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36 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>" "titulo" => "MODY 3 diabetes, not every early onset diabetes is type 1 diabetes" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "271" "paginaFinal" => "272" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Diabetes tipo MODY-3, no todo debut es diabetes tipo 1" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María José Sánchez Malo, Marta Arrudi Moreno, Gracia María Lou Francés" "autores" => array:3 [ 0 => array:2 [ "nombre" => "María José" "apellidos" => "Sánchez Malo" ] 1 => array:2 [ "nombre" => "Marta" "apellidos" => "Arrudi Moreno" ] 2 => array:2 [ "nombre" => "Gracia María" "apellidos" => "Lou Francés" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => 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"autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Lorena García, María Fernández, Nuria Bengoa, Rosario Pintor, Francisco Arrieta" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Lorena" "apellidos" => "García" ] 1 => array:2 [ "nombre" => "María" "apellidos" => "Fernández" ] 2 => array:2 [ "nombre" => "Nuria" "apellidos" => "Bengoa" ] 3 => array:2 [ "nombre" => "Rosario" "apellidos" => "Pintor" ] 4 => array:4 [ "nombre" => "Francisco" "apellidos" => "Arrieta" "email" => array:1 [ 0 => "arri68@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Hospital Universitario Ramón y Cajal, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nutrición parenteral: albúmina versus proteínas totales en la valoración del calcio plasmático para ajustar la nutrición parenteral: a propósito de una serie de casos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 273 "Ancho" => 1782 "Tamanyo" => 57358 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Equations for total calcium correction for total proteins and serum albumin.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Plasma calcium is the parameter most commonly used to determine patient calcium levels in clinical practice. However, in certain physiological conditions, plasma calcium may not reflect the true clinical situation of the patient. Calcemia (blood calcium concentration) is closely regulated in the body, with total calcium values between 2.2 and 2.6<span class="elsevierStyleHsp" style=""></span>mmol/l (9–10.5<span class="elsevierStyleHsp" style=""></span>mg/dl) and ionic calcium values between 1.1 and 1.4<span class="elsevierStyleHsp" style=""></span>mmol/l (4.5–5.6<span class="elsevierStyleHsp" style=""></span>mg/dl). Forty percent of circulating plasma calcium is bound to proteins (mainly albumin, but also to globulins), 6% is bound to phosphates, citrate and bicarbonate, and the remaining 54% corresponds to ionic calcium.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The total calcium values change when the plasma protein levels change, while ionic calcium remains unchanged.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,3</span></a> Situations where calcemia can be strongly influenced by changes in plasma protein levels include volume overload, malnutrition and nephrotic syndrome. Hypoalbuminemia can also be found in patients with cancer or surgical complications (bleeding, fistula, intestinal perforation, etc.). In these cases, we observe a decrease in total plasma calcium, but not in ionic calcium, a situation known as pseudohypocalcemia.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> There are other circumstances in which total calcium is hardly evaluable, such as a reduced glomerular filtration rate and alkalosis, since alterations in acid-base equilibrium cause H<span class="elsevierStyleSup">+</span> ions to compete with Ca<span class="elsevierStyleSup">2+</span> for the protein binding points, though total calcium remains unchanged.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5–7</span></a> However, when there are alterations in acid-base equilibrium, the free calcium fraction is modified, and the patients clinically manifest hypocalcemia due to a decrease in ionic calcium, thereby underlining the importance of determining it through laboratory tests.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Of note is the high frequency of hypoproteinemia in patients subjected to total parenteral nutrition (TPN) (approximately 85%<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a>), which points to the need for strict control in such cases. When interpreting the biochemical parameters of a patient, uncorrected plasma calcium is of no diagnostic value and must be confirmed by the measurement of ionic calcium as the gold standard. When ionic calcium cannot be determined, the total protein (TP) or albumin correction methods can be used (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,5</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">A series of cases are presented below, corresponding to patients receiving TPN and followed-up on by the Nutrition Unit of Hospital Universitario Ramón y Cajal (Madrid, Spain). An analysis is made of the best calcium adjustment method for the diagnosis of hypocalcemia, using equations that correct the plasma calcium levels and afford estimates that are closer to the real concentration.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The indications of TPN were as follows: case 1: a 53-year-old woman operated upon due to a pelvic tumour; case 2: a 54-year-old male with perforation of the sigmoid colon and peritonitis; case 3: a 60-year-old woman with peritoneal pseudomyxoma and peritoneal carcinomatosis; case 4: a 72-year-old male with urothelial carcinoma, chronic calcifying pancreatitis and acute lithiasic cholecystitis; case 5: a 79-year-old woman operated upon due to postsurgery eventration; case 6: a 56-year-old male with esophageal adenocarcinoma; and case 7: a 74-year-old male with a metal mitral valve prosthesis and annuloplasty, pneumonia and respiratory distress syndrome.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Total plasma calcium, TP and albumin were analysed with the ARCHITECT c16000 Abbot system (the routine protocol in the laboratory of our hospital), and TP and albumin correction methods were used. Ionic calcium was determined by potentiometry (GEM Premier 4000 gasometer). In order for hypocalcemia to be symptomatic (Trousseau and Chvostek signs), calcium levels must be <8<span class="elsevierStyleHsp" style=""></span>mg/dl. The above-mentioned patients had low calcium levels without clinical manifestations, no history of hypocalcemia, and were not receiving drugs capable of inducing hypocalcemia. With correction, plasma calcium was seen to exceed 8<span class="elsevierStyleHsp" style=""></span>mg/dl. Fifty-seven percent of the patients continued to show hypocalcemia after calcium correction for proteins, but only 14% showed hypocalcemia after correction for albumin. On contrasting these values with those of ionic calcium, all the calcium values were found to be normal (pseudohypocalcemia) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Our study indicates that calcemia correction for albumin is more reliable for correctly diagnosing hypocalcemia.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> The cases presented reflect the influence of protein/albumin upon the calcium levels, as previously reported in the literature, mainly in patients with renal failure.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> This may result in an incorrect diagnosis, which in some cases could lead to the provision of TPN with more calcium than necessary. Routine biochemical testing usually reports total calcium levels and protein-corrected levels, but not albumin-corrected or ionic calcium levels. However, there is still controversy in the literature regarding the best method for measuring plasma calcium, with significant differences in terms of costs and clinical sensitivity.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">We conclude that it is essential to accurately determine calcemia in patients receiving TPN as well as in all hospitalized patients in general. It is therefore advisable to request albumin in the laboratory tests and, in the event of doubt, to determine ionic calcium, particularly in patients with alkalosis and/or altered renal function. If albumin or blood gases are not immediately available, the laboratory test results should be examined with caution, especially if the reported calcium concentration is <8<span class="elsevierStyleHsp" style=""></span>mg/dl. In such a case, the clinical condition of the patient should be prioritised, TPN being supplemented with calcium only in the presence of symptoms of hypocalcemia. However, while the study suggests that calcium correction for albumin is more useful in clinical practice, and specifically for adjusting parenteral nutrition, than correction for proteins, studies involving larger samples are needed to consolidate these findings.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Financial support</span><p id="par0035" class="elsevierStylePara elsevierViewall">The present study has received no specific support from public, commercial or non-profit sources.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Financial support" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: García L, Fernández M, Bengoa N, Pintor R, Arrieta F. Nutrición parenteral: albúmina versus proteínas totales en la valoración del calcio plasmático para ajustar la nutrición parenteral: a propósito de una serie de casos. Endocrinol Diabetes Nutr. 2019;66:272–274.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 273 "Ancho" => 1782 "Tamanyo" => 57358 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Equations for total calcium correction for total proteins and serum albumin.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">TP: total proteins.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Case \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Plasma calcium (mg/dl)Reference[8.9–10.3] \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">TP (g/dl)Reference[6.4–8.3] \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Serum albumin (g/dl)Reference[3.5–5.0] \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Calcium corrected for TP (mg/dl)Reference[8.9–10.3] \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Calcium corrected for serum albumin (mg/dl)Reference[8.9–10.3] \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ionic calcium (mg/dl)Reference[4.2–5.4] \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n 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align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n 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\t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.30 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.56 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => 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Guillén" 1 => "M.A. Hawkins" 2 => "B. Mislov" 3 => "V. Flores" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Revista Médica Científica" "fecha" => "2001" "volumen" => "14" "paginaInicial" => "12" "paginaFinal" => "18" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ionized calcium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.S. Baird" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cca.2011.01.004" "Revista" => array:6 [ "tituloSerie" => "Clin Chim Acta" "fecha" => "2011" "volumen" => "412" "paginaInicial" => "696" "paginaFinal" => "701" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21238441" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endocrinología clínica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.F. Pallardo Sánchez" 1 => "T. Lucas Morante" 2 => "M. Marazuela Azpiroz" 3 => "A. Rovira Loscos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2013" "editorial" => "Ed. Díaz de Santos SA" "editorialLocalizacion" => "Madrid" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spurious electrolyte disorders: a diagnostic challenge for clinicians" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Liamis" 1 => "E. Liberopoulos" 2 => "F. Barkas" 3 => "M. Elisaf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000351804" "Revista" => array:6 [ "tituloSerie" => "Am J Nephrol" "fecha" => "2013" "volumen" => "38" "paginaInicial" => "50" "paginaFinal" => "57" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23817179" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recomendaciones para la medida del calcio ionizado" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Muñoz Pérez" 1 => "A. Buño Soto" 2 => "R. Díaz García" 3 => "A. Galán Ortega" 4 => "P. Guevara Ramírez" 5 => "E. Guillén Campuzano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Documentos de la SEQC" "fecha" => "2010" "paginaInicial" => "7" "paginaFinal" => "11" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Approximation of corrected calcium concentrations in advanced chronic kidney disease patients with or without dialysis therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Kaku" 1 => "S. Ookawara" 2 => "H. Miyazawa" 3 => "K. Ito" 4 => "Y. Ueda" 5 => "K. Hirai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000437215" "Revista" => array:6 [ "tituloSerie" => "Nephron Extra" "fecha" => "2015" "volumen" => "5" "paginaInicial" => "39" "paginaFinal" => "49" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26557841" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypocalcemia in the critically ill patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Kelly" 1 => "M.A. Levine" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0885066611411543" "Revista" => array:6 [ "tituloSerie" => "J Intensive Care Med" "fecha" => "2013" "volumen" => "28" "paginaInicial" => "166" "paginaFinal" => "177" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21841146" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Albumin adjustment of total calcium does not improve the estimation of calcium status" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Ridefelt" 1 => "J. Helmersson-Karlqvist" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/00365513.2017.1336568" "Revista" => array:6 [ "tituloSerie" => "Scand J Clin Lab Invest" "fecha" => "2017" "volumen" => "77" "paginaInicial" => "442" "paginaFinal" => "447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28613958" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hyponatremia in patients receiving parenteral nutrition: the importance of correcting serum sodium for total proteins. The role of the composition of parenteral nutrition in the development of hiponatremia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Gómez Hoyos" 1 => "S. Fernández-Peña" 2 => "M. Cuesta" 3 => "A. Ortolá" 4 => "P. Matía" 5 => "N. Pérez-Ferre" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/s41430-017-0026-5" "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Nutr" "fecha" => "2018" "volumen" => "72" "paginaInicial" => "446" "paginaFinal" => "451" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29187749" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pseudohypocalcemia in cancer patients: a recommendation for the postanalytical correction of serum calcium in patients with hypoalbuminemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B. Carroll" 1 => "M. Fleisher" 2 => "M.S. Pessin" 3 => "S. Richardson" 4 => "L.V. Ramanathan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1373/clinchem.2017.272997" "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "2017" "volumen" => "63" "paginaInicial" => "1302" "paginaFinal" => "1304" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28515104" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/25300180/0000006600000004/v1_201905290847/S2530018019300587/v1_201905290847/en/main.assets" "Apartado" => array:4 [ "identificador" => "64494" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/25300180/0000006600000004/v1_201905290847/S2530018019300587/v1_201905290847/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2530018019300587?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 12 | 4 | 16 |
2024 October | 38 | 15 | 53 |
2024 September | 63 | 35 | 98 |
2024 August | 58 | 24 | 82 |
2024 July | 51 | 24 | 75 |
2024 June | 60 | 13 | 73 |
2024 May | 54 | 10 | 64 |
2024 April | 54 | 25 | 79 |
2024 March | 66 | 9 | 75 |
2024 February | 80 | 8 | 88 |
2024 January | 60 | 5 | 65 |
2023 December | 64 | 6 | 70 |
2023 November | 82 | 15 | 97 |
2023 October | 76 | 5 | 81 |
2023 September | 66 | 5 | 71 |
2023 August | 49 | 7 | 56 |
2023 July | 70 | 13 | 83 |
2023 June | 71 | 6 | 77 |
2023 May | 81 | 5 | 86 |
2023 April | 89 | 1 | 90 |
2023 March | 85 | 8 | 93 |
2023 February | 37 | 13 | 50 |
2023 January | 49 | 13 | 62 |
2022 December | 78 | 12 | 90 |
2022 November | 73 | 24 | 97 |
2022 October | 95 | 10 | 105 |
2022 September | 86 | 20 | 106 |
2022 August | 68 | 9 | 77 |
2022 July | 88 | 11 | 99 |
2022 June | 95 | 9 | 104 |
2022 May | 61 | 6 | 67 |
2022 April | 82 | 13 | 95 |
2022 March | 124 | 13 | 137 |
2022 February | 149 | 8 | 157 |
2022 January | 142 | 13 | 155 |
2021 December | 87 | 12 | 99 |
2021 November | 80 | 7 | 87 |
2021 October | 69 | 16 | 85 |
2021 September | 57 | 12 | 69 |
2021 August | 88 | 8 | 96 |
2021 July | 84 | 13 | 97 |
2021 June | 62 | 11 | 73 |
2021 May | 69 | 12 | 81 |
2021 April | 277 | 47 | 324 |
2021 March | 127 | 11 | 138 |
2021 February | 104 | 12 | 116 |
2021 January | 111 | 21 | 132 |
2020 December | 117 | 11 | 128 |
2020 November | 123 | 12 | 135 |
2020 October | 63 | 4 | 67 |
2020 September | 78 | 16 | 94 |
2020 August | 68 | 12 | 80 |
2020 July | 63 | 4 | 67 |
2020 June | 51 | 9 | 60 |
2020 May | 61 | 8 | 69 |
2020 April | 64 | 5 | 69 |
2020 March | 63 | 6 | 69 |
2020 February | 41 | 6 | 47 |
2020 January | 31 | 5 | 36 |
2019 December | 9 | 5 | 14 |
2019 November | 1 | 4 | 5 |
2019 October | 3 | 7 | 10 |