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B) Vista lateral. C) Cicatriz posquirúrgica a los 5 meses, sin recidiva. D) Extirpación quirúrgica del quiste subcutáneo. E) Espécimen macroscópico encapsulado, bilobulado, con secreción amarillenta. F) Histopatología con infiltrado inflamatorio y células multinucleadas (H&E 40×). G) Histopatología con infiltrado inflamatorio, necrosis e hifas pigmentadas septadas (flechas negras) (H&E 40×).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Daniela Valencia-Brito, Janeth Villanueva-Reyes" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Daniela" "apellidos" => "Valencia-Brito" ] 1 => array:2 [ "nombre" => "Janeth" "apellidos" => "Villanueva-Reyes" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2529993X23002459" "doi" => "10.1016/j.eimce.2023.07.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X23002459?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X2300174X?idApp=UINPBA00004N" "url" => "/0213005X/0000004100000009/v1_202311020958/S0213005X2300174X/v1_202311020958/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0213005X23000095" "issn" => "0213005X" "doi" => "10.1016/j.eimc.2022.12.010" "estado" => "S300" "fechaPublicacion" => "2023-11-01" "aid" => "2690" "copyright" => "Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Enferm Infecc Microbiol Clin. 2023;41:577-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Diagnóstico a primera vista</span>" "titulo" => "«Cuando la falta de protección nos acerca a nuestros orígenes». El inicio de una pandemia" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "577" "paginaFinal" => "578" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "«When lack of protection brings us closer to our origins». The start of a pandemic" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 564 "Ancho" => 755 "Tamanyo" => 65299 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Lesiones pustulosas y ulceradas de dispersión perianal con centro necrótico y bordes sobreelevados.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Irene Carrillo, Margarita Jo Velasco, Laura Fuertes de Vega, Beatriz Álvarez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Irene" "apellidos" => "Carrillo" ] 1 => array:2 [ "nombre" => "Margarita Jo" "apellidos" => "Velasco" ] 2 => array:2 [ "nombre" => "Laura" "apellidos" => "Fuertes de Vega" ] 3 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Álvarez" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2529993X23001193" "doi" => "10.1016/j.eimce.2023.04.014" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529993X23001193?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X23000095?idApp=UINPBA00004N" "url" => "/0213005X/0000004100000009/v1_202311020958/S0213005X23000095/v1_202311020958/es/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Diagnosis at first sight</span>" "titulo" => "Unusual peripheric facial palsy" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "579" "paginaFinal" => "580" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Sandra Aixut, Giulia Pisano, Maria Luisa Aznar, Joan Martínez-Campreciós" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Sandra" "apellidos" => "Aixut" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "Giulia" "apellidos" => "Pisano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "Maria Luisa" "apellidos" => "Aznar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:4 [ "nombre" => "Joan" "apellidos" => "Martínez-Campreciós" "email" => array:1 [ 0 => "jmc3689@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Infectious Diseases, Vall d’Hebron University Hospital, PROSICS Barcelona, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Pediatrics, La Fe University Hospital, Valencia, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Parálisis facial periférica de causa inusual" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2084 "Ancho" => 2340 "Tamanyo" => 484664 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Note de lymph-node enlargement on the right cervical area and the peripheric facial palsy (A). Chest X-ray showing a soft infiltrate in the left lung-base (B). After two months of Tuberculosis treatment (C, D).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case clinical description</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 2-year-old boy was admitted to our hospital with a 4-month history of fever, cough, weight loss and right laterocervical swelling. Purulent discharge from the right cervical region and ear was reported. The father had been treated for pulmonary tuberculosis (TB) the year before. At the time of admission, the patient was afebrile, with proper oxygen saturation but tachycardic. He presented severe acute malnutrition (<span class="elsevierStyleItalic">z</span>-score −4 SD). Moreover, one could observe at a glance the presence of a large mass on the right laterocervical area without clear fistulas, hard on touch and which extended to the submandibular angle. Additionally, a right peripherical facial palsy could be noticed (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). On chest auscultation, we heard left lung-base crackles.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Evolution</span><p id="par0010" class="elsevierStylePara elsevierViewall">In the chest X-ray, we observed a soft infiltrate in the left base without perihilar or mediastinal masses. Rapid capillary HIV test (Alere Determine HIV 1/2, Abbott) was negative. Molecular testing (Xpert MTB/RIF ultra, Cepheid) of a nasogastric aspirate sample was negative for TB, and later on, positive in a purulent sample taken from the ear. No rifampicin resistance was detected. Under the diagnosis of a peripheric facial palsy caused by a TB otomastoiditis associated to a cervical scrofula, standard four first-line TB treatment was initiated. Due to its absence, and the impossibility of transferring the patient to a tertiary hospital, no other radiological tests could be made. Given the impossibility to perform a surgical facial nerve decompression, corticosteroid treatment was considered but finally rejected due to the poor nutritional status and increased risk of infection. Local right-eye care was recommended. In addition, the patient presented a <span class="elsevierStyleItalic">P. falciparum</span> infection that was treated with an artemisinin-based regimen, received a short course of ceftriaxone for suspected left basal pneumonia as well as nutritional support with therapeutic milk. After two months of follow-up the child was gaining weight, systemic symptoms had disappeared and cervical swelling and facial palsy had improved (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Final comment</span><p id="par0015" class="elsevierStylePara elsevierViewall">Otomastoiditis is a rare form of extrapulmonary TB (0.1% of all cases) accounting for less than 1% of chronic middle ear infections.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> It can occur by aspiration of mucus through the eustachian tube, by direct implantation through the external auditory canal, or as a result of hematogenous spread.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a> Otorrhea is the main symptom reported. Although uncommon, the triad of painless otorrhea, multiple perforation of the tympanic membrane and peripheral facial palsy should raise suspicion of TB. Diagnosis is often delayed, especially in regions with a low burden of TB and in cases of chronic isolated non-painful otorrhea. Acid-fast staining, molecular testing and culture from local discharge or biopsy samples can give the diagnosis. Concomitant pulmonary involvement is reported in up to 50% of cases. Local complications such as tympanic perforation, hearing loss, mastoiditis, subperiosteal abscesses or facial paralysis are frequent and can lead to persistent sequelae. Intracranial extension is infrequent.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> Antituberculostatics given for 6–9 months is the mainstay of treatment. In case of complications, surgical approaches such as mastoidectomy or facial nerve decompression must be considered.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Authors’ contribution</span><p id="par0020" class="elsevierStylePara elsevierViewall">We were all involved in the patient's care and diagnosis. S.A. and J.M.C. wrote the first draft of the manuscript which was edited and finally approved by G.P., A.N. and M.L.A.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Informed consent</span><p id="par0025" class="elsevierStylePara elsevierViewall">Written consent for publication was obtained from the patient's mother.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Financial disclosure</span><p id="par0030" class="elsevierStylePara elsevierViewall">This research received no specific grant from any funding agency in the public, commercial, or non-profit sectors.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conflict of interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interests.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Case clinical description" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Evolution" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Final comment" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Authors’ contribution" ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Informed consent" ] 5 => array:2 [ "identificador" => "sec0030" "titulo" => "Financial disclosure" ] 6 => array:2 [ "identificador" => "sec0035" "titulo" => "Conflict of interest" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2084 "Ancho" => 2340 "Tamanyo" => 484664 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Note de lymph-node enlargement on the right cervical area and the peripheric facial palsy (A). Chest X-ray showing a soft infiltrate in the left lung-base (B). After two months of Tuberculosis treatment (C, D).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis of the middle ear: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "K.K. Pai" 1 => "A.O. Omiunu" 2 => "D.K. Peddu" 3 => "V.H. Au" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjoto.2022.103571" "Revista" => array:5 [ "tituloSerie" => "Am J Otolaryngol" "fecha" => "2022" "volumen" => "43" "paginaInicial" => "103571" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35963106" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0025" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculous otitis media: a case presentation and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.K. Aremu" 1 => "B.S. Alabi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bcr.02.2010.2721" "Revista" => array:3 [ "tituloSerie" => "BMJ Case Rep" "fecha" => "2010" "volumen" => "2010" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculous otomastoiditis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.M. Hand" 1 => "G.A. Pankey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/microbiolspec.TNMI7-0020-2016" "Revista" => array:3 [ "tituloSerie" => "Microbiol Spectr" "fecha" => "2016" "volumen" => "4" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/0213005X/0000004100000009/v1_202311020958/S0213005X23000186/v1_202311020958/en/main.assets" "Apartado" => array:4 [ "identificador" => "8596" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Diagnóstico a primera vista" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/0213005X/0000004100000009/v1_202311020958/S0213005X23000186/v1_202311020958/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213005X23000186?idApp=UINPBA00004N" ]
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