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Original article
Impact of gastrointestinal symptoms and psychological disturbances on patients’ quality of life after restrictive or malabsorptive bariatric surgery
Impacto de los síntomas gastrointestinales y alteraciones psicológicas sobre la calidad de vida en los pacientes sometidos a cirugía bariátrica restrictiva o malabsortiva
Laura Uribarri-Gonzaleza,
Corresponding author
luribarrigonzalez@gmail.com

Corresponding author.
, Laura Nieto-Garciab, Aurelio Martis-Sueiroc, J. Enrique Dominguez-Muñoza,b
a Department of Gastroenterology, University Hospital of Santiago de Compostela, Spain
b Health Research Institute of Santiago de Compostela (IDIS), Spain
c Department of Endocrinology, University Hospital of Santiago de Compostela, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Obesity is a chronic multifactorial disease associated with significant physical and psychological burden&#46; More than 80&#37; of obese patients suffer from metabolic syndrome &#40;dyslipidaemia&#44; impaired glucose tolerance or diabetes and arterial hypertension&#41; leading to a high cardiovascular risk&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">1&#44;2</span></a> Bariatric surgery induces significant weight loss and is an effective treatment for obesity-related disorders&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">3&#44;4</span></a> The International Federation for the Surgery of Obesity and Metabolic Disorders &#40;IFSO&#41; submitted data from 51 different countries with 394&#44;431 bariatric surgical procedures performed since 2014&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">5</span></a> According to it&#44; sleeve gastrectomy &#40;SG&#41; and Roux-en-Y gastric bypass &#40;RYGB&#41; are currently the most frequently performed procedures&#44; whereas biliopancreatic diversion with duodenal switch &#40;BPD&#47;DS&#41; is less frequently reported&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Gastrointestinal &#40;GI&#41; anatomical changes after bariatric surgery may lead to relevant GI symptoms&#44; such as abdominal pain&#44; early satiety&#44; postprandial fullness&#44; abdominal distention&#44; bloating&#44; flatulence&#44; and disturbed bowel habit&#44; that may have a significant negative impact on patients&#8217; quality of life &#40;QoL&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The North American Health Institute recommended in 1991 the development of validated tools to monitor the expectations of patients regarding psychosocial changes and their experiences during the periods of weight loss and maintenance after different surgical procedures&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">8</span></a> SF-36 is an internationally renowned multidimensional tool that evaluates the domains of functional capacity&#44; physical aspects&#44; pain&#44; and general state of health&#44; vitality&#44; social aspects&#44; emotional aspects&#44; and mental health&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">9</span></a> SF-36 was developed for generic health-related QoL evaluation&#44; and it enables incorporating the opinion of patients into clinical decision-making&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">10</span></a> GI QoL index &#40;GIQLI&#41; is a well-validated tool for assessing the specific QoL and GI symptoms in patients with GI diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">11</span></a> This questionnaire has been additionally used in the context of GI surgery for gastric cancer&#44; gastroesophageal reflux disease&#44; achalasia&#44; obesity&#44; and other diseases like diabetes&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">12</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Although satisfaction with weight loss after surgery may outweigh the negative impact of other factors&#44; the development of GI symptoms after bariatric surgery may affect patients&#8217; QoL&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">13</span></a> Despite a higher incidence of GI symptoms and complications after BPD&#47;DS&#44; no significant differences in QoL have been reported between patients after SG&#44; RYGB and BPD&#47;DS by using the Multidimensional Anxiety Questionnaire &#40;MAQ&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">7&#44;14</span></a> However&#44; MAQ may not be the optimal tool&#44; and be less appropriate than SF-36 and GIQLI to evaluate this association&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The aim of this study was to evaluate the relationship between QoL and GI symptoms&#44; physical and psychological disturbances in patients after different bariatric surgical procedures&#46; In addition&#44; the impact of bariatric surgery on QoL and GI&#44; physical and psychological burden was compared in patients after different surgical procedures&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Design of the study</span><p id="par0030" class="elsevierStylePara elsevierViewall">A prospective&#44; observational&#44; cross-sectional&#44; single centre&#44; comparative study was designed&#46; Patients older than 18 years&#44; who underwent bariatric surgery for morbid obesity&#44; either RYGB&#44; SG or BPD&#47;DS&#44; between January 2001 and December 2016 were considered for inclusion&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A multidisciplinary team &#40;MDT&#41; that included endocrinologists&#44; bariatric surgeons&#44; psychologists&#44; psychiatrists and anaesthetists made the decision on the surgical procedure to be performed in each patient&#46; All procedures were performed by two experienced bariatric surgeons&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Previous GI or pancreatic surgery&#44; other types of bariatric surgery&#44; chronic GI diseases &#40;celiac disease&#44; inflammatory bowel disease&#44; diabetic gastroparesis&#41;&#44; any severe concomitant disease limiting life expectancy&#44; and inability or refusal to perform the study-related procedures or to sign the written informed consent were considered as exclusion criteria&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Demographic data&#44; comorbidities &#40;diabetes&#44; obstructive sleep apnoea syndrome &#40;OSAS&#41;&#44; arterial hypertension&#44; dyslipidaemia&#41;&#44; anthropometry &#40;weight loss and change in body mass index &#8211; BMI&#8211;&#41;&#44; time after surgery&#44; GI symptoms and signs&#44; and psychological disorders &#40;anxiety&#47;depression&#41; were evaluated and recorded at inclusion&#46; Pre-operative comorbidities were recorded retrospectively from the electronic medical records&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Weight loss was defined as the difference between the greatest preoperative weight and the weight at the time of the study&#46; The percentage of excess BMI loss &#40;&#37;EBMIL&#41; was calculated using the formula &#40;preoperative BMI<span class="elsevierStyleHsp" style=""></span>&#8722;<span class="elsevierStyleHsp" style=""></span>BMI at inclusion&#41;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>100&#47;&#40;preoperative BMI<span class="elsevierStyleHsp" style=""></span>&#8722;<span class="elsevierStyleHsp" style=""></span>25&#41;&#46; Time after surgery was defined as the time &#40;months&#41; from surgery to inclusion in the study&#46; Psychological disorders were evaluated before and during follow-up after surgery by a dedicated psychologist&#46; For the purposes of the study&#44; depression and anxiety were considered as related to surgery if newly diagnosed or if gotten worse during the follow-up after surgery&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Surgical procedures</span><p id="par0055" class="elsevierStylePara elsevierViewall">RYGB and BPD&#47;DS were routinely performed at our institution in morbid obese patients&#46; The RYGB procedure was performed with a 100&#8211;150<span class="elsevierStyleHsp" style=""></span>cm Roux-limb and a 50<span class="elsevierStyleHsp" style=""></span>cm biliary limb&#46; In the BPD&#47;DS procedure&#44; duodenum was divided distal to the pylorus and a sleeve gastrectomy was performed&#46; A retrocolic duodeno-ileostomy was constructed with a 150<span class="elsevierStyleHsp" style=""></span>cm alimentary limb and a 100<span class="elsevierStyleHsp" style=""></span>cm common limb&#46; The remaining small bowel formed the biliary limb&#46; SG was performed following standard procedures and removing about 75&#37; of the stomach&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">QoL evaluation</span><p id="par0060" class="elsevierStylePara elsevierViewall">QoL was evaluated by both the GIQLI and the SF-36 questionnaires&#46; The GIQLI is a 36-item patient reported outcomes instrument designed to assess GI specific health-related QoL in clinical practice and clinical trials of patients with GI disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">11</span></a> It consists of five domains &#40;GI symptoms&#44; emotion&#44; physical function&#44; social function&#44; and medical treatment&#41;&#46; Each item is scored from 0 to 4 and the total GIQLI score ranges from 0 to 144&#46; Higher scores are related to better GI health related QoL&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The SF-36 is a brief psychometric QoL measure of eight health dimensions that has been considered the method of choice in obesity research by the United States Task Force on Developing Obesity Outcomes and Learning Standards&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">15</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">GI symptoms and signs</span><p id="par0070" class="elsevierStylePara elsevierViewall">GI symptoms including abdominal pain&#44; early satiety&#44; postprandial fullness&#44; gas bloating&#44; abdominal distention and flatulence were recorded and scored as none&#44; mild&#44; moderate and severe&#46; For the purposes of the study&#44; abdominal symptoms were considered as related to surgery if they newly developed or got worse during follow-up after surgery&#46; Stool characteristics were recorded by using a 7-day Bristol Stool Form Scale &#40;BSFS&#41; diary&#46; This tool has been validated and has been shown to correlate with the intestinal transit time&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">16&#8211;18</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistical analysis</span><p id="par0075" class="elsevierStylePara elsevierViewall">Categorical variables are shown as absolute numbers and percentages and were compared using <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span> test or Fischer&#39;s exact test as appropriate&#46; Continuous data are presented as mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD or median and range for normally or non-normally distributed data&#44; respectively&#46; Normally distributed continuous variables were analysed by the Student-<span class="elsevierStyleItalic">t</span> test&#44; and non-normally distributed variables by the Mann&#8211;Whitney <span class="elsevierStyleItalic">U-test</span> when comparing two groups&#46; Normally distributed continuous variables were analysed by one-way analysis of variance &#40;ANOVA&#41; and non-normally distributed variables by the Kruskal&#8211;Wallis test when comparing more than two groups&#46; Shapiro&#8211;Wilk test was used to assess the normality of data distribution&#46; The Pearson product-moment correlation coefficient was used to measure the strength and direction of the association between two variables&#46; GIQLI and SF-36 scores obtained in the study population were compared with the standard scores reported for the Spanish population&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">19</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Linear regression analysis was used to test any potential association between time from surgery and GI symptoms&#46; Comparisons with a <span class="elsevierStyleItalic">p</span>-value<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 were deemed statistically significant&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Ethical aspects</span><p id="par0085" class="elsevierStylePara elsevierViewall">The study was approved by the Clinical Research Ethics Committee with the approval number AD-04-014&#46; All patients provided written informed consent to the study&#46; The study protocol conforms to the ethical guidelines of the 1975 Declaration of Helsinki and the study was conducted in accordance with the Declaration of Helsinki&#44; its amendments&#44; and Good Clinical Practice guidelines&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0090" class="elsevierStylePara elsevierViewall">A total of 304 patients underwent bariatric surgery over the study period and were evaluated&#46; 209 patients were excluded due to the presence of other GI diseases &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>55&#41;&#44; other bariatric surgical procedure &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>79&#41; or unwillingness to participate in the study &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>75&#41;&#46; Finally&#44; 95 patients were included &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Mean age was 50&#46;5 years &#40;range 22&#8211;70 years&#41;&#59; 76 patients were female &#40;80&#37;&#41;&#59; 36 patients had undergone RYGB &#40;37&#46;9&#37;&#41;&#44; 36 patients BPD&#47;DS &#40;37&#46;9&#37;&#41; and 23 patients SG &#40;24&#46;2&#37;&#41;&#46; The three groups of patients were similar in terms of age and gender distribution &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Mean time from bariatric surgery to inclusion into the study was of 62<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>45&#46;9 months&#44; longer after BPD&#47;DS &#40;86&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>56&#46;9 months&#41; than after RYGB &#40;48&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>30&#46;1 months&#41; or SG &#40;44&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#46;1 months&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Mean preoperative BMI was 52&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;5<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span> and mean body weight 134&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#46;9<span class="elsevierStyleHsp" style=""></span>kg&#44; lower in those patients who underwent RYGB than in those who underwent BPD&#47;DS or SG &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Mean weight loss after surgery was 46&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>42<span class="elsevierStyleHsp" style=""></span>kg&#44; greater after BPD&#47;DS &#40;58&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>26&#46;3<span class="elsevierStyleHsp" style=""></span>kg&#41; compared to RYGB &#40;40&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;9<span class="elsevierStyleHsp" style=""></span>kg&#41; and SG &#40;36&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&#46;8<span class="elsevierStyleHsp" style=""></span>kg&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The &#37;EBMIL after the two malabsorptive procedures was similar &#40;72&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#46;18&#37; after RYGB and 71&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;25&#37; after BPD&#47;DS&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;69&#41; and greater than after SG &#40;50&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;44&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Prevalence of obesity-related comorbidities before surgery was similar among groups &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Diabetes resolved in most patients after malabsorptive surgical procedures but only in half of the patients who underwent SG &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46; Arterial hypertension&#44; OSAS and dyslipidaemia resolved in most of the patients after bariatric surgery regardless of the surgical procedure performed &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">GI symptoms&#44; and psychological disturbances</span><p id="par0105" class="elsevierStylePara elsevierViewall">No patient was symptom free at the time of inclusion in the study&#46; Fifty-one patients &#40;53&#46;7&#37;&#41; referred soft stools &#40;BSFS 5&#8211;7&#41;&#44; more often those who underwent BPD&#47;DS than those who underwent RYGB or SG &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Compared to patients after SG&#44; patients after malabsorptive surgery referred more often bloating &#40;77&#46;8&#37; vs 56&#46;5&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Early satiety was a consistent finding in most patients&#44; but it was significantly less frequent in patients who underwent BPD&#47;DS &#40;86&#46;1&#37; vs 98&#46;3&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41;&#46; Other GI symptoms were less frequently reported and were independent of the surgical procedure performed &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">GI symptoms were independent of mean weight loss and &#37;EBMIL&#44; except patients with bloating&#44; who had greater &#37;EBMIL &#40;69&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;46&#37; vs 59&#46;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;72&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">A worsening of their initial psychological condition &#40;depression or anxiety&#41; was present in 41&#46;1&#37; of the patients after surgery&#44; more frequently in those who underwent SG than in those after RYGB or BPD&#47;DS &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Quality of life</span><p id="par0120" class="elsevierStylePara elsevierViewall">QoL as evaluated by the SF-36 questionnaire was significantly worse in patients after SG &#40;mean score 54&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#46;1&#41; compared with RYGB &#40;mean score 73&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;3&#41; and BPD&#47;DS &#40;mean score 73&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; The prevalence of patients with a poor QoL&#44; defined as an abnormally low SF-36 score as compared to the general population&#44; was significantly greater in patients after SG than in those after RYGB or BPD&#47;DS in all dimensions except in pain and emotional health &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">GI symptoms-related QoL was better after RYGB than after SG or BPD&#47;DS &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; No significant association was found between the time from bariatric surgery and the GI symptoms &#40;correlation coefficient of 0&#46;492 for SG&#44; 0&#46;488 for RYGB and 0&#46;771 for BPD&#47;DS&#41;&#46; On the other side&#44; physical&#44; emotional&#44; and social function scores&#44; as evaluated by the GIQLI&#44; were significantly lower in patients after SG than in those after RYGB or BPD&#47;DS &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; The proportion of patients with a poor QoL as defined by an abnormally low GIQLI score was significantly greater in patients after SG than in those after RYGB or BPD&#47;DS in all dimensions except in GI symptoms &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">QoL scores as evaluated by both SF36 questionnaire and GIQLI showed a significant positive correlation with the &#37;EBMIL &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; Postprandial fullness correlated negatively with QoL as evaluated by both SF-36 and GIQLI&#46; Abdominal distention and flatulence correlated negatively with QoL as evaluated by GIQLI&#46; Other GI symptoms did not correlate with QoL &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Finally&#44; patients with a worsening of their initial psychological condition had a worse QoL than those who did not have it&#44; both in SF-36 &#40;61&#46;68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;95 vs&#46; 73&#46;59<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#46;83&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; and GIQLI total score &#40;96&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#46;51 vs&#46; 108&#46;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;56&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discussion</span><p id="par0140" class="elsevierStylePara elsevierViewall">By using the SF-36 questionnaire and GIQLI&#44; the present study shows that GI symptoms&#44; mainly postprandial fullness&#44; abdominal distention&#44; and flatulence&#44; negatively affect QoL in patients after different bariatric surgical procedures&#46; Although a worsening of their initial psychological condition and weight loss are major determinants of QoL after bariatric surgery&#44; GI symptoms play a significant role&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Bariatric surgery has proven to be an effective approach for the treatment of morbid obesity and related morbidities&#46; However&#44; GI symptoms and psychological alterations are frequently present in these patients even long-term after surgery&#46; Although most obese patients experience a short-term reduction in anxiety and depression symptoms after surgery&#44; these symptoms may tend to increase later&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">20</span></a> About 40&#37; of our patients presented psychological disturbances &#40;depression or anxiety&#41;&#44; mainly in the SG group&#44; which could be partly related to the lower &#37;EBMIL in these patients undergoing restrictive bariatric surgery&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Patients after bariatric surgery present with GI symptoms&#44; independently of the surgical procedure performed&#46; More than half of the patients referred soft stools&#44; mainly those after BPD&#47;DS&#46; Early satiety is a consistent finding after SG&#44; but it also appears very frequently after malabsorptive procedures&#46; On the contrary&#44; as expected&#44; bloating is more frequently referred by patients after malabsorptive procedures than after SG&#46; Nevertheless&#44; neither early satiety nor bloating affect significantly patients&#8217; QoL&#46; According to our data&#44; postprandial fullness&#44; abdominal distention&#44; and flatulence are the symptoms affecting QoL significantly in patients after bariatric surgery&#46; GI symptoms-related QoL as evaluated by GIQLI was best after RYGB compared with SG or BPD&#47;DS&#46; In the present study&#44; GI symptoms were not influenced by the time after different surgical procedures&#46; In addition&#44; patients after SG showed the worse physical&#44; emotional&#44; and social function scores&#44; and the proportion of patients with a poor QoL as defined by an abnormally low GIQLI was significantly greater in patients after SG than in those after RYGB or BPD&#47;DS in most dimensions&#46; Abdominal pain was present in one out of each five patients of our study&#44; and it has been described as one of the most common complaints after RYGB&#44;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">13</span></a> but it had no impact on patients&#8217; QoL&#46; All these data support RYGB over SG as the surgical procedure for obesity&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">QoL as evaluated by the SF-36 questionnaire was significantly worse in patients after SG in most dimensions too&#46; These patients had the lowest &#37;EBMIL and the highest prevalence of depression or anxiety compared with those undergoing malabsorptive procedures&#44; which may explain the negative effect on QoL&#46; In fact&#44; percentage of weight loss has been shown to be significantly associated with QoL&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">21&#8211;23</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">Our study has several strengths and limitations&#46; On the one hand&#44; it is a prospective and comparative study reflecting daily clinical practice&#46; We are not aware of any other study evaluating and comparing SF-36 and GIQLI scores in patients after SG&#44; RYBG and BPD&#47;DS&#46; We observed a worsening of their baseline physical and psychological condition&#44; depending on the type of surgery&#44; and it is well known that GI anatomical changes are a major determinant of these changes&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">24&#8211;28</span></a> On the other hand&#44; the time from bariatric surgery to inclusion into the study was different in patients after different surgical procedures&#44; which could affect both QoL and GI symptoms&#46; In addition&#44; no information was available prior to surgery about non-diagnosed functional disorders&#44; QoL and objectively measured psychological state&#44; which could be unevenly distributed&#46; Finally&#44; the intensity and frequency of abdominal symptoms had not been assessed before surgery&#44; which may influence QoL&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conclusions</span><p id="par0165" class="elsevierStylePara elsevierViewall">In conclusion&#44; our study shows that both restrictive and malabsorptive bariatric surgical procedures are associated with GI symptoms physical and psychological disturbances negatively affecting patients&#8217; QoL&#46; Although the presence of different GI symptoms is a consistent finding after any bariatric procedure&#44; postprandial fullness&#44; abdominal distention and flatulence are those significantly affecting QoL in these patients&#46; Compared to SG and BPD&#47;DS&#44; patients after RYGB showed the best GI symptoms-related QoL&#44; which can be used as an additional information for clinical decision making in individual obese patients&#46; Therefore&#44; GI symptoms-related QoL as evaluated by the GIQLI may provide with clinical information that is relevant to the management of patients after bariatric surgery&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflict of interest</span><p id="par0170" class="elsevierStylePara elsevierViewall">L&#46; Uribarri-Gonzalez&#44; L&#46; Nieto-Garc&#237;a&#44; A&#46; Martis-Sueiro&#44; and J&#46;E&#46; Dom&#237;nguez-Mu&#241;oz have no conflicts of interest to declare&#46;</p></span></span>"
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          "titulo" => "Patients and methods"
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            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Design of the study"
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            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Surgical procedures"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "QoL evaluation"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "GI symptoms and signs"
            ]
            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Statistical analysis"
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            5 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Ethical aspects"
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        ]
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          "identificador" => "sec0045"
          "titulo" => "Results"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "GI symptoms&#44; and psychological disturbances"
            ]
            1 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "Quality of life"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Discussion"
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          "identificador" => "sec0065"
          "titulo" => "Conclusions"
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        9 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Conflict of interest"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2021-11-04"
    "fechaAceptado" => "2022-02-28"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1605699"
          "palabras" => array:5 [
            0 => "Gastrointestinal symptoms"
            1 => "Physical changes"
            2 => "Psychological changes"
            3 => "Quality of life"
            4 => "Bariatric surgery"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1605698"
          "palabras" => array:5 [
            0 => "S&#237;ntomas gastrointestinales"
            1 => "Cambios f&#237;sicos"
            2 => "Cambios psicol&#243;gicos"
            3 => "Calidad de vida"
            4 => "Cirug&#237;a bari&#225;trica"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Aim</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to evaluate and compare the presence and impact of Gastrointestinal &#40;GI&#41; symptoms&#44; physical and psychological disturbances on patients&#8217; QoL after sleeve gastrectomy &#40;SG&#41;&#44; Roux-en-Y gastric bypass &#40;RYGB&#41; and biliopancreatic diversion with duodenal switch &#40;BPD&#47;DS&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A prospective&#44; observational&#44; cross-sectional&#44; comparative study was carried-out&#46; GI symptoms and patients&#8217; QoL were evaluated by the SF-36 questionnaire and the GI quality of life index &#40;GIQLI&#41;&#46; Correlation between GI symptoms&#44; psychological disturbances and QoL scores was analysed&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">95 patients were included &#40;mean age 50&#46;5 years&#44; range 22&#8211;70&#59; 76 females&#41;&#46; Presence of GI symptoms was a consistent finding in all patients&#44; and postprandial fullness&#44; abdominal distention and flatulence had a negative impact on patients&#8217; QoL&#46; Patients after SG showed a worsening of their initial psychological condition and the lowest QoL scores&#46; Patients after RYGB showed the best GI symptoms-related QoL&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Both restrictive and malabsorptive bariatric surgical procedures are associated with GI symptoms negatively affecting patients&#8217; QoL&#46; Compared to SG and BPD&#47;DS&#44; patients after RYGB showed the best GI symptoms-related QoL&#44; which can be used as additional information to help in the clinical decision making of the bariatric procedure to be performed&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Aim"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
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          2 => array:2 [
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            "titulo" => "Results"
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            "titulo" => "Conclusions"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio fue evaluar y comparar la presencia e impacto de los s&#237;ntomas gastrointestinales &#40;GI&#41;&#44; los cambios f&#237;sicos y psicol&#243;gicos en la calidad de vida &#40;CV&#41; de los pacientes sometidos a tubulaci&#243;n g&#225;strica &#40;TG&#41;&#44; <span class="elsevierStyleItalic">bypass</span> g&#225;strico en Y de Roux &#40;BGYR&#41; y derivaci&#243;n biliopancre&#225;tica con cruce duodenal &#40;DBP&#47;CD&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un estudio prospectivo&#44; observacional&#44; transversal y comparativo&#46; Los s&#237;ntomas gastrointestinales y la CV de los pacientes fueron evaluados mediante el cuestionario SF-36 y el &#237;ndice gastrointestinal de calidad de vida &#40;GIQLI&#41;&#46; Se analiz&#243; la relaci&#243;n entre los s&#237;ntomas gastrointestinales&#44; los trastornos psicol&#243;gicos y las puntuaciones de CV&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 95 pacientes &#40;edad media&#58; 50&#44;5 a&#241;os&#44; rango&#58; 22-70&#59; 76 mujeres&#41;&#46; La presencia de s&#237;ntomas gastrointestinales fue un hallazgo constante en todos los pacientes&#44; y la pesadez posprandial&#44; la distensi&#243;n abdominal y la flatulencia tuvieron un impacto negativo en la CV de los pacientes&#46; Los pacientes despu&#233;s de la TG mostraron un empeoramiento de su estado psicol&#243;gico inicial y unas puntuaciones m&#225;s bajas en la CV&#46; Los pacientes despu&#233;s del BGYR presentaron la mejor CV relacionada con los s&#237;ntomas gastrointestinales&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los procedimientos de cirug&#237;a bari&#225;trica tanto restrictivos como malabsortivos se asocian a s&#237;ntomas GI que afectan negativamente la CV de los pacientes&#46; En comparaci&#243;n con la TG y la DBP&#47;CD&#44; los pacientes tras el BGYR presentaron la mejor CV relacionada con los s&#237;ntomas GI&#44; lo que puede utilizarse como informaci&#243;n adicional para ayudar en la toma de decisiones cl&#237;nicas sobre el procedimiento bari&#225;trico a realizar&#46;</p></span>"
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        "etiqueta" => "Figure 1"
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        "mostrarDisplay" => false
        "figura" => array:1 [
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            "imagen" => "gr1.jpeg"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Flow-chart of patients evaluated for the study&#46; RYGB&#44; Roux-en-Y gastric bypass&#59; BPD&#47;DS&#44; biliopancreatic diversion with duodenal switch&#59; SG&#44; sleeve gastrectomy&#46;</p>"
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Percentage of patients after different bariatric surgical procedures with different stool consistencies according to the BSFS&#46; BSFS&#44; Bristol Stool Form Scale&#59; RYGB&#44; Roux-en-Y gastric bypass&#59; BPD&#47;DS&#44; biliopancreatic diversion with duodenal switch&#59; SG&#44; sleeve gastrectomy&#46;</p>"
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">SF36 questionnaire&#46; QoL scores evaluated by the SF36 questionnaire after different bariatric surgical procedures&#46; QoL&#44; Quality of life&#59; RYGB&#44; Roux-en-Y gastric bypass&#59; BPD&#47;DS&#44; biliopancreatic diversion with duodenal switch&#59; SG&#44; sleeve gastrectomy&#46;</p>"
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        "mostrarFloat" => true
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        "figura" => array:1 [
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          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">SF36 questionnaire&#46; Percentage of patients with altered results compared with the QoL scores reported for the Spanish general population&#46; QoL&#44; Quality of life&#59; RYGB&#44; Roux-en-Y gastric bypass&#59; BPD&#47;DS&#44; biliopancreatic diversion with duodenal switch&#59; SG&#44; sleeve gastrectomy&#46;</p>"
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        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
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        "figura" => array:1 [
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">GIQLI questionnaire&#46; Percentage of patients with altered results compared with the QoL scores reported for the Spanish general population&#46; GIQLI&#44; Gastrointestinal quality of life index&#59; QoL&#44; quality of life&#59; RYGB&#44; Roux-en-Y gastric bypass&#59; BPD&#47;DS&#44; biliopancreatic diversion with duodenal switch&#59; SG&#44; sleeve gastrectomy&#46;</p>"
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">RYGB&#44; Roux-en-Y gastric bypass&#59; BDP&#47;DS&#44; biliopancreatic diversion with duodenal switch&#59; SG&#44; sleeve gastrectomy&#59; BMI&#44; body max index&#59; OSAS&#44; obstructive sleep apnea syndrome&#46;</p>"
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">RYGB<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>36&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> value&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">51&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;&nbsp;\t\t\t\t\t\t\n
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                  <table border="0" frame="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">BPD&#47;DS<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SG<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Abdominal pain</span>no&#46; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;22&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;22&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;17&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Abdominal distension</span>no&#46; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34 &#40;35&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;43&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Postprandial fullness</span>no&#46; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">21 &#40;58&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;58&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;65&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Early satiety</span>no&#46; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90 &#40;94&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;97&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;86&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Gas bloating</span>no&#46; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69 &#40;72&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;80&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;56&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Flatulence</span>no&#46; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46 &#40;48&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;47&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;44&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;56&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Psychological disturbances</span>no&#46; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">39 &#40;41&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;27&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;38&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">15 &#40;65&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;02&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">RYGB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">BPD&#47;DS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gastrointestinal symptoms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Physical function&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Emotional function&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Social function&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Medical treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">112&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">101<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">QoL scores &#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41; evaluated by the GIQLI after RYGB&#44; BPD&#47;DS and SG&#46;</p>"
        ]
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      8 => array:8 [
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        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
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            "detalle" => "Table "
            "rol" => "short"
          ]
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">QoL&#44; quality of life&#59; GIQLI&#44; gastrointestinal quality of life index&#59; BMI&#44; body max index&#59; EBMIL&#44; excess body max index loss&#59; GI&#44; gastrointestinal&#46;</p>"
          "tablatextoimagen" => array:1 [
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                0 => """
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SF-36&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> value&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> value&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">&#37;EBMIL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;232&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;279&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#60;0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Psichological disturbances&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#8722;0&#46;269&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;292&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Abdominal pain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;171&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Abdominal distention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;0&#46;264&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Postprandial fullness&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Pearson&#39;s correlation between QoL&#44; as evaluated by the SF-36 questionnaire and GIQLI&#44; and loss of BMI excess &#40;&#37;EBMIL&#41;&#44; psychological disturbances and GI symptoms after bariatric surgery&#46;</p>"
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos