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Scientific and Technological Research
Predictors of mortality and early detection strategies for hepatopulmonary syndrome in liver transplant patients
Factores predictores de mortalidad y estrategias de detección precoz de sindrome hepatopulmonar en pacientes trasplantados hepáticos
Margarita Orozco-Delgadoa,
Corresponding author
margaorozco@hotmail.com

Corresponding author at: Calle vicente raga 3, esc 2, 3-B 46023 Valencia, Spain.
, Martha López-Canterob, Vanessa Zampellaa, Rosario Vicentec,d, Juan Galáne
a MD, Resident of Anesthesiology and Resuscitation, Hospital Universitari i politecnic La Fe, Valencia, Spain
b MD, Assistant Physician of Anesthesiology and Resuscitation, Hospital la Fe, Valencia, Spain
c Head of the Anesthesiology and Resuscitation Department, Hospital Universitari i politecnic La Fe, Valencia, Spain
d Coordinator of Resuscitation, Critical Care and Organ Transplants, Associate Professor, Universidad de Valencia, Valencia, Spain
e Sectorial Transplant Coordinator, Head of the Transplant Coordination Service, Hospital Universitari i politecnic La Fe, Valencia, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The first publication evidencing the association between liver and pulmonary disorders was in 1884 by Fluckieger&#59; however&#44; it was not until 1977 that Kennedy and Knudson coined the term hepatopulmonary syndrome &#40;HPS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a> It was initially thought that this was a reversible condition and hence LT was contraindicated&#46; The observation that HPS could be resolved after LT and that this was the only effective treatment to revert the condition was only made early in the 90s&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">HPS is a low prevalence condition but with high morbidity and morality that may severely compromise the functional status of patients with advanced liver disease and&#47;or portal hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a> HPS results from impaired liver clearance of various vascular mediators leading to an imbalance between vasodilators and vasoconstrictors that causes abnormal intrapulmonary vasodilation and intrapulmonary shunt&#46; The resulting disruption in arterial oxygenation not always improves with supplemental O<span class="elsevierStyleInf">2</span>&#44; with a clinical presentation of platypnea &#40;dyspnea induced by upright posture&#41; and orthodeoxia &#40;&#62;5&#37; desaturation or &#62;4<span class="elsevierStyleHsp" style=""></span>mmHg PaO<span class="elsevierStyleInf">2</span> drop when moving from decubitus to an upright posture&#41;&#46; These PaO<span class="elsevierStyleInf">2</span> alterations are mainly the result of a ventilation&#47;perfusion imbalance&#44; with pulmonary shunt in addition to an impaired oxygen diffusion capacity due to the increased capillary diameter and reduced transit time of the erythrocytes through the capillaries as a consequence of the elevated cardiac output characteristic of HPS&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The echocardiographic finding of an extracardiac and intrapulmonary shunt confirms the diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">4</span></a> To differentiate whether the shunt is intra or extra cardiac the observation of whether the passage of microbubbles following an intravenous injection o cold stirred serum from both right and left cavities is early &#40;&#60;3 cardiac cycles&#41;&#44; which will indicate intracardiac shunting&#44; or late &#40;&#62;3 cardiac cycles&#41; which will be diagnostic for intrapulmonary shunting&#46; The diagnostic criteria for HPS are&#58; &#8220;Partial oxygen pressure<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>mmHg or oxygen alveolar&#8211;arterial gradient<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>mmHg while breathing room air&#44; positive findings in the contrast&#44; portal hypertension &#40;more common&#41; with or without cirrhosis&#46; With an alveolar&#8211;arterial oxygen gradient<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>mmHg the severity grade depends on the partial oxygen pressure&#44; where mild severity is PO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>mmHg&#44; moderate severity is PO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>60 to &#60;<span class="elsevierStyleHsp" style=""></span>80<span class="elsevierStyleHsp" style=""></span>mmHg&#44; severe is PO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>50 to &#60;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>mmHg and extremly severe is PO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>50<span class="elsevierStyleHsp" style=""></span>mmHg&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Up until now&#44; the only effective treatment is liver transplantation in properly selected cases and when the procedure is indicated at a particular time moment of the pulmonary disease&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">We have completed an observational descriptive trial with retrospective data collection from patients who received a LT between April 2006 and August 2014&#46; From a total of 815 transplants performed during that period&#44; there were 8 patients &#40;1&#37;&#41; diagnosed with HPS&#44; 7 of which were males &#40;87&#46;5&#37;&#41; and 1 &#40;12&#46;5&#37;&#41; was a female&#46; The age range was 32&#8211;60 years at the time of the LT&#46; All patients had been diagnosed with HPS through pulmonary scan or echocardiography&#46; Additionally&#44; the patients presented with altered oxygenation in the arterial gases&#46; The trial was approved by the institutional ethics committee under code 2016&#47;0125&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The clinical data collected included age&#44; gender&#44; MELD and Child&#8211;Pugh&#44; etiology of the liver pathology&#44; last gasometry immediately before transplantation&#44; preoperative home oxygen requirements&#44; postoperative mechanical ventilation &#40;MV&#41; time&#44; length of stay in resuscitation and causes of death&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">For the qualitative variable distribution&#44; the absolute frequencies of each category were used and Fisher&#39;s test was administered&#46; The dependent variable was survival and the independent variables were&#58; pre-LT home O<span class="elsevierStyleInf">2</span> requirements&#44; signs of reperfusion syndrome during LT&#44; post-extubation non-invasive mechanical ventilation &#40;NIMV&#41; requirements&#44; and whether the patient has a long postoperative resuscitation unit stay with 48<span class="elsevierStyleHsp" style=""></span>h being the estimated normal length of stay&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The statistical analysis of quantitative variables used the mean and standard deviation of living and death patients &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 1</a>&#41;&#46; Likewise&#44; a multivariable study<span class="elsevierStyleHsp" style=""></span>&#8211;<span class="elsevierStyleHsp" style=""></span>stepwise forward logistic regression analysis<span class="elsevierStyleHsp" style=""></span>&#8211;<span class="elsevierStyleHsp" style=""></span>was performed to determine which variable could significantly predict the risk of death&#46; The statistical significance value was set at 0&#46;05&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">The baseline characteristics of the 8 patients transplanted with HPS during the trial period are presented in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 2</a> and refer to the typology and the severity of the liver disease&#44; as well as the data used to evaluate the pre and post-operative pulmonary status&#46; The etiology of liver failure was defined as&#58; enolic cirrhosis&#44; hepatitis C virus &#40;HCV&#41;&#44; cryptogenic cirrhosis&#44; and 1 case of HPS due to non-cirrhotic portal hypertension of presinusoidal prehepatic origin&#46; The Child&#8211;Pugh status distribution of the sample was 1 patient in Stage A&#44; 3 in stage B&#44; and the other 4 in stage C&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">All of them had variable levels of altered oxygenation according to the arterial gases&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">According to our statistical analysis&#44; the fatality outcome could only have been significantly predicted based on PaO<span class="elsevierStyleInf">2</span> &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;&#46; The other variables were not significant predictors of the risk of death&#58; age &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;798&#41;&#44; PCO<span class="elsevierStyleInf">2</span> &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;672&#41;&#44; Child&#8211;Pugh &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;496&#41;&#44; MELD &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;560&#41;&#44; and MV time &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;284&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The average pre-LT PaO<span class="elsevierStyleInf">2</span> of the patients that died was 51&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;49 SD&#44; and the average of patients that survived was 70&#46;54<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;86 SD&#44; with a statistically significant difference &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Of the total number of patients studied&#44; 3 &#40;37&#46;5&#37;&#41; died during the postop&#44; between days 3 and 33&#46; The causes of death were&#58; 2 patients died from sepsis and the third one due to multiple organ failure in the context of global respiratory failure&#46; It should be highlighted that the most frequent cause of mortality is the same as in non HPS transplanted patients&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The patients that survived had a follow-up period ranging from 5 to 979 days until the trial was closed &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Similarly&#44; there was a attempt to establish possibility for the studied variables to predict reversibility of the HPS&#44; considering total reversibility as improvement in hypoxemia &#40;PaO<span class="elsevierStyleInf">2</span>&#41; and partial reversibility as a reduction in the home O<span class="elsevierStyleInf">2</span> requirements&#46; Keeping in mind the same test and the same variables&#44; none of them was statistically significant &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#59; of the 5 patients that were alive&#44; 3 had total HPS reversal&#44; 2 at hospital discharge and 1 6 months after the LT&#46; 2 patients presented a partial HPS reversal with reduced home O<span class="elsevierStyleInf">2</span> requirements versus the pre-transplantation requirements&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">The LT due to HPS represent 1&#37; of the liver transplants performed in our center during the period described&#44; with an approximate post-LT survival of 62&#46;5&#37;&#44; as compared to the series in other transplant centers that report a variable prevalence of 4&#8211;30&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a> This reflects on the one hand a potential over-diagnosis of the institution in certain series&#44; and on the other an underestimation in our own series&#46; The reason is the difficulty to identify the condition until advanced stages of the disease when dyspnea is already present and the overall condition of the patients&#44; particularly the respiratory status&#44; could have excluded them from being candidates for transplantation&#46; It seems that during the study period some cases where LT could have been the first line treatment would have been excluded in our center because they were missed&#46; This leads us to reflect on the need to do routine pulmonary screening beyond the functional respiratory tests &#40;FRT&#41; that are normal in many patients with HPS&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Liver transplantation controls HPS by correcting the intrapulmonary shunt and improving arterial circulation&#46; Consequently&#44; LT should be a priority in this patients in the light of the significant survival in properly selected cases that are identified at a stage in which the LT is still feasible&#44; with a postoperative morbidity similar to non-HPS LTs&#44; with the sale level of pre-LT liver disease&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">10</span></a> According to the current information&#44; the worsening of hypoxemia is progressive and refractory to medical treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">11</span></a> Several trials have shown a mortality increase in patients with HPS-associated cirrhosis and consequently&#44; LT is suggested as the only effective treatment for this rare but lethal condition&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">12</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Neither the etiology nor the severity of the liver disease affects the development of the syndrome&#46; This contributes to the hypothesis of a genetic predisposition as the cause of HPS in patients with liver disease&#46; However&#44; a significant association with portal hypertension has been identified&#44; as is the case in Budd&#8211;Chiari syndrome or in liver fibrosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">13&#44;14</span></a> Consequently&#44; maybe the way to approach a HPS screening program could be in patients diagnosed with portal hypertension with cirrhosis and&#47;or syndromes associated with the occurrence of cirrhosis&#44; despite a normal liver function&#44; but that additionally present with non-specific respiratory problems such as dyspnea&#44; that could represent a warning sign for some level of clinical suspicion&#46; In this setting&#44; the accuracy and usefulness of pulse oximetry becomes relevant&#46; Numerous studies have shown that an O<span class="elsevierStyleInf">2</span> peripheral saturation &#40;SpO<span class="elsevierStyleInf">2</span>&#41; equal to or less than 94&#37; identifies any subject with a PaO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>mmHg&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">15</span></a> This cost-effectiveness analyses conclude that it is a simple and low-cost technique&#44; in addition to being non-invasive&#44; precise&#44; reliable and applicable at the time of the hepatology visit for regular follow-up&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a> It should be noted however&#44; that after the initial screening&#44; the dyspnea and&#47;or hypoxia of the patients identified could be the result of cardiac causes of usual pulmonary diseases that coexist in up to one third of liver disease patients&#44;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">17</span></a> more specific tests such as contrast echocardiography&#44; pulmonary angiography&#44; and comprehensive pulmonary function tests shall be indicated&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">The fact that pre-LT PaO<span class="elsevierStyleInf">2</span> is suggested as a significant post-LT predictor of mortality&#44; and is considered to be the primary tool for decision-making regarding the timeliness for LT&#44; it becomes necessary to establish a range of PO<span class="elsevierStyleInf">2</span> for which LT should be prioritized to optimize the success of therapy&#46; Other groups with large series of LTs with HPS set PO<span class="elsevierStyleInf">2</span> levels between 50&#8211;60<span class="elsevierStyleHsp" style=""></span>mmHg as the appropriate range for LT indication&#46; In general&#44; patients with PaO<span class="elsevierStyleInf">2</span> values under 50<span class="elsevierStyleHsp" style=""></span>mmHg are excluded from the procedure and a PO<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>30<span class="elsevierStyleHsp" style=""></span>mmHg is considered by some groups as contraindicated for the procedure&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">18</span></a> However&#44; here are some cases with successful post LT outcomes with a higher survival than non-transplanted cases within the same gasometry range with pre-LT PaO<span class="elsevierStyleInf">2</span> below 50<span class="elsevierStyleHsp" style=""></span>mmHg&#46; This means that some cases of HPS with severe hypoxemia shall be comprehensively evaluated and the liver transplant shall be indicated regardless of the severity of hypoxemia&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">19</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">The finding that PO<span class="elsevierStyleInf">2</span> is the only predictor of mortality may be explained on the basis the pulmonary shunt present if HPS individuals&#44; due to the disrupted oxygen diffusion capacity as a consequence of capillary vasodilation&#44; in addition to a shortened erythrocyte transit time through the capillaries and an elevated cardiac output&#46; This alteration tends to be relatively permanent if not corrected promptly&#46; Therefore&#44; patients with a not excessively low PO<span class="elsevierStyleInf">2</span> are excellent candidates for priority liver transplant&#59; on the contrary&#44; patients with low PO<span class="elsevierStyleInf">2</span> have a poor prognosis and poor ventilator response&#44; even before transplantation&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The rest of our study variables do not significantly predict the risk of death or reversibility&#44; meaning that they cannot be related since probably these results are limited by the size of the sample&#46; It will be necessary to work on larger samples to assess those variables&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Moreover&#44; keep in mind that in terms of the level of liver disease&#44; MELD is not prognostic in liver cancer-associated HPS patients&#44; neither in metabolic diseases&#44; portal hypertension syndromes&#44; and any other clinical condition not directly associated to the extent of cirrhosis&#46; In this cases&#44; the prioritization for LT indication shall be done based on progression of the disease and patients should be closely monitored for a level of hypoxemia that may question the indication of liver transplantation on account of the high postoperative morbidity and mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">20</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">It should be highlighted however that in terms of the patients that died during the immediate postoperative period&#44; the primary cause of death was unrelated to respiratory failure but rather is mostly associated with primary graft dysfunction&#44; biliary complications&#44; perioperative bleeding&#44; sepsis&#44; and other usual morbimortality causes in non-HPS LT&#44; as demonstrated by the Toronto group paper in 2010&#44; involving a large series of cases in two transplantation centers for 6 years&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">21</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">All patients that survived the LT had improved arterial oxygenation&#44; although the systematic literature reviews of large series of cases show more variable results in terms of the reversibility of post LT hypoxemia&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">22</span></a> Notwithstanding the fact there was some level of persistent hypoxemia in 2 patients&#44; the condition improved gradually in the course of further control visits&#44; with reduced home O<span class="elsevierStyleInf">2</span> requirements &#40;partial HPS reversibility&#41;&#46; This ratifies the significance of liver dysfunction in the HPS pathogenesis&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">In conclusion&#44; according to our series&#44; despite the low prevalence of HPS among the patients who are candidates for LT&#44; a considerable morbimortality exists with the current medical treatment modalities&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">23</span></a> PO<span class="elsevierStyleInf">2</span> has been identified as a statistically significant predictor of postoperative mortality and must be taken into consideration when prioritizing patients in the waiting list for LT&#46; PO<span class="elsevierStyleInf">2</span> should be the key tool for screening programs to identify concomitant and potentially reversible lung disease&#46; Although the other variables studied fail to significantly predict the risk of death or reversibility&#44; additional studies with larger samples are needed&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of interest</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Funding</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors did not receive sponsorship to carry out this article&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Hepatopulmonary syndrome &#40;HPS&#41; is a serious&#44; progressive disease&#46; Its pathophysiology resides in a hypoxic intrapulmonary shunt and severe clinical deterioration&#46; Liver transplantation &#40;LT&#41; is the only effective treatment in appropriately selected patients&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To acknowledge the importance of early diagnosis of HPS&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Patients and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Observational&#44; descriptive&#44; retrospective trial including 8 patients with HPS that received LT between April 2006 and August 2014&#46; The clinical data prior to transplantation and follow-up after the procedure were reviewed&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A multivariate analysis &#40;stepwise forward logistic regression analysis&#41; was used to identify the variable that could potentially increase the risk of death&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Of the 8 patients&#44; death could only be significantly predicted based on the pre-LT arterial blood partial oxygen pressure &#40;PaO<span class="elsevierStyleInf">2</span>&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The average pre-LT PaO<span class="elsevierStyleInf">2</span> of the patients that died was 51&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;49 SD&#44; with a statistically significant difference &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#41;&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">None of the variables was statistically significant for HPS reversibility&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The survival rate of patients diagnosed with HPS following the LT was 62&#46;5&#37;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The level of pre-LT hypoxemia is an important predictor for immediate postoperative mortality&#46; Early detection of the condition is critical to reduce the post LT morbidity and mortality so that the indication for transplant is made at the right time&#44; regardless of the stage of liver disease&#46; The most efficient clinical strategy could be the use of appropriate early detection protocols for HPS through screening of hypoxemia in patients with portal hypertension&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
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          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Patients and methods"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
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          4 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusions"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introducci&#243;n</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome hepatopulmonar &#40;SHP&#41; es una enfermedad grave y progresiva cuya fisiopatolog&#237;a reside en un shunt intrapulmonar con hipoxia y deterioro cl&#237;nico severo&#46; Como &#250;nico tratamiento efectivo se ha postulado el trasplante hep&#225;tico &#40;TH&#41;&#44; en pacientes adecuadamente seleccionados&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Reconocer la importancia del diagnostico temprano del SHP&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Pacientes y m&#233;todos</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Mediante un estudio observacional&#44; descriptivo&#44; con car&#225;cter retrospectivo de 8 pacientes con SHP&#44; a los que se les realiz&#243; TH en el per&#237;odo entre Abril 2006-Agosto 2014&#46; Se han revisado los datos cl&#237;nicos previos al trasplante y el seguimiento tras este&#46;</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Se emple&#243; un estudio multivariante &#40;stepwise forward logistic regression analisis&#41;&#44; para determinar cual variable podr&#237;a incrementar el riesgo de muerte&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">De los 8 pacientes&#44; el resultado de muerte s&#243;lo pudo ser predicho significativamente por el factor presi&#243;n parcial de ox&#237;geno en sangre arterial &#40;PaO2&#41; pre-TH &#40;p&#61;0&#44;002&#41;&#46;</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">La PaO2 pre-TH promedio de los pacientes que fallecieron era de 51&#44;5 &#43;&#47;- 2&#44;49 DS&#44; siendo la diferencia estad&#237;sticamente significativa &#40;p&#61;0&#44;002&#41;&#46;</p><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Ninguna variable result&#243; estad&#237;sticamente significativa para reversibilidad del SHP&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">La supervivencia de los pacientes con criterio de SHP posterior al TH fue de 62&#44;5&#37;&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">El grado de hipoxemia pre-TH es un factor predictor importante de mortalidad en el postoperatorio inmediato&#46; La precocidad en la detecci&#243;n de la entidad es fundamental tanto para disminuir la morbimortalidad post TH como para indicar &#233;ste en el momento &#243;ptimo independientemente del estad&#237;o de la enfermedad hep&#225;tica&#46; Protocolos adecuados de detecci&#243;n precoz del SHP mediante screening de hipoxemias en pacientes con hipertensi&#243;n portal&#44; puede ser la estrategia cl&#237;nica m&#225;s eficiente&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Introducci&#243;n"
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          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Objetivo"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Pacientes y m&#233;todos"
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          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Conclusiones"
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        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Orozco-Delgado M&#44; L&#243;pez-Cantero M&#44; Zampella V&#44; Vicente R&#44; Gal&#225;n J&#46; Factores predictores de mortalidad y estrategias de detecci&#243;n precoz de sindrome hepatopulmonar en pacientes trasplantados hep&#225;ticos&#46; Rev Colomb Anestesiol&#46; 2016&#59;44&#58;311&#8211;316&#46;</p>"
      ]
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          "en" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">Survival curve&#46; None of the qualitative variables studied was associated with death &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p> <p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Source&#58; authors&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Living&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PO<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;86 SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;49 SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PCO<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;91 SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;69 SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;672&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">AGE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;55 SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;18 SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;798&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Child&#8211;Pugh&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;65 SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;67<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;58 SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;496&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MELD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;18 SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#46;33<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;53 SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;560&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TIME VM&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">165<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>272&#46;22 SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;284&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">Demographic and clinical characteristics and hepatic functional status&#46;</p>"
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          "leyenda" => "<p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">NIMV&#44; non-invasive mechanical ventilation&#59; MV&#44; mechanical ventilation&#59; LT&#44; liver transplant&#59; Res&#44; resuscitation&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Etiology of liver disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HCV<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Enolic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HCV<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Enolic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Non-cirrhotic portal HP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Enolic cirrhosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Enolic cirrhosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cryptogenic cirrhosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Enolic cirrhosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HCV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pre LT pH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pre LT PO<span class="elsevierStyleInf">2</span> &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">71&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">54&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pre LT PCO<span class="elsevierStyleInf">2</span> &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MELD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Child&#8211;Pugh&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">C &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">C &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">C &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">C &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pre LT home O<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Perfusion syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Postoperative MV time &#40;h&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">480&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NOMV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Res unit length of stay &#62;48<span class="elsevierStyleHsp" style=""></span>h&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cause of death&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sepsis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sepsis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Primary graft dysfunction&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "imagenFichero" => array:1 [
                0 => "xTab1217106.png"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Clinical aspects&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:23 [
            0 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatopulmonary syndorme&#58; current concepts in diagnostic and therapeutic considerations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Krowka"
                            1 => "D&#46; Cortese"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1994"
                        "volumen" => "105"
                        "paginaInicial" => "1528"
                        "paginaFinal" => "1537"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8181347"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Portopulmonary hypertension and hepatopulmonary syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Aldenkortt"
                            1 => "M&#46; Aldenkortt"
                            2 => "L&#46; Caviezel"
                            3 => "J&#46;L&#46; Waeber"
                            4 => "A&#46; Weber"
                            5 => "E&#46; Schiffer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3748/wjg.v20.i25.8072"
                      "Revista" => array:6 [
                        "tituloSerie" => "World J Gastroenterol"
                        "fecha" => "2014"
                        "volumen" => "20"
                        "paginaInicial" => "8072"
                        "paginaFinal" => "8081"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25009379"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary vascular complications of cronic liver disease&#58; pathophysiology&#44; imaging&#44; and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;N&#46; Khan"
                            1 => "H&#46; Al-Jahdali"
                            2 => "K&#46; Abdullah"
                            3 => "K&#46;L&#46; Irion"
                            4 => "Q&#46; Sabih"
                            5 => "A&#46; Gouda"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/1817-1737.78412"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann thorac Med"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "57"
                        "paginaFinal" => "65"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21572693"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Cardiac diagnosis by contrast echocardiography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;J&#46; Brugts"
                            1 => "M&#46; Michels"
                            2 => "C&#46;A&#46; Den Uil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/heartjnl-2014-305523"
                      "Revista" => array:6 [
                        "tituloSerie" => "Heart"
                        "fecha" => "2014"
                        "volumen" => "100"
                        "paginaInicial" => "657"
                        "paginaFinal" => "661"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24659309"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0140"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatopulmonary syndrome &#8211; a liver-induced lung vascular disorder"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Rodriguez-Roisin"
                            1 => "M&#46;J&#46; Krowka"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra0707185"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2008"
                        "volumen" => "358"
                        "paginaInicial" => "2378"
                        "paginaFinal" => "2387"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18509123"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatopulmonary s&#237;ndrome and liver transplantation&#58; who&#44; when&#44; and where&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Tanikella"
                            1 => "M&#46;B&#46; Fallon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.26367"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "2013"
                        "volumen" => "57"
                        "paginaInicial" => "2097"
                        "paginaFinal" => "2099"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23471874"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence anda severity oh hepatopulmonary s&#237;ndrome and its influence on survival in cirrhotic patients evaluated for liver transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Pascasio"
                            1 => "I&#46; Grilo"
                            2 => "F&#46;J&#46; L&#243;pez-Pardo"
                            3 => "F&#46; Ortega-Ru&#237;z"
                            4 => "J&#46;L&#46; Tirado"
                            5 => "J&#46;M&#46; Sousa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Am J Transplant"
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                        "paginaInicial" => "1391"
                        "paginaFinal" => "1399"
                        "link" => array:1 [
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                          "autores" => array:2 [
                            0 => "A&#46; Valenti"
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                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Ter"
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                        "paginaInicial" => "123"
                        "paginaFinal" => "128"
                      ]
                    ]
                  ]
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                        0 => array:2 [
                          "etal" => false
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                            4 => "I&#46;R&#46; Parepa"
                            5 => "A&#46;P&#46; Suceveanu"
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                        "tituloSerie" => "Chirurgia &#40;Bucur&#41;"
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                        "paginaInicial" => "684"
                        "paginaFinal" => "688"
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              ]
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                    0 => array:2 [
                      "titulo" => "Pulmonary contraindications&#44; indications and MELD exceptions for liver transplantation&#58; a contemporary review and look forward"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            2 => "J&#46;K&#46; Heimbach"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.jhep.2013.03.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "2013"
                        "volumen" => "59"
                        "paginaInicial" => "367"
                        "paginaFinal" => "374"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23557870"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "Hypoxia among patients on the liver-transplant waiting list"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;S&#46; Nacif"
                            1 => "W&#46; Andraus"
                            2 => "K&#46; Sartori"
                            3 => "C&#46;M&#46; Benites"
                            4 => "V&#46;R&#46; Santos"
                            5 => "J&#46;A&#46; Rocha-Filho"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Arq Bras Cir Dig"
                        "fecha" => "2014"
                        "volumen" => "27"
                        "paginaInicial" => "56"
                        "paginaFinal" => "58"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25409968"
                            "web" => "Medline"
                          ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hepatopulmonary syndrome"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;G&#46; Koch"
                            1 => "M&#46;B&#46; Fallon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cld.2014.01.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Liver Dis"
                        "fecha" => "2014"
                        "volumen" => "18"
                        "paginaInicial" => "407"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24679503"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0180"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recurrence of hepatopulmonary syndrome post-orthotopic liver transplantation in a patient with noncirrhotic portal hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Casey"
                            1 => "A&#46; Schellenman"
                            2 => "P&#46; Angus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepaotology"
                        "fecha" => "2013"
                        "volumen" => "58"
                        "paginaInicial" => "2205"
                        "paginaFinal" => "2206"
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              "etiqueta" => "14"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Congenital hepatic fibrosis with extra-hepatic porto-systemic shunt and hepatopulmonary syndrome successfully managed with living related liver transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Taneja"
                            1 => "Manavwadhawan"
                            2 => "S&#46; Gupta"
                            3 => "Neeravgoyal"
                            4 => "K&#46;V&#46; Ramaswamy"
                            5 => "A&#46; Chaudhary"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Trop Gastroenterol"
                        "fecha" => "2014"
                        "volumen" => "35"
                        "paginaInicial" => "116"
                        "paginaFinal" => "118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25508503"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0190"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Utility of pulse oximetry in the detection of arterial hipoxemia in liver transplant candidates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46;A&#46; Abrams"
                            1 => "M&#46;K&#46; Sanders"
                            2 => "M&#46;B&#46; Fallon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/jlts.2002.32252"
                      "Revista" => array:7 [
                        "tituloSerie" => "Liver Transpl"
                        "fecha" => "2002"
                        "volumen" => "8"
                        "paginaInicial" => "391"
                        "paginaFinal" => "396"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11965585"
                            "web" => "Medline"
                          ]
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              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cost-effectiveness of screening for hepatopulmonary syndrome in liver transplant candidates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "N&#46;D&#46; Roberts"
                            1 => "M&#46;R&#46; Arguedas"
                            2 => "M&#46;B&#46; Fallon"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/lt.20931"
                      "Revista" => array:6 [
                        "tituloSerie" => "Liver Transpl"
                        "fecha" => "2007"
                        "volumen" => "13"
                        "paginaInicial" => "206"
                        "paginaFinal" => "214"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17205561"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Hepatopulmonary syndrome&#58; update on pathogenesis and clinical features"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Zhang"
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                      ]
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                    0 => array:2 [
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                        "tituloSerie" => "Nat Rev Gastroenterol Hepatol"
                        "fecha" => "2012"
                        "volumen" => "9"
                        "paginaInicial" => "539"
                        "paginaFinal" => "549"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22751459"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Hepatopulmonary syndrome&#58; the anaesthetic considerations"
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                            0 => "P&#46; Fauconnet"
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                        "tituloSerie" => "Eur J Anaesthesiol"
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                        "paginaInicial" => "721"
                        "paginaFinal" => "730"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24161936"
                            "web" => "Medline"
                          ]
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                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
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              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Successful resolution of severe hepatopulmonary syndrome following liver transplantation"
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                        0 => array:2 [
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                          "autores" => array:6 [
                            0 => "S&#46; Asthana"
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                            2 => "L&#46; Lou"
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                            4 => "V&#46; Bain"
                            5 => "D&#46;R&#46; Townsend"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Traspl Int"
                        "fecha" => "2010"
                        "volumen" => "23"
                        "paginaInicial" => "432"
                        "paginaFinal" => "435"
                      ]
                    ]
                  ]
                ]
              ]
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            19 => array:3 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Hepatopulmonary syndorme&#58; is it time to redefine the MELD exception score for better organ allocation and outcomes&#63;"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Hepatol"
                        "fecha" => "2014"
                        "volumen" => "13"
                        "paginaInicial" => "468"
                        "paginaFinal" => "470"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24927621"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Improved survival after liver transplantation in patients with hepatopulmonary syndrome"
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                        "tituloSerie" => "Am J Transplant"
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                        "paginaFinal" => "363"
                        "link" => array:1 [
                          0 => array:2 [
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                      "Revista" => array:5 [
                        "tituloSerie" => "Exp Rev Clin Pharmacol"
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                        "paginaFinal" => "42"
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos