was read the article
array:24 [ "pii" => "S2173509314001469" "issn" => "21735093" "doi" => "10.1016/j.endoen.2014.07.004" "estado" => "S300" "fechaPublicacion" => "2014-10-01" "aid" => "584" "copyright" => "SEEN" "copyrightAnyo" => "2014" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Endocrinol Nutr. 2014;61:404-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1440 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1136 "PDF" => 296 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S1575092214000916" "issn" => "15750922" "doi" => "10.1016/j.endonu.2014.02.005" "estado" => "S300" "fechaPublicacion" => "2014-10-01" "aid" => "584" "copyright" => "SEEN" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Endocrinol Nutr. 2014;61:404-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2013 "formatos" => array:3 [ "EPUB" => 13 "HTML" => 1500 "PDF" => 500 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>" "titulo" => "Nutrición de yodo en mujeres embarazadas del área de Oviedo. ¿Es necesaria la suplementación con yodo?" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "404" "paginaFinal" => "409" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Iodine nutrition in pregnant women from Oviedo area. Is iodine supplementation necessary?" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 868 "Ancho" => 1644 "Tamanyo" => 76388 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Distribución en intervalos de las yodurias según tomen o no suplementos yodados.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Edelmiro Menéndez Torre, Elías Delgado Alvarez, Antonio Rabal Artal, Lorena Suárez Gutiérrez, María Galiana Rodríguez Caballero, Jessica Ares Blanco, Lucía Díaz Naya, Juan Carlos Fernández Fernández" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Edelmiro" "apellidos" => "Menéndez Torre" ] 1 => array:2 [ "nombre" => "Elías" "apellidos" => "Delgado Alvarez" ] 2 => array:2 [ "nombre" => "Antonio" "apellidos" => "Rabal Artal" ] 3 => array:2 [ "nombre" => "Lorena" "apellidos" => "Suárez Gutiérrez" ] 4 => array:2 [ "nombre" => "María Galiana" "apellidos" => "Rodríguez Caballero" ] 5 => array:2 [ "nombre" => "Jessica" "apellidos" => "Ares Blanco" ] 6 => array:2 [ "nombre" => "Lucía" "apellidos" => "Díaz Naya" ] 7 => array:2 [ "nombre" => "Juan Carlos" "apellidos" => "Fernández Fernández" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173509314001469" "doi" => "10.1016/j.endoen.2014.07.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173509314001469?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1575092214000916?idApp=UINPBA00004N" "url" => "/15750922/0000006100000008/v1_201409200130/S1575092214000916/v1_201409200130/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173509314001433" "issn" => "21735093" "doi" => "10.1016/j.endoen.2014.07.002" "estado" => "S300" "fechaPublicacion" => "2014-10-01" "aid" => "596" "copyright" => "SEEN" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Endocrinol Nutr. 2014;61:410-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2958 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 2558 "PDF" => 391 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Endoscopic endonasal surgery for pituitary tumors. Results in a series of 121 patients operated at the same center and by the same neurosurgeon" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "410" "paginaFinal" => "416" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Cirugía endoscópica endonasal en tumores de hipófisis. Resultados en una serie de 121 casos operados en un mismo centro y por un mismo neurocirujano" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1414 "Ancho" => 1624 "Tamanyo" => 118604 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Knosp's classification based on cavernous sinus invasion.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jorge Torales, Irene Halperin, Felicia Hanzu, Mireia Mora, Isam Alobid, Mateo De Notaris, Enrique Ferrer, Joaquim Enseñat" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Jorge" "apellidos" => "Torales" ] 1 => array:2 [ "nombre" => "Irene" "apellidos" => "Halperin" ] 2 => array:2 [ "nombre" => "Felicia" "apellidos" => "Hanzu" ] 3 => array:2 [ "nombre" => "Mireia" "apellidos" => "Mora" ] 4 => array:2 [ "nombre" => "Isam" "apellidos" => "Alobid" ] 5 => array:2 [ "nombre" => "Mateo" "apellidos" => "De Notaris" ] 6 => array:2 [ "nombre" => "Enrique" "apellidos" => "Ferrer" ] 7 => array:2 [ "nombre" => "Joaquim" "apellidos" => "Enseñat" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1575092214001314" "doi" => "10.1016/j.endonu.2014.03.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1575092214001314?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173509314001433?idApp=UINPBA00004N" "url" => "/21735093/0000006100000008/v1_201410080024/S2173509314001433/v1_201410080024/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173509314001457" "issn" => "21735093" "doi" => "10.1016/j.endoen.2014.02.017" "estado" => "S300" "fechaPublicacion" => "2014-10-01" "aid" => "585" "copyright" => "SEEN" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Endocrinol Nutr. 2014;61:398-403" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1036 "formatos" => array:3 [ "EPUB" => 12 "HTML" => 729 "PDF" => 295 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Demographic, clinical, and genetic characteristics of patients with medullary thyroid cancer in the past 16 years in Castilla-La Mancha" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "398" "paginaFinal" => "403" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Demografía, características clínicas y genéticas de pacientes con carcinoma medular de tiroides en los últimos 16 años en Castilla-La Mancha" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lynda Louhibi, Amparo Marco, Pedro J. Pinés, José C. Padillo, Inés Gómez, Miguel A. Valero, Mubarak Alramadán, Sandra Herranz, Miguel Aguirre, Antonio Hernández" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Lynda" "apellidos" => "Louhibi" ] 1 => array:2 [ "nombre" => "Amparo" "apellidos" => "Marco" ] 2 => array:2 [ "nombre" => "Pedro J." "apellidos" => "Pinés" ] 3 => array:2 [ "nombre" => "José C." "apellidos" => "Padillo" ] 4 => array:2 [ "nombre" => "Inés" "apellidos" => "Gómez" ] 5 => array:2 [ "nombre" => "Miguel A." "apellidos" => "Valero" ] 6 => array:2 [ "nombre" => "Mubarak" "apellidos" => "Alramadán" ] 7 => array:2 [ "nombre" => "Sandra" "apellidos" => "Herranz" ] 8 => array:2 [ "nombre" => "Miguel" "apellidos" => "Aguirre" ] 9 => array:2 [ "nombre" => "Antonio" "apellidos" => "Hernández" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1575092214000928" "doi" => "10.1016/j.endonu.2014.02.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1575092214000928?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173509314001457?idApp=UINPBA00004N" "url" => "/21735093/0000006100000008/v1_201410080024/S2173509314001457/v1_201410080024/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Iodine nutrition in pregnant women in the Oviedo area. Is iodine supplementation required?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "404" "paginaFinal" => "409" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Edelmiro Menéndez Torre, Elías Delgado Alvarez, Antonio Rabal Artal, Lorena Suárez Gutiérrez, María Galiana Rodríguez Caballero, Jessica Ares Blanco, Lucía Díaz Naya, Juan Carlos Fernández Fernández" "autores" => array:8 [ 0 => array:4 [ "nombre" => "Edelmiro" "apellidos" => "Menéndez Torre" "email" => array:2 [ 0 => "edel@telecable.es" 1 => "edelangot@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Elías" "apellidos" => "Delgado Alvarez" ] 2 => array:2 [ "nombre" => "Antonio" "apellidos" => "Rabal Artal" ] 3 => array:2 [ "nombre" => "Lorena" "apellidos" => "Suárez Gutiérrez" ] 4 => array:2 [ "nombre" => "María Galiana" "apellidos" => "Rodríguez Caballero" ] 5 => array:2 [ "nombre" => "Jessica" "apellidos" => "Ares Blanco" ] 6 => array:2 [ "nombre" => "Lucía" "apellidos" => "Díaz Naya" ] 7 => array:2 [ "nombre" => "Juan Carlos" "apellidos" => "Fernández Fernández" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Endocrinología y Nutrición, Hospital Universitario Central de Asturias, Oviedo, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nutrición de yodo en mujeres embarazadas del área de Oviedo. ¿Es necesaria la suplementación con yodo?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 879 "Ancho" => 1644 "Tamanyo" => 76706 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Interval distribution of urinary iodine levels in women taking and not taking iodinated supplements.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Iodine deficiency (ID) was documented in Asturias in the school population in the 1980s of the past century.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> After marketing of iodinated salt<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and continuous work by the Department of Endocrinology and Nutrition of Hospital Universitario Central de Asturias and the Department of Health of the Asturias government, iodine deficiency was eradicated from the school population in 2000 as the result of a high consumption rate of iodinated salt.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However, as in other Spanish regions,<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a> iodine intake was inadequate to cover the increased iodine requirements during pregnancy due to the combination of greater renal loss, placental deiodination, and additional thyroxine requirements by the fetus.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> This is the reason why iodide supplementation is recommended in Spain to all women during pregnancy and lactation.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In recent years, however, increased urinary iodine levels have been found in both schoolchildren and adults.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> These are attributed to increased iodine concentrations in milk.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> On the other hand, administration of iodide supplements to pregnant women has not shown a consistent impact on development of their children.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,10</span></a> Because of this, some organizations<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> have advised against universal iodine supplementation in pregnant and breast-feeding women, and only recommend use of supplements in those at high risk of inadequate iodine intake or thyroid dysfunction development at these stages. Moreover, some studies have found higher TSH levels and lower thyroid hormone levels in women receiving iodine supplements during pregnancy,<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12,13</span></a> and it has therefore been postulated that supplementation with iodine salts may have an effect contrary to the expected in some women.</p><p id="par0015" class="elsevierStylePara elsevierViewall">In order to ascertain the current nutritional status of pregnant women in our healthcare area, we conducted a study of urinary iodine levels and thyroid function in a sample of women enrolled in their first visit to the healthcare system for pregnancy.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">The sample consisted of 173 pregnant women from the healthcare area <span class="elsevierStyleSmallCaps">IV</span> of Asturias consecutively enrolled at their first visit to the midwife of their healthcare center on May and June 2013 and who gave their consent to participate in the study.</p><p id="par0025" class="elsevierStylePara elsevierViewall">All women were collected on the following day a random urine sample to measure urinary iodine levels, and were drawn a blood sample to test TSH, free thyroxine (T4), and thyroid peroxidase antibodies (anti-TPO Ab).</p><p id="par0030" class="elsevierStylePara elsevierViewall">Urinary iodine levels were measured using HPLC-ECD (high-performance ion-pair chromatography coupled to electrochemical detection). TSH (normal range [NR], 0.17–4.15<span class="elsevierStyleHsp" style=""></span>mU/L and coefficient of variation [CV], 0.8–2.9%),<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> FT4 (NR, 0.99–1.67<span class="elsevierStyleHsp" style=""></span>ng/mL, and CV, 1.8–3.2%) and anti-TPO antibodies (NR, <20<span class="elsevierStyleHsp" style=""></span>U/L) using a chemiluminescence immunoassay of Roche Diagnostics.</p><p id="par0035" class="elsevierStylePara elsevierViewall">A survey was also conducted on use of iodine supplements, iodinated salt, and dairy products. Iodinated salt consumption was considered to be positive when it occurred regularly from at least one year before the recent pregnancy. To estimate consumption of dairy products, subjects were asked about the daily number of glasses of milk and yoghurts taken and the weekly number of cheese servings. A serving was defined as a glass of milk, 2 yoghurts, or 100<span class="elsevierStyleHsp" style=""></span>g of cheese.</p><p id="par0040" class="elsevierStylePara elsevierViewall">SPSS version 15.0 software was used for statistical processing. A Student's t test was used for differences in quantitative variables, an ANOVA test was used for qualitative variables, and Spearman's correlation coefficient was used for bivariate correlations. A Kolmogorov–Smirnov test was used for non-normally distributed variables.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The study was approved by the clinical research ethics committee of Hospital Universitario Central de Asturias.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">Mean urinary iodine level was 229.6<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>162.3<span class="elsevierStyleHsp" style=""></span>μg/L (17–777), with a median of 197<span class="elsevierStyleHsp" style=""></span>μg/L.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Among the total 173 women, 88 had taken iodinated supplements for at least the past seven days, and 85 were not taking supplements. No differences were seen between the groups in age, presence of anti-TPO Ab, dairy product consumption, or use of iodinated salt (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">As shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>, women taking iodinated supplements had significantly higher (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001) urinary iodine levels than those not taking supplements. Median values were 247 and 138<span class="elsevierStyleHsp" style=""></span>μg/L respectively.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> shows distribution of urinary iodine levels in both groups. It may be seen that, among women taking iodinated supplements, 33 (37.5%) had urinary iodine levels higher than 300<span class="elsevierStyleHsp" style=""></span>μg/L and 12 (13.6%) had levels higher than 500<span class="elsevierStyleHsp" style=""></span>μg/L. Inadequate urinary iodine levels (less than 150<span class="elsevierStyleHsp" style=""></span>μg/L) were found in 20.5% of women taking supplements and in 51.8% of those who did not take them.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Most women (70%) were taking two or more daily servings of dairy products. Dairy product consumption did not correlate with urinary iodine levels, which were however lower (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05) in those taking two or less daily servings (208<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>145<span class="elsevierStyleHsp" style=""></span>μg/L; median, 191<span class="elsevierStyleHsp" style=""></span>μg/L) as compared to those taking more than two daily servings (250<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>175<span class="elsevierStyleHsp" style=""></span>μg/L; median, 230<span class="elsevierStyleHsp" style=""></span>μg/L).</p><p id="par0075" class="elsevierStylePara elsevierViewall">After excluding women with anti-TPO Ab, mean TSH levels were 2.13<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.16 mU/L; a trend to higher TSH levels was seen in the group taking supplements, but the difference was not significant (2.30<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.26 vs 1.94<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.04). There was no difference in plasma free T4 levels between the groups (1.18<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.15 vs 1.16<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.15). Among women taking iodinated supplements, 42.5% had TSH levels higher than 2.5<span class="elsevierStyleHsp" style=""></span>mU/L, as compared to only 26.5% of women not taking supplements (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05).</p><p id="par0080" class="elsevierStylePara elsevierViewall">In women not taking iodinated supplements but who routinely used iodinated salt, mean urinary iodine level was 183.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>109.2<span class="elsevierStyleHsp" style=""></span>μg/L, with a median of 190<span class="elsevierStyleHsp" style=""></span>μg/L. Mean urinary iodine level in women using iodinated salt was 140.7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>79.2<span class="elsevierStyleHsp" style=""></span>μg/L, with a median of 121<span class="elsevierStyleHsp" style=""></span>μg/L. There was no difference in dairy product consumption between the groups (2.4<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.3 vs 2.2<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.2 servings).</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">Iodine is indispensable for formation of thyroid hormones, thyroxine (T4) and triiodothyronine (T3), which are essential for maturation and development of the central nervous system of the fetus.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">Iodine requirements increase by more than 50% during pregnancy because of increased renal iodine clearance and increased needs for thyroid hormone synthesis to cover fetal requirements. Iodine requirements have been estimated at 250<span class="elsevierStyleHsp" style=""></span>μg daily.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Because of this, even women living in areas with iodine sufficiency are at risk of experiencing iodine deficiency during pregnancy.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17,18</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Severe iodine deficiency in pregnancy is associated to cretinism, impaired mental development, and other neurocognitive changes in children.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19,20</span></a> When iodine deficiency is mild or moderate, it has a milder and more subtle impact, but several studies conducted in recent years have reported poorer results in different neurocognitive and school achievement tests in children born to mothers with inadequate iodine nutrition during their pregnancies.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21,22</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Spain is considered by the World Health Organization (WHO) as a country with no iodine deficiency since 10 years ago.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> Iodine intake was however not sufficient to guarantee adequate iodine nutrition in pregnant women, as shown by the results of studies conducted both in Asturias<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and in other Spanish regions. Median urinary iodine levels were in all these cases lower than 150<span class="elsevierStyleHsp" style=""></span>μg/L, suggesting inadequate iodine intake, except in the mountain area of Catalonia.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Because of this evidence, the Ministry of Health approved in 2005 marketing of potassium iodide supplements for prophylaxis of iodine deficiency in pregnant women, which were reimbursable by the National Health System,<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> and both the Spanish Society of Endocrinology and Nutrition (SEEN) and other scientific societies recommend use of iodinated supplements in pregnant women.</p><p id="par0105" class="elsevierStylePara elsevierViewall">After marketing of iodinated supplements, results of most new studies conducted at different Spanish areas have shown that median urinary iodine levels in the first trimester of pregnancy, although higher than the previous levels, continued to be inadequate<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26,27</span></a>; by contrast, iodine sufficiency was already seen in other areas such as Guipuzcoa<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> due to high use of iodide supplements. In Asturias, data from 2008 also showed iodine sufficiency, with median urinary iodine levels of 155.7<span class="elsevierStyleHsp" style=""></span>μg/L. Seventy-seven percent of pregnant women reported use of iodinated supplements.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> However, a study conducted in 2010 on women of childbearing age who took no supplements already showed a median urinary iodine level of 169<span class="elsevierStyleHsp" style=""></span>μg/L, only slightly lower than that found in schoolchildren aged 6–14 years, in whom the value was 181<span class="elsevierStyleHsp" style=""></span>μg/L.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">In the current study, conducted during May and June 2013 on women in the Oviedo area during their first trimester of pregnancy, median urinary iodine level seen was 197<span class="elsevierStyleHsp" style=""></span>μg/L, clearly higher than 150<span class="elsevierStyleHsp" style=""></span>μg/L; this was due to the fact that 51% were taking iodinated supplements, and also probably to increased intake of iodine from milk and dairy products, which have been shown in recent years to have a high iodine content in several countries,<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> and also in Spain,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> including Asturias.</p><p id="par0115" class="elsevierStylePara elsevierViewall">An analysis of women in this group who took iodinated supplements revealed that a significant proportion had urinary iodine levels higher than 300<span class="elsevierStyleHsp" style=""></span>μg/L, an excessive level according to WHO criteria<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a>; this may be the origin of another finding made in our study: that this group of women had higher TSH levels than those not taking supplements, a fact already reported in other observational studies conducted in Spain<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> and Italy.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> In the latter study, authors attributed the finding to a transient phenomenon of thyroid gland stunning, and therefore advised against iodinated supplementation, and recommended that supplementation is started instead several months before pregnancy to avoid a sharp increase in iodine provision during pregnancy.</p><p id="par0120" class="elsevierStylePara elsevierViewall">After dividing the study sample into two groups based on whether or not they were previously taking iodinated supplements, women not taking supplements were seen to have median urinary iodine levels of 121<span class="elsevierStyleHsp" style=""></span>μg/L, lower than recommended. However, women not taking iodinated supplements but routinely using iodinated salt had median urinary iodine levels within the recommended limits (190<span class="elsevierStyleHsp" style=""></span>μg/L); we therefore think that these women would not require iodinated supplements, and a recommendation to continue using iodinated salt would suffice. Iodinated salt used in Spain is among the salts with the greatest iodine contents in Europe, 60<span class="elsevierStyleHsp" style=""></span>ppm, so that adequate iodine intake may be achieved with 3<span class="elsevierStyleHsp" style=""></span>g daily.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Although no correlation was seen in our study between dairy product consumption and urinary iodine levels, most women were taking two or more servings daily, which is the amount recommended for all pregnant women,<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> taking into account that organic milks are poor in iodine.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">The fact that pregnant women who routinely use iodinated salt have an adequate iodine intake should not lead us to forget that only 47% of women in our study used that salt, similarly to what occurs in other Spanish regions.<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28,36</span></a> Public health measures should therefore be implemented to achieve at least 90% consumption of iodinated salt, as recommended by the ICCD-WHO,<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> because it is advisable to ensure adequate replenishment of thyroid iodine deposits before pregnancy.</p><p id="par0130" class="elsevierStylePara elsevierViewall">On the other hand, and as recommended by the working group of SEEN,<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> epidemiological monitoring of iodine nutrition is indispensable in women of childbearing age because of potential inadvertent changes in iodine contents in diet. Increased urinary iodine levels seen in the current study were due to an inadvertent increase in iodine intake, probably caused by its increased concentration in dairy products during recent years as the result of changes in cattle feed composition. An inadvertent public health success has occurred, similar to that reported in the United Kingdom some years ago.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">It should also be taken into account that some countries which have been considered iodine-sufficient for many years, such as the USA,<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">39–41</span></a> Australia,<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> or the United Kingdom,<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> currently have lower than recommended median urinary iodine levels in pregnant women.</p><p id="par0140" class="elsevierStylePara elsevierViewall">As a conclusion, we think that iodinated supplements would currently be unnecessary in pregnant women in our environment who have routinely used iodinated salt, because their iodine intake with usual diet would be adequate. These women should be advised to continue to use iodinated salt in the amount recommended for pregnancy, and to take at least two daily servings of milk or dairy products (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><p id="par0145" class="elsevierStylePara elsevierViewall">Health authorities are obliged to continue to promote use of iodinated salt in diet in order to achieve that all women reach pregnancy under optimal iodine nutrition conditions.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors state that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:2 [ "identificador" => "xres374673" "titulo" => array:5 [ 0 => "Abstract" 1 => "Background and objective" 2 => "Material and methods" 3 => "Results" 4 => "Conclusions" ] ] 1 => array:2 [ "identificador" => "xpalclavsec353786" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres374672" "titulo" => array:5 [ 0 => "Resumen" 1 => "Introducción y objetivo" 2 => "Material y métodos" 3 => "Resultados" 4 => "Conclusión" ] ] 3 => array:2 [ "identificador" => "xpalclavsec353785" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Patients and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-01-16" "fechaAceptado" => "2014-02-23" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec353786" "palabras" => array:3 [ 0 => "Iodine" 1 => "Pregnancy" 2 => "Thyroid function" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec353785" "palabras" => array:3 [ 0 => "Yodo" 1 => "Embarazo" 2 => "Función tiroidea" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0010">Background and objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In Asturias, where iodine deficiency was eradicated in school children by the year 2000, iodine deficiency persisted in pregnant women, who were recommended to use of iodine supplementation. The aim of this study was to determine the iodine nutrition of pregnant women in our area and whether or not iodine supplements are needed.</p> <span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Throughout May and June 2013 we studied the iodine nutrition and thyroid function during the first trimester of pregnancy in 173 women in the health area of Oviedo.</p> <span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The median urinary iodine was 197<span class="elsevierStyleHsp" style=""></span>μg/L. Iodinated supplements were used by 47% of women, which had a yoduria median higher than those not taking iodinated supplements (247 vs 138<span class="elsevierStyleHsp" style=""></span>μg/L; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001), and also a higher TSH (2.30 vs 1.94<span class="elsevierStyleHsp" style=""></span>mU/L) although not significantly different. Yoduria was also higher in women who took more than two servings of dairy products (median: 230<span class="elsevierStyleHsp" style=""></span>μg/L) than those who took less (median: 191<span class="elsevierStyleHsp" style=""></span>μg/L). Within the group of women who were not taking iodine supplements, those regularly using iodized salt in the kitchen (47%) had a median urinary iodine concentration of 190<span class="elsevierStyleHsp" style=""></span>μg/L indicating iodine sufficiency.</p> <span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Iodinated supplements seem unnecessary nowadays in pregnant women of Oviedo who regularly take iodized salt and our recommendation in these cases should be to continue the use of iodized salt in the recommended amounts during pregnancy and consume at least two daily servings of milk or dairy products.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle" id="sect0035">Introducción y objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En Asturias, donde la deficiencia de yodo fue erradicada en los escolares en el año 2000, persistía una deficiencia de yodo en las mujeres embarazadas, por lo que se les recomendaba la utilización de suplementos yodados. El objetivo de este estudio es conocer la nutrición de yodo de las mujeres embarazadas de nuestra área y la necesidad o no de suplementos yodados.</p> <span class="elsevierStyleSectionTitle" id="sect0040">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Durante mayo y junio de 2013 hemos estudiado la nutrición de yodo y la función tiroidea en el primer trimestre del embarazo de 173 mujeres del área sanitaria de Oviedo.</p> <span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La mediana de la yoduria fue 197<span class="elsevierStyleHsp" style=""></span>μg/L. Tomaban suplementos yodados el 47% de las mujeres, con una mediana de yoduria superior a la de las que no tomaban suplementos yodados (247 vs 138<span class="elsevierStyleHsp" style=""></span>μg/L; < 0,001) y también una TSH superior (2,30 vs 1,94<span class="elsevierStyleHsp" style=""></span>mU/L), aunque no significativamente diferente. La yoduria fue también superior en las mujeres que tomaban más de 2 raciones de productos lácteos (mediana: 230<span class="elsevierStyleHsp" style=""></span>μg/L) que en aquellas que tomaban menos de 2 raciones (mediana: 191<span class="elsevierStyleHsp" style=""></span>μg/L). Dentro del grupo de mujeres que no tomaban suplementos yodados, aquellas que utilizaban habitualmente sal yodada en la cocina (47%), tenían una mediana de yoduria de 190<span class="elsevierStyleHsp" style=""></span>μg/L, indicativa de suficiencia de yodo.</p> <span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En la actualidad los suplementos yodados serían innecesarios en las mujeres embarazadas de nuestra entorno que consumen de forma habitual sal yodada y la recomendación en estos casos debería ser la de continuar utilizando la sal yodada en la cantidad recomendada en la gestación, así como consumir al menos dos raciones diarias de leche o productos lácteos.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Menéndez Torre E, Delgado Alvarez E, Rabal Artal A, Suárez Gutiérrez L, Rodríguez Caballero MG, Ares Blanco J, et al. Nutrición de yodo en mujeres embarazadas del área de Oviedo. ¿Es necesaria la suplementación con yodo? Endocrinol Nutr. 2014;61:404–409.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 879 "Ancho" => 1644 "Tamanyo" => 76706 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Interval distribution of urinary iodine levels in women taking and not taking iodinated supplements.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Taking iodinated supplement \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Not taking iodinated supplement \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Total \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">173 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33.8<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>5.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>7.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32.8<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>6.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Gestational age (weeks) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Using iodinated salt \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43 (48.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38 (44.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">81 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Servings of dairy products \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.3<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.4<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Anti-TPO Ab (+) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (9.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (9.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 (9.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab568010.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Sample characteristics.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">IR: interquartile range.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Total</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Taking iodinated salt</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Not taking iodinated salt</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">n \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Urinary iodine levels (μg/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">n \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Urinary iodine levels (μg/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">n \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Urinary iodine levels (μg/L) \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Taking iodinated supplement \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">297<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>184Median: 247(IR: 217) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">275<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>17Median: 258(IR: 182) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">319<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>195Median: 245(IR: 221) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Not taking iodinated supplement \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">160<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>96Median: 138(IR: 125) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">183<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>109Median: 190(IR: 128) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">141<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>79Median: 121(IR: 124) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab568009.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Urinary iodine levels as a function of intake of iodinated supplements and routine use of iodinated salt.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:43 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio epidemiológico del bocio endémico en la población escolar asturiana" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Menéndez Torre" 1 => "F.J. Díaz Cadórniga" 2 => "P. Boix Pallares" 3 => "J. Aranda Regules" 4 => "J. Aller Granda" 5 => "A. Rabal Artal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Endocrinología" "fecha" => "1987" "volumen" => "34" "paginaInicial" => "29" "paginaFinal" => "34" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Real Decreto 1424/1983, de 27 de Abr, por el que se aprueba la Reglamentación Técnico-Sanitaria para la obtención, circulación y venta de la sal y salmueras, comestibles, BOE 130" ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1983" "paginaInicial" => "1" "paginaFinal" => "7" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Erradicación de los trastornos por deficiencia de yodo en Asturias (España): 18 años de yodoprofilaxis con sal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Delgado Álvarez" 1 => "F.J. Díaz Cadórniga" 2 => "T. Tartón" 3 => "M.L. Bobis" 4 => "M.M. Valdés" 5 => "A. Méndez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Endocrinol Nutr" "fecha" => "2004" "volumen" => "51" "paginaInicial" => "492" "paginaFinal" => "496" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio sobre la nutrición de yodo en embarazadas asturianas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. García Delgado" 1 => "E. Delgado Álvarez" 2 => "F.J. Díaz Cadórniga" 3 => "J.A. Álvarez" 4 => "M.M. Valdés" 5 => "A. Méndez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Endocrinol Nutr" "fecha" => "2003" "volumen" => "50" "paginaInicial" => "5" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Déficit de yodo y función tiroidea en una población de mujeres embarazadas sanas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Domínguez" 1 => "S. Reviriego" 2 => "G. Rojo-Martínez" 3 => "M.J. Valdés" 4 => "R. Carrasco" 5 => "I. Coronas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2004" "volumen" => "122" "paginaInicial" => "449" "paginaFinal" => "453" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of iodine nutrition in populations: past, present, and future" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.B. Zimmermann" 1 => "M. Andersson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1753-4887.2012.00528.x" "Revista" => array:6 [ "tituloSerie" => "Nutr Rev" "fecha" => "2012" "volumen" => "70" "paginaInicial" => "553" "paginaFinal" => "570" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23035804" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Milk intake and iodine nutrition" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Riestra Fernández" 1 => "E. Menéndez Torre" 2 => "E. Delgado Álvarez" 3 => "J.C. Fernández Fernández" 4 => "F.J. Díaz Cadórniga" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Endocr Rev" "fecha" => "2013" "volumen" => "34" "numero" => "03_MeetingAbstracts" "paginaInicial" => "461" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine concentration in cow's milk and its relation with urinary iodine concentrations in the population" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Soriguer" 1 => "C. Gutierrez-Repiso" 2 => "S. Gonzalez-Romero" 3 => "G. Olveira" 4 => "M.J. Garriga" 5 => "I. Velasco" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clnu.2010.07.001" "Revista" => array:6 [ "tituloSerie" => "Clin Nutr" "fecha" => "2011" "volumen" => "30" "paginaInicial" => "44" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20675020" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mild iodine deficiency in pregnancy in Europe and its consequences for cognitive and psychomotor development of children: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Trumpff" 1 => "J. de Schepper" 2 => "J. Tafforeau" 3 => "H. van Oyen" 4 => "J. Vanderfaeillie" 5 => "S. Vandevijvere" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jtemb.2013.01.002" "Revista" => array:6 [ "tituloSerie" => "J Trace Elem Med Biol" "fecha" => "2013" "volumen" => "27" "paginaInicial" => "174" "paginaFinal" => "183" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23395294" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapy of endocrine disease: impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.N. Taylor" 1 => "O.E. Okosieme" 2 => "C.M. Dayan" 3 => "J.H. Lazarus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1530/EJE-13-0651" "Revista" => array:6 [ "tituloSerie" => "Eur J Endocrinol" "fecha" => "2013" "volumen" => "170" "paginaInicial" => "R1" "paginaFinal" => "R15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24088547" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Osakidetza, de Salut AV (Eds.), Suplementación con yodo y ácido fólico durante el embarazo y la lactancia. Available from: <a id="intr0010" class="elsevierStyleInterRef" href="http://www.osakidetza.euskadi.net/r85-gkgnrl00/es/contenidos/informacion/publicaciones_informes_estudio/es_pub/adjuntos/Taller_yodo_embarazo_lactancia.pdf">http://www.osakidetza.euskadi.net/r85-gkgnrl00/es/contenidos/informacion/publicaciones_informes_estudio/es_pub/adjuntos/Taller_yodo_embarazo_lactancia.pdf</a> [accessed 05.01.14]" ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 year of age" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Murcia" 1 => "M. Rebagliato" 2 => "C. Iniguez" 3 => "M.J. Lopez-Espinosa" 4 => "M. Estarlich" 5 => "B. Plaza" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/aje/kwq424" "Revista" => array:6 [ "tituloSerie" => "Am J Epidemiol" "fecha" => "2011" "volumen" => "173" "paginaInicial" => "804" "paginaFinal" => "812" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21385833" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maternal thyroid function in different conditions of iodine nutrition in pregnant women exposed to mild–moderate iodine deficiency: an observational study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Moleti" 1 => "B. di Bella" 2 => "G. Giorgianni" 3 => "A. Mancuso" 4 => "A. de Vivo" 5 => "A. Alibrandi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Endocrinol" "fecha" => "2011" "volumen" => "74" "paginaInicial" => "762" "paginaFinal" => "768" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Valores de referencia de tirotropina en el primer trimestre del embarazo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Aller Granda" 1 => "A. Rabal Artal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.endonu.2013.02.002" "Revista" => array:6 [ "tituloSerie" => "Endocrinol Nutr" "fecha" => "2013" "volumen" => "60" "paginaInicial" => "405" "paginaFinal" => "406" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23669510" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of thyroid hormone during early brain development" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Morreale de Escobar" 1 => "M.J. Obregon" 2 => "F. Escobar del Rey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur J Endocrinol" "fecha" => "2004" "volumen" => "151" "numero" => "Suppl. 3" "paginaInicial" => "U25" "paginaFinal" => "U37" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15554884" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reaching optimal iodine nutrition in pregnant and lactating women and young children: programmatic recommendations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "WHO" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Public Health Nutr" "fecha" => "2007" "volumen" => "10" "paginaInicial" => "1527" "paginaFinal" => "1529" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18333291" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case for universal salt iodisation to correct iodine deficiency in pregnancy: another salutary lesson from Tasmania" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.R. Burgess" 1 => "J.A. Seal" 2 => "G.M. Stilwell" 3 => "P.J. Reynolds" 4 => "E.R. Taylor" 5 => "V. Parameswaran" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med J Aust" "fecha" => "2007" "volumen" => "186" "paginaInicial" => "574" "paginaFinal" => "576" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17547546" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Urinary iodine concentrations indicate iodine deficiency in pregnant thai women but iodine sufficiency in their school-aged children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Gowachirapant" 1 => "P. Winichagoon" 2 => "L. Wyss" 3 => "B. Tong" 4 => "J. Baumgartner" 5 => "A. Melse-Boonstra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3945/jn.108.100438" "Revista" => array:6 [ "tituloSerie" => "J Nutr" "fecha" => "2009" "volumen" => "139" "paginaInicial" => "1169" "paginaFinal" => "1172" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19403711" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine deficiency disorders (IDD) and their eradication" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.S. Hetzel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1983" "volumen" => "2" "paginaInicial" => "1126" "paginaFinal" => "1129" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2903335" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine deficiency" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.B. Zimmermann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/er.2009-0011" "Revista" => array:6 [ "tituloSerie" => "Endocr Rev" "fecha" => "2009" "volumen" => "30" "paginaInicial" => "376" "paginaFinal" => "408" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19460960" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mild iodine deficiency during pregnancy is associated with reduced educational outcomes in the offspring: 9-year follow-up of the gestational iodine cohort" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.L. Hynes" 1 => "P. Otahal" 2 => "I. Hay" 3 => "J.R. Burgess" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2012-4249" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2013" "volumen" => "98" "paginaInicial" => "1954" "paginaFinal" => "1962" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23633204" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of parents and children (ALSPAC)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.C. Bath" 1 => "C.D. Steer" 2 => "J. Golding" 3 => "P. Emmett" 4 => "M.P. Rayman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(13)60436-5" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2013" "volumen" => "382" "paginaInicial" => "331" "paginaFinal" => "337" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23706508" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current global iodine status and progress over the last decade towards the elimination of iodine deficiency" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Andersson" 1 => "B. Takkouche" 2 => "I. Egli" 3 => "H.E. Allen" 4 => "B. de Benoist" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Bull World Health Org" "fecha" => "2005" "volumen" => "83" "paginaInicial" => "518" "paginaFinal" => "525" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16175826" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine nutritional status in pregnant women of two historically different iodine-deficient areas of Catalonia, Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Vila" 1 => "M. Serra-Prat" 2 => "A. de Castro" 3 => "E. Palomera" 4 => "R. Casamitjana" 5 => "G. Legaz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.nut.2010.11.012" "Revista" => array:6 [ "tituloSerie" => "Nutrition" "fecha" => "2011" "volumen" => "27" "paginaInicial" => "1029" "paginaFinal" => "1033" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21621389" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Uso racional del yoduro potásico durante el embarazo y la lactancia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Donnay Candil" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1575-0922(08)70633-8" "Revista" => array:6 [ "tituloSerie" => "Endocrinol Nutr" "fecha" => "2008" "volumen" => "55" "paginaInicial" => "29" "paginaFinal" => "34" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22967849" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Yododeficiencia en mujeres gestantes del Área Sanitaria de Palencia (España)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Maldonado Ruiz" 1 => "E. Guerrero Martínez" 2 => "M.A. Rodríguez Rodríguez" 3 => "J.M. Andrés de Llano" 4 => "C. Frontela Hernández" 5 => "M. Moreira Rodríguez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1575-0922(09)73313-3" "Revista" => array:6 [ "tituloSerie" => "Endocrinol Nutr" "fecha" => "2009" "volumen" => "56" "paginaInicial" => "452" "paginaFinal" => "457" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20114015" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of iodine nutritional status and thyroxine levels in pregnant women from different geographic areas of the Castile and Leon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.C. González Mateo" 1 => "M. Fernández Fernández" 2 => "V. Valdazo Revenga" 3 => "L. García Menéndez" 4 => "A. Díez Hernández" 5 => "R. Rodríguez Rodríguez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.endonu.2011.05.014" "Revista" => array:6 [ "tituloSerie" => "Endocrinol Nutr" "fecha" => "2011" "volumen" => "58" "paginaInicial" => "416" "paginaFinal" => "421" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21820982" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine intake in a population of pregnant women: INMA mother and child cohort study, Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Murcia" 1 => "M. Rebagliato" 2 => "M. Espada" 3 => "J. Vioque" 4 => "L. Santa Marina" 5 => "M. Alvarez-Pedrerol" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Epidemiol Commun Health" "fecha" => "2010" "volumen" => "64" "paginaInicial" => "1094" "paginaFinal" => "1099" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio de la función tiroidea en el embarazo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Herrero Ruiz" 1 => "A. Torres Torres" 2 => "C. Sánchez Ragnarssön" 3 => "M. Diéguez Felechosa" 4 => "E. Delgado Álvarez" 5 => "E. Menéndez Torre" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1575-0922(08)70651-X" "Revista" => array:5 [ "tituloSerie" => "Endocrinol Nutr" "fecha" => "2008" "volumen" => "55" "paginaInicial" => "142" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22967881" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Yoduria en población escolar como marcador de nutrición de yodo en mujeres en edad fértil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Riestra Fernández" 1 => "E. Menéndez Torre" 2 => "E. Delgado Álvarez" 3 => "J.C. Fernández Fernández" 4 => "M. Diéguez Felechosa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Endocrinol Nutr" "fecha" => "2013" "volumen" => "60" "numero" => "Suppl. 1" "paginaInicial" => "42" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sources of dietary iodine: bread, cows’ milk, and infant formula in the Boston area" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E.N. Pearce" 1 => "S. Pino" 2 => "X. He" 3 => "H.R. Bazrafshan" 4 => "S.L. Lee" 5 => "L.E. Braverman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/jc.2003-032002" "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2004" "volumen" => "89" "paginaInicial" => "3421" "paginaFinal" => "3424" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15240625" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of iodine deficiency disorders and monitoring their elimination" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Disorders ICFCOID, UNICEF, World Health Organization" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:2 [ "fecha" => "2007" "paginaInicial" => "1" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine intake and maternal thyroid function during pregnancy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Rebagliato" 1 => "M. Murcia" 2 => "M. Espada" 3 => "M. Álvarez-Pedrerol" 4 => "F. Bolúmar" 5 => "J. Vioque" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/EDE.0b013e3181c1592b" "Revista" => array:6 [ "tituloSerie" => "Epidemiology" "fecha" => "2010" "volumen" => "21" "paginaInicial" => "62" "paginaFinal" => "69" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19940773" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine deficiency in pregnant women living in the South East of the UK: the influence of diet and nutritional supplements on iodine status" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.C. Bath" 1 => "A. Walter" 2 => "A. Taylor" 3 => "J. Wright" 4 => "M.P. Rayman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1017/S0007114514002177" "Revista" => array:5 [ "tituloSerie" => "Br J Nutr" "fecha" => "2014" "paginaInicial" => "1" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25196744" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine concentration of organic and conventional milk: implications for iodine intake" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.C. Bath" 1 => "S. Button" 2 => "M.P. Rayman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1017/S0007114511003059" "Revista" => array:6 [ "tituloSerie" => "Br J Nutr" "fecha" => "2011" "volumen" => "107" "paginaInicial" => "935" "paginaFinal" => "940" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21781365" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evolución del estado de nutrición de yodo en los escolares de la Comunidad Autónoma del País Vasco" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.J. Arrizabalaga" 1 => "N. Larrañaga" 2 => "M. Espada" 3 => "P. Amiano" 4 => "J. Bidaurrazaga" 5 => "K. Latorre" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.endonu.2012.03.012" "Revista" => array:7 [ "tituloSerie" => "Endocrinol Nutr" "fecha" => "2012" "volumen" => "59" "paginaInicial" => "474" "paginaFinal" => "484" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682534" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1470204507700438" "estado" => "S300" "issn" => "14702045" ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La Sociedad Española de Endocrinología y Nutrición de ENDG de TSTRCLD de YYDT" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Donnay" 1 => "J. Arena" 2 => "A. Lucas" 3 => "I. Velasco" 4 => "S. Ares" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.endonu.2013.05.004" "Revista" => array:6 [ "tituloSerie" => "Endocrinol Nutr" "fecha" => "2014" "volumen" => "61" "paginaInicial" => "27" "paginaFinal" => "34" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24035326" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine, milk, and the elimination of endemic goitre in Britain: the story of an accidental public health triumph" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.I. Phillips" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Epidemiol Commun Health" "fecha" => "1997" "volumen" => "51" "paginaInicial" => "391" "paginaFinal" => "393" ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine status in pregnant women in the National Children's Study and in U.S. women (15–44 years), National Health and Nutrition Examination Survey 2005–2010" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K.L. Caldwell" 1 => "Y. Pan" 2 => "M.E. Mortensen" 3 => "A. Makhmudov" 4 => "L. Merrill" 5 => "J. Moye" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/thy.2013.0012" "Revista" => array:6 [ "tituloSerie" => "Thyroid" "fecha" => "2013" "volumen" => "23" "paginaInicial" => "927" "paginaFinal" => "937" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23488982" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine and pregnancy: a call to action" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Stagnaro-Green" 1 => "E.N. Pearce" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet Elsevier Ltd" "fecha" => "2013" "volumen" => "382" "paginaInicial" => "292" "paginaFinal" => "293" ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The state of U.S. iodine nutrition: how can we ensure adequate iodine for all?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.N. Pearce" 1 => "A.M. Leung" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/thy.2013.0295" "Revista" => array:6 [ "tituloSerie" => "Thyroid" "fecha" => "2013" "volumen" => "23" "paginaInicial" => "924" "paginaFinal" => "925" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23691971" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine status in pregnant women and their newborns: are our babies at risk of iodine deficiency?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.A. Travers" 1 => "K. Guttikonda" 2 => "C.A. Norton" 3 => "P.R. Lewis" 4 => "L.J. Mollart" 5 => "V. Wiley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med J Aust" "fecha" => "2006" "volumen" => "184" "paginaInicial" => "617" "paginaFinal" => "620" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16803441" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine deficiency in the UK: an overlooked cause of impaired neurodevelopment?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.C. Bath" 1 => "M.P. Rayman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1017/S0029665113001006" "Revista" => array:6 [ "tituloSerie" => "Proc Nutr Soc" "fecha" => "2013" "volumen" => "72" "paginaInicial" => "226" "paginaFinal" => "235" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23570907" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735093/0000006100000008/v1_201410080024/S2173509314001469/v1_201410080024/en/main.assets" "Apartado" => array:4 [ "identificador" => "5824" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735093/0000006100000008/v1_201410080024/S2173509314001469/v1_201410080024/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173509314001469?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 October | 3 | 7 | 10 |
2024 September | 24 | 7 | 31 |
2024 August | 15 | 8 | 23 |
2024 July | 10 | 14 | 24 |
2024 June | 11 | 4 | 15 |
2024 May | 11 | 7 | 18 |
2024 April | 16 | 4 | 20 |
2024 March | 31 | 8 | 39 |
2024 February | 15 | 5 | 20 |
2024 January | 10 | 9 | 19 |
2023 December | 19 | 8 | 27 |
2023 November | 7 | 10 | 17 |
2023 October | 18 | 17 | 35 |
2023 September | 17 | 11 | 28 |
2023 August | 11 | 10 | 21 |
2023 July | 9 | 11 | 20 |
2023 June | 14 | 3 | 17 |
2023 May | 7 | 17 | 24 |
2023 April | 18 | 4 | 22 |
2023 March | 21 | 2 | 23 |
2023 February | 26 | 9 | 35 |
2023 January | 27 | 8 | 35 |
2022 December | 37 | 6 | 43 |
2022 November | 55 | 14 | 69 |
2022 October | 24 | 9 | 33 |
2022 September | 13 | 15 | 28 |
2022 August | 16 | 7 | 23 |
2022 July | 6 | 14 | 20 |
2022 June | 13 | 11 | 24 |
2022 May | 15 | 11 | 26 |
2022 April | 9 | 13 | 22 |
2022 March | 16 | 12 | 28 |
2022 February | 13 | 9 | 22 |
2022 January | 22 | 15 | 37 |
2021 December | 13 | 12 | 25 |
2021 November | 6 | 9 | 15 |
2021 October | 19 | 12 | 31 |
2021 September | 16 | 15 | 31 |
2021 August | 7 | 20 | 27 |
2021 July | 14 | 9 | 23 |
2021 June | 19 | 15 | 34 |
2021 May | 15 | 9 | 24 |
2021 April | 27 | 10 | 37 |
2021 March | 21 | 15 | 36 |
2021 February | 17 | 7 | 24 |
2021 January | 17 | 9 | 26 |
2020 December | 13 | 12 | 25 |
2020 November | 16 | 8 | 24 |
2020 October | 18 | 4 | 22 |
2020 September | 21 | 9 | 30 |
2020 August | 17 | 11 | 28 |
2020 July | 12 | 11 | 23 |
2020 June | 25 | 11 | 36 |
2020 May | 20 | 7 | 27 |
2020 April | 16 | 3 | 19 |
2020 March | 20 | 7 | 27 |
2020 February | 14 | 8 | 22 |
2020 January | 10 | 6 | 16 |
2019 December | 24 | 9 | 33 |
2019 November | 14 | 10 | 24 |
2019 October | 17 | 6 | 23 |
2019 September | 18 | 4 | 22 |
2019 August | 18 | 10 | 28 |
2019 July | 21 | 11 | 32 |
2019 June | 47 | 11 | 58 |
2019 May | 112 | 17 | 129 |
2019 April | 47 | 20 | 67 |
2019 March | 8 | 6 | 14 |
2019 February | 20 | 7 | 27 |
2019 January | 8 | 5 | 13 |
2018 December | 13 | 3 | 16 |
2018 November | 15 | 0 | 15 |
2018 October | 15 | 2 | 17 |
2018 September | 24 | 6 | 30 |
2018 August | 8 | 0 | 8 |
2018 July | 13 | 0 | 13 |
2018 June | 14 | 2 | 16 |
2018 May | 15 | 2 | 17 |
2018 April | 92 | 3 | 95 |
2018 March | 8 | 0 | 8 |
2018 February | 4 | 0 | 4 |
2018 January | 7 | 1 | 8 |
2017 December | 14 | 0 | 14 |
2017 November | 8 | 1 | 9 |
2017 October | 12 | 1 | 13 |
2017 September | 10 | 6 | 16 |
2017 August | 17 | 0 | 17 |
2017 July | 17 | 1 | 18 |
2017 June | 29 | 15 | 44 |
2017 May | 38 | 13 | 51 |
2017 April | 22 | 12 | 34 |
2017 March | 24 | 15 | 39 |
2017 February | 42 | 5 | 47 |
2017 January | 11 | 1 | 12 |
2016 December | 25 | 10 | 35 |
2016 November | 17 | 3 | 20 |
2016 October | 35 | 3 | 38 |
2016 September | 21 | 6 | 27 |
2016 August | 16 | 5 | 21 |
2016 July | 20 | 1 | 21 |
2016 June | 18 | 11 | 29 |
2016 May | 20 | 1 | 21 |
2016 April | 15 | 14 | 29 |
2016 March | 14 | 3 | 17 |
2016 February | 21 | 5 | 26 |
2016 January | 24 | 6 | 30 |
2015 December | 24 | 4 | 28 |
2015 November | 24 | 6 | 30 |
2015 January | 0 | 1 | 1 |
2014 October | 0 | 1 | 1 |