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Case report
Case report: Subdural anesthesia in the obstetric patient
Informe de caso: Anestesia subdural en la paciente obstétrica
Carlos Andrés Palacio-Garcíaa,
Corresponding author
cpalacio65@gmail.com

Corresponding author at: Departamento de Anestesiología, Universidad del Valle, Edificio 112, Hospital Universitario del Valle, Piso 4. Campus San Fernando. Calle 5, No. 36-08, Cali, Colombia.
, Juan Manuel Gómez-Menéndezb
a MD, 3rd Year Resident of Anesthesiology, Universidad del Valle, Cali, Colombia
b MD, Anesthetist Centro Médico IMBANACO, Professor Universidad del Valle, Cali, Colombia
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This case illustrates an unusual presentation&#44; the risk factors involved&#44; and the preventive actions that could be adopted&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The subdural space has been classically described as a virtual space occupied by serous fluid contained between the dura mater and the arachnoid&#46; Consistent with this anatomical denomination it could be similar to other serous cavities such as the pericardium or the pleurae&#59; this means two layers in contact with a serous structure that promotes friction in the absence of any intercellular bonds&#46; However&#44; recent studies in dead human bodies and using electron microscopy show that this space does not actually exist and if present is the result of pathologic or iatrogenic factors&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">7&#8211;10</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Histologically speaking&#44; the &#8220;subdural space&#8221; is made up by a neuroepithelium of elongated&#44; spindle-shaped and branched cells with lax intercellular bonds surrounded by few collagen fibers and some blood vessels resulting in low mechanical resistance<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">11&#44;12</span></a> &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; The subdural space is localized between the most inner segment of the dura mater &#8211; a very tough tissue composed of 80 layers of web-shaped collagen fibers that that run in multiple directions and the arachnoid mater composed of several cellular planes connected by desmosome-type specialized narrow intercellular bonds that make it the primary barrier against the passage of substances&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a> The subdural neuroepithelium is concentrically oriented around the dural sac and&#44; in contrast to the epidural space&#44; it is not limited by the foramen magnum&#46; This is the most frail tissue inside the meninges that may sustain injuries and result in a pathological space whose size and shape are determined by the strength of the generating force and represents is a critical factor for the direction and distribution of any substances administered in that area&#46; In the case of local anesthetic agents this accounts for the huge variability of clinical presentations&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2&#44;5&#44;6</span></a> Finally the clinical presentation of the anesthetic block is determined by the meningeal structures permeated&#46; If the dura mater is not permeated&#44; the characteristics will mimic an epidural anesthesia but if the dura mater is disrupted while the arachnoid is preserved&#44; the clinical presentation will resemble a subdural anesthesia&#46; Lastly&#44; if the arachnoid is disrupted and the anesthetic agent deposits in the subarachnoid cavity &#40;intrathecal&#41;&#44; the anesthesia will be spinal or subarachnoid&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">13&#44;14</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Case report</span><p id="par0020" class="elsevierStylePara elsevierViewall">22-year old patient&#44; 39 weeks in her first pregnancy&#44; 80<span class="elsevierStyleHsp" style=""></span>kg of body weight&#44; previously healthy&#44; scheduled for cesarean section due to a breech presentation&#44; negative history&#44; vital signs&#58; Blood pressure&#58; 110&#47;70&#44; heart rate&#58; 80&#47;Min&#44; respiratory rate&#58; 18&#47;Min&#44; body temperature&#58; 37&#176;C&#44; arterial oxygen saturation&#58; 99&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The decision was made to administer epidural anesthesia after obtaining the patient&#39;s informed consent and using non-invasive monitoring&#44; following a strict aseptic technique&#44; a single attempt L3&#8211;L4 Tuohy &#35; 18 needle puncture was performed&#46; The epidural space was identified using the loss of resistance to air technique&#44; leaving in place a 3<span class="elsevierStyleHsp" style=""></span>cm catheter&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A test dose with 3<span class="elsevierStyleHsp" style=""></span>cc of lidocaine 2&#37;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>100<span class="elsevierStyleHsp" style=""></span>mcg fentanyl was administered with no signs of intrathecal or intravenous injection&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">7<span class="elsevierStyleHsp" style=""></span>cc of lidocaine 2&#37; and 10<span class="elsevierStyleHsp" style=""></span>cc of bupivacaine 0&#46;5&#37; were added to complete the volume of anesthetic&#46; A T6 sensory level was achieved and the surgery began uneventfully&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">A male baby was born 12<span class="elsevierStyleHsp" style=""></span>min later with an Apgar score of 9&#8211;10&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">20<span class="elsevierStyleHsp" style=""></span>min into the procedure the patient developed upper limb paresthesia and respiratory distress&#44; became anxious and the monitor then indicated the following vital signs&#58; BP 90&#47;60 HR 54<span class="elsevierStyleHsp" style=""></span>min<span class="elsevierStyleSup">&#8211;1</span> SaO<span class="elsevierStyleInf">2</span> 94&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Sensory block was evidenced with level C5 upper extremities involvement&#44; with no motor block&#46; The patient was managed with a bolus of lactated Ringer&#39;s solution and increased FiO<span class="elsevierStyleInf">2</span> and there were no major complications afterwards&#46; The procedure was then completed with no further deterioration of the patient&#46; No additional doses of anesthetic were required via the epidural catheter&#44; which was then removed at the completion of surgery&#46; The sensory block lasted for 6<span class="elsevierStyleHsp" style=""></span>h&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Discussion</span><p id="par0055" class="elsevierStylePara elsevierViewall">Different scenarios may evolve in terms of the mechanisms leading to subdural anesthesia&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0060" class="elsevierStylePara elsevierViewall">The spinal or epidural needle may perforate the dura mater and the arachnoid with the orifice located between the two spaces&#46; In this context we must keep in mind the pressure difference since pressure is below the atmospheric pressure in the subdural tissue but positive in the CSF&#44; giving rise to positive aspiration of CSF&#46; However&#44; the anesthetic injection will take the path of less resistance&#44; i&#46;e&#46; the subdural space which is the mechanism accounting for failed subarachnoid anesthesia&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a></p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0065" class="elsevierStylePara elsevierViewall">The spinal or epidural needle may perforate the dura with no involvement of the arachnoid&#46; In this case&#44; the CSF aspiration will be negative&#44; while the loss of resistance in air or water will be positive and a catheter may be easily placed inside this tissue&#46; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; This is the mechanism accounting for the occurrence of subdural anesthesia&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">8</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></li></ul></p><p id="par0070" class="elsevierStylePara elsevierViewall">There are some other less common mechanisms such as the multi-orifice catheters with a subdural placement of the distal end while the proximal orifices that may be placed in the epidural space&#46; This results in a normal presentation with low rate infusions allowing for perfusion through the proximal ends&#59; however&#44; a bolus administration will lead to a clinical presentation of subdural anesthesia&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">15</span></a> Catheter migration is yet another mechanism&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">8&#44;15</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Other subdural anesthesia-associated factors have been identified with the common denominator of physically damaging the dura mater&#59; these are&#58;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Post lumbar puncture&#44; prior subdural injection&#44; rotation of the epidural needle&#44; a history of spine surgery&#44; and repeated attempts at the same site&#59; however&#44; there is no relationship with the level of experience&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;6&#44;8</span></a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The clinical presentation is quite variable&#44; ranging from a normal presentation of epidural anesthesia&#44; unilateral blocks&#44; patchy blocks or involving some dermatomes&#44; or a very high sensory block in contrast with a minimal or non-existent motor block&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1&#44;2&#44;14&#44;16</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Such heterogeneity results from the above-mentioned characteristics&#46; The prevalence of a sensory over a motor block is due to the fact that the space is created and the access is posterior allowing selectivity of the for dorsal roots&#44; in addition to the fact that the dura mater and the arachnoid tend to be fused on the anterior root&#44; limiting the diffusion at this level&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">11&#44;12</span></a> Furthermore&#44; based on the volume and pressure used&#44; extensive&#44; patchy or unilateral may be expected&#44; depending on the dissection plane that the injected fluid follows into the &#8220;subdural space&#8221;&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">11&#44;12</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">An accurate diagnosis is made by injecting 6<span class="elsevierStyleHsp" style=""></span>cc of contrast medium and obtaining AP and lateral X-rays&#44; or with the use of fluoroscopy or CT&#44; delivering a characteristic subdural distribution pattern<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1&#44;4</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>A&#8211;C&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Several signs or symptoms are suspicious of a subdural placement of the catheter or the needle&#59; i&#46;e&#46;&#44; the absence or evident loss of resistance&#59; frontal headache or pain following the application&#46; Any of these symptoms call for a radiological confirmation of the position or changing space as a last resort&#46; When neither of the above recommendations is feasible&#44; quit the technique&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">In terms of the test dose typically used&#44; such dose is of little use for identifying subdural anesthesia&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">8&#44;9&#44;17&#44;18</span></a> However&#44; the use of the neurostimulator has been considered useful because a response below 1<span class="elsevierStyleHsp" style=""></span>mA when the localization is in the subdural space gives a diffuse response with the involvement of multiple dermatomes&#44; while if the localization is in the epidural space with stimuli between 1 and 10<span class="elsevierStyleHsp" style=""></span>mA&#44; the responses obtained will correspond to the dermatome where the needle is placed&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">16&#44;19</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Hoftman and Ferrante<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> recently developed some diagnostic criteria for subdural anesthesia without imaging&#44; using as major criteria for the epidural technique the negative outflow of CSF associated to tactile sensation due to loss of resistance and they suggest two scenarios&#58; excessive or restricted block&#46; In each case&#44; the following minor criteria are considered&#44; though one is enough to make a diagnosis&#58;</p><p id="par0115" class="elsevierStylePara elsevierViewall">For excessive block &#40;93&#37; sensitivity&#41; the criteria are&#58; starts after more than 20<span class="elsevierStyleHsp" style=""></span>min&#44; cardiovascular stability&#44; sensory involvement with minimum or absent motor activity&#44; patchy or asymmetrical distribution&#44; respiratory failure and head or face anesthesia&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In the case of restricted block &#40;sensitivity 100&#37;&#41;&#44; the criteria include a start after more than 20<span class="elsevierStyleHsp" style=""></span>min and sensory involvement with minimum or absent motor effect&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">In terms of the subarachnoid technique&#44; Hoftman and Ferrante<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a> say that in the presence of tactile sensation of a subarachnoid puncture and CSF leak as major criterion&#44; one of the following conditions is enough to make the diagnosis&#58; excessive &#40;no cases reported&#41;&#44; restricted &#40;sensitivity 100&#37;&#41;&#44; start beyond 20<span class="elsevierStyleHsp" style=""></span>min&#44; sensitive involvement with minimal or absent motor effect and failed block&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">No deaths have been reported due to subdural block&#46; Management is based on support therapy&#44; atropine for bradycardia control&#44; crystalloids or colloids boluses for hypotension&#44; trendelemburg position&#44; and vasopressors if needed&#46; Ventilation support may be required and although some subdural catheters may behave normally&#44; the recommendation is to remove them due to their unpredictable nature&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">5</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Although the patient did not report any symptoms such as headache or pain upon advancing the catheter&#44; nor was the loss of resistance during the identification of the epidural space reported as &#8220;vague&#8221;&#44; all of these signs and symptoms are too subtle&#46; Additionally&#44; saline solution instead of air shall be used for the identification of the epidural space&#44; since according to a recent meta-analysis the former has been associated with less post-puncture headaches and fewer attempts&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">20</span></a> It should be noted that the number of attempts and post-puncture headaches are associated with meningeal lesions&#44; a critical event in subdural anesthesia&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">11&#44;12</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conclusion</span><p id="par0140" class="elsevierStylePara elsevierViewall">Notwithstanding the fact that the diagnosis of subdural block is confirmed radiologically using the above-mentioned criteria&#44; there is evidence of good diagnostic sensitivity based on clinical criteria&#46; In our case&#44; according to Hoffman&#39;s criteria&#44; the sensitivity was 93&#37;&#46; There were no incidents alerting us about a subdural localization during the catheter insertion&#46; However&#44; we should be attentive to these signs and symptoms and in case of doubt proceed with a radiological verification&#44; use the neurostimulator&#44; and when neither of these options is available&#44; change the intervertebral space or the anesthetic&#47;analgesic technique&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Ethical disclosures</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Protection of human and animal subjects</span><p id="par0170" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Confidentiality of data</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Right to privacy and informed consent</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors did not receive sponsorship to carry out this article&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflict of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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            0 => "Subdural space"
            1 => "Anesthesia&#44; epidural"
            2 => "Cesarean section"
            3 => "Autonomic nerve block"
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            0 => "Espacio subdural"
            1 => "Anestesia epidural"
            2 => "Ces&#225;rea"
            3 => "Bloqueo nervioso aut&#243;nomo"
            4 => "Factores de riesgo"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Subdural anesthesia is a relatively frequent complication though seldom recognized&#46; It has a broad spectrum of presentations ranging from an unexpectedly high sensory block with limited motor block&#44; to substantial hemodynamic and respiratory involvement&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Case presentation</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A 22-year old woman undergoing cesarean section under epidural anesthesia with evidence of long-lasting higher than expected sensory block and respiratory distress&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conclusion</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Neuraxial anesthesia comprises a number of versatile and safe techniques&#44; though not exempt from complications including subdural anesthesia&#46; We should be aware of this possibility in our clinical practice&#44; know the risk factors and the diagnostic criteria&#46;</p></span>"
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        "resumen" => "<span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introducci&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La anestesia subdural es una complicaci&#243;n de la anestesia neuroaxial relativamente frecuente pero poco reconocida&#44; tiene un espectro de presentaci&#243;n bastante amplio que va desde un bloqueo sensitivo inesperadamente alto con poco bloqueo motor&#44; hasta compromiso hemodin&#225;mico y respiratorio importante&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Presentaci&#243;n del caso</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Mujer de 22 a&#241;os que es llevada a ces&#225;rea con anestesia epidural&#44; con evidencia de bloqueo sensitivo m&#225;s alto de lo esperado&#44; de larga duraci&#243;n y dificultad respiratoria&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusi&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La anestesia neuroaxial es un conjunto de t&#233;cnicas vers&#225;tiles y seguras&#44; aunque no exentas de complicaciones como lo es la anestesia subdural&#46; En la pr&#225;ctica cl&#237;nica debemos estar atentos a esta posibilidad&#44; conocer los factores de riesgo y los criterios diagn&#243;sticos&#46;</p></span>"
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Article information
ISSN: 22562087
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos