" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0065" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain aneurysms and arteriovenous malformations: advancements and emerging treatments in endovascular embolization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I. Linfante" 1 => "A.K. Wakhloo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Structure" "fecha" => "2007" "volumen" => "38" "paginaInicial" => "1411" "paginaFinal" => "1417" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0070" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracranial angioplasty & stenting for cerebral atherosclerosis: a position statement of the American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology, and the American Society of Neuroradiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "R.T. Higashida" 1 => "P.M. Meyers" 2 => "J.J. Connors" 3 => "D. Sacks" 4 => "C.M. Strother" 5 => "J.D. Barr" 6 => "J.C. Wojak" 7 => "G.R. Duckwiler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AJNR Am J Neuroradiol" "fecha" => "2005" "volumen" => "26" "paginaInicial" => "2323" "paginaFinal" => "2327" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16221663" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0075" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: A randomized controlled trial. Prolyse in acute cerebral thromboembolism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:12 [ 0 => "A. Furlan" 1 => "R. Higashida" 2 => "L. Wechsler" 3 => "M. Gent" 4 => "H. Rowley" 5 => "C. Kase" 6 => "M. Pessin" 7 => "A. Ahuja" 8 => "F. Callahan" 9 => "W.M. Clark" 10 => "F. Silver" 11 => "F. Rivera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1999" "volumen" => "282" "paginaInicial" => "2003" "paginaFinal" => "2011" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10591382" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0080" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physiologic monitoring and anesthesia considerations in acute ischemic stroke" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.Z. Lee" 1 => "L. Litt" 2 => "T. Hashimoto" 3 => "W.L. Young" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Vasc Interv Radiol" "fecha" => "2004" "volumen" => "15" "paginaInicial" => "S13" "paginaFinal" => "S19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15101512" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0085" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anesthetic management and outcome in patients during endovascular therapy for acute stroke" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "M.J. Davis" 1 => "B.K. Menon" 2 => "L.B. Baghirzada" 3 => "C.R. Campos-Herrera" 4 => "M. Goyal" 5 => "M.D. Hill" 6 => "D.P. Archer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ALN.0b013e318242a5d2" "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "2012" "volumen" => "116" "paginaInicial" => "396" "paginaFinal" => "405" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22222475" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0025" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.R. Arain" 1 => "T.J. Ebert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesth Analg" "fecha" => "2002" "volumen" => "95" "paginaInicial" => "461" "paginaFinal" => "466" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12145072" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0030" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Perioperative management of coagulation in non-traumatic intracerebral hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V. Degos" 1 => "E.M. Westbroek" 2 => "M.T. Lawton" 3 => "J.C. Hemphill" 4 => "G.J. del Zoppo" 5 => "W.L. Young" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ALN.0b013e318297c18a" "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "2013" "volumen" => "119" "paginaInicial" => "218" "paginaFinal" => "227" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23695175" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0035" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adenosine-induced ventricular asystole to induce transient profound systemic hypotension in patients undergoing endovascular therapy. Dose–response characteristics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T. Hashimoto" 1 => "W.L. Young" 2 => "B.D. Aagaard" 3 => "S. Joshi" 4 => "N.D. Ostapkovich" 5 => "J. Pile-Spellman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "2000" "volumen" => "93" "paginaInicial" => "998" "paginaFinal" => "1001" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11020753" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0040" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurosurgical anesthesia (chapter 63)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.C. Drummond" 1 => "P.M. 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Halbach" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "2000" "volumen" => "47" "paginaInicial" => "335" "paginaFinal" => "343" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10942006" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0050" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracranial hemorrhage and cerebral hyperperfusion syndrome after extracranial carotid artery angioplasty and stent placement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "C.C. Phatouros" 1 => "P.M. Meyers" 2 => "R.T. Higashida" 3 => "A.M. Malek" 4 => "T.E. Lempert" 5 => "C.F. Dowd" 6 => "V.V. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 20 | 4 | 24 |
| 2024 October | 52 | 20 | 72 |
| 2024 September | 79 | 13 | 92 |
| 2024 August | 67 | 27 | 94 |
| 2024 July | 59 | 25 | 84 |
| 2024 June | 59 | 14 | 73 |
| 2024 May | 32 | 12 | 44 |
| 2024 April | 48 | 18 | 66 |
| 2024 March | 76 | 14 | 90 |
| 2024 February | 55 | 20 | 75 |
| 2024 January | 70 | 15 | 85 |
| 2023 December | 66 | 16 | 82 |
| 2023 November | 58 | 14 | 72 |
| 2023 October | 53 | 14 | 67 |
| 2023 September | 47 | 8 | 55 |
| 2023 August | 57 | 14 | 71 |
| 2023 July | 53 | 15 | 68 |
| 2023 June | 41 | 8 | 49 |
| 2023 May | 68 | 9 | 77 |
| 2023 April | 58 | 8 | 66 |
| 2023 March | 40 | 6 | 46 |
| 2023 February | 27 | 16 | 43 |
| 2023 January | 35 | 3 | 38 |
| 2022 December | 36 | 4 | 40 |
| 2022 November | 56 | 13 | 69 |
| 2022 October | 36 | 14 | 50 |
| 2022 September | 40 | 8 | 48 |
| 2022 August | 56 | 14 | 70 |
| 2022 July | 43 | 12 | 55 |
| 2022 June | 43 | 9 | 52 |
| 2022 May | 23 | 6 | 29 |
| 2022 April | 30 | 10 | 40 |
| 2022 March | 31 | 12 | 43 |
| 2022 February | 36 | 9 | 45 |
| 2022 January | 66 | 15 | 81 |
| 2021 December | 43 | 17 | 60 |
| 2021 November | 18 | 9 | 27 |
| 2021 October | 17 | 17 | 34 |
| 2021 September | 17 | 12 | 29 |
| 2021 August | 28 | 15 | 43 |
| 2021 July | 23 | 13 | 36 |
| 2021 June | 20 | 17 | 37 |
| 2021 May | 34 | 16 | 50 |
| 2021 April | 121 | 22 | 143 |
| 2021 March | 37 | 7 | 44 |
| 2021 February | 18 | 7 | 25 |
| 2021 January | 9 | 9 | 18 |
| 2020 December | 19 | 11 | 30 |
| 2020 November | 9 | 7 | 16 |
| 2020 October | 8 | 5 | 13 |
| 2020 September | 12 | 9 | 21 |
| 2020 August | 7 | 9 | 16 |
| 2020 July | 8 | 5 | 13 |
| 2020 June | 5 | 3 | 8 |
| 2020 May | 5 | 5 | 10 |
| 2020 April | 6 | 5 | 11 |
| 2020 March | 4 | 1 | 5 |
| 2020 February | 5 | 3 | 8 |
| 2020 January | 6 | 4 | 10 |
| 2019 December | 11 | 6 | 17 |
| 2019 November | 5 | 1 | 6 |
| 2019 October | 5 | 4 | 9 |
| 2019 September | 3 | 0 | 3 |
| 2019 August | 2 | 0 | 2 |
| 2019 July | 1 | 6 | 7 |
| 2019 June | 2 | 2 | 4 |
| 2019 May | 0 | 12 | 12 |
| 2019 April | 1 | 0 | 1 |
| 2018 December | 0 | 3 | 3 |
| 2018 September | 1 | 0 | 1 |
| 2018 August | 0 | 2 | 2 |
| 2018 June | 2 | 4 | 6 |
| 2018 May | 45 | 14 | 59 |
| 2018 April | 41 | 9 | 50 |
| 2018 March | 21 | 9 | 30 |
| 2018 February | 20 | 10 | 30 |
| 2018 January | 44 | 9 | 53 |
| 2017 December | 28 | 8 | 36 |
| 2017 November | 20 | 6 | 26 |
| 2017 October | 27 | 11 | 38 |
| 2017 September | 38 | 10 | 48 |
| 2017 August | 48 | 17 | 65 |
| 2017 July | 36 | 13 | 49 |
| 2017 June | 53 | 35 | 88 |
| 2017 May | 50 | 11 | 61 |
| 2017 April | 60 | 16 | 76 |
| 2017 March | 34 | 37 | 71 |
| 2017 February | 22 | 8 | 30 |
| 2017 January | 15 | 15 | 30 |
| 2016 December | 45 | 10 | 55 |
| 2016 November | 34 | 11 | 45 |
| 2016 October | 26 | 15 | 41 |
| 2016 September | 33 | 10 | 43 |
| 2016 August | 49 | 23 | 72 |
| 2016 July | 20 | 12 | 32 |
| 2016 June | 0 | 7 | 7 |
| 2016 May | 4 | 0 | 4 |
| 2016 March | 2 | 0 | 2 |
| 2016 February | 6 | 0 | 6 |
| 2015 December | 20 | 15 | 35 |
| 2015 November | 37 | 16 | 53 |
| 2015 October | 69 | 23 | 92 |
| 2015 September | 31 | 9 | 40 |
| 2015 August | 35 | 10 | 45 |
| 2015 July | 28 | 14 | 42 |
| 2015 June | 28 | 10 | 38 |
| 2015 May | 42 | 13 | 55 |
| 2015 April | 34 | 16 | 50 |
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