Relationship between dietary calcium intake and adiposity in female adolescents | Endocrinología y Nutrición (English Edition)

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"IntroductionNon-communicable chronic diseases represent a worldwide health problem.<a class="elsevierStyleCrossRef" href="#bib0155">1</a> They have a substantial impact on health and have serious adverse effects on the quality of life, favor early mortality, and cause high costs to society. Cardiovascular disease, cancer, chronic respiratory tract disease, and diabetes account for 60% of deaths worldwide. It is estimated that 41 million people will die from non-communicable chronic diseases in 2015.<a class="elsevierStyleCrossRef" href="#bib0160">2</a>Obesity is considered by the World Health Organization to be the “epidemic of the 21st century”, and its prevalence has increased and continues to increase in developed countries, as well as in countries with economies in transition, and has acquired epidemic proportions. Overweight and obesity account for approximately 2.6 million deaths annually. Considering its multifactorial etiology, genetic factors appear to have played only a secondary role in the increased prevalence of obesity, while environmental factors such as diet and physical inactivity emerge as the most significant determinants of increased adiposity in the past 30 years.<a class="elsevierStyleCrossRef" href="#bib0160">2</a>The prevalence and magnitude of obesity are also rapidly increasing in children and adolescents.<a class="elsevierStyleCrossRef" href="#bib0165">3</a> Childhood obesity is the most common cause of insulin resistance in children and adolescents and is associated with dyslipidemia, type 2 diabetes mellitus, long-term vascular complications, and usually with increased morbidity and mortality in adulthood.<a class="elsevierStyleCrossRefs" href="#bib0165">3,4</a>Research has often focused on the identification of combinations of macronutrients able to regulate body weight, but the effects of micronutrients need to be further explored. Some minerals are involved in energy metabolism and in insulin secretion and action, and may interfere with obesity control.<a class="elsevierStyleCrossRef" href="#bib0175">5</a>Studies searching for epidemiological explanations of increased adiposity have identified dietary calcium intake as one of the factors inversely correlated to the body mass index (BMI). Thus, consistent evidence concerning the role of calcium and dairy product consumption in obesity prevention has started to appear in recent years. The first report by McCarron, two decades ago, of the finding of lower body weights in US people who reported higher calcium intake in the National Health Survey opened a line of basic, clinical, and molecular research aimed at first confirming, and then explaining the mechanisms by which a mineral apparently unrelated to the energy equation could contribute to weight loss.<a class="elsevierStyleCrossRef" href="#bib0180">6</a> Short-term studies have reported negative associations between calcium consumption and the BMI, percent fat, and waist circumference.<a class="elsevierStyleCrossRef" href="#bib0185">7</a> Experimental studies in rats to determine the effect of subchronic dietary calcium intake on body weight and lipid metabolism showed that the administration of calcium added to a high-fat diet decreased body weight and abdominal fat contents during treatment, from which a potential decrease in fat absorption and a potential increase in fatty tissue apoptosis was inferred.<a class="elsevierStyleCrossRefs" href="#bib0190">8–10</a>A reanalysis of several prospective studies designed to assess the effect of dairy products on the prevention of osteoporosis showed that groups treated with calcium or with a greater intake of dairy products consistently had less risk of overweight.<a class="elsevierStyleCrossRef" href="#bib0205">11</a> A greater relative risk of high body adiposity was found in people with the lowest calcium intake, and the risk gradually decreased as calcium intake increased; relative risk was 0.75 for the second quartile, 0.40 for the third quartile, and 0.16 for the fourth quartile of calcium intake in women. The intake of dairy products, dietary protein, and calcium was associated with more favorable body composition in obese males and females.<a class="elsevierStyleCrossRefs" href="#bib0210">12–14</a>The results of clinical studies of calcium intake found significant negative associations between calcium intake and body weight in all age groups, and the range of probability to be overweight (BMI >25) was 2.25 for females in the lower half of calcium intake.<a class="elsevierStyleCrossRefs" href="#bib0225">15–17</a>On the other hand, some studies have reported that increased consumption of dairy products with no energy restriction does not lead to a significant change in body weight or composition.<a class="elsevierStyleCrossRef" href="#bib0240">18</a>Based on the foregoing and because of the inconsistency of the effects of dairy products on body weight and composition reported by various observational and experimental studies, a study was undertaken to assess whether the intake of calcium and dairy products in diet correlated to the degree of adiposity and development of overweight in a group of female adolescents.ObjectivesTo determine whether dietary calcium intake correlates to the BMI and body fat distribution in female adolescents.To determine whether dairy product intake correlates to the BMI and body fat distribution in female adolescents.Materials and methodsThis was a cross-sectional, observational, epidemiological study that enrolled 244 female adolescents aged 12–19 years, randomly selected from public and private schools from the list of schools of the Ministry of Education of Ecuador.All participants voluntarily agreed to take part in the study, and written informed consent signed by their parents or tutors was obtained. Adolescents with any physical disability that made the taking of anthropometric measurements difficult and those who had a clinical history of endocrine or metabolic problems, or cardiovascular, respiratory or musculoskeletal disease were excluded from the study.The study was approved by the bioethics committee of Universidad San Francisco in Quito.The sample was estimated with Epi Info (version 6) software using the following parameters: 95% confidence interval, expected prevalence of overweight of 12%, and 7% precision.Definition of variablesAnthropometrics. The following anthropometric measurements were taken: body weight: using a SECA scale (Germany); height: using a stadiometer; waist circumference: measured halfway between the costal margin and the iliac crest; and hip circumference: measured at the widest part of the hip, at the level of the greater trochanters, using a non-stretchable measuring tape.The BMI was calculated as: weight (kg)/height (m2).Overweight and obesity. Overweight and obesity were defined based on the BMI. Overweight was defined as a BMI above the 85th percentile, and obesity as a BMI above the 95th percentile. The resulting values were compared to those provided in the tables of the National Center for Health Statistics (NCHS) according to age and sex.<a class="elsevierStyleCrossRef" href="#bib0245">19</a>Fat distribution. The waist/hip ratio was used to determine body fat distribution.Intake of calories, macronutrients, calcium, and dairy products. This was calculated using a 24h recall instrument. To facilitate recall of the size of portions and to decrease recall bias, participants were shown the book with pictures of food portions of the American Dietetic Association. To determine differences between week days and weekends, three recalls per person were used in adolescents from state schools, and two recalls in those from private schools. The information thus collected was analyzed with Food Processor software (Nutrition Analysis ESHA), with which total calorie and macronutrient intake, percent macronutrients in total calories, and daily calcium intake were determined.Based on the frequency distributions obtained for this group of adolescents, calcium consumption was divided into three groups: adequate intake: adolescents who consumed 1200mg/day or more; low intake: those consuming less than 1200mg/day; very low intake: those consuming 600mg/day of calcium or less.A consumption frequency questionnaire was used to assess the consumption of dairy products (milk, cheese, and yogurt). Adequate intake was defined as the consumption of one or more portions of dairy products daily, and low intake as the consumption of less than one portion daily.Data analysis. Variables were analyzed using descriptive statistics and are given as mean±one standard deviation for continuous variables, and as percentages for nominal variables. The differences between groups were analyzed using a Student's t test for continuous variables and a χChi-square for categorical variables. To establish the association of the BMI, waist circumference, hip circumference, and waist/hip ratio with predictive variables, multiple regression analyses were performed. Values of p≤0.05 were considered statistically significant. Excel 2013 software was used to record data, and SPSS version 22 for Windows was used for processing and statistical analysis.ResultsMultiple regression analysis showed that calcium intake adjusted for calorie intake negatively correlated to the BMI (p<0.05), waist circumference (p<0.05), hip circumference (p>0.05), and waist/hip ratio (p<0.05) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>As regards the relationship between nutritional state and calcium intake, adolescents with overweight were found to have a lower mean calcium intake than adolescents of normal weight (p=0.06); adolescents with overweight were also found to have a lower calorie intake as compared to adolescents of normal weight (p=0.005) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>With regard to the association of calcium intake and body weight, overweight and obese adolescents were found to have a very low and low calcium intake, and no adolescent in these groups had an adequate calcium intake (p=0.48) (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>Finally, adolescents with a low intake of dairy products (milk, cheese, and yogurt) had on average greater values of BMI (20.09 vs 19.58) and waist circumference (71.3 vs 69.18) as compared to adolescents with adequate intake (p>0.05).DiscussionThe results of this study show that the dietary intake of calcium and dairy products was inversely correlated to body adiposity and overweight and obesity in these female adolescents.Other similar cross-sectional studies conducted on adolescents have also shown a negative correlation between calcium intake and anthropometric indicators (weight, the BMI, fat mass, and percent fat).<a class="elsevierStyleCrossRef" href="#bib0250">20</a> The pathophysiological mechanism of this association appears to be related to the oxidative capacity of adipose tissue, with high calcium intake inducing a decrease in intracellular calcium levels in adipose tissue, so promoting fat oxidation, rather than fat deposition, and, by contrast, low dietary calcium intake having the reverse effect.<a class="elsevierStyleCrossRef" href="#bib0255">21</a> Various studies in humans have similarly shown an inverse relationship between high calcium intake and the presence of metabolic disorders related to obesity such as high blood pressure, diabetes, and insulin resistance.<a class="elsevierStyleCrossRef" href="#bib0260">22</a>In addition, some studies have reported that the consumption of calcium from dairy products promotes the loss of fat mass in premenopausal obese women.<a class="elsevierStyleCrossRef" href="#bib0265">23</a> Finally, animal models have provided a potential mechanism through which low calcium intake could influence body fat deposits.<a class="elsevierStyleCrossRef" href="#bib0270">24</a> Among these mechanisms, it has been suggested that a low calcium diet increases intracellular calcium concentrations by stimulating calciotropic hormones such as 1,25 dihydroxyvitamin D and parathormone, which may increase intra-adipocyte calcium. These elevated intra-adipocyte calcium concentrations may then increase the rate of lipogenesis and inhibit lipolysis, resulting in increased adiposity. Thus, an increased dietary calcium intake could be proposed to prevent the triggering of this cascade by maintaining low calciotropic hormone levels, therefore decreasing intracellular calcium and lipid contents in adipocytes.<a class="elsevierStyleCrossRef" href="#bib0275">25</a>On the other hand, calcium has been seen to dose-dependently increase the fecal excretion of fatty acids. A person consuming 2500kcal with one third of the energy coming from fat and also taking 2g of elemental calcium daily, could be expected to excrete an additional 1% of energy from fat daily, and an energy loss of 3010kcal/year in feces could be anticipated. This energy deficiency could cause a change in body weight of −0.4kg/year. The effects of calcium on fat excretion are however insufficient to explain the greater difference in body weight shown by some studies in animals and humans, particularly of calcium from dairy products. Studies conducted in transgenic mice have also shown that high calcium diets stimulate the expression of the uncoupling proteins in adipose tissue (UCP)2 and skeletal muscle (UCP)3.<a class="elsevierStyleCrossRefs" href="#bib0280">26,27</a>An additional mechanism by which dietary calcium intake may affect body adiposity is an effect on triacylglycerol absorption from the gastrointestinal tract. Calcium fortification has been shown to increase the percentage of saturated fat excreted in feces by 6–13% daily. A high calcium diet also significantly decreased total cholesterol by 6%, LDL cholesterol by 13%, and the apolipoprotein B level by 7% as compared to a low calcium diet. Dietary calcium intake may therefore be inversely related to the development of metabolic syndrome.<a class="elsevierStyleCrossRef" href="#bib0290">28</a> It would be interesting to assess whether greater calcium intake, mainly from diet, not only decreases the risk of developing overweight or obesity, but also whether the apparent lowering effect on lipid and glucose levels is able to reduce long-term cardiovascular risk.Our study mainly found that dietary calcium intake is the factor with the greatest correlation to total and abdominal adiposity, and also to the presence of overweight and obesity, while the intake of dairy products also showed a negative correlation, although not a significant one. This agrees with most studies, which found a negative correlation between the dietary intake of calcium, especially from dairy products, and the development of overweight and obesity.<a class="elsevierStyleCrossRef" href="#bib0295">29</a>The explanation for the lack of a significant correlation in our study between dairy product intake and adiposity level, in contrast to the significant association found for dietary calcium, may be that no differentiation was made of the type of dairy products preferentially consumed, i.e. if they were whole milk or skimmed milk products. Most probably, in agreement with our dietary habits, a majority consumed whole milk dairy products with high fat contents, which would explain the poor correlation between the consumption of dairy products and body adiposity, while total calcium intake was negatively and significantly associated with total adiposity, and especially with clinically important abdominal adiposity, which is closely related to glucose metabolism, hypertriglyceridemia, low HDL cholesterol, increased blood pressure, metabolic syndrome, type 2 diabetes, and cardiovascular disease.<a class="elsevierStyleCrossRef" href="#bib0300">30</a> An alternative explanation for the non-significant association between dairy product intake and the development of overweight may be the small sample size of the study.In any case, regardless of the mechanism involved, most studies support the conclusion that dietary calcium may play a role in body fat regulation and the hypothesis that increased dietary calcium intake may decrease future weight gain and reduce the risk of developing cardiometabolic disorders. However, only small clinical studies specifically designed for exploring the effects of dietary calcium on body weight, total adiposity, and lipid and glucose levels have been conducted. Prospective clinical studies should be conducted to determine whether body weight may be modified by calcium supplementation or by increasing low-fat dairy products in diet, and whether these measures may also decrease the risk of developing those metabolic changes related to visceral fat accumulation, such as diabetes or cardiovascular disease.FundingThe authors state that they have received no funding for the conduct of this research.Conflicts of interestThe authors state that they have no conflicts of interest related to the conduct of this research study." "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:3 [ "identificador" => "xres618587" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background and objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Materials and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec632612" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres618588" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Antecedentes y objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Materiales y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec632613" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Objectives" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Materials and methods" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Definition of variables" ] ] ] 7 => array:2 [ "identificador" => "sec0025" "titulo" => "Results" ] 8 => array:2 [ "identificador" => "sec0030" "titulo" => "Discussion" ] 9 => array:2 [ "identificador" => "sec0035" "titulo" => "Funding" ] 10 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of interest" ] 11 => array:2 [ "identificador" => "xack208212" "titulo" => "Acknowledgments" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-09-03" "fechaAceptado" => "2015-10-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec632612" "palabras" => array:5 [ 0 => "Adolescents" 1 => "Calcium" 2 => "Intake" 3 => "Adiposity" 4 => "Overweight" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec632613" "palabras" => array:5 [ 0 => "Adolescentes" 1 => "Calcio" 2 => "Ingesta" 3 => "Adiposidad" 4 => "Sobrepeso" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "Background and objectiveThe prevalence and magnitude of obesity in children and adolescents increase rapidly. Besides genetic and environmental factors, calcium intake has recently been identified as a dietary factor that is inversely related with body mass index and development of overweight and obesity.The purpose of this study was to assess the correlation between dietary calcium intake and body mass index and fat distribution in female adolescents. Materials and methodsThis was a cross-sectional study where anthropometric variables (weight, height, body mass index, waist and hip circumference) were collected in 244 female adolescents to establish total body adiposity and fat distribution. A 24-h recall and a food frequency questionnaire were used to assess total calorie, calcium, and dairy products intake. ResultsCalcium intake was inversely related to body mass index (p<.05), waist circumference (p<.05), hip circumference (p>.05), and waist to hip ratio (p<.05).Overweight (8.3%) and obese (0.7%) adolescents had a lower mean calcium intake than adolescents of normal weight (p=.06). ConclusionsDietary calcium intake and, to a lesser extent, consumption of dairy products are inversely related to total and abdominal adiposity, and also to the prevalence of overweight in this group of adolescents." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background and objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Materials and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "Antecedentes y objetivoLa prevalencia y magnitud de la obesidad en niños y adolescentes se incrementa aceleradamente. Aparte de los factores genéticos y ambientales, se ha identificado recientemente la ingesta de calcio dietético como uno de los factores que se correlaciona inversamente con el índice de masa corporal y con el desarrollo de sobrepeso y obesidad.El objetivo del presente estudio es determinar la correlación entre la ingesta dietética de calcio con el índice de masa corporal y la distribución de la grasa en adolescentes mujeres. Materiales y métodosEs un estudio de corte transversal en el cual se realizó la evaluación antropométrica (peso, talla, índice de masa corporal, circunferencia de cintura, circunferencia de cadera) en 244 adolescentes mujeres, para establecer la adiposidad corporal total y la distribución de la grasa. Se utilizó el recordatorio de 24h y un cuestionario de frecuencia de consumo para determinar la ingesta calórica total, ingesta de calcio y consumo de lácteos. ResultadosLa ingesta de calcio se correlacionó inversamente con el índice de masa corporal (p<0,05), circunferencia de cintura (p<0,05), circunferencia de cadera (p>0,05) e índice cintura cadera (p<0,05).Las adolescentes con sobrepeso (8,3%) y obesidad (0,7%) tuvieron una ingesta promedio de calcio inferior al de las adolescentes de peso normal (p=0,06). ConclusionesLa ingesta dietética de calcio y en menor grado el consumo de productos lácteos se relaciona inversamente con la adiposidad total y abdominal así como con la prevalencia de sobrepeso en las adolescentes estudiadas." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Antecedentes y objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Materiales y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Castro Burbano J, Fajardo Vanegas P, Robles Rodríguez J, Pazmiño Estévez K. Relación entre ingesta dietética de calcio y adiposidad corporal en adolescentes mujeres. Endocrinol Nutr. 2016;63:58–63." ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Predictive variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Anthropometric measurements \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">r \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Calcium intake (mg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Body mass index (BMI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">BMI percentile \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.040 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Waist circumference \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.007 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hip circumference \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.081 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.20 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Waist/hip ratio \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.026 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1012681.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Multiple regression analysis between calcium intake and different anthropometric parameters." ] ] 1 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Nutritional status \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Mean intake of</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Calcium (mg) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SD \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Calories \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SD \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">No. \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Low weight \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">453.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">338.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.992.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">789.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Normal weight \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">507.84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">367.98 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.736.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">742 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">206 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Overweight \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">494.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">386.84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1336.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">483.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">485.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">364.36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.738.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">738.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">244 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">p=0.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">p=0.005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1012682.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Calorie and calcium intake by nutritional status." ] ] 2 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Calcium intake \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Low weight \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Normal \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Overweight \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Obesity \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Very low \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (57%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">97 (47.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (63.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Low \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (35.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">97 (47.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (36.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Adequate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (7.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (5.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">206 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">p=0.48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1012683.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Relationship between calcium intake and body weight." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0155" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Doenças crônicas não transmissíveis no Brasil: carga e desafios atuais. The Lancet Saúde no Brasil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.I. Schmidt" 1 => "B.B. Duncan" 2 => "G. Azevedo e Silva" 3 => "A.M. Menezes" 4 => "C.A. Monteiro" 5 => "S.M. 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Relationship between dietary calcium intake and adiposity in female adolescents

Relación entre ingesta dietética de calcio y adiposidad corporal en adolescentes mujeres

José Castro Burbano

Corresponding author

jcastro@internacional.edu.ec

Corresponding author.

, Pamela Fajardo Vanegas, Julieta Robles Rodríguez, Karina Pazmiño Estévez

Escuela de Nutriología, Universidad Internacional del Ecuador, Quito, Ecuador

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and its prevalence has increased and continues to increase in developed countries&#44; as well as in countries with economies in transition&#44; and has acquired epidemic proportions&#46; Overweight and obesity account for approximately 2&#46;6 million deaths annually&#46; Considering its multifactorial etiology&#44; genetic factors appear to have played only a secondary role in the increased prevalence of obesity&#44; while environmental factors such as diet and physical inactivity emerge as the most significant determinants of increased adiposity in the past 30 years&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The prevalence and magnitude of obesity are also rapidly increasing in children and adolescents&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> Childhood obesity is the most common cause of insulin resistance in children and adolescents and is associated with dyslipidemia&#44; type 2 diabetes mellitus&#44; long-term vascular complications&#44; and usually with increased morbidity and mortality in adulthood&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Research has often focused on the identification of combinations of macronutrients able to regulate body weight&#44; but the effects of micronutrients need to be further explored&#46; Some minerals are involved in energy metabolism and in insulin secretion and action&#44; and may interfere with obesity control&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Studies searching for epidemiological explanations of increased adiposity have identified dietary calcium intake as one of the factors inversely correlated to the body mass index &#40;BMI&#41;&#46; Thus&#44; consistent evidence concerning the role of calcium and dairy product consumption in obesity prevention has started to appear in recent years&#46; The first report by McCarron&#44; two decades ago&#44; of the finding of lower body weights in US people who reported higher calcium intake in the National Health Survey opened a line of basic&#44; clinical&#44; and molecular research aimed at first confirming&#44; and then explaining the mechanisms by which a mineral apparently unrelated to the energy equation could contribute to weight loss&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a> Short-term studies have reported negative associations between calcium consumption and the BMI&#44; percent fat&#44; and waist circumference&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a> Experimental studies in rats to determine the effect of subchronic dietary calcium intake on body weight and lipid metabolism showed that the administration of calcium added to a high-fat diet decreased body weight and abdominal fat contents during treatment&#44; from which a potential decrease in fat absorption and a potential increase in fatty tissue apoptosis was inferred&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">A reanalysis of several prospective studies designed to assess the effect of dairy products on the prevention of osteoporosis showed that groups treated with calcium or with a greater intake of dairy products consistently had less risk of overweight&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> A greater relative risk of high body adiposity was found in people with the lowest calcium intake&#44; and the risk gradually decreased as calcium intake increased&#59; relative risk was 0&#46;75 for the second quartile&#44; 0&#46;40 for the third quartile&#44; and 0&#46;16 for the fourth quartile of calcium intake in women&#46; The intake of dairy products&#44; dietary protein&#44; and calcium was associated with more favorable body composition in obese males and females&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">12&#8211;14</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The results of clinical studies of calcium intake found significant negative associations between calcium intake and body weight in all age groups&#44; and the range of probability to be overweight &#40;BMI &#62;25&#41; was 2&#46;25 for females in the lower half of calcium intake&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">15&#8211;17</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">On the other hand&#44; some studies have reported that increased consumption of dairy products with no energy restriction does not lead to a significant change in body weight or composition&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">18</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Based on the foregoing and because of the inconsistency of the effects of dairy products on body weight and composition reported by various observational and experimental studies&#44; a study was undertaken to assess whether the intake of calcium and dairy products in diet correlated to the degree of adiposity and development of overweight in a group of female adolescents&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Objectives</span><p id="par0050" class="elsevierStylePara elsevierViewall">To determine whether dietary calcium intake correlates to the BMI and body fat distribution in female adolescents&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">To determine whether dairy product intake correlates to the BMI and body fat distribution in female adolescents&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Materials and methods</span><p id="par0060" class="elsevierStylePara elsevierViewall">This was a cross-sectional&#44; observational&#44; epidemiological study that enrolled 244 female adolescents aged 12&#8211;19 years&#44; randomly selected from public and private schools from the list of schools of the Ministry of Education of Ecuador&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">All participants voluntarily agreed to take part in the study&#44; and written informed consent signed by their parents or tutors was obtained&#46; Adolescents with any physical disability that made the taking of anthropometric measurements difficult and those who had a clinical history of endocrine or metabolic problems&#44; or cardiovascular&#44; respiratory or musculoskeletal disease were excluded from the study&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The study was approved by the bioethics committee of Universidad San Francisco in Quito&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The sample was estimated with Epi Info &#40;version 6&#41; software using the following parameters&#58; 95&#37; confidence interval&#44; expected prevalence of overweight of 12&#37;&#44; and 7&#37; precision&#46;</p><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Definition of variables</span><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Anthropometrics</span>&#46; The following anthropometric measurements were taken&#58; body weight&#58; using a SECA scale &#40;Germany&#41;&#59; height&#58; using a stadiometer&#59; waist circumference&#58; measured halfway between the costal margin and the iliac crest&#59; and hip circumference&#58; measured at the widest part of the hip&#44; at the level of the greater trochanters&#44; using a non-stretchable measuring tape&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The BMI was calculated as&#58; weight &#40;kg&#41;&#47;height &#40;m<span class="elsevierStyleSup">2</span>&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Overweight and obesity</span>&#46; Overweight and obesity were defined based on the BMI&#46; Overweight was defined as a BMI above the 85th percentile&#44; and obesity as a BMI above the 95th percentile&#46; The resulting values were compared to those provided in the tables of the National Center for Health Statistics &#40;NCHS&#41; according to age and sex&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">19</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Fat distribution</span>&#46; The waist&#47;hip ratio was used to determine body fat distribution&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Intake of calories&#44; macronutrients&#44; calcium&#44; and dairy products</span>&#46; This was calculated using a 24<span class="elsevierStyleHsp" style=""></span>h recall instrument&#46; To facilitate recall of the size of portions and to decrease recall bias&#44; participants were shown the book with pictures of food portions of the American Dietetic Association&#46; To determine differences between week days and weekends&#44; three recalls per person were used in adolescents from state schools&#44; and two recalls in those from private schools&#46; The information thus collected was analyzed with Food Processor software &#40;Nutrition Analysis ESHA&#41;&#44; with which total calorie and macronutrient intake&#44; percent macronutrients in total calories&#44; and daily calcium intake were determined&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Based on the frequency distributions obtained for this group of adolescents&#44; calcium consumption was divided into three groups&#58; adequate intake&#58; adolescents who consumed 1200<span class="elsevierStyleHsp" style=""></span>mg&#47;day or more&#59; low intake&#58; those consuming less than 1200<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#59; very low intake&#58; those consuming 600<span class="elsevierStyleHsp" style=""></span>mg&#47;day of calcium or less&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">A consumption frequency questionnaire was used to assess the consumption of dairy products &#40;milk&#44; cheese&#44; and yogurt&#41;&#46; Adequate intake was defined as the consumption of one or more portions of dairy products daily&#44; and low intake as the consumption of less than one portion daily&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Data analysis</span>&#46; Variables were analyzed using descriptive statistics and are given as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>one standard deviation for continuous variables&#44; and as percentages for nominal variables&#46; The differences between groups were analyzed using a Student&#39;s <span class="elsevierStyleItalic">t</span> test for continuous variables and a <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">Chi</span></span>-square for categorical variables&#46; To establish the association of the BMI&#44; waist circumference&#44; hip circumference&#44; and waist&#47;hip ratio with predictive variables&#44; multiple regression analyses were performed&#46; Values of <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#46;05 were considered statistically significant&#46; Excel 2013 software was used to record data&#44; and SPSS version 22 for Windows was used for processing and statistical analysis&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0120" class="elsevierStylePara elsevierViewall">Multiple regression analysis showed that calcium intake adjusted for calorie intake negatively correlated to the BMI &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#44; waist circumference &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#44; hip circumference &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#44; and waist&#47;hip ratio &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">As regards the relationship between nutritional state and calcium intake&#44; adolescents with overweight were found to have a lower mean calcium intake than adolescents of normal weight &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;06&#41;&#59; adolescents with overweight were also found to have a lower calorie intake as compared to adolescents of normal weight &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">With regard to the association of calcium intake and body weight&#44; overweight and obese adolescents were found to have a very low and low calcium intake&#44; and no adolescent in these groups had an adequate calcium intake &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;48&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Finally&#44; adolescents with a low intake of dairy products &#40;milk&#44; cheese&#44; and yogurt&#41; had on average greater values of BMI &#40;20&#46;09 vs 19&#46;58&#41; and waist circumference &#40;71&#46;3 vs 69&#46;18&#41; as compared to adolescents with adequate intake &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0140" class="elsevierStylePara elsevierViewall">The results of this study show that the dietary intake of calcium and dairy products was inversely correlated to body adiposity and overweight and obesity in these female adolescents&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Other similar cross-sectional studies conducted on adolescents have also shown a negative correlation between calcium intake and anthropometric indicators &#40;weight&#44; the BMI&#44; fat mass&#44; and percent fat&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">20</span></a> The pathophysiological mechanism of this association appears to be related to the oxidative capacity of adipose tissue&#44; with high calcium intake inducing a decrease in intracellular calcium levels in adipose tissue&#44; so promoting fat oxidation&#44; rather than fat deposition&#44; and&#44; by contrast&#44; low dietary calcium intake having the reverse effect&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a> Various studies in humans have similarly shown an inverse relationship between high calcium intake and the presence of metabolic disorders related to obesity such as high blood pressure&#44; diabetes&#44; and insulin resistance&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">In addition&#44; some studies have reported that the consumption of calcium from dairy products promotes the loss of fat mass in premenopausal obese women&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a> Finally&#44; animal models have provided a potential mechanism through which low calcium intake could influence body fat deposits&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a> Among these mechanisms&#44; it has been suggested that a low calcium diet increases intracellular calcium concentrations by stimulating calciotropic hormones such as 1&#44;25 dihydroxyvitamin D and parathormone&#44; which may increase intra-adipocyte calcium&#46; These elevated intra-adipocyte calcium concentrations may then increase the rate of lipogenesis and inhibit lipolysis&#44; resulting in increased adiposity&#46; Thus&#44; an increased dietary calcium intake could be proposed to prevent the triggering of this cascade by maintaining low calciotropic hormone levels&#44; therefore decreasing intracellular calcium and lipid contents in adipocytes&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">25</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">On the other hand&#44; calcium has been seen to dose-dependently increase the fecal excretion of fatty acids&#46; A person consuming 2500<span class="elsevierStyleHsp" style=""></span>kcal with one third of the energy coming from fat and also taking 2<span class="elsevierStyleHsp" style=""></span>g of elemental calcium daily&#44; could be expected to excrete an additional 1&#37; of energy from fat daily&#44; and an energy loss of 3010<span class="elsevierStyleHsp" style=""></span>kcal&#47;year in feces could be anticipated&#46; This energy deficiency could cause a change in body weight of &#8722;0&#46;4<span class="elsevierStyleHsp" style=""></span>kg&#47;year&#46; The effects of calcium on fat excretion are however insufficient to explain the greater difference in body weight shown by some studies in animals and humans&#44; particularly of calcium from dairy products&#46; Studies conducted in transgenic mice have also shown that high calcium diets stimulate the expression of the uncoupling proteins in adipose tissue &#40;UCP&#41;2 and skeletal muscle &#40;UCP&#41;3&#46;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">26&#44;27</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">An additional mechanism by which dietary calcium intake may affect body adiposity is an effect on triacylglycerol absorption from the gastrointestinal tract&#46; Calcium fortification has been shown to increase the percentage of saturated fat excreted in feces by 6&#8211;13&#37; daily&#46; A high calcium diet also significantly decreased total cholesterol by 6&#37;&#44; LDL cholesterol by 13&#37;&#44; and the apolipoprotein B level by 7&#37; as compared to a low calcium diet&#46; Dietary calcium intake may therefore be inversely related to the development of metabolic syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">28</span></a> It would be interesting to assess whether greater calcium intake&#44; mainly from diet&#44; not only decreases the risk of developing overweight or obesity&#44; but also whether the apparent lowering effect on lipid and glucose levels is able to reduce long-term cardiovascular risk&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Our study mainly found that dietary calcium intake is the factor with the greatest correlation to total and abdominal adiposity&#44; and also to the presence of overweight and obesity&#44; while the intake of dairy products also showed a negative correlation&#44; although not a significant one&#46; This agrees with most studies&#44; which found a negative correlation between the dietary intake of calcium&#44; especially from dairy products&#44; and the development of overweight and obesity&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">29</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">The explanation for the lack of a significant correlation in our study between dairy product intake and adiposity level&#44; in contrast to the significant association found for dietary calcium&#44; may be that no differentiation was made of the type of dairy products preferentially consumed&#44; i&#46;e&#46; if they were whole milk or skimmed milk products&#46; Most probably&#44; in agreement with our dietary habits&#44; a majority consumed whole milk dairy products with high fat contents&#44; which would explain the poor correlation between the consumption of dairy products and body adiposity&#44; while total calcium intake was negatively and significantly associated with total adiposity&#44; and especially with clinically important abdominal adiposity&#44; which is closely related to glucose metabolism&#44; hypertriglyceridemia&#44; low HDL cholesterol&#44; increased blood pressure&#44; metabolic syndrome&#44; type 2 diabetes&#44; and cardiovascular disease&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> An alternative explanation for the non-significant association between dairy product intake and the development of overweight may be the small sample size of the study&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">In any case&#44; regardless of the mechanism involved&#44; most studies support the conclusion that dietary calcium may play a role in body fat regulation and the hypothesis that increased dietary calcium intake may decrease future weight gain and reduce the risk of developing cardiometabolic disorders&#46; However&#44; only small clinical studies specifically designed for exploring the effects of dietary calcium on body weight&#44; total adiposity&#44; and lipid and glucose levels have been conducted&#46; Prospective clinical studies should be conducted to determine whether body weight may be modified by calcium supplementation or by increasing low-fat dairy products in diet&#44; and whether these measures may also decrease the risk of developing those metabolic changes related to visceral fat accumulation&#44; such as diabetes or cardiovascular disease&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors state that they have received no funding for the conduct of this research&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of interest</span><p id="par0185" class="elsevierStylePara elsevierViewall">The authors state that they have no conflicts of interest related to the conduct of this research study&#46;</p></span></span>"
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            4 => "Overweight"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The prevalence and magnitude of obesity in children and adolescents increase rapidly&#46; Besides genetic and environmental factors&#44; calcium intake has recently been identified as a dietary factor that is inversely related with body mass index and development of overweight and obesity&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The purpose of this study was to assess the correlation between dietary calcium intake and body mass index and fat distribution in female adolescents&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">This was a cross-sectional study where anthropometric variables &#40;weight&#44; height&#44; body mass index&#44; waist and hip circumference&#41; were collected in 244 female adolescents to establish total body adiposity and fat distribution&#46; A 24-h recall and a food frequency questionnaire were used to assess total calorie&#44; calcium&#44; and dairy products intake&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Calcium intake was inversely related to body mass index &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#44; waist circumference &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#44; hip circumference &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#44; and waist to hip ratio &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46;Overweight &#40;8&#46;3&#37;&#41; and obese &#40;0&#46;7&#37;&#41; adolescents had a lower mean calcium intake than adolescents of normal weight &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;06&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Dietary calcium intake and&#44; to a lesser extent&#44; consumption of dairy products are inversely related to total and abdominal adiposity&#44; and also to the prevalence of overweight in this group of adolescents&#46;</p></span>"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La prevalencia y magnitud de la obesidad en ni&#241;os y adolescentes se incrementa aceleradamente&#46; Aparte de los factores gen&#233;ticos y ambientales&#44; se ha identificado recientemente la ingesta de calcio diet&#233;tico como uno de los factores que se correlaciona inversamente con el &#237;ndice de masa corporal y con el desarrollo de sobrepeso y obesidad&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El objetivo del presente estudio es determinar la correlaci&#243;n entre la ingesta diet&#233;tica de calcio con el &#237;ndice de masa corporal y la distribuci&#243;n de la grasa en adolescentes mujeres&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materiales y m&#233;todos</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Es un estudio de corte transversal en el cual se realiz&#243; la evaluaci&#243;n antropom&#233;trica &#40;peso&#44; talla&#44; &#237;ndice de masa corporal&#44; circunferencia de cintura&#44; circunferencia de cadera&#41; en 244 adolescentes mujeres&#44; para establecer la adiposidad corporal total y la distribuci&#243;n de la grasa&#46; Se utiliz&#243; el recordatorio de 24<span class="elsevierStyleHsp" style=""></span>h y un cuestionario de frecuencia de consumo para determinar la ingesta cal&#243;rica total&#44; ingesta de calcio y consumo de l&#225;cteos&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La ingesta de calcio se correlacion&#243; inversamente con el &#237;ndice de masa corporal &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#44; circunferencia de cintura &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#44; circunferencia de cadera &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; e &#237;ndice cintura cadera &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Las adolescentes con sobrepeso &#40;8&#44;3&#37;&#41; y obesidad &#40;0&#44;7&#37;&#41; tuvieron una ingesta promedio de calcio inferior al de las adolescentes de peso normal &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;06&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">La ingesta diet&#233;tica de calcio y en menor grado el consumo de productos l&#225;cteos se relaciona inversamente con la adiposidad total y abdominal as&#237; como con la prevalencia de sobrepeso en las adolescentes estudiadas&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Antecedentes y objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Materiales y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Castro Burbano J&#44; Fajardo Vanegas P&#44; Robles Rodr&#237;guez J&#44; Pazmi&#241;o Est&#233;vez K&#46; Relaci&#243;n entre ingesta diet&#233;tica de calcio y adiposidad corporal en adolescentes mujeres&#46; Endocrinol Nutr&#46; 2016&#59;63&#58;58&#8211;63&#46;</p>"
      ]
    ]
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      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Predictive variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Anthropometric measurements&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">r</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Calcium intake &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Body mass index &#40;BMI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">BMI percentile&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;040&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Waist circumference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hip circumference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;081&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Waist&#47;hip ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;026&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1012681.png"
              ]
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          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Multiple regression analysis between calcium intake and different anthropometric parameters&#46;</p>"
        ]
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      1 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Nutritional status&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Mean intake of</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Calcium &#40;mg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Calories&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">No&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Low weight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">453&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">338&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;992&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">789&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Normal weight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">507&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">367&#46;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;736&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">742&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">206&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Overweight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">494&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">386&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1336&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">483&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">485&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">364&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;738&#46;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">738&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">244&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Calorie and calcium intake by nutritional status&#46;</p>"
        ]
      ]
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        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Calcium intake&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Low weight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Overweight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Obesity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Very low&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;57&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">97 &#40;47&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;63&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Low&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;35&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">97 &#40;47&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;36&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Adequate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;7&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;5&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">206&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Relationship between calcium intake and body weight&#46;</p>"
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:30 [
            0 => array:3 [
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Article information

ISSN: 21735093
Original language: English

DOI:10.1016/j.endoen.2016.02.007

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	2	0	2
2024 October	24	5	29
2024 September	31	7	38
2024 August	31	3	34
2024 July	19	6	25
2024 June	29	0	29
2024 May	24	11	35
2024 April	32	6	38
2024 March	31	2	33
2024 February	22	8	30
2024 January	15	3	18
2023 December	23	7	30
2023 November	27	7	34
2023 October	23	5	28
2023 September	18	0	18
2023 August	16	8	24
2023 July	19	6	25
2023 June	15	5	20
2023 May	16	4	20
2023 April	20	5	25
2023 March	21	4	25
2023 February	25	1	26
2023 January	16	4	20
2022 December	28	7	35
2022 November	40	5	45
2022 October	52	44	96
2022 September	25	14	39
2022 August	21	9	30
2022 July	11	5	16
2022 June	14	7	21
2022 May	13	7	20
2022 April	33	8	41
2022 March	33	13	46
2022 February	36	9	45
2022 January	57	23	80
2021 December	51	9	60
2021 November	40	13	53
2021 October	44	25	69
2021 September	30	15	45
2021 August	51	6	57
2021 July	25	13	38
2021 June	19	12	31
2021 May	28	9	37
2021 April	79	31	110
2021 March	78	10	88
2021 February	47	15	62
2021 January	66	24	90
2020 December	62	30	92
2020 November	111	40	151
2020 October	77	16	93
2020 September	42	13	55
2020 August	41	14	55
2020 July	55	16	71
2020 June	24	10	34
2020 May	35	9	44
2020 April	27	5	32
2020 March	41	5	46
2020 February	32	12	44
2020 January	31	5	36
2019 December	25	13	38
2019 November	27	17	44
2019 October	18	3	21
2019 September	27	11	38
2019 August	13	8	21
2019 July	21	17	38
2019 June	25	13	38
2019 May	86	20	106
2019 April	21	26	47
2019 March	10	5	15
2019 February	13	11	24
2019 January	6	4	10
2018 December	8	2	10
2018 November	7	4	11
2018 October	10	5	15
2018 September	23	5	28
2018 August	4	1	5
2018 July	3	7	10
2018 June	7	5	12
2018 May	12	2	14
2018 April	7	3	10
2018 March	3	0	3
2018 February	10	1	11
2018 January	5	2	7
2017 December	13	0	13
2017 November	12	1	13
2017 October	12	3	15
2017 September	12	3	15
2017 August	20	0	20
2017 July	4	5	9
2017 June	18	15	33
2017 May	19	6	25
2017 April	7	33	40
2017 March	26	35	61
2017 February	40	3	43
2017 January	15	1	16
2016 December	17	3	20
2016 November	14	2	16
2016 October	43	3	46
2016 September	40	7	47
2016 August	23	1	24
2016 May	0	1	1

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Now is Endocrinología, Diabetes y Nutrición (English ed.). More information

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