Scientific letter
Oesophageal ulcer: An uncommon presentation of tuberculous lymphadenitis mimicking an oesophageal carcinoma
Úlcera esofágica: una infrecuente forma de presentación de una linfadenitis tuberculosa simulando un carcinoma de esófago
Santiago de Cossíoa,
, Blas Labradorb, Ramón Yarzac, Laura Corbellad, Mario Fernández-Ruizd
Corresponding author
a Servicio de Medicina Interna, Hospital Universitario “12 de Octubre”, Madrid, Spain
b Servicio de Medicina de Aparato Digestivo, Hospital Universitario “12 de Octubre”, Madrid, Spain
c Servicio de Oncología, Hospital Universitario “12 de Octubre”, Madrid, Spain
d Unidad de Enfermedades Infecciosas, Hospital Universitario “12 de Octubre”, Instituto de Investigación Hospital “12 de Octubre” (imas12), Madrid, Spain
Read
1227
Timeswas read the article
214
Total PDF
1013
Total HTML
Share statistics
array:24 [ "pii" => "S0210570519302523" "issn" => "02105705" "doi" => "10.1016/j.gastrohep.2019.10.002" "estado" => "S300" "fechaPublicacion" => "2020-03-01" "aid" => "1459" "copyright" => "Elsevier España, S.L.U.. All rights reserved" "copyrightAnyo" => "2019" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Gastroenterol Hepatol. 2020;43:133-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3 "PDF" => 3 ] "Traduccion" => array:1 [ "en" => array:19 [ "pii" => "S2444382420300195" "issn" => "24443824" "doi" => "10.1016/j.gastre.2019.10.006" "estado" => "S300" "fechaPublicacion" => "2020-03-01" "aid" => "1459" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Gastroenterol Hepatol. 2020;43:133-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>" "titulo" => "Oesophageal ulcer: An uncommon presentation of tuberculous lymphadenitis mimicking an oesophageal carcinoma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "133" "paginaFinal" => "134" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Úlcera esofágica: una infrecuente forma de presentación de una linfadenitis tuberculosa simulando un carcinoma de esófago" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 400 "Ancho" => 1755 "Tamanyo" => 82257 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a) Endoscopic examination revealing a malignant-appearing ulcerative lesion in the mid-thoracic esophagus; (b) CT scan at admission, with enlarged lymph nodes (33<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>22<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>28<span class="elsevierStyleHsp" style=""></span>mm) in left paratracheal region compressing the esophageal lumen; (c) CT scan after two months of four-drug anti-tuberculous therapy, showing marked reduction in lymph node sizes and recanalization of the esophageal occlusion.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Santiago de Cossío, Blas Labrador, Ramón Yarza, Laura Corbella, Mario Fernández-Ruiz" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Santiago" "apellidos" => "de Cossío" ] 1 => array:2 [ "nombre" => "Blas" "apellidos" => "Labrador" ] 2 => array:2 [ "nombre" => "Ramón" "apellidos" => "Yarza" ] 3 => array:2 [ "nombre" => "Laura" "apellidos" => "Corbella" ] 4 => array:2 [ "nombre" => "Mario" "apellidos" => "Fernández-Ruiz" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0210570519302523" "doi" => "10.1016/j.gastrohep.2019.10.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570519302523?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382420300195?idApp=UINPBA00004N" "url" => "/24443824/0000004300000003/v1_202004030631/S2444382420300195/v1_202004030631/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0210570519302006" "issn" => "02105705" "doi" => "10.1016/j.gastrohep.2019.08.005" "estado" => "S300" "fechaPublicacion" => "2020-03-01" "aid" => "1440" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Gastroenterol Hepatol. 2020;43:134-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científica</span>" "titulo" => "Hepatotoxicidad por <span class="elsevierStyleItalic">Garcinia cambogia</span>" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "134" "paginaFinal" => "135" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Hepatotoxicity caused by <span class="elsevierStyleItalic">Garcinia cambogia</span>" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Antoni Mas Ordeig, Noel Bordón García" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Antoni" "apellidos" => "Mas Ordeig" ] 1 => array:2 [ "nombre" => "Noel" "apellidos" => "Bordón García" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2444382420300298" "doi" => "10.1016/j.gastre.2019.08.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382420300298?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570519302006?idApp=UINPBA00004N" "url" => "/02105705/0000004300000003/v2_202010310705/S0210570519302006/v2_202010310705/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0210570519302584" "issn" => "02105705" "doi" => "10.1016/j.gastrohep.2019.09.011" "estado" => "S300" "fechaPublicacion" => "2020-03-01" "aid" => "1465" "copyright" => "Elsevier España, S.L.U." "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Gastroenterol Hepatol. 2020;43:126-32" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 34 "PDF" => 34 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Eficacia y seguridad de ustekinumab en la práctica clínica real. Estudio multicéntrico retrospectivo. Cohorte ARAINF" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "126" "paginaFinal" => "132" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Efficacy and safety of ustekinumab in real clinical practice. Retrospective multicentre study. ARAINF cohort" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1737 "Ancho" => 2092 "Tamanyo" => 96661 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Respuesta clínica tras la inducción en la semana 16.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Diego Casas Deza, Santiago García López, Miguel Lafuente Blasco, Raquel Vicente Lidón, Juan Nerín de la Puerta, Elena Peña Gonzalez, Yolanda Ber Nieto, Mara Charro Calvillo, María José Alcalá Escriche, Fernando Gomollón García, Maite Arroyo Villarino" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Diego" "apellidos" => "Casas Deza" ] 1 => array:2 [ "nombre" => "Santiago" "apellidos" => "García López" ] 2 => array:2 [ "nombre" => "Miguel" "apellidos" => "Lafuente Blasco" ] 3 => array:2 [ "nombre" => "Raquel" "apellidos" => "Vicente Lidón" ] 4 => array:2 [ "nombre" => "Juan" "apellidos" => "Nerín de la Puerta" ] 5 => array:2 [ "nombre" => "Elena" "apellidos" => "Peña Gonzalez" ] 6 => array:2 [ "nombre" => "Yolanda" "apellidos" => "Ber Nieto" ] 7 => array:2 [ "nombre" => "Mara" "apellidos" => "Charro Calvillo" ] 8 => array:2 [ "nombre" => "María José" "apellidos" => "Alcalá Escriche" ] 9 => array:2 [ "nombre" => "Fernando" "apellidos" => "Gomollón García" ] 10 => array:2 [ "nombre" => "Maite" "apellidos" => "Arroyo Villarino" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2444382420300286" "doi" => "10.1016/j.gastre.2019.09.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444382420300286?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570519302584?idApp=UINPBA00004N" "url" => "/02105705/0000004300000003/v2_202010310705/S0210570519302584/v2_202010310705/es/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>" "titulo" => "Oesophageal ulcer: An uncommon presentation of tuberculous lymphadenitis mimicking an oesophageal carcinoma" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "133" "paginaFinal" => "134" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Santiago de Cossío, Blas Labrador, Ramón Yarza, Laura Corbella, Mario Fernández-Ruiz" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Santiago" "apellidos" => "de Cossío" "email" => array:1 [ 0 => "santiagodecossio@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Blas" "apellidos" => "Labrador" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Ramón" "apellidos" => "Yarza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Laura" "apellidos" => "Corbella" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "Mario" "apellidos" => "Fernández-Ruiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital Universitario “12 de Octubre”, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Medicina de Aparato Digestivo, Hospital Universitario “12 de Octubre”, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Oncología, Hospital Universitario “12 de Octubre”, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Unidad de Enfermedades Infecciosas, Hospital Universitario “12 de Octubre”, Instituto de Investigación Hospital “12 de Octubre” (imas12), Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Úlcera esofágica: una infrecuente forma de presentación de una linfadenitis tuberculosa simulando un carcinoma de esófago" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 400 "Ancho" => 1755 "Tamanyo" => 82257 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a) Endoscopic examination revealing a malignant-appearing ulcerative lesion in the mid-thoracic esophagus; (b) CT scan at admission, with enlarged lymph nodes (33<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>22<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>28<span class="elsevierStyleHsp" style=""></span>mm) in left paratracheal region compressing the esophageal lumen; (c) CT scan after two months of four-drug anti-tuberculous therapy, showing marked reduction in lymph node sizes and recanalization of the esophageal occlusion.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Esophageal ulcers constitute a relatively common cause of dysphagia and odynophagia. Gastroesophageal reflux and consumption of nonsteroidal anti-inflammatory drugs (NSAIDs) account for most of the cases. Malignancies and infectious esophagitis due to <span class="elsevierStyleItalic">Candida</span> or herpesviruses may also present as dysphagia.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> The endoscopic appearance of the ulcer is often useful to differentiate between these conditions, with further confirmation by histopathological examination. We report herein a malignant-appearing esophageal ulcer due to paraesophageal tuberculous lymphadenitis in an immunocompetent patient that resolved after anti-tuberculosis therapy. Although lymph node tuberculosis is among the most common extrapulmonary sites of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> infection, esophageal involvement presenting as esophageal ulcer is rare, with only a few cases previously reported in the literature.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2–5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A 40-year-old Bolivian male presented to the Emergency Department complaining of upper abdominal pain accompanied by progressive dysphagia and odynophagia over the previous month. Past medical history was remarkable for non-complicated peptic ulcer ten years ago. He denied both alcohol and tobacco consumption or illicit drugs use. The patient reported moderate epigastric burning feeling with further development of non-colicky pain as well as progressive dysphagia, first to solids and later to liquids. The patient eventually suffered from severe odynophagia, for which he had taken occasional acetaminophen without symptomatic relief. Review of systems was unremarkable for nausea, vomiting or halitosis. He had not experienced weight loss, decrease in appetite or fever. On physical examination the patient appeared well-nourished and hydrated. Oral cavity examination excluded the presence of exudates. No cervical lymphadenopathy was noted and cardiopulmonary examination was unremarkable. Laboratory testing showed normal complete blood count and renal and hepatic function tests. Chest X-ray revealed no abnormalities. Further testing for human immunodeficiency and hepatitis B and C viruses was negative.</p><p id="par0015" class="elsevierStylePara elsevierViewall">As part of the diagnostic approach to progressive dysphagia, the patient underwent upper endoscopic examination which revealed a 1<span class="elsevierStyleHsp" style=""></span>cm size ulcer in the middle third (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>a). Tissue samples were obtained. A contrast-enhanced computerized tomography (CT) scan revealed the presence of multiple enlarged lymph nodes affecting the left paratracheal (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>b), left supraclavicular and right paratracheal regions. These nodes caused extrinsic compression of the esophageal structures with subsequent stenosis. Neither parenchymal infiltration within pulmonary or intraabdominal structures nor pleural effusion was noted. Histopathologic findings were consistent with the presence of scattered epithelioid granulomas showing central necrosis surrounded by abundant granulation tissue. A tuberculin skin test (TST) was positive (20<span class="elsevierStyleHsp" style=""></span>mm) and a new endoscopic examination was performed for further microbiological studies. The aforementioned lesion was shown to have progressed, measuring approximately 1.5<span class="elsevierStyleHsp" style=""></span>cm. The patient had no sputum production, and the PCR assay for <span class="elsevierStyleItalic">M. tuberculosis</span> complex (Xpert MTB/RIF, Cepheid, Sunnyvale, CA) in the gastric aspirate was negative. Despite both acid-fast bacilli smear and specific mycobacterial cultures were negative, a diagnosis of tuberculous lymphadenitis was presumptively made given the histological and radiological findings in the presence of a clearly positive TST and compatible epidemiological history. Patient was started on antituberculosis therapy. Symptoms gradually improved over the next weeks. After completing the two-month intensive phase of therapy with four drugs, a follow-up endoscopic assessment showed complete remission of the lesion, whereas a significant reduction in lymph nodes sizes was observed in the CT scan (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>c). The two-drug continuation phase (isoniazid and rifampicin) was uneventfully maintained for four further months, with complete symptom resolution.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Tuberculosis is a rare cause of dysphagia that should be considered in patients from endemic regions with uncertain esophageal lesions.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2,3</span></a> In addition, dysphagia may also result from the extrinsic compression of the esophagus by mediastinal or neck lymph nodes (as occurred in the present case) or due to the development of tracheoesophageal fistula. Esophageal ulcer is the most common endoscopic finding, whose appearance is often suggestive of malignancy.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> However, as mentioned above, other endoscopic findings reported in patients with esophageal tuberculosis include esophageal stenosis, tracheoesophageal fistula or exophytic mass, widening the differential. Therefore, histological and microbiological examination plays a crucial role. Culture positivity for <span class="elsevierStyleItalic">M. tuberculosis</span> on tissue samples is uncommon, and the diagnosis is only established by demonstrating clinical, radiological and endoscopic response to anti-tuberculosis treatment, as exemplified by our experience.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> In the absence of culture confirmation, endoscopic ultrasound-guided fine needle aspiration of the lymph node represents a valuable diagnostic tool, particularly taking into account the need of ruling out alternative Follow-up endoscopic assessment is mandatory in order to confirm endoscopic healing of lesions, since malignancy and esophageal tuberculosis may coexist.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Of note, a case of esophageal tuberculosis diagnosed after an esophagectomy performed due to esophageal stricture with histologic features of high-grade dysplasia has been described, stressing the need of considering tuberculosis in the differential diagnosis.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> In conclusion, the possibility of esophageal ulcer caused by paraesophageal tuberculous lymphadenitis with mucosal involvement should be kept in mind in patients from high-prevalence countries and evidence of esophageal granulomas, even if <span class="elsevierStyleItalic">M. tuberculosis</span> is not isolated in tissue cultures. Anti-tuberculosis therapy is usually curative in this uncommon condition.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that there are no conflicts of interest in relation to this work.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 400 "Ancho" => 1755 "Tamanyo" => 82257 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a) Endoscopic examination revealing a malignant-appearing ulcerative lesion in the mid-thoracic esophagus; (b) CT scan at admission, with enlarged lymph nodes (33<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>22<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>28<span class="elsevierStyleHsp" style=""></span>mm) in left paratracheal region compressing the esophageal lumen; (c) CT scan after two months of four-drug anti-tuberculous therapy, showing marked reduction in lymph node sizes and recanalization of the esophageal occlusion.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infectious esophagitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F.M. Sutton" 1 => "D.Y. Graham" 2 => "R.W. Goodgame" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastrointest Endosc Clin N Am" "fecha" => "1994" "volumen" => "4" "paginaInicial" => "713" "paginaFinal" => "729" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7812643" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis of the gastrointestinal tract and peritoneum" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.B. Marshal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "1993" "volumen" => "88" "paginaInicial" => "989" "paginaFinal" => "999" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8317433" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis of the esophagus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.A. Perdomo" 1 => "Y. Naomoto" 2 => "M. Haisa" 3 => "T. Yamatsuji" 4 => "Y. Kamikawa" 5 => "N. Tanaka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/dote/11.1.72" "Revista" => array:6 [ "tituloSerie" => "Dis Esophagus" "fecha" => "2017" "volumen" => "11" "paginaInicial" => "72" "paginaFinal" => "74" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29040488" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Esophageal tuberculosis: is it so rare? Report of 12 cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.K. Jain" 1 => "S. Jain" 2 => "M. Jain" 3 => "A. Yaduvanshi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2002" "volumen" => "97" "paginaInicial" => "287" "paginaFinal" => "291" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculosis as primary cause for oesophageal stricture: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Mbiine" 1 => "R. Kabuye" 2 => "H.M. Lekuya" 3 => "W. Manyillirah" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Cardiothorac Surg" "fecha" => "2018" "paginaInicial" => "743" "paginaFinal" => "744" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/02105705/0000004300000003/v2_202010310705/S0210570519302523/v2_202010310705/en/main.assets" "Apartado" => array:4 [ "identificador" => "9030" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Cartas científicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02105705/0000004300000003/v2_202010310705/S0210570519302523/v2_202010310705/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210570519302523?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 0 | 8 |
| 2024 October | 60 | 8 | 68 |
| 2024 September | 50 | 16 | 66 |
| 2024 August | 54 | 8 | 62 |
| 2024 July | 45 | 3 | 48 |
| 2024 June | 43 | 15 | 58 |
| 2024 May | 38 | 7 | 45 |
| 2024 April | 44 | 10 | 54 |
| 2024 March | 50 | 6 | 56 |
| 2024 February | 39 | 2 | 41 |
| 2024 January | 71 | 1 | 72 |
| 2023 December | 52 | 2 | 54 |
| 2023 November | 54 | 4 | 58 |
| 2023 October | 33 | 1 | 34 |
| 2023 September | 18 | 1 | 19 |
| 2023 August | 14 | 0 | 14 |
| 2023 July | 13 | 2 | 15 |
| 2023 June | 13 | 2 | 15 |
| 2023 May | 13 | 1 | 14 |
| 2023 April | 10 | 1 | 11 |
| 2023 March | 12 | 2 | 14 |
| 2023 February | 9 | 5 | 14 |
| 2023 January | 19 | 4 | 23 |
| 2022 December | 14 | 3 | 17 |
| 2022 November | 20 | 9 | 29 |
| 2022 October | 23 | 9 | 32 |
| 2022 September | 26 | 11 | 37 |
| 2022 August | 28 | 12 | 40 |
| 2022 July | 18 | 13 | 31 |
| 2022 June | 17 | 13 | 30 |
| 2022 May | 13 | 6 | 19 |
| 2022 April | 27 | 6 | 33 |
| 2022 March | 40 | 9 | 49 |
| 2020 December | 0 | 2 | 2 |
| 2020 July | 1 | 0 | 1 |
| 2020 April | 3 | 6 | 9 |
| 2020 March | 21 | 11 | 32 |
| 2020 January | 0 | 3 | 3 |
Show all
