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Magnesium changes during hemodialysis alter the QTc interval and QTc dispersion
Los cambios de la concentración de magnesio durante la hemodiálisis alteran el intervalo Qtc y la dispersión de Qtc
Basturk Taner
Corresponding author
tanerbast@yahoo.com

Corresponding author.
, Unsal Abdulkadir, Koc Yener, Sakaci Tamer, Yilmaz Murvet, Ahbap Elbis
Department of Nephrology, Sisli Etfal Research and Education, Istanbul, Turkey
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Mortality risk related to cardiovascular disease in patients having kidney insufficiency is 10-fold higher compared with overall population&#44; vast majority of death events comprise heart insufficiency&#44; myocardium infarction and sudden cardiac deaths&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Responsible mechanism for the sudden increase in risk of cardiac death is not completely known and also&#44; at the end of the Holter monitoring&#44; during hemodialysis and just after it arrhythmia and high incidence of early ventricular pulses were shown&#46; During dialysis there is rapid change in intracellular and extracellular electrolytes causing these arrhythmias&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#8211;6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">QTc interval and QTc dispersion measurements are non-invasive methods&#46; This is non-invasive measurement of myocardial repolarization in homogeneity and hence predisposition to re-entry arrhythmias&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> The purpose of our study was to determine the QTc interval and QTc dispersion in CKD and HD patients&#44; and to assess the effect of HD on QTc interval and QTc dispersion&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Material and method</span><p id="par0020" class="elsevierStylePara elsevierViewall">This cross-sectional study was performed in Department of Nephrology between May 2008 and October 2008&#46; Twenty-five HD patients &#40;13 males&#44; mean age&#58; 43&#46;04<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;04 years&#41; and 20 CKD patients &#40;9 males&#44; mean age&#58; 45&#46;51<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;84 years&#44; mean GFR&#58; 42&#46;05<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#46;6<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#41; were enrolled in the study&#46; The patients signed a written informed consent form to participate in the study&#46; The study was approved by the local ethics committee&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">All patients were usually treated with a dialytic regimen of bicarbonate dialysis at the following electrolyte concentrations in the bath&#58; K<span class="elsevierStyleSup">&#43;</span>&#44; 2&#46;0<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#59; Ca<span class="elsevierStyleSup">2&#43;</span>&#44; 1&#46;5<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#59; Mg<span class="elsevierStyleSup">2&#43;</span>&#44; 0&#46;5<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#59; HCO<span class="elsevierStyleInf">3</span><span class="elsevierStyleSup">&#8722;</span>&#44; 32<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#59; F60 &#40;Polysulfon&#41; dialysers&#44; blood flow 350<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#44; dialysate flow 500<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#46; All subjects were on HD treatment for at least 3 months and they performed 4<span class="elsevierStyleHsp" style=""></span>h HD sessions three times a week&#46; Twenty CKD patients were normotensive with GFR 59&#8211;15<span class="elsevierStyleHsp" style=""></span>ml&#47;min &#40;stages 3 and 4&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Exclusion criteria were &#40;i&#41; diabetes&#44; &#40;ii&#41; overt ischaemic heart disease &#40;IHD&#41;&#44; &#40;iii&#41; ECG evidence of left ventricular hypertrophy &#40;LVH&#41; or left bundle-branch block &#40;LBBB&#41;&#44; &#40;iv&#41; atrial fibrillation&#44; &#40;v&#41; patients taking class I or class III anti-arrhythmic drugs&#44; and &#40;vi&#41; patients taking anti-hypertensives&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">ECGs of the patients with CKD coming to policlinic follow-up were taken at a speed of 25<span class="elsevierStyleHsp" style=""></span>mm&#47;s and taking their blood samples their plasma electrolyte levels &#40;K<span class="elsevierStyleSup">&#43;</span>&#44; Ca<span class="elsevierStyleSup">2</span>&#44; Mg<span class="elsevierStyleSup">2</span>&#41; were detected on the same day&#46; Standard dialysis was performed for 4<span class="elsevierStyleHsp" style=""></span>h&#44; three times a week&#46; Twelve-lead ECGs were performed &#40;Hewlett-Packard Page writer 100 with a 25<span class="elsevierStyleHsp" style=""></span>mm&#47;s paper speed&#44; gain 10<span class="elsevierStyleHsp" style=""></span>mm&#47;mV&#41; under identical conditions for all patients&#58; 30<span class="elsevierStyleHsp" style=""></span>min before and 30<span class="elsevierStyleHsp" style=""></span>min after the morning&#44; mid-week HD session&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The QT interval was measured from the onset of the QRS complex to the end of the T wave&#44; defined by the return of the terminal T wave to the isoelectric TP baseline&#46; When U waves were present&#44; the end of the T wave was taken as the nadir between the T and U waves&#46; If the end of the T wave was not clear in a particular lead then it was excluded from analysis&#59; for any particular ECG&#44; no more than three leads were excluded&#46; Three successive QT interval measurements were performed in each of the 12 leads&#44; and the mean value was calculated&#46; The maximum QT interval was corrected for heart rate &#40;QTc-max&#41; using Bazett&#39;s formula QTc<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>QT&#47;&#40;RR&#41;<span class="elsevierStyleSup">1&#47;2</span>&#46; The QT &#40;QTc&#41; dispersion was determined as the difference between the maximum and the minimum of the QT &#40;QTc&#41; in different leads &#40;minimum 10&#41; on the same recording&#46; All ECGs were manually investigated by one person&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Serum potassium&#44; calcium&#44; magnesium&#44; creatinine and albumin were measured with an autoanalyzer&#46; Calcium was corrected for hypoalbuminemia by adding 0&#46;8<span class="elsevierStyleHsp" style=""></span>mg&#47;dl to the calcium concentration for each 1<span class="elsevierStyleHsp" style=""></span>g&#47;dl decrease in albumin concentration from the normal 4&#46;0<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">CKD was defined according to the presence or absence of kidney damage and the level of kidney function&#46; Kidney damage was defined as pathologic abnormalities or markers of damage&#44; including abnormalities in blood or urine tests or imaging studies&#46; Among individuals with CKD&#44; the stage was defined by the level of e-GFR &#40;stages 1&#8211;5&#41;&#46; Estimated glomerular filtration rate &#40;e-GFR&#41; was calculated by using the Cockcroft and Gault formula&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Statistics</span><p id="par0055" class="elsevierStylePara elsevierViewall">For statistical study SPSS 13&#46;0 packet computer statistic program was used&#46; Results are expressed as a mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>sd&#46; Statistical evaluation was performed with the two-tailed paired and unpaired Student&#39;s test and Pearson correlation test&#46; Differences were considered as statistically significant when the <span class="elsevierStyleItalic">p</span> value was &#60;0&#46;05&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">In the HD patients&#44; chronic glomerulonephritis and polycystic kidney disease&#44; in the CKD patients&#44; chronic glomerulonephritis and tubulointerstitial nephritis were the most common causes&#46; We did not found significant difference in age and gender&#44; as compared to all of patients &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;In 5 of the patients with CKD abnormally prolonged QTc interval was found&#46; In addition to the prolonged QTc dispersion was detected in three patients&#46; Among pre-HD patients&#44; 14 patients prolonged QT interval&#44; and 12 patients had prolonged QTc dispersion&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">In patients with HD&#44; QTc interval was prolonged in pre- &#40;446<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>53<span class="elsevierStyleHsp" style=""></span>ms&#41; and post-HD patients &#40;470<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>51<span class="elsevierStyleHsp" style=""></span>ms&#41; compared to the patients with CKD &#40;408<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>ms&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Pre and post HD in terms of QTc dispersion&#44; there was no statistically significant variation between the patients with HD &#40;42<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#47;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18<span class="elsevierStyleHsp" style=""></span>ms&#41; and CKD &#40;39<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>ms&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">QTc interval was prolonged significantly in post-HD compared to pre-HD &#40;470<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>51<span class="elsevierStyleHsp" style=""></span>ms vs 446<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5 3<span class="elsevierStyleHsp" style=""></span>ms&#41; &#40;<span class="elsevierStyleItalic">p</span>&#58; 0&#46;007&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; This increase in QTc interval was not homogeneous&#59; QTc interval increased in 16 patients&#44; it reduced in 5 patients reduced&#44; in 4 patients did not change&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">No significant difference was found in QTc dispersion post-HD &#40;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18<span class="elsevierStyleHsp" style=""></span>ms&#41; compared to pre-HD &#40;42<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>ms&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Post-HD while QTc dispersion increased in 12 patients&#44; it remained constant in 2 patients&#44; and decreased in the remaining 11 patients &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The serum K<span class="elsevierStyleSup">&#43;</span> &#40;5&#46;62<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;94 and 3&#46;35<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;72<span class="elsevierStyleHsp" style=""></span>mEql&#47;l&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and Mg<span class="elsevierStyleSup">2</span> &#40;3&#46;06<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;75 and 2&#46;43<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;58<span class="elsevierStyleHsp" style=""></span>mg&#47;dl <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; concentrations significantly decreased&#44; whereas the Ca<span class="elsevierStyleSup">2&#43;</span> &#40;8&#46;31<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;63 and 9&#46;68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;87<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; concentrations significantly increased in post-HD compared to pre-HD patients&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">After HD&#44; in patients with prolonged QTc interval &#40;<span class="elsevierStyleItalic">n</span>&#58; 16&#59; 478<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>55<span class="elsevierStyleHsp" style=""></span>ms&#41; and QTc dispersion &#40;<span class="elsevierStyleItalic">n</span>&#58; 14&#59; 52<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20<span class="elsevierStyleHsp" style=""></span>ms&#41;&#44; serum Mg levels decreased &#40;2&#46;99 <span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;87&#47;2&#46;30<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;35<span class="elsevierStyleHsp" style=""></span>mg&#47;dl and 3&#46;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;63&#47;2&#46;20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;43<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; respectively&#41;&#46; There was significant correlation between the prolonged QTc interval and QTc dispersion and serum Mg level changes &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;326&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0095" class="elsevierStylePara elsevierViewall">Our study demonstrates that&#44; HD patients &#40;pre-HD and post-HD&#41; had an abnormally prolonged QT interval compared to CKD patients&#46; In patients with prolonged QT interval and QT dispersion after HD&#44; only the level of Mg<span class="elsevierStyleSup">2</span> significantly decreased&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Patients with advanced CKD have increased cardiovascular mortality of multifactorial aetiology including cardiac arrhythmia&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Prolonged QT interval may be responsible for some of the cardiac deaths&#46; The QT interval is a measure of the duration of ventricular depolarization and repolarization&#44; and prolongation of the QT interval can predict cardiovascular death&#46; QT dispersion is a marker of variability of ventricular repolarization and is known to be increased in various high-risk groups&#46; Moreover recently these electrical markers were found to be independent predictors of total and cardiovascular mortality in both nonuremia and ureamic populations&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">The normal QTc interval varies from 350 to 450 milliseconds &#40;ms&#41;&#46; The normal range for QT dispersion is 40&#8211;50<span class="elsevierStyleHsp" style=""></span>ms with a maximum of 65<span class="elsevierStyleHsp" style=""></span>ms&#46; In our study&#44; HD and CRF patients were found to have longer QT interval and QT dispersion&#44; so this group of patients may be at higher risk of sudden cardiac death and ventricular arrhythmia&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">As a result of the studies conducted&#44; in HD patients&#44; compared with normal healthy individuals&#44; QTc interval and QTc dispersion as a predisposal for sudden cardiac death and intensified ventricular arrhythmia were found long&#44; and among the samples having long QTc interval and QTc dispersion cardiovascular death and cardiac morbidity were found to be higher&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">The hemodialysis patients have a wide variety of ECG abnormalities and&#44; in certain instances&#59; hemodialysis itself seems to be a cause of ECG changes and different kinds of dysrhythmias&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Cardiac arrhythmia is more frequent in HD patients&#44; during HD in intracellular and extracellular electrolytes&#44; especially related to fast alterations emerged subject to dialyzable cations&#8217;&#59; Ca&#44; Mg and K concentrations&#44; it had the possibility to emerge during HD and just after HD&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Yetkin et al&#46; showed that after HD a significant correlation between the increase in QTc interval&#44; QTc dispersion and serum electrolyte variants occurred&#44; and this relation might provide new insights into the evaluation of the ionic bases involved in inhomogeneous ventricular repolarization&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Covic et al&#46;&#44; in their study carried out over 68 non-diabetic patients found that&#44; the increase in HD patients&#8217; QTc interval was most of the times related with the rapid change in plasma electrolyte concentration&#44; and impact over QTc dispersion was found less significant&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">In our study&#59; the mean of pre- and post-dialysis cycle QT interval increased significantly &#40;<span class="elsevierStyleItalic">p</span>&#58; 0&#46;007&#41;&#44; there was no change in QT dispersion &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; This change in QTc interval and QT dispersion was not homogeneous&#46; Prolonged QT interval&#44; a measure of heterogeneity of vascular repolarization&#44; has been linked with increased risk of sudden death in dialyzed patients and it may be more prolonged&#44; after hemodialysis&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The serum K<span class="elsevierStyleSup">&#43;</span> and Mg<span class="elsevierStyleSup">2</span> concentrations significantly decreased&#44; whereas the Ca<span class="elsevierStyleSup">2&#43;</span> concentrations significantly increased&#46; In post-HD patients with prolonged QT interval and QT dispersion&#44; only the level of Mg<span class="elsevierStyleSup">2</span> significantly decreased&#46; The level of serum K<span class="elsevierStyleSup">&#43;</span> and Ca<span class="elsevierStyleSup">2&#43;</span> showed no significant difference&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Potassium and magnesium are two of the most important factors for the electrical stability of the myocardium&#44; involved in creating normal cellular excitability&#44; impulse propagation&#44; and regular ventricular recovery&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Magnesium depletion in general is associated with changes in the ECG&#46; Widening of the QRS complex and peaking of T waves have been described with modest magnesium loss&#44; whereas more severe magnesium depletion can lead to prolongation of the PR and QT intervals&#44; progressive widening of the QRS complex&#44; and diminution of the T wave&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Possible candidates for this are free fatty acids<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> catecholamines&#44; and sympathetic stimulation&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Cardiac arrhythmias are an important complication of magnesium depletion&#46; This is an important concept because increases in QTc and QTc dispersion suggest that ventricular repolarization is delayed when intracellular magnesium concentrations are low&#44; leading to increased risk for developing ventricular arrhythmia&#46; In addition magnesium levels alter the generation of potassium into the cell through the membrane ATP&#46; QT interval elongation in magnesium deficiency possibly arises from the incomplete membrane transportation of potassium&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#44;20</span></a> Cupisti et al&#46; have suggested that magnesium could be the main cause of increased QT dispersion&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusion</span><p id="par0145" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0150" class="elsevierStylePara elsevierViewall">Our study demonstrates that&#44; HD patients &#40;pre-HD and post-HD&#41; had an abnormally prolonged QT interval compared to CKD patients&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0155" class="elsevierStylePara elsevierViewall">Hemodialysis increases the QTc interval in ESRD patients&#46; However&#44; the impact on QTc dispersion is not important&#46; These changes are not homogeneous&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0160" class="elsevierStylePara elsevierViewall">The prolonged QT interval and QT dispersion in post-HD patients were only reduced at the level of Mg&#46; The low Mg level may predispose HD patients to risk factor for cardiac arrhythmias&#46; Therefore&#44; further studies with different concentration of Mg<span class="elsevierStyleSup">2</span> containing dialysate &#40;i&#46;e&#46; 0&#46;75&#47;1<span class="elsevierStyleHsp" style=""></span>mmol&#47;l&#41; should be made&#46;</p></li></ul></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interest</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
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    "fechaRecibido" => "2011-05-18"
    "fechaAceptado" => "2011-06-14"
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          "clase" => "keyword"
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          "palabras" => array:4 [
            0 => "QTc interval"
            1 => "QTc dispersion"
            2 => "Hemodialysis"
            3 => "CKD"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec91836"
          "palabras" => array:4 [
            0 => "Intervalo QTc"
            1 => "dispersi&#243;n QTc"
            2 => "Hemodi&#225;lisis"
            3 => "NPC"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The purpose of our study was to determine the QTc interval&#44; QTc dispersion in CKD and HD patients&#44; and to assess the effect of HD on QTc interval&#44; QTc dispersion&#46; Twenty-five HD and 20 CKD patients were included in the study&#46; Serum concentrations of K<span class="elsevierStyleSup">&#43;</span>&#44; Ca<span class="elsevierStyleSup">2</span>&#44; Mg<span class="elsevierStyleSup">2</span>&#44; creatinine&#44; and albumin were monitored and QT interval and QT dispersion were measured from 12 lead ECG&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">In 5 of the patients with CKD abnormally prolonged QTc interval was found&#46; In addition to the prolonged QTc dispersion was detected in three patients&#46; Among pre-HD patients&#44; 14 patients had prolonged QT interval&#44; and 12 had QTc dispersion&#46; The HD patients &#40;pre-HD and post-HD&#41; were found to have prolonged QTc interval compared to patients with CKD &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">QTc interval increased significantly in post-HD&#44; compared to pre-HD &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;007&#41;&#46; This increase in QTc interval was not homogeneous&#59; QTc interval increased in 16 patients&#44; it reduced in 5 patients&#44; in 4 patients it did not change&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No significant difference in QTc dispersion was found in post-HD compared to pre-HD &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Post-HD while QTc dispersion increased in 14 patients&#44; remained constant in 2 patients&#44; in the remaining 11 patients decreased&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The patients with prolonged QT interval &#40;<span class="elsevierStyleItalic">n</span>&#58; 16&#41; and QT dispersion &#40;<span class="elsevierStyleItalic">n</span>&#58; 14&#41; in post-HD&#44; only at the level of Mg<span class="elsevierStyleSup">2</span> significantly decreased &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">HD patients &#40;pre-HD and post-HD&#41; had an abnormally prolonged QT interval compared to CKD patients&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The patients with prolonged QT interval and QT dispersion in after HD&#44; only at the level of Mg<span class="elsevierStyleSup">2</span> significantly decreased&#46; The low Mg level may predispose HD patients to risk factor for cardiac arrhythmias&#46;</p>"
      ]
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        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El objetivo del presente estudio fue determinar el intervalo QTc&#44; la dispersi&#243;n de QTc en pacientes con nefropat&#237;a cr&#243;nica &#40;NPC&#41; y en pacientes sometidos a hemodi&#225;lisis &#40;HD&#41; y valorar el efecto de la HD sobre el intervalo QTc y dispersi&#243;n de QTc&#46; En el estudio se incluyeron 25 pacientes HD y 20 NPC&#46; Se monitorizaron las concentraciones s&#233;ricas de K<span class="elsevierStyleSup">&#43;</span>&#44; Ca<span class="elsevierStyleSup">2</span>&#44; Mg<span class="elsevierStyleSup">2</span>&#44; creatinina y alb&#250;mina y se determinaron el intervalo QT y la dispersi&#243;n QT a partir de un electrocardiograma &#40;ECG&#41; de 12 derivaciones&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">En cinco de los pacientes con NPC se detect&#243; un intervalo QTc prolongado anormalmente&#46; Adem&#225;s&#44; en tres pacientes se detect&#243; dispersi&#243;n QTc prolongada&#46; Entre pacientes pre-HD&#44; en 14 se detect&#243; un intervalo QT prolongado y en 12&#44; una dispersi&#243;n QT prolongada&#46; Los pacientes HD &#40;pre-HD y post-HD&#41; manifestaron un intervalo QTc prolongado&#44; comparado con los pacientes NPC &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El intervalo QTc aument&#243; significativamente despu&#233;s de la HD&#44; comparado con antes de ella &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;007&#41;&#46; Este aumento del intervalo QTc no fue homog&#233;neo&#59; el intervalo QTc de 16 pacientes aument&#243;&#44; en cinco disminuy&#243; y en cuatro no se modific&#243;&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">No se observ&#243; una diferencia significativa de la dispersi&#243;n QTc post-HD en comparaci&#243;n con pre-HD &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Mientras que la dispersi&#243;n QTc post-HD aument&#243; en 14 pacientes&#44; permaneci&#243; constante en dos y en los 11 pacientes restantes disminuy&#243;&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">En el per&#237;odo post-HD&#44; en los pacientes con prolongaci&#243;n del intervalo QT &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41; y dispersi&#243;n de QT &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#41;&#44; solo se identific&#243; una disminuci&#243;n significativa de la concentraci&#243;n de Mg<span class="elsevierStyleSup">2</span> &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">En pacientes HD &#40;pre-HD y post-HD&#41; se identific&#243; una prolongaci&#243;n an&#243;mala del intervalo QT en comparaci&#243;n con pacientes NPC&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">En los pacientes con prolongaci&#243;n del intervalo QT y dispersi&#243;n de QT despu&#233;s de HD&#44; solo se detect&#243; una disminuci&#243;n significativa de la concentraci&#243;n de Mg<span class="elsevierStyleSup">2</span>&#46; La baja concentraci&#243;n de Mg puede predisponer a los pacientes HD a un factor de riesgo de arritmias card&#237;acas&#46;</p>"
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                  \t\t\t\t\tvoid\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">HD patients &#40;<span class="elsevierStyleItalic">n</span>&#58; 25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">CRF patient &#40;<span class="elsevierStyleItalic">n</span>&#58; 20&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">43&#46;04<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;04&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">45&#46;51<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Causes of renal failure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chronic glomerulonephritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tubulointerstitial nephritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Polycystic kidney disease&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Obstructive nephropaty&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Drugs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristics of the study patients&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
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                          "etal" => false
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                            2 => "I&#46;F&#46; Yang"
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                        "volumen" => "7"
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                      "titulo" => "Increased QT interval dispersion after hemodialysis&#58; role of peridialytic electrolyte gradients"
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                          "etal" => true
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                            2 => "I&#46; Tando&#287;an"
                            3 => "M&#46; Boran"
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ISSN: 18862845
Original language: English
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es en pt

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