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Scientific and Technological Research
Association between fibrinogen levels and the severity of postpartum haemorrhage
Asociacion entre el nivel de fibrinogeno y severidad en la hemorragia posparto
Victoria García Velásqueza,
Corresponding author
victoriagarcia1982@hotmail.com

Corresponding author at: Departamento de Medicina Crítica y Cuidado Intensivo, Clínica del Prado, Medellín, Colombia. Carrera 50A #64-42 Unidad de Cuidados Intensivos Clínica del Prado.
, Marco González Agudelob, Arturo Cardona Ospinac, Ricardo Ardila Castellanosd
a Specialist in Obstetrics and Gynaecology, Critical Care Medicine and Intensive Care; Specialist at Women's ICU, Clínica del Prado, Medellín, Colombia
b Specialist in Internal Medicine, Critical Care Medicine and Intensive Care, Master in Epidemiology; Coordinator at Women's ICU, Clínica del Prado, Medellín, Colombia
c Specialist in Obstetrics and Gynaecology, Fetal Medicine, Maternal-Fetal Unit Coordinator, Clínica del Prado, Medellín, Colombia
d Specialist in Internal Medicine, Pulmonology, Epidemiology; Fellow in Critical Care Medicine and Intensive Care, UNAB, Colombia
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Worldwide&#44; in developed as well as developing countries&#44; obstetric haemorrhage continues to be a significant cause or mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> Postpartum bleeding is the main cause&#44; and atony accounts for 70&#37; of cases and continues to be the main trigger of massive postpartum haemorrhage &#40;PPH&#41; and complications due to coagulopathy&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The evaluation of postpartum bleeding includes clinical&#44; haemodynamic and laboratory variables used to classify the severity<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">3</span></a> and assess patients that benefit from early massive transfusions<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a> and admission to the intensive care unit&#44; and women at risk of developing complications due to severe haemorrhagic shock&#46; The most important cause of maternal mortality due to postpartum haemorrhage secondary to uterine atony is the inadequate use of transfusion therapy and insufficient intravascular volume replacement&#44;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">5</span></a> as well as inadequate bleeding control in patients that appear clinically &#8220;stable&#8221;&#46; Consequently&#44; early identification of patients that may progress to organ dysfunction and increased risk to their lives is of critical importance&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Procoagulant activity increases two-fold towards the end of pregnancy and&#44; therefore&#44; when postpartum bleeding develops&#44; thrombin and partial thromboplastin times may appear normal&#44; masking patients that are evolving towards early coagulopathy&#46; When fibrinogen values drop to &#60;100<span class="elsevierStyleHsp" style=""></span>mg&#47;dL they are associated with the loss of 1&#46;4 blood volumes&#44; establishing a relationship between fibrinogen values and the severity of postpartum haemorrhage&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The objective of this study was to determine whether fibrinogen levels at the onset of postpartum bleeding are associated with the probability of maternal complications&#44; and to define cut-off points related with the outcome&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Materials and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">Secondary analysis of a cohort study<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a> with data collected prospectively in an obstetrical Intensive Care Unit in mothers presenting with a diagnosis of postpartum haemorrhage between February 1st&#44; 2012 and January 31st&#44; 2013&#46; Based on the records of that cohort of patients&#44; fibrinogen levels on admission were evaluated and outcomes were correlated with the presence or absence of complications secondary to the haemorrhage upon discharge from the unit&#46; Postpartum haemorrhage was defined as every blood loss greater than 1000<span class="elsevierStyleHsp" style=""></span>mL following vaginal delivery or caesarean section&#44; estimated by the attendant obstetrician at the time&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Bleeding severity was defined on the basis of the worst clinical parameter in the haemorrhagic shock classification &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; or an initial estimated blood loss of more than 2000<span class="elsevierStyleHsp" style=""></span>mL&#46; Mothers with associated diseases such as sepsis&#44; prior liver disease&#44; ketoacidosis and heart disease were excluded&#44; considering that the study was a secondary analysis of a study that assessed lactic acid as a prognostic marker in obstetric haemorrhage and the above disorders may elevate lactic acid levels&#46; Moreover&#44; these disorders are associated with altered coagulation parameters&#44; leading to altered fibrinogen levels not related to the severity of postpartum bleeding&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Fibrinogen levels were measured once&#44; at the onset of postpartum bleeding&#44; in accordance with the protocol used at the Unit for the management of these patients&#46; The initial value was then compared with the gold standard which&#44; in this case&#44; was clinical follow-up upon discharge&#44; and the presence or absence of complications&#44; defined as acute renal injury&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a> disseminated intravascular coagulation &#40;DIC&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">9</span></a> death&#44; reintervention for hysterectomy&#44; and adult respiratory distress syndrome &#40;ARDS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> The endpoint was the presence or absence of complications&#44; not the degree of bleeding severity&#44; which was classified according to the usual clinical standard previously described&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The ROC curve was performed in order to determine the diagnostic accuracy of fibrinogen levels in relation to the presence of complications upon patient discharge from the unit&#46; The area under the curve was estimated in order to assess the accuracy of fibrinogen levels in evaluating the probability of complications in postpartum haemorrhage&#44; and the cut-off point with the highest sensitivity and specificity was determined&#46; A value of <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 was defined as significant&#46; Version 17 of the SPSS package was used for the statistical analysis&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Considering that the information was collected from records and there was no intervention or modification of patient variables&#44; this study is considered as research with no risk&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a> The study followed the ethical principles that apply to human research&#44; stated in the Declaration of Helsinki by the World Medical Association&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> and data collection for the study was approved by the ethics and research committee of the institution&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">Data were collected for 79 patients with obstetric postpartum haemorrhage in the initial cohort&#44; with a mean age of 24&#46;6 years&#59; 19 patients &#40;24&#46;1&#37;&#41; developed severe PPH compared with 60 patients &#40;75&#46;9&#37;&#41; who presented with mild and moderate PPH&#46; All patient charts contained the initial fibrinogen value&#44; hence their inclusion in the analysis&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The demographic characteristics are described in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; No significant differences were found between age&#44; number of previous pregnancies or route of delivery in relation to bleeding severity &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">In terms of the causes of postpartum haemorrhage&#44; the majority &#40;62&#37;&#41; were due to uterine atony&#44; followed by cervical or vaginal tear&#44; 13&#46;9&#37;&#59; abruptio placenta&#44; uterine rupture&#44; placenta accreta and placental retention&#44; 5&#46;1&#37; each&#59; placenta praevia&#44; 2&#46;5&#37;&#59; and uterine inversion&#44; 1&#46;3&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; No relationship was found between the cause of the bleeding and its severity&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">The main comorbidity was pregnancy-associated hypertensive disorder&#44; found in 21 patients &#40;26&#46;6&#37;&#41;&#59; however&#44; no relationship was found with bleeding severity in patients with this comorbidity&#46; There were complications in 12 patients &#40;15&#46;2&#37;&#41;&#44; including 9 cases &#40;11&#46;4&#37;&#41; of acute renal injury &#40;all AKIN I&#41;&#44; 2 cases &#40;2&#46;5&#37;&#41; of disseminated intravascular coagulation&#44; and 1 death &#40;1&#46;3&#37;&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Resuscitation treatment was similar in all patients&#44; based on haemodynamic targets and perfusion parameters&#46; The use of blood products was based on the judgement of the physician in charge of the unit&#44; with a total of 30 patients &#40;38&#37;&#41; receiving transfusion&#46; Of them&#44; 4 were classified as mild &#40;12&#46;9&#37;&#41;&#44; 11 as moderate &#40;35&#46;5&#37;&#41; and 15 as severe &#40;88&#46;2&#37;&#41;&#46; Some patients required additional procedures besides pharmacological treatment to control the bleeding &#40;25&#46;4&#37;&#41;&#44; including Bakri balloon placement in 7 &#40;8&#46;9&#37;&#41;&#44; use of B-Lynch suture in 10 &#40;12&#46;7&#37;&#41; and hysterectomy in 3 &#40;3&#46;8&#37;&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Al patients with fibrinogen levels equal to or lower than 200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL presented with severe haemorrhage&#44; 12 of them with complications &#40;12&#47;19&#44; 63&#37;&#41;&#44; accounting for 100&#37; of all the patients who developed complications&#46; However&#44; 20&#46;5&#37; of patients with fibrinogen levels greater than 200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL were also classified as severe&#44; but none of them had complications secondary to bleeding&#46; The AUC-ROC for fibrinogen levels and their relationship to complications was 0&#46;71&#44; with a cut-off point &#8804;200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL for predicting complications &#40;PPV 100&#37;&#41; and a cut-off point &#8805;515<span class="elsevierStyleHsp" style=""></span>mg&#47;dL for predicting absence of complications following postpartum haemorrhage &#40;71&#37; sensitivity&#44; 65&#37; specificity&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">Procoagulant activity increases two-fold towards the end of pregnancy as a way to respond to the need of providing fast and effective haemostasis at the time of placental detachment in order to prevent exsanguination&#46; The main changes observed are increased plasma concentrations of fibrinogen&#44; Factor-VIII and Von Willebrand&#39;s factor&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">In cases of severe postpartum haemorrhage requiring massive amounts of infused intravascular volume&#44; dilutional coagulopathy is usually observed with prolonged PTT and PT&#44; and a drop in fibrinogen levels and platelet counts&#44; the majority being late changes&#46; Moreover&#44; there is additional consumption of coagulation factors for thrombus formation at vascular injury sites&#44; with plasma levels &#8211; fibrinogen included &#8211; dropping below the haemostatic threshold&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">In our study&#44; when initial fibrinogen values dropped below 200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL there was a correlation with the severity of the postpartum bleeding and the presence of complications&#44; as described by Cortet et al&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">15</span></a> These authors found fibrinogen levels to be an independent factor for postpartum haemorrhage severity&#44; with an OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;90 &#40;95&#37; CI&#58; 1&#46;16&#8211;3&#46;09&#41; for a fibrinogen value between 200 and 300<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; and a better correlation with fibrinogen levels under 200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#46;99&#59; 95&#37; CI&#58; 2&#46;56&#8211;56&#46;06&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Along the same lines&#44; Charbit et al&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">16</span></a> showed that a fibrinogen value &#60;200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL had a 100&#37; PPV for severe PPH&#46; We found that this cut-off point in obstetrics&#44; as well as in the studies mentioned above&#44; is similar to the recommended cut-off point in trauma resuscitation in non-pregnant women&#44; where the association with severity is found in patients with fibrinogen levels below 150&#8211;200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">17</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">The use of fibrinogen as a predictor of severe PPH is a reference tool in the identification and classification of severity in this group of patients&#44; given the difficulty for the intensive care physician that has not been present at the onset of postpartum bleeding and may often underestimate the severity of the blood loss&#46; This may result in suboptimal resuscitation&#44; considering that physiological variables undergo late changes in this age group&#44; in otherwise healthy patients with good cardiopulmonary reserve&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Additionally&#44; the finding of a fibrinogen level &#60;200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL at the onset of postpartum haemorrhage in a patient with hypovolemic shock secondary to severe PPH will facilitate adequate intravascular resuscitation therapy with other blood products besides red blood cells&#44; such as fresh frozen plasma&#44; cryoprecipitate or fibrinogen concentrate&#44; as recommended in current massive transfusion protocols&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">18&#8211;20</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">The study has some limitations&#44; including the subjective assessment of the initial blood loss by the attendant obstetrician&#46; This is a relevant fact in terms of the initial classification&#44; although it is a recurrent finding in the vast majority of studies in patients with massive bleeding&#44; obstetric or otherwise&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Despite the above&#44; this subjectivity is actually found in daily practice in delivery rooms and intensive care units&#46; In this sense&#44; our study reflects the reality of mothers in our units and underscores the importance of an objective measurement to guide the physician in determining the true severity of the haemorrhage&#44; as is the case with fibrinogen values at the onset of postpartum bleeding&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusion</span><p id="par0120" class="elsevierStylePara elsevierViewall">Fibrinogen levels measured at the onset of bleeding may be used to guide treatment and resuscitation in patients with postpartum haemorrhage&#46; A cut-off point of &#60;200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL must warn the practitioner about the high risk of severe haemorrhage and complications despite the finding of stable physiological parameters and vital constants&#44; and may be an indication for aggressive transfusion therapy with replacement of coagulation factors&#44; including fibrinogen&#46; In patients with fibrinogen values &#62;200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; clinical and physiological variables may continue to be used for severity classification&#44; together with other paraclinical tissue perfusion parameters to help distinguish&#44; early on&#44; patients who will develop complications from those that will not&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Funding</span><p id="par0125" class="elsevierStylePara elsevierViewall">The authors did not receive sponsorship to undertake this article&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Ethical disclosures</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Protection of human and animal subjects</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Confidentiality of data</span><p id="par0140" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Right to privacy and informed consent</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflict of interest</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors report no conflict of interest&#46;</p></span></span>"
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            0 => "Postpartum hemorrhage"
            1 => "Fibrin fibrinogen degradation products"
            2 => "Blood transfusion"
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            4 => "Maternal mortality"
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            0 => "Hemorragia postparto"
            1 => "Productos de degradaci&#243;n de la fibrina-fibrin&#243;geno"
            2 => "Transfusi&#243;n sangu&#237;nea"
            3 => "Coagulaci&#243;n sangu&#237;nea"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine if the level of fibrinogen at the onset of postpartum haemorrhage is associated with bleeding severity and a higher number of complications&#59; to determine outcome-related cut-off points&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Secondary analysis of a cohort study conducted with 79 mothers admitted to the Intensive Care Unit between February 1st&#44; 2012 and January 31st&#44; 2013&#44; with a diagnosis of postpartum haemorrhage&#44; defined as all cases of blood loss greater than 1000<span class="elsevierStyleHsp" style=""></span>mL&#46; Fibrinogen levels were measured at the onset of the postpartum haemorrhage&#46; Fibrinogen values were compared between patients with severe obstetric bleeding and those with mild-to-moderate bleeding&#44; in order to establish the correlation with severity of blood loss and complications&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Overall&#44; 24&#46;1&#37; of the patients showed severe postpartum haemorrhage compared to 75&#46;9&#37; of the patients classified as having mild-to-moderate haemorrhage&#46; There were 12 complications &#40;15&#46;2&#37;&#41;&#44; including 9 cases of acute renal injury&#44; 2 cases of disseminated intravascular coagulation&#44; and one death&#44; all of them only in patients with severe obstetric haemorrhage&#46; Regarding the initial fibrinogen value&#44; the AUC-ROC for fibrinogen levels and their relationship with the severity was 0&#46;71&#44; with a cut-off point of &#60;200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL to predict severity &#40;100&#37; positive predictive value&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The initial fibrinogen level in obstetric postpartum haemorrhage is a predictor of severity that helps in alerting to the need for treatment in these patients&#46;</p></span>"
        "secciones" => array:4 [
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            "titulo" => "Materials and methods"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">determinar si el nivel de fibrin&#243;geno al inicio de la hemorragia posparto se asocia con la severidad del sangrado y mayor n&#250;mero de complicaciones&#59; adem&#225;s definir los puntos de corte que se relacionan con el desenlace&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materiales y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">an&#225;lisis secundario de un estudio de cohortes realizado en 79 madres que ingresaron con diagn&#243;stico de hemorragia posparto&#44; definido como todo sangrado mayor de 1000<span class="elsevierStyleHsp" style=""></span>mL&#44; a la Unidad de Cuidados Intensivos entre el 1 de febrero de 2012 al 31 de enero de 2013&#46; Los niveles de fibrin&#243;geno se realizaron al inicio de la hemorragia posparto&#46; Se compar&#243; el valor de fibrin&#243;geno entre las pacientes que presentaron hemorragia obst&#233;trica severa contra las hemorragias obst&#233;tricas leve-moderada&#44; y de esta forma se correlaciona el valor del fibrin&#243;geno con la severidad de la hemorragia y las complicaciones presentadas en las pacientes&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">el 24&#44;1&#37; de las pacientes presentaron hemorragia posparto severa y se compar&#243; contra el 75&#44;9&#37; de las pacientes clasificadas como leve y moderada&#46; Se presentaron 12 complicaciones &#40;15&#44;2&#37;&#41;&#44; 9 fueron injuria renal aguda&#44; 2 coagulaci&#243;n intravascular diseminada y muerte en 1 paciente&#44; s&#243;lo en las pacientes con hemorragia obst&#233;trica severa&#46; En cuanto al nivel inicial de fibrin&#243;geno&#44; el AUC-ROC para el valor de fibrin&#243;geno y su relaci&#243;n con severidad fue de 0&#44;71 con un punto de corte<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>200<span class="elsevierStyleHsp" style=""></span>mg&#47;dL para predecir severidad &#40;valor predictivo positivo 100&#37;&#41;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">el nivel de fibrin&#243;geno inicial en hemorragia obst&#233;trica posparto es un predictor de severidad que ayuda a alertar el tratamiento en estas pacientes&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Garc&#237;a-Vel&#225;squez V&#44; Gonz&#225;lez-Agudelo M&#44; Cardona-Ospina A&#44; Ardila-Castellanos R&#46; Asociacion entre el nivel de fibrinogeno y severidad en la hemorragia posparto&#46; Rev Colomb Anestesiol&#46; 2015&#59;43&#58;136&#8211;141&#46;</p>"
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        0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "WHO analysis of cases of maternal death&#58; a systematic review"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46;S&#46; Khan"
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                            2 => "L&#46; Say"
                            3 => "A&#46;M&#46; Gulmezoglu"
                            4 => "P&#46;F&#46; Van Look"
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                      "doi" => "10.1016/S0140-6736(06)68397-9"
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                    0 => array:2 [
                      "titulo" => "Postpartum hemorrhage&#58; when uterotonics and sutures fail"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;H&#46; James"
                            1 => "C&#46; McLintock"
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                      "doi" => "10.1002/ajh.23156"
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                    0 => array:2 [
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                      "titulo" => "Postpartum hemorrhage treated with a massive transfusion protocol at a tertiary obstetric center&#58; a retrospective study"
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                      "titulo" => "Severe postpartum hemorrhage from uterine atony&#58; a multicentric study"
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                            4 => "M&#46;C&#46; Bustillo"
                            5 => "F&#46; Marin"
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos