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Ketoacidosis as a debut to type 1B diabetes mellitus in a patient with Turner's syndrome
Cetoacidosis como inicio de diabetes mellitus tipo 1B en una paciente con síndrome de Turner
Constanza Navarro Morenoa,
Corresponding author
conavarro80@hotmail.com

Corresponding author.
, Francisco Cañabate Recheb, Antonio Vicente Pintorb, Francisco Vela Enríquezb, M. del Rosario Benavides Románb
a Servicio de Pediatría, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, Spain
b Servicio de Pediatría, Empresa Pública Hospital de Poniente, El Ejido, Almería, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In Turner syndrome &#40;TS&#41;&#44; mortality is three times higher as compared to the population with a normal karyotype&#46; This is partly explained by the increasing incidence of diabetes mellitus &#40;DM&#41; and cardiovascular diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> There is an increased risk of developing both type 2 DM &#40;relative risk&#44; 4&#46;4&#41; and type 1 DM &#40;DM1&#41; &#40;relative risk&#44; 11&#46;6&#41; as compared to the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Development of frank DM during childhood is however exceptional&#44; and is usually more commonly associated to treatment with GH or sex hormones&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The unusual case of a two-year-old patient with DM1 of a non-autoimmune origin in whom TS was diagnosed is reported&#46; Few patients with TS in whom DM1 has developed in childhood have been reported&#44;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;6</span></a> and this is the youngest known&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Our patient was a Roumanian girl aged 2 years and 4 months with polyuria&#44; polydipsia&#44; and weight stagnation for the past two weeks&#46; She weighed 8&#46;100<span class="elsevierStyleHsp" style=""></span>kg &#40;&#8722;3&#46;6 SDS&#41; and measured 77&#46;5<span class="elsevierStyleHsp" style=""></span>cm in height &#40;&#8722;3&#46;8 SDS&#41;&#46; The patient had a unique phenotype&#44; with anteverted&#44; low-set pinnae&#44; slight hypertelorism&#44; and mandibular hypoplasia&#46; Hyperglycemia &#40;682<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41; and metabolic acidosis &#40;pH 7&#46;13&#44; pCO<span class="elsevierStyleInf">2</span> 20<span class="elsevierStyleHsp" style=""></span>mmHg&#44; HCO<span class="elsevierStyleInf">3</span> 6&#46;7<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#44; BE &#8722;20&#46;6<span class="elsevierStyleHsp" style=""></span>mmol&#47;L&#41; were detected&#44; which allowed for diagnosing diabetic ketoacidosis&#46; Diabetes work-up was completed by measurement of HbA1c &#40;11&#46;1&#37;&#41; and C peptide &#40;0&#46;25<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; normal&#58; 0&#46;90&#8211;4<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#41;&#44; the latter by immunoluminescence&#46; Tests for diabetes antibodies were requested &#40;indirect immunofluorescence method&#58; islet cell antibodies&#59; radioisotopic method&#58; insulin&#44; glutamic acid decarboxylase&#44; and tyrosine phosphatase antibodies&#41; and they were all negative&#46; There was no family history of autoimmune diseases&#46; Type B DM1 was diagnosed based on the lack of evidence of autoimmunity&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Because of the unique features and low height&#44; karyotype was requested and was found to be consistent with TS&#46; A cytogenetic study of 15 metaphases was performed from a culture stimulated with phytohemagglutinin&#44; with a resolution of 400 bands&#44; and an isodicentric X chromosome with long arms was seen&#44; which was confirmed by the band technique C&#58; 46&#44;X&#44;psu idic&#40;X&#41;&#40;p11&#46;2&#41;&#91;15&#93;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">TS is associated to autoimmune conditions&#46; Thus&#44; when DM1 is diagnosed it appears logical to think that it is of the 1A type&#59; however&#44; some authors state that autoantibodies are more frequently negative in TS&#46; This statement may however be conditioned by classification of DM based on the presence or absence of insulin dependence&#44; which may lead to a wrong diagnosis of DM1 in patients with type 2 DM&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;7</span></a> On the other hand&#44; some authors postulate the existence of mechanisms of destruction of pancreatic beta cells &#40;PBCs&#41; other than autoimmunity&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Insulin deficiency secondary to PBC dysfunction and worsening with age has been reported in TS&#46; At the earliest ages&#44; this insulin deficiency is compensated by increased insulin sensitivity&#44; but this would gradually decrease over time&#44; which would lead to carbohydrate intolerance or even DM&#46; Pathogenesis of this condition is independent from increases in body mass index and hypogonadism associated to TS&#44; and is similar to pathogenesis of the mature-onset diabetes of the young &#40;MODY&#41;&#44; secondary to haploinsufficiency of some transcription factors affecting PBC function&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">A potential relationship has been seen between metabolic diseases and presence of an isochromosome of the long arm of the X chromosome &#40;iXq&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Schoemaker et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> investigated causes of death in TS and found that in iXq karyotypes increased mortality was related to DM&#46; It is hypothesized that there are genes in X chromosome involved in PBC function&#44; and that haploinsufficiency of such genes could account for DM occurrence&#46; This is also supported by the close similarity between type MODY diabetes and changes in carbohydrate metabolism in patients with TS&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> There are also studies reporting a greater prevalence of DM1 related to findings made in the short arm of the X chromosome &#40;Xp&#41;&#46; Bakalov et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> suggested that the greater incidence of DM in TS may be due to haploinsufficiency of genes located in chromosome Xp&#44; so that DM incidence will be higher in patients with Xp monosomy &#40;45X&#59; delXp&#59; iXq&#41;&#44; with a normal incidence in long arm deletions &#40;delXq&#41;&#44; where both Xp arms are preserved&#46; However&#44; the greater incidence of DM in iXq patients may also be explained by overexpression of genes located in chromosome Xq which would escape inactivation&#44; and which would be related to PBC function&#44; and to another series of systemic processes which would promote a pro-inflammatory state&#46; These statements are supported by a study conducted in 2008 showing a higher mortality rate in iXq patients&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and by the fact that there is also a greater incidence of DM in patients with Klinefelter syndrome &#40;47XXY&#41; and in 48 XXYY patients&#44; in whom there are supernumerary copies of Xq&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Association of TS and DM1 may actually be due to mechanisms inherent to chromosomal findings&#46; Association of TS to autoimmunity is however widely known&#44; and a potential&#44; currently undetectable autoimmune basis cannot therefore be ruled out with full certainty&#46; Regular autoantibody monitoring is therefore recommended&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Association of DM to genetic syndromes provides unique information for studying the genetic cases of carbohydrate metabolism&#46; There is still a long road ahead before knowing the pathophysiological and genetic bases justifying DM1 occurrence in TS&#46; New advances in genetic testing&#44; as well as creation of multicenter databases&#44; will allow for more complete understanding of this syndrome and PBC pathophysiology&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors state that they have no conflicts of interest&#46;</p></span></span>"
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