Article information
Resumen
La estomatitis aftosa récurrente es una de las patologías orales más frecuentes. Su etiología es todavía controvertida y se caracteriza por la aparición de úlceras dolorosas de tamaño, localización y duración variable, que recidivan periodicamente. En este trabajo analizamos las principales caracteristicas epidemiológicas, etiopatogénicas y clinico-patológicas de esta común patologia oral.
Palabras clave:
Estomatitis
aftas
recurrente
Summary
Recurrent aphtous stomatitis is one of the most frequent oral pathology. It has a controversial ethiology and it is characterised by the apparition of painful and recurrent ulcers with a variable size, location and duration. In this paper we analyse the most important epidemiological, ethiological, pathological and clinical features of this common oral pathology.
Key words:
Stomatitis
aphtae
recurrent
Laburpena
“Estomatitis aftosa recurrente” deritzon patologia, ahoan agertzen den ugarienetako bat da. Honen etiologia eztabaidagarria da. Ultzera mingarri batzu bezela agertzen da, tamainu, kokapena eta iraunkortasuna aldakorra izanik. Hauek periodiki beragertzen dira. Lan honetan patologia arrunt honetan ezaugarri epidemiologiko, etiopatogeniko eta klinikopatologiko garrantsitsuenak analizatzen ditugu. Gako hitzak: estomatitis, aftak, baliatzaile.
Gako hitzak:
estomatitis
aftak
baliatzaile
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Referencias bibliográficas
[1.]
Ship J.A..
Recurrent aphtous stomatitis. An update.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 81 (1996), pp. 141-147
[2.]
Woo S.B., Sonis S.T..
Recurrent aphtous ulcers: a review of diagnosis and treatment.
J Am Dent Assoc, 127 (1996), pp. 1202-1213
[3.]
Esparza G., Cerero R., Moreno L.A..
Estomatitis aftosa recurrente.
Gac Dent, 104 (2000), pp. 44-52
[4.]
Piantanida E.W., Samlaska C.P..
Recurrent aphtous stomatitis.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 82 (1996), pp. 472
[5.]
Rees T.D., Binnie W.H..
Recurrent aphtous stomatitis.
Dermatol Clin, 21 (1996), pp. 36-47
[6.]
Carozzo M., Carbone M., Gandolfo S..
Stomatite aftosa ricorrente: attuali concentti eziopathogenetici e terapeutici.
Minerva Stomatol, 44 (1995), pp. 467-475
[7.]
Rogers R.S..
Recurrent aphtous stomatitis: clinical characteristics and associated systemic disorders.
Semin Cutan Med Surg, 16 (1997), pp. 278-283
[8.]
Shashy R.G., Ridley M.B..
Aphtous ulcers: a difficult clinical entity.
Am J Otolarygol, 21 (2000), pp. 398-493
[9.]
Murray L.N., Amedee R.G..
Recurrent aphtous stomatitis.
J La State Med Soc, 152 (2000), pp. 10-14
[10.]
Porter S.R., Scully C., Pedersen A..
Recurrent aphtous stomatitis.
Crit Rev Oral Biol Med, 9 (1998), pp. 306-321
[11.]
Ship J.A., Chavez E.M., Doerr P.A., Henson B.S., Sarmedi M..
Recurrent aphtous stomatitis.
Quintessence Int, 31 (2000), pp. 95-112
[12.]
Reichart P.A..
Oral mucosal lesions in a representative cross-sectional study of aging Germans.
Community Dent Oral Epidemiol, 28 (2000), pp. 390-398
[13.]
Kovac-Kovacic M., Skaleric U..
The prevalence of oral mucosal lesions in a population in Ljubljana, Slovenia.
J Oral Pathol Med, 29 (2000), pp. 331-335
[14.]
Ramirez V.A., Esquivel L., Orozco R..
Frecuency of oral conditions in a dermatology clinic.
Int J Dermatol, 39 (2000), pp. 501-505
[15.]
Zain R.B..
Oral recurrent ulcers/stomatitis: prevalence in Malaysia and epidemiological update.
J Oral Sci, 42 (2000), pp. 15-19
[16.]
Ship I.I..
Epidemiologic aspects of recurrent aphtous ulcerations.
Oral Surg Oral Med Oral Pathol, 33 (1972), pp. 400-406
[17.]
Crivelli M.R., Aguas S., Adler I., Quarracino C., Bazerque P..
Influence of socioeconomic status on oral mucosa lesion prevalence in schoolchildren.
Community Dent Oral Epidemiol, 16 (1988), pp. 58-60
[18.]
Bagán J.V., Esparza G..
Estomatitis aftosa recidivante.
pp. 137-150
[19.]
Axell T., Henricsson V..
The ocurrence of recurrent aphtous stomatitis in an adult swedish population.
Acta Odontol Scand, 43 (1985), pp. 121-125
[20.]
Kleinman D.V., Swango P.A., Pindborg J.J..
Epidemiology of oral mucosal lesions in United States Schoolchildren: 1986-1987.
Community Dent Oral Epidemiol, 22 (1994), pp. 243-253
[21.]
Field E.A., Brookes V., Tyldesley W.R..
Recurrent aphtous ulceration in children. A review.
Int J Paedriatr Dent, 2 (1992), pp. 1-10
[22.]
Herbert A.A., Berg J.H..
Oral mucous membrane diseases of childhood: I Mucositis and xerostomía. II Recurrent aphtous stomatitis. III Herpetic Stomatitis.
Semin Dermatol, 11 (1992), pp. 80-87
[23.]
Ship I.I..
Inheritance of aphtous ulcers of the mouth.
J Dent Oral Epidemiol, 16 (1988), pp. 58-60
[24.]
Miller M.F., Garfunkel A.A., Ram C.A., Ship I.I..
The inheritance of recurrent aphtous stomatitis. Observations on susceptibility.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 40 (1980), pp. 409-412
[25.]
Miller M.F., Garfunkel A.A., Ram C.A., Ship I.I..
Inheritance patterns in recurrent aphtous ulcers: twin and pedigree data.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 43 (1977), pp. 886-891
[26.]
Scully C., Porter S.R..
Recurrent aphtous stomatitis: current concepts of etiology, pathogenesis and management.
J Oral Pathol Med, 18 (1989), pp. 21-27
[27.]
Lenher T., Welsh K.I., Batcheldor J.R..
The relationship of HLA-B and DR phenotypes to Behçets syndrome, recurrent oral ulceration and the class of inmune complexes.
Inmunol, 47 (1982), pp. 581-587
[28.]
Challacombe J.J., Batcheldor J.R., Kenedy L.A., Lenher T..
HLA anttigens in recurrent oral ulcerations.
Arch Derm, 113 (1977), pp. 1717-1719
[29.]
Albanidou-Farmaki E., Kayavis I.G., Polymenidis Z., Papanayotou P..
HLA-A, B, C, and DR antigens in recurrent oral ulcers.
Ann Dent, 47 (1988), pp. 5-8
[30.]
Gallina G., Cumbo V., Messina P., Caruso C..
HLA-A, B, C, DR, MT and MB antigen in recurrent aphtous stomatitis.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 59 (1985), pp. 364-370
[31.]
Ozbakir F., Yacini H., Mat C., Tuzun Y., Yurdakul S., Yilmazer S..
HLA antigens in recurrent oral ulceration: evidence against a common disease spectrum with Behçets syndrome.
Clin Exp Rheumatol, 18 (1987), pp. 21-27
[32.]
Weinberger A..
Human lymphocyte antigen (HLA) B51 is more frequent in patients with recurrent aphtous stomatitis (RAS).
Clin Exp Rheumatol, 15 (1997), pp. 118-119
[33.]
Jaber L., Weimberger A., Klein T., Yaniv I., Mukamel M..
Close association of HLA-B44 antigens in Israeli Arab adolescents with recurrent aphtous stomatitis.
Arch Otolaryngol Head Nech Surg, 127 (2001), pp. 184-187
[34.]
Bruno I.J., Huff J.C., Weston W.L., Cook D.T., Brice S.L..
Elevated levels of interferon gamma, tumor necrosis factor alpha, interleukins 2, 4, and 5, but not 10, are present in recurrent aphtous stomatitis.
Arch Dermatol, 134 (1998), pp. 827-831
[35.]
Stone O.J..
Aphtous stomatitis (canker sores): a consequence of high oral submucosal viscosity (the role of the extracellular matrix and the possible role of lectins.
Med Hyptheses, 36 (1991), pp. 341-344
[36.]
Yamamoto T., Yoneda K., Ueta E., Osaki T..
Serum cytokines, interleukin 2 receptor and soluble intracellular adhesion molecule-1 in oral disorders.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 78 (1994), pp. 727-735
[37.]
Hayrinen-Immonen R., Sorsa T., Nordstrom D., Malmstrom M., Konttinen Y.T..
Collagenase and stromelysin in recurrent aphtous ulcers (RAU).
Int J Oral Maxillofac Surg, 22 (1993), pp. 46-49
[38.]
Eversole L.R..
Immunopathology of oral mucosal ulcerative, dequamative and bullous diseases. Selective review of the literature.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 77 (1994), pp. 555-571
[39.]
Sun A., Chiang C.P., Chiang C.P., Chiou P.S., Wang P.S., Liu B.Y., Wu Y.C..
Immunomodulation by levamisole in patients with recurrent aphtous ulcers or oral lichen planus.
J Oral Pathol Med, 23 (1994), pp. 172-177
[40.]
Pedersen A., Hougen H.P., Kenrad B..
T-Lymphocyte in oral mucosa of patients with recurrent aphtous ulceration.
J Oral Pathol Med, 21 (1992), pp. 176-180
[41.]
Sisting S., Cekic-Arambasin A., Rabatic S., Vucicevic-Boras V., Kleinheinz J., Piffko F..
Natural immunity in recurrent aphtous ulceration.
J Oral Pathol Med, 30 (2001), pp. 275-280
[42.]
Sun A., Chu C.T., Liu B.Y., Wang J.T., Leu J.J., Chang C.P..
Expression of interleukin 2 receptor by activated peripheal blood lymphocytes upregulated by the plasma level of interleukin 2 in patients with aphtous recurrent ulcers.
Proc Natl Sci Counc Repub China B, 24 (2000), pp. 116-122
[43.]
Freysdottir J., Lau S., Fortune F..
Gammadelta T cells in Behçets disease and recurrent aphtous stomatitis.
Clin Exp Inmunol, 118 (1999), pp. 451-457
[44.]
Bachtiar E.W., Cornain S., Siregar B., Raharjo T.W..
Decreased CD4/CD8 ratio in the major type of recurrent aphtous ulcers: comparing mayor to minor types of ulcers.
Asian Pac J Allergy Immunol, 16 (1998), pp. 75-79
[45.]
Savage N.W., Mananonda R., Seymour G.J..
The proportion of supessor-inducer T-Lymphocytes is reduced in recurrent aphtous stomatitis.
J oral Pathol, 17 (1988), pp. 293-297
[46.]
Landesberg R., Fallon M., Insel R..
Alterations of T helper/inducer and T supressor/inducer cells in patients with recurrent aphtous ulcers.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 69 (1990), pp. 205-208
[47.]
Pedersen A., Pedersen B.K..
Natural killer cell funtion and number of peripheral blood are bot altered in recurrent aphtous ulceration.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 76 (1993), pp. 616-619
[48.]
Ueta E., Umazume M., Yamamoto T., Osaki T..
Leukocyte dysfunction in oral mucous membrane diseases.
J oral Pathol Med, 22 (1993), pp. 120-125
[49.]
Rodriguez-Archilla A., Urquia M., Gomez Moreno G., Ceballos A..
Anti-DNA antibodies and circulating immune complexes (C1q-IgG) in recurrent aphtous stomatitis.
Bull Group Int Rech Sci Stomatol Odontol, 37 (1994), pp. 31-35
[50.]
Porter S.R., Scully C., Bowden J..
Immunoglobulin G in recurrent aphtous stomatitis.
J Oral Pathol Med, 21 (1992), pp. 26-27
[51.]
Vicente M., Soria A., Mosqueda A., Perez J., Lamas A., Castellano T., Ramos A..
Immunoglobulin G subclass measuraments in recurrent aphtous stomatitis.
J Oral Pathol Med, 25 (1996), pp. 538-540
[52.]
Pedersen A., Hornsleth A..
Recurrent aphtous ulceration: a possible clinical manifestation of reactivation of varicella zoster or cytomegalovirus infection.
J Oral Pathol Med, 22 (1993), pp. 648
[53.]
Sun A., Chang J.G., Kao L.L., Liu B.Y., Wang J.J., Chu C.T., Yuan J.H., Chiang C.P..
Human cytomegalovirus as a potential etiologic agent in recurrent aphtous ulcers and Behçet's disease.
J Oral Pathol Med, 25 (1996), pp. 212-218
[54.]
Pedersen A..
Are recurrent aphtous ulcers of viral etiology ?.
Med Hypotheses, 36 (1991), pp. 206-210
[55.]
Brice S.L., Cook D., Leahy M., Huff J.C., Weston W.R..
Examination of the oral mucosa and peripheral blood cells of patients with recurrent aphtous ulceration for human herpesvirus DNA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 89 (2000), pp. 193-198
[56.]
Pedersen A., Hornsleth A..
Recurrent aphtous ulceration: virological and immunological aspects.
APMIS, 101 (1993), pp. 5-37
[57.]
Ghodratnama F., Riggio M.P., Wray D..
Search for human herpesvirus 6, human cytomegalovirus and varicela zoster virus DNA in recurrent aphtous stomatitis tissue.
J Oral Pathol Med, 26 (1997), pp. 192-197
[58.]
Pedersen A., Madsen H.O., Vestergaard B.F., Ryder L.P..
Varicella zoster virus DNA in recurrent aphtous ulcers.
Scand J Dent Res, 101 (1993), pp. 311-313
[59.]
Raab-Traub N., Webster-Cyriaque J..
Epstein-Barr virus infection and expression in oral lesions.
Oral Dis, 3 (1997), pp. 164-170
[60.]
Birek C., Grandhi C., Mcneill K., Singer D., Ficarra G., Bowden G..
Detection of Helicobacter pylori in oral aphtous ulcers.
J Oral Pathol Med, 28 (1999), pp. 197-203
[61.]
Simoyama T., Horie N., Kato T., Kaneko T., Komiyama K..
Helicobacter pylori in oral ulcerations.
J Oral Sci, 42 (2000), pp. 225-229
[62.]
Porter M.P., Lennon A., Wray D..
Detection of Helicobacter pylori DNA in recurrent aphtous stomatitis tissue by PCR.
J Oral Pathol Med, 29 (2000), pp. 507-513
[63.]
Riggio M.P., Lennon A., Ghodratnama F., Wray D..
Lack of association between Streptococcus oralis and recurrent aphtous stomatitis.
J Oral Pathol Med, 29 (2000), pp. 26-32
[64.]
Porter S.R., Barker G.R., Scully C., Macfarlane G., Bain L..
Serun IgG antibodies to Helicobacter Pylori in patients with recurrent aphtous stomnatitis and other oral disorders.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 83 (1997), pp. 325-328
[65.]
Greenspan J.S., Gadol N., Olson J.A..
Lymphocite function in recurrent aphtous ulceration.
J Oral Pathol, 14 (1985), pp. 492-502
[66.]
Thomas H.C., Ferguson A., McLennan J.G., Mason D.K..
Food antibodies in oral disease. A study of serum antibodies to food proteins in oral aphtous ulceration and other oral diseases.
J Clin Pathol, 26 (1973), pp. 371-374
[67.]
Wright A., Ryan F.P., Willingham S.E..
Food allergy or intolerance in severe recurrent aphtous ulceration of the oral cavity.
Br Med J, 292 (1986), pp. 1237-1238
[68.]
Nolan A., Lamey P.J., Milligan K.A., Frosyth A..
Recurrent aphtous ulceration and food sensibility.
J Oral Pathol Med, 20 (1991), pp. 473-475
[69.]
Hay K.D., Reade P.C..
The use of an elimination diet in the treatment of recurrent aphtous ulceration of the oral cavity.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 57 (1984), pp. 504-507
[70.]
Hunter I.P., Ferguson M.M., Scully C., Gallonay A.R., Main A.N., Russell R.I..
Effects of dietary gluten elimination in patients with minor recurrent aphtous stomatitis and no detectable gluten enteropathy.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 75 (1993), pp. 595-598
[71.]
Wray D..
Gluten-sensitive recurrent aphtous stomatitis.
Dig Dis Sci, 26 (1981), pp. 737-740
[72.]
McCartan B.E., Sullivan A..
The association of menstrual cycle, pregnancy and menopause with recurrent oral aphtous stomatitis. A review and critique.
Obstet Gynecol, 80 (1992), pp. 455-458
[73.]
McCartan B.E., Lamey P.J., Wallace A.M..
Salivary cortisol and anxiety in recurrent aphtous stomatitis.
J Oral Pathol Med, 25 (1996), pp. 357-359
[74.]
Andrews V.H., Hall H.E..
The effects of relaxation/imagery training on recurrent aphtous stomatitis: a preliminar study.
Psychosom Med, 52 (1990), pp. 526-535
[75.]
Nolan A., Mcintosh W.B., Allam B.F., Lamey P.J..
Recurrent aphtous ulceration: vitamin B1, B2 and B6 status and response to replacement therapy.
J Oral Pathol Med, 20 (1991), pp. 389-391
[76.]
Porter S.R., Kingsmill V., Scully C..
Audit of diagnosis and investigation in patients with recurrent aphtous stomatitis.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 76 (1993), pp. 449-452
[77.]
Barnadas M.A., Remacha A., Condomines J., de Moragas J.M..
Estudio de los déficits hematológicos en los enfermos afectados de aftas orales recidivantes.
Med Clin, 14 (1997), pp. 85-87
[78.]
Ogura M., Yamamoto T., Morita M., Watanabe T..
A case-control study on food intake of patients with recurrent aphtous stomatitis.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 91 (2001), pp. 45-49
[79.]
Haisraeli-Shalish M., Livmeh A., Katz J., Doolman R., Sela B.A..
Recurrent aphtous stomatitis and thiamine deficiency.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 82 (1996), pp. 634-636
[80.]
Porter S., Flint S., Scully C., Keith O..
Recurrent aphtous stomatitis: the efficacy of replacement therapy in patients with underlying hematinic deficiencies.
Ann Dent, 51 (1992), pp. 14-16
[81.]
Endre L..
Recurrent aphtous ulceration with zinc deficiency and cellular immune deficiency.
Oral Srg Oral Med Oral Pathol Oral Radiol Endod, 72 (1991), pp. 559-561
[82.]
Wray D., Graykowski E.A., Notkins A.L..
Role of mucosal injury in initiating recurrent aphtous stomatitis.
Br Med J, 283 (1981), pp. 1569-1570
[83.]
Axell T., Henricsson V..
Association between recurrent aphtous ulcers and tobacco habits.
Scand J Dent Res, 93 (1985), pp. 239-242
[85.]
Baron J.A..
Beneficial effects of nicotine and cigarrette smoking: the real, the possible and the spurious.
Br Med Bull, 52 (1996), pp. 58-73
[86.]
Tuzun B., Wolf R., Tuzun Y., Serdaroglu S..
Recurrent aphtous stomatitis and smoking.
Int J Dermatol, 39 (2000), pp. 358-360
[87.]
Grady D., Ernster V.L., Stillman L., Greenspan J..
Smokeless tobaco use prevents aphtous stomatitis.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 74 (1992), pp. 463-465
[88.]
Herlofson B.B., Barkvoll P..
Sodium lauryl sulfate and recurrent aphtous ulcers. A preliminary study.
Acta Odontol Scand, 52 (1994), pp. 257-259
[89.]
Chahine L., Sempson N., Wagoner C..
The effect of sodium lauryl sulfate on recurrent aphtous ulcers: a clinical study.
Compend Contin Educ Dent, 18 (1997), pp. 1238-1240
[90.]
Fakhry Smith S., Din C., Nthoo S.A., Gaffar A..
Clearance of sodium lauryl sulfate from the oral cavity.
J Clin Periodontol, 24 (1997), pp. 313-317
[91.]
Herlofson B.B., Barkvoll P..
The effect of two toothpaste detergens on the frecuency of recurrent aphtous ulcers.
Acta Odontol Sacand, 54 (1996), pp. 150-153
[92.]
Healy C.M., Paterson M., Joyston-Bechal J., Williams D.M., Thornhill M.H..
The effect of a sodium lauryl sulfate-free dentifrice on patients with recurrent oral ulceration.
Oral Dis, 5 (1999), pp. 39-43
[93.]
Rogers R.S..
Recurrent aphtous stomatitis: clinical characteristics and associated systemic disorders.
Semin Cutan Med Surg, 16 (1997), pp. 278-283
[94.]
Bagán J.V., Sanchis J.M., Millán M.A., Peñarrocha M., Silvestre F.J..
Recurrent aphtous stomatitis. A study of the clinical characteristics of lesions in 93 cases.
J Oral Pathol Med, 20 (1991), pp. 395-397
[95.]
Schneider L.C., Schneider A.E..
Diagnosis of oral ulcers.
Mt Sinai J Med, 65 (1998), pp. 383-387
[96.]
Vincent S.D., Lilly G.E..
Clinical, historic, and therapeutic features of aphtous stomatitis. Literature review and open clinical trial employing steroids.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 74 (1992), pp. 79-86
[97.]
Yel L., Tezcan I., Hasturk H., Ersoy F., Sanal O., Yavuzyilmaz E..
Oral findings, treatment and follow up of a case with major aphtous stomatitis (Sutton's disease).
J Clin Pediat Dent, 19 (1994), pp. 49-53
[98.]
Burruano F., Tortorici S..
Stomatite aftosa major (malattia di Sutton). Etiopatogenesi, quadri istologici ed aspetti clinici.
Minerva Stomatol, 49 (2000), pp. 41-50
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