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Eikenella corrodens causing deep-seated infections. Six-year experience in a University Hospital in Madrid
Infecciones por Eikenella corrodens en localizaciones profundas. Experiencia de 6 años en un hospital universitario de Madrid
Lourdes Rodríguez-Rojasa,b, Amaya Suarez-Lópeza,b,
Corresponding author
amayinsl@gmail.com

Corresponding author.
, Rafael Cantóna,b, Patricia Ruiz-Garbajosaa,b
a Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
b Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Eikenella corrodens</span> &#40;EC&#41; belongs to the family <span class="elsevierStyleItalic">Neisseriaceae</span>&#46; It is a small&#44; non-motile&#44; non-spore-forming&#44; facultatively anaerobic gramnegative rod&#46; It grows slowly on blood or chocolate agar at 37<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; Colonies are greyish&#44; sometimes surrounded by a greenish discoloration on the blood agar&#44; and produce a bleach-like odour&#46; About 50&#37; of the strains pit or corrode the agar&#44; and this characteristic gave the microorganism its name&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Nowadays&#44; matrix-assisted laser desorption ionisation&#8211;time of flight &#40;MALDI-TOF&#41; mass spectrometry is a rapid and accurate tool for the identification of <span class="elsevierStyleItalic">E&#46; corrodens</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">E&#46; corrodens</span> is a component of the normal microbiota of the oropharynx and is a common cause of periodontitis and opportunistic infections of the head and neck&#46; It is also a typical pathogen of human bite wounds or clenched-fist injuries&#46; Deep-seated infections such as pleuropulmonary and abdominal infections have been described&#46; Pleuropulmonary infections are seen in patients with medical history of aspirative pneumonia and alcoholism&#44; and abdominal infections are often preceded by surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Intravenous drug users are at risk of bacteraemia and endocarditis&#46; Osteomyelitis can occur following a puncture wound with objects such as forks&#44; toothpicks and fish bones&#44; or after a human bite or clenched-fist injury&#46; Thyroid abscesses and central nervous system infections have been described in children&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Deep-seated infections caused by this micoorganism are unusual and its identification may raise some doubts regarding antibiotic choice and length of treatment&#46; Despite appropriate antimicrobial therapy&#44; <span class="elsevierStyleItalic">E&#46; corrodens</span> infections tend to relapse if treatment is withhold too early and drainage may be necessary to achieve cure&#46; We describe 9 cases of deep-seated infections located in anatomical regions different from the head and neck diagnosed at our hospital between 2010 and 2015&#46; We decided to review these cases in order to describe the clinical characteristics&#44; management&#44; and outcomes of this infection these infections&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">E&#46; corrodens</span> isolates cultured from abscesses or usually sterile sites were identified preforming a restrospective review of the laboratory database and clinical and surgical records of these patients&#44; during the years 2010&#8211;2015&#46; Identification of <span class="elsevierStyleItalic">E&#46; corrodens</span> was performed using conventional culture techniques and biochemical tests&#44; and mass spectrometry &#40;MALDI-TOF MS&#59; Bruker Daltonics&#44; Leipzig&#44; Germany&#41;&#46; Susceptibility testing was performed with MIC gradient strips &#40;Etest&#44; BioMerieux&#44; France&#41; and interpreted according to the Clinical and Laboratory Standards Institute &#40;CLSI&#41; criteria&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">E&#46; corrodens</span> was isolated from 39 clinical samples during the study period&#58; 21 head and neck abscesses&#44; 9 superficial wounds&#44; and 9 deep-seated abscesses or usually sterile sites or fluids&#46; These last nine cases were selected for the study&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Case reports</span><p id="par0035" class="elsevierStylePara elsevierViewall">Patient &#35;1&#58; 72-year-old man who presented with asymptomatic jaundice and was diagnosed of adenocarcinoma of the pancreatic head and underwent cephalic pancreaticoduodenectomy&#46; Postoperatively&#44; the patient was febrile and had elevated sepsis markers&#46; An abdominal computed tomography &#40;CT&#41; scan showed a single suprahepatic collection that was drained percutaneously and grew <span class="elsevierStyleItalic">E&#46; corrodens</span> in pure culture&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Patient &#35;2&#58; 66-year-old man&#44; admitted for urgent surgery due to acute abdomen secondary to a perforated tumoral mass on the transverse colon&#46; Two weeks after surgery the patient was febrile and the CT scan showed a subphrenic collection&#44; which was drained through a percutaneous catheter&#46; <span class="elsevierStyleItalic">E&#46; corrodens</span> was isolated in pure culture&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Patient &#35;3&#58; 49-year-old man on peritoneal dialysis for 2 years&#44; who noted suppuration around the insertion point of the catheter&#46; The catheter was removed and samples of the discharge and peritoneal fluid were submitted for culture&#44; and pure growth of <span class="elsevierStyleItalic">E&#46; corrodens</span> was obtained&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Patient &#35;4&#58; 68-year old man who presented to the emergency room two weeks after laparoscopic cholecystectomy because of persistent fever and right upper quadrant pain&#46; The CT scan showed a 10<span class="elsevierStyleHsp" style=""></span>cm liver abscess&#46; The sample obtained from the drainage of the abscess grew a pure culture of <span class="elsevierStyleItalic">E&#46; corrodens</span>&#46; Blood cultures were also positive for this organism&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Patient &#35;5&#58; 83-year-old diabetic woman who complained of productive cough and right-sided chest pain&#46; CT scan revealed a pleural effusion occupying the whole hemithorax&#44; which was drained through a chest tube&#46; The sample thus obtained was purulent and grew <span class="elsevierStyleItalic">E&#46; corrodens</span> and <span class="elsevierStyleItalic">Staphylococcus intermedius</span>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Patient &#35;6&#58; 49-year-old woman with no relevant medical history&#44; who consulted for chest pain and cough in the last 72<span class="elsevierStyleHsp" style=""></span>h&#46; She referred that 2 months ago she noted suppuration through the right inguinal region that ceased spontaneously&#46; Physical examination revealed hypoventilation in the right lung&#46; A thoracoabdominal CT scan showed a pleural effusion occupying two thirds of the lung&#44; a pararenal fluid collection affecting the psoas muscle&#44; and a liver abscess&#46; The empyema and the psoas abscess were drained&#44; whereas the liver abscess was monitored through imaging and resolved with antibiotic therapy alone&#46; <span class="elsevierStyleItalic">E&#46; corrodens</span> was found in both pleural fluid and psoas abscess samples&#46; In addition&#44; <span class="elsevierStyleItalic">Prevotella</span> spp&#46; was isolated form the pleural fluid and <span class="elsevierStyleItalic">Fusobacterium spp&#46;</span> from the psoas abscess sample&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Patient &#35;7&#58; 47-year-old alcoholic man who complained of fever and purulent sputum&#46; Poor oral hygiene was noted during physical examination&#46; CT scan imaging revealed a lung cavitation with an air-fluid level in the left upper lobe&#46; Drainage was performed through transthoracic puncture and grew <span class="elsevierStyleItalic">E&#46; corrodens</span>&#44; <span class="elsevierStyleItalic">Corynebacterium</span> spp&#46;&#44; and <span class="elsevierStyleItalic">Streptococcus</span> spp&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Patient &#35;8&#58; 54-year-old woman with a history of recent bariatric surgery and postoperative nosocomial pneumonia&#44; presenting a month after discharge with dyspnoea and chest pain&#46; Massive left empyema was diagnosed through CT scan and drainage&#46; <span class="elsevierStyleItalic">E&#46; corrodens</span> was identified in the sample&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Patient &#35;9&#58; 66-year-old man presenting a worsening of the respiratory function and a bilious fluid drain from the chest tube on the postoperative phase of esophagectomy used to treat a locally advanced oesophageal cancer&#46; The CT scan showed bilateral pleural effusion and the fluid sent for culture grew <span class="elsevierStyleItalic">E&#46; corrodens</span>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The mean age was 61 years &#40;&#177;12&#46;25 SD&#41;&#46; Six of the 9 patients were male&#46; <span class="elsevierStyleItalic">E&#46; corrodens</span> grew in pure culture in 6 cases&#44; whereas in 3 cases the infection was polymicrobial&#46; <span class="elsevierStyleItalic">E&#46; corrodens</span> isolates were susceptible to penicillin &#40;85&#46;7&#37;&#41;&#44; ampicillin &#40;85&#46;7&#37;&#41;&#44; amoxicillin-clavulanate &#40;85&#46;7&#37;&#41;&#44; cefotaxime &#40;100&#37;&#41;&#44; imipenem &#40;100&#37;&#41;&#44; ciprofloxacin &#40;100&#37;&#41;&#44; tetracycline &#40;100&#37;&#41;&#44; cotrimoxazole &#40;77&#46;7&#37;&#41; and rifampicin &#40;75&#37;&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">All patients were treated with antibiotics for at least 4 weeks&#44; except the patient on peritoneal dialysis &#40;patient &#35;2&#41;&#44; who recovered after 2 weeks of treatment&#46; All infections resolved after antibiotics and draining if needed &#40;see <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">E&#46; corrodens</span> is an opportunistic pathogen that shows a propensity towards the formation of abscesses in any location&#46; Infections tend to be indolent and benign&#44; but invasive infections and relapse have been described&#46; This slow-growing&#44; fastidious bacterium is often involved in polymicrobial infections and thus might be underdiagnosed because it is outgrown by coinfecting microorganisms in conventional culture media&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">It has been described that <span class="elsevierStyleItalic">E&#46; corrodens</span> shows exponential growth in the presence of different strains of <span class="elsevierStyleItalic">Streptotoccus</span> spp&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Polymicrobial infections are in fact frequent and in some series account for up to 65&#37; of cases&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;6</span></a> with <span class="elsevierStyleItalic">Streptococcus</span> spp&#46; and anaerobes being the species usually involved&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In the present study we have found that a break in mucocutaneous barriers &#40;invasive procedures&#44; surgery&#44; peritoneal catheter&#41; can lead to bacteraemia and deep-seated <span class="elsevierStyleItalic">E&#46; corrodens</span> infections&#46; Five of the patients in this series had undergone such a procedure&#46; In a small series&#44; several <span class="elsevierStyleItalic">E&#46; corrodens</span> abdominal abscesses secondary to surgery have been reported&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> Microaspiration could be a mechanism of respiratory infections&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Most <span class="elsevierStyleItalic">E&#46; corrodens</span> isolates are susceptible to penicillin&#44; ampicillin&#44; second- and third-generation cephalosporins&#44; carbapenems&#44; fluoroquinolones&#44; and tetracyclines&#46; All strains are resistant to clindamycin and metronidazole&#46; Some strains are &#946;-lactamase producers&#44; and the &#946;-lactamase is inhibited by clavulanic acid and sulbactam&#46; The production of &#946;-lactamase and the resistance to streptomycin and sulphonamides has been associated with a plasmid&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> and with a transposon&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> A non-inducible &#946;-lactamase encoded by the chromosome has also been described in this organism&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> The 9 cases presented here were successfully treated with &#946;-lactams or levofloxacin and 7 patients required surgical drainage&#46; Incision and drainage of the abscesses and debridement of necrotic tissue have been found essential to achieve proper healing&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a><span class="elsevierStyleItalic">E&#46; corrodens</span> infections are prone to cause relapses even with appropriate therapy&#44; so avoiding early cessation of antibiotic and assessing the necessity of new imaging are recommended in order to assess the development of collections when response to treatment is poor are recommended&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">In conclusion&#44; deep-seated infections in which <span class="elsevierStyleItalic">E&#46; corrodens</span> is involved are often present in patients with comorbid conditions and subjected to invasive procedures that may serve as the route of entry for the pathogen&#46; Despite being a bacterium susceptible to several antibiotics&#44; patients are often treated with broad-spectrum antibiotics for a long period of time&#44; even in the absence of no coinfecting microorganisms where cultured&#46; This may be explained by the clinical suspicion of a polymicrobial infection or due to the characteristic torpid evolution of abscesses caused by <span class="elsevierStyleItalic">E&#46; corrodens</span>&#44; which tend to relapse if antibiotic therapy is stopped too early&#46; Proper imaging to assess the evolution of the collections is important to monitor the response to therapy&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Funding</span><p id="par0115" class="elsevierStylePara elsevierViewall">The present investigation has not received specific subsidies from agencies of the public sector&#44; commercial sector or non-profit entities&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of interests</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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          "titulo" => "Resumen"
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              "titulo" => "Introducci&#243;n"
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          "titulo" => "Palabras clave"
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          "titulo" => "Case reports"
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          "titulo" => "Discussion"
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    "fechaRecibido" => "2019-01-07"
    "fechaAceptado" => "2019-04-03"
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        0 => array:4 [
          "clase" => "keyword"
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          "identificador" => "xpalclavsec1197697"
          "palabras" => array:3 [
            0 => "<span class="elsevierStyleItalic">Eikenella corrodens</span>"
            1 => "Deep-seated infections"
            2 => "Abscess"
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:3 [
            0 => "<span class="elsevierStyleItalic">Eikenella corrodens</span>"
            1 => "Infecciones en localizaciones profundas"
            2 => "Absceso"
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    "resumen" => array:2 [
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Eikenella corrodens</span> &#40;EC&#41; is part of the normal microbiota of the oropharynx and a recognised opportunistic pathogen&#46; It is mainly involved in head and neck infections&#44; but it has also been identified as a cause of pleuropulmonary and intraabdominal infections&#46; Its identification could be difficult due to its fastidious growth requirements&#44; especially in the context of polymicrobial infection and is probably underreported&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We carried out a retrospective 5-year review of clinical charts and laboratory database&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We describe the clinical and microbiological characteristics of 9 deep-seated infections caused by EC&#44; diagnosed in locations different from the head and neck&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">EC deep-seated infections are often found in patients with comorbid conditions and a history of interventional procedures&#46; Due to the characteristic torpid evolution of EC abscesses&#44; imaging to assess the necessity of debridement and avoid early cessation of antibiotics is necessary&#46;</p></span>"
        "secciones" => array:4 [
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            "titulo" => "Introduction"
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            "titulo" => "Methods"
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            "titulo" => "Results"
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            "titulo" => "Conclusion"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Eikenella corrodens</span> &#40;EC&#41; es parte de la microbiota habitual orofar&#237;ngea y un conocido pat&#243;geno oportunista&#46; Est&#225; involucrado principalmente en infecciones de cabeza y cuello&#44; pero tambi&#233;n causa de infecciones pleuropulmonares e intraabdominales&#46; Su identificaci&#243;n podr&#237;a ser dif&#237;cil debido a sus exigentes requisitos de crecimiento&#44; especialmente en el contexto de la infecci&#243;n polimicrobiana y probablemente sea un microorganismo infradiagnosticado&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Realizamos una revisi&#243;n retrospectiva de 5 a&#241;os de las historias cl&#237;nicas y la base de datos del laboratorio&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Describimos las caracter&#237;sticas cl&#237;nicas y microbiol&#243;gicas de 9 casos de infecciones en localizaciones profundas causadas por EC&#44; diagnosticadas en localizaciones diferentes de la cabeza y el cuello&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Las infecciones profundas por EC aparecen con frecuencia en pacientes con comorbilidades y antecedentes de procedimientos invasivos&#46; Dada la evoluci&#243;n t&#243;rpida caracter&#237;stica de los abscesos causados por EC&#44; emplear t&#233;cnicas de imagen para valorar la necesidad de desbridamiento y evitar la retirada prematura de los antimicrobianos&#46;</p></span>"
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            "titulo" => "Resultados"
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            "titulo" => "Conclusiones"
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        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patient&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Site of infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Underlying disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Possible route of entry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Polymicrobial infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Drainage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Antibiotic treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraabdominal abscess&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pancreatic adenocarcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Piperacillin-tazobactam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intraabdominal abscess&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Perforated colonic adenocarcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Piperacillin-tazobactam&#44; gentamicin&#44; metronidazole&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peritonitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chronic kidney disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peritoneal dyalisis catheter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Levofloxacin&#44; vancomycin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Liver abscess&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acute cholecystitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Laparoscopic colecistechtomy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Piperacillin-tazobactam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Empyema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">S&#46; intermedius</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Piperacillin-tazobactam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Liver and psoas abscess&#44; empyema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Unknown&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Prevotella</span> spp&#44; <span class="elsevierStyleItalic">Fusobacterium</span> spp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Meropenem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Empyema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alcohol abuse&#44; periodontal disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aspiration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Streptococcus</span> spp&#44; <span class="elsevierStyleItalic">Corynebacterium</span> spp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ertapenem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Empyema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Morbid obesity&#44; post-surgery pneumonia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Piperacillin-tazobactam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Empyema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Oesophageal cancer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Meropenem&#44; linezolid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Clinical characteristics and treatment of deep-seated <span class="elsevierStyleItalic">Eikenella corrodens</span> infections&#46;</p>"
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      "titulo" => "References"
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        0 => array:2 [
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            0 => array:3 [
              "identificador" => "bib0055"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;<span class="elsevierStyleItalic">Eikenella corrodens</span>&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Muhlhauser"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4067/S0716-10182013000200007"
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Chilena Infectol"
                        "fecha" => "2013"
                        "volumen" => "30"
                        "paginaInicial" => "163"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23677155"
                            "web" => "Medline"
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                          "pii" => "S0967586812006510"
                          "estado" => "S300"
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            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of HACEK clinical isolates by matrix-assisted laser desorption ionization-time of flight mass spectrometry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;R&#46; Couturier"
                            1 => "E&#46; Mehinovic"
                            2 => "A&#46;C&#46; Croft"
                            3 => "M&#46;A&#46; Fisher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Microbiol"
                        "fecha" => "2011"
                        "volumen" => "4"
                        "paginaInicial" => "1104"
                        "paginaFinal" => "1106"
                      ]
                    ]
                  ]
                ]
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            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical features of patients with invasive <span class="elsevierStyleItalic">Eikenella corrodens</span> infections and microbiological characteristics of the causative isolates"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "W&#46;S&#46; Sheng"
                            1 => "P&#46;R&#46; Hsueh"
                            2 => "C&#46;C&#46; Hung"
                            3 => "L&#46;J&#46; Teng"
                            4 => "Y&#46;C&#46; Chen"
                            5 => "K&#46;T&#46; Luh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/pl00011259"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Clin Microbiol Infect Dis"
                        "fecha" => "2001"
                        "volumen" => "20"
                        "paginaInicial" => "231"
                        "paginaFinal" => "236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11399011"
                            "web" => "Medline"
                          ]
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            3 => array:3 [
              "identificador" => "bib0070"
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                0 => array:2 [
                  "contribucion" => array:1 [
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                        "editores" => "J&#46;Cherry, G&#46;Demmler-Harrison, S&#46;Kaplan, W&#46;Steinbach, P&#46;Hotez"
                        "titulo" => "Feigin and Cherry&#39;s Textbook of Pediatric Infectious Diseases"
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                        "serieFecha" => "2013"
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                      "titulo" => "Interactions between <span class="elsevierStyleItalic">Eikenella corrodens</span> and &#8216;<span class="elsevierStyleItalic">Streptococcus milleri</span>-group&#8217; organisms&#58; possible mechanisms of pathogenicity in mixed infections"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46;A&#46; Young"
                            1 => "R&#46;P&#46; Allaker"
                            2 => "J&#46;M&#46; Hardie"
                            3 => "R&#46;A&#46; Whiley"
                          ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/bf00399626"
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                        "tituloSerie" => "Antonie Van Leeuwenhoek"
                        "fecha" => "1996"
                        "volumen" => "69"
                        "paginaInicial" => "371"
                        "paginaFinal" => "373"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8836435"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Eikenella corrodens</span> infections in children and adolescents&#58; case reports and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Paul"
                            1 => "S&#46;S&#46; Patel"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/320883"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2001"
                        "volumen" => "33"
                        "paginaInicial" => "54"
                        "paginaFinal" => "61"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11389495"
                            "web" => "Medline"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Five cases of extraoral infection associated with <span class="elsevierStyleItalic">Eikenella corrodens</span>"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Nebreda"
                            1 => "F&#46;J&#46; Merino"
                            2 => "A&#46; Campos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/bf01709594"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Clin Microbiol Infect Dis"
                        "fecha" => "1997"
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Article information
ISSN: 0213005X
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

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Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos